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Investigations on Bio-mineralization of reduced graphene oxide aerogel in thepresence of various polymers

Materials Today: Proceedings 2019年 9卷 389-396页

作者： S. Asha G. Vanitha Kumar A. Nimrodh Ananth Sujin.P. Jose M.A. Jothi Rajan Bio-Nano Laboratory PG and Research Department of physics Arul Anandar College Madurai India MOE Key Laboratory for Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University PR China School of Physics Madurai Kamaraj University Madurai 625 024 India

Reduced graphene oxide (RGO) based light weight aerogel scaffolds were prepared using a simple hydrothermal method with ascorbic acid as a reducing agent. Hydroxyapatite was biomimetically mineralized on the surface of these scaffolds by soaking RGO aerogels in simulated body fluid which consists of calcium and phosphorous precursors. The biomimetic mineralization of these samples was also studied after functionalizing RGO aerogelwith various biocompatible polymerssuch as collagen, chitosan and poly-L-glutamic acid. The influence of these polymers towards mineralization were studied using various characterization methods. It was observed that polymer functionalized RGO aerogel exhibited increased rate of mineralization due to the presence of more functional groups which aids in mineralization and growth of apatite. Thus, mineralized spherical apatite was found to be uniformly assembled on the surface and the interior of the aerogel. The electrical properties of these samples were studied using a source meter and the electrical conductivity of these samples varied depending upon the functionalized polymers.

关键词： Reduced graphene oxide Biomineralization Polymers Simulated body fluid Hydroxyapatite

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Author Correction: Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression

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Nature chemical biology 2024年第11期20卷 1547页

作者： Min Li Zheng Wang Jingjing Tao Hongfei Jiang Huang Yang Dong Guo Hong Zhao Xuxiao He Shudi Luo Xiaoming Jiang Li Yuan Liwei Xiao Haiyan He Rilei Yu Jing Fang Tingbo Liang Zhengwei Mao Daqian Xu Zhimin Lu Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated Hospital and Institute of Translational Medicine Zhejiang University School of Medicine Zhejiang University Hangzhou China. Cancer Center Zhejiang University Hangzhou China. The Affiliated Hospital of Qingdao University and Qingdao Cancer Institute Qingdao China. MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou China. Key Laboratory of Marine Drugs Chinese Ministry of Education School of Medicine and Pharmacy Ocean University of China Qingdao China. Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated Hospital and Institute of Translational Medicine Zhejiang University School of Medicine Zhejiang University Hangzhou China. xudaqian@***. Cancer Center Zhejiang University Hangzhou China. xudaqian@***. Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated Hospital and Institute of Translational Medicine Zhejiang University School of Medicine Zhejiang University Hangzhou China. zhiminlu@***. Cancer Center Zhejiang University Hangzhou China. zhiminlu@***.

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Nanostructured Polyelectrolyte-surfactant Complex Pervaporation Membranes for Ethanol Recovery:the Relationship between the Membrane Structure and Separation Performance

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Chinese Journal of Polymer Science 2018年第1期36卷 25-33页

作者： Pei-Yao Zheng Ping Zhang Zhi-Wei Sun Chen-Hui Zhu Quan-Fu An Ministry of Education Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science&EngineeringZhejiang UniversityHangzhou 310027China Materials Science Division of Lawrence Berkeley National Laboratory BerkeleyCA 94720USA Advanced Light Source Lawrence Berkeley National LaboratoryBerkeleyCA94720USA Beijing Key Laboratory for Green Catalysis and Separation College of Environmental and Energy EngineeringBeijing University of TechnologyBeijing100124China

Polyelectrolyte-surfactant complexes（PESCs） were fabricated through the interaction of poly（acrylic acid） and four different cationic surfactants or their mixtures. PESC membranes were prepared by solution casting method and were applied in ethanol recovery from aqueous solution via pervaporation. Elemental analysis（EA）, Fourier transform infrared spectroscopy（FTIR）, water contact angle（CA） measurement, differential scanning calorimetry（DSC） and X-ray scattering were employed to characterize the composition, structure and properties of PESCs. The results reveal that the investigated PESCs are similar in hydrophobicity but different in hierarchical nanostructures. In separating 5 wt% ethanol/water mixture, PESC membranes with high crystallinity will have both low flux and ethanol selectivity because of the high packing density and low permeability of crystalline regions. Meanwhile, the hierarchical nanostructures of PESC membranes change under pervaporation environment as was revealed by in situ synchrotron radiation X-ray scattering measurement. That is, the crystalline region could melt at high temperature in swelling state, thus consequently enhancing the ethanol selectivity.

关键词： Polyelectrolyte-surfactant complex Pervaporation Ethanol recovery Crystallinity

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Negatively Curved Octagon-Incorporated Aza-nanographene and its Assembly with Fullerenes

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Angewandte Chemie 2024年第15期136卷

作者： Jun Liu Juan Hong Zhenxing Liao Dr. Jingyun Tan Haoliang Liu Dr. Evgenia Dmitrieva Long Zhou Dr. Jie Ren Prof. Xiao-Yu Cao Dr. Alexey A. Popov Prof. Yingping Zou Prof. Akimitsu Narita Prof. Yunbin Hu College of Chemistry and Chemical Engineering Central South University 410083 Changsha China These authors contributed equally to this work Organic and Carbon Nanomaterials Unit Okinawa Institute of Science and Technology Graduate University 1919-1 Tancha Onna-son Kunigami-gun Okinawa 904-0495 Japan Department of Chemistry and Chemical Engineering Xiamen University 361005 Xiamen China Center of Spectroelectrochemistry Leibniz Institute for Solid State and Materials Research Helmholtzstrasse 20 01069 Dresden Germany MOE Key Laboratory of Macromolecular Synthesis and Functionalization International Research Center for X Polymers Department of Polymer Science and Engineering Zhejiang University 310027 Hangzhou China

A negatively curved aza-nanographene (NG) containing two octagons was synthesized by a regioselective and stepwise cyclodehydrogenation procedure, in which a double aza[7]helicene was simultaneously formed as an intermediate. Their saddle-shaped structures with negative curvature were unambiguously confirmed by X-ray crystallography, thereby enabling the exploration of the structure–property relationship by photophysical, electrochemical and conformational studies. Moreover, the assembly of the octagon-embedded aza-NG with fullerenes was probed by fluorescence spectral titration, with record-high binding constants ( K a =9.5×10 3 M −1 with C 60 , K a =3.7×10 4 M −1 with C 70 ) found among reported negatively curved polycyclic aromatic compounds. The tight association of aza-NG with C 60 was further elucidated by X-ray diffraction analysis of their co-crystal, which showed the formation of a 1 : 1 complex with substantial concave-convex interactions.

关键词： Nanographenes Helicenes Negative Curvature Fullerene Hosts Chiroptical Properties

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Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesion

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Science China Chemistry 2018年第1期61卷 54-63页

作者： Haolan Zhang Danyu Wang Xue Lin Nikolaos Politakos Jimena S. Tuninetti Sergio Enrique Moya Changyou Gao Key Laboratory of Macromolecular Synthesis and Functionalization Ministry of Education Department of Polymer Science and Engineering Zhej iang University Hangzhou 310027 China Centre for Cooperative Research in Biomaterials San Sebastian 20009 Gipuzkoa Spain Dr. Li Dak Sum & Iqp Chin Center for Stem Cell and Regenerative Medicine Zhejiang University Hangzhou 310058 China

Multilayers incorporated with stimuli-responsive substances by means of layer-by-layer(LbL) self-assembly are much attractive due to their advantages of stimuli-responsiveness and potential applications in different fields. In this study, pyrenemethyl acrylate(PA) was synthesized, and was copolymerized with acrylic acid(AA) to obtain the amphiphilic and photodegradable P(PA-co-AA)polymers with a PA:AA molar ratio of 1.3:3, and an average molecular weight of 6.9 kDa and polydispersity index of 1.04. They formed micelles spontaneously when dispersed in aqueous solution with a size of 27.5 nm in a dry state and 136.6 nm in a wet state. The micelles were readily decomposed to form aggregates as a result of the cleavage of the pyrenemethyl ester bonds under UV-irradiation. UV-responsive micelles-containing multilayers were prepared by LbL self-assembly of the UV-responsive micelles and polyallylamine hydrochloride(PAH). UV-irradiation of the multilayers resulted in the decomposition of micelles, leading to larger surface roughness, and enhanced swelling ratio and wettability of the multilayers. In vitro culture of A549, HepG2 and endothelial cells showed significantly better adhesion at 4 h on the UV-illuminated multilayers, whereas the cell proliferation was not affected significantly until 5 d.

关键词： biomaterials multilayers surfaces photo-responsive cell adhesion

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Corrigendum to “Supramolecular hydrogel-loaded Prussian blue nanoparticles with photothermal and ROS scavenging ability for tumor postoperative treatments” [Compos Part B: Eng, 237 (2022) 1–11 109872]

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Composites Part B: Engineering 2025年 292卷

作者： Zongrui Tong Quanshi Guo Guangyu Xu Yong Gao Huang Yang Yuan Ding Weilin Wang Zhengwei Mao Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310009 PR China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 PR China Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province Hangzhou Zhejiang 310009 PR China Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province Clinical Research Center of Hepatobiliary and Pancreatic Diseases of Zhejiang Province Hangzhou Zhejiang 310009 PR China Clinical Medicine Innovation Center of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Disease of Zhejiang University Hangzhou Zhejiang PR China Clinical Research Center of Hepatobiliary and Pancreatic Diseases of Zhejiang Province Hangzhou Zhejiang 310009 PR China

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Amphiphilic Seven-arm Star Triblock Copolymers with Diverse Morphologies in Aqueous Solution Induced by Crystallization and pH

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Chemical Research in Chinese Universities 2018年第1期34卷 132-137页

作者： SUN Rui WANG Ying GOU Pengfei ZUO Min LI Xiaodong ZHU Weipu SHEN Zhiquan Department of Oral and Maxillofacial Surgery Affiliated Stomatology Hospital College of Medicine Zhejiang University Hangzhou 310006 P. R. China Key Laboratory of Macromolecular Synthesis and Functionalization Ministry of EducationDepartment of Polymer Science and Engineering Zhejiang University Hangzhou 310027 P. R. China

Well-defined amphiphilic seven-arm star triblock copolymers containing hydrophobic crystalline poly（e-caprolactoneXPCL） blocks, hydrophobic non-crystalline poly（tert-butyl acrylate）（PtBA） blocks and hydrophilic poly（ethylene glycol）（PEG） blocks were precisely synthesized by a combination of ring-opening polymerization（ROP）, atom transfer radical polymerization（ATRP） and ＂click＂ reaction. Such star copolymers could self-assemble into ＂core-shell-corona＂ micelles and ＂multi-layer＂ vesicles depending on the fraction of each block. Meanwhile, the selective hydrolysis of middle PtBA blocks into the poly（acrylic acidXPAA） blocks allowed the star block copolymers to further change their morphologies of aqueous aggregates m response to pH values.

关键词： Amphiphile Crystallization Hydrolysis Self-assembly Star block copolymer

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Unique therapeutic potentialities of exosomes based nanodrug carriers to target tumor microenvironment in cancer therapy

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OpenNano 2022年 8卷

作者： Khan, Safir Ullah Khan, Munir Ullah Gao, Yanyan Khan, Muhammad Imran Puswal, Sabah Mushtaq Zubair, Muhammad Khan, Muhammad Ammar Farwa, Rahat Gao, Shuang Ali, Rizwan Hussain, Nazim Hefei National Laboratory for Physical Sciences at the Microscale School of Life Sciences University of Science and Technology of China Hefei 230027 China MOE Key Laboratory of Macromolecular Synthesis and Functionalization International Research Center for X Polymers Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China Anhui Tianlun Infertility Hospital Hefei Hefei China School of Life Sciences and Medicine University of Science and Technology of China Hefei 230027 China Hefei National Laboratory for Physical Sciences at the Microscale and Centre for Biomedical Imaging University of Science and Technology of China Hefei 230027 China Department of Pathology District Headquarters Hospital Punjab Province Jhang 35200 Pakistan Gastroenterology and Hepatology Unit Department of Medicine District Headquarters Hospital Punjab Province Jhang 35200 Pakistan Department of Gynecology and Obstetrics District Headquarters Hospital Punjab Province Jhang 35200 Pakistan Centre for Applied Molecular Biology (CAMB) University of the Punjab Quaid-e-Azam Campus Lahore 54000 Pakistan

Cancer is a complex syndrome with a high mortality rate worldwide due to the lack of effective treatments. The lack of effective coordination between tumor cells and immune system components may be an important reason for the failure of tumor cells to be successfully eliminated after treatment. Tumor microenvironment (TME) barriers hinder the entry and dispersion of nanotherapeutic medicines in tumors. Extracellular vesicles (EVs) are membrane-bound structures responsible for cell-to-cell coordination and carry different biomolecules responsible for physiological and pathological communication between cells. Their role has been a mystery for decades, and over the past two decades, their structure and content have revealed some amazing *** studies have shown that exosomes play a key role in intercellular communication during the pathogenesis of diseases such as cancer and are responsible for cancer proliferation and metastasis. Inspired by the structure of their endogenous lipid membranes, researchers have tried to mimic their fine structure in the laboratory and tried to load certain biological and chemical drugs. Therefore, exosomes have received particular attention in nanotechnology, and these lipid polymeric micelles have emerged as potential candidates for nanocarriers in nanotechnology to overcome various obstacles in targeted drug delivery. In view of the importance of exosomes, this review highlights the potential of exosomes for use in nanodrug-based medication delivery. The majority of the investigation in these fields has not yet moved out of the laboratory. It will take a lot of time and work to implement these experimental findings in clinical settings. © 2022

关键词： Cancer Exosome Hybridization Polymeric micelles Targeted drug delivery Tumor microenvironment

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Interfacial Polymerization at the Alkane/Ionic Liquid Interface

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Angewandte Chemie 2021年第26期133卷

作者： Chang Liu Dr. Jing Yang Bian-Bian Guo Prof. Seema Agarwal Prof. Andreas Greiner Prof. Zhi-Kang Xu MOE Key Laboratory of Macromolecular Synthesis and Functionalization Key Laboratory of Adsorption and Separation Materials & Technologies of Zhejiang Province Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China College of Material Chemistry and Chemical Engineering Hangzhou Normal University Hangzhou 310036 China Macromolecular Chemistry and Bavarian Polymer Institute University of Bayreuth Universitatsstrasse 30 95440 Bayreuth Germany College of Chemical and Biological Engineering Zhejiang University Hangzhou 310027 China

Polymerization at the liquid–liquid interface has attracted much attention for synthesizing ultrathin polymer films for molecular sieving. However, it remains a major challenge to conduct this process outside the alkane–water interface since it not only suffers water-caused side reactions but also is limited to water-soluble monomers. Here, we report the interfacial polymerization at the alkane/ionic liquid interface (IP@AILI) where the ionic liquid acts as the universal solvent for diversified amines to synthesize task-specific polyamide nanofilms. We propose that IP@AILI occurs when acyl chloride diffuses from the alkane into the ionic liquid instead of being triggered by the diffusion of amines as in the conventional alkane–water system, which is demonstrated by thermodynamic partitioning and kinetic monitoring. The prepared polyamide nanofilms with precisely adjustable pore sizes display unprecedented permeability and selectivity in various separation processes.

关键词： interfacial polymerization ionic liquids membranes nanofilms polyamides

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Aggregation-induced emission: right there shining

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Science China Materials 2019年第9期62卷 1227-1235页

作者： Nan Jiang Tanxiao Shen Jing Zhi Sun Ben Zhong Tang MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China Department of Chemistry the Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced Study The Hong Kong University of Science and Technology Hong Kong 999077 China Center for Aggregation-Induced Emission SCUT-HKUST Joint Research Institute State Key Laboratory of Luminescent Materials and Devices South China University of Technology Guangzhou 510640 China

The emergence of fluorescent probes has enabled researchers to find and observe invisible matter from the investigated object without light emitting. For example, green fluorescent protein (GFP), an invention that received the Nobel Prize for Chemistry in 2008, works as a visible fluorescent reporter to monitor the localization and movement of protein-GFP chimeras, protein-protein interactions, gene expression, and many other biological events in living cells in real time. GFP and its analogs have innovated research techniques and features in biological and life sciences.

关键词：发光荧光探针分子溶胶-凝胶转变玻璃化转变温度分子聚集高分子链壳聚糖溶液溶剂效应

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