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Engineered thumbtack needle for augmented acupuncture therapy

Cell Biomaterials 2025年第1期1卷

作者： Ruisi Cai Sheng Zhao Ziyi Lu Jiahuan You Hao Wang Anni Xie Shiqi Wang Quanquan Han Ying Zhang Jicheng Yu Bo Chen Chunhai Fan Zhen Gu Yuqi Zhang State Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang Provincial Key Laboratory for Advanced Drug Delivery Systems College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China Department of General Surgery Sir Run-Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China Department of Hematology First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Jinhua Institute of Zhejiang University Jinhua 321299 China Department of Burns and Wound Care Center Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China Liangzhu Laboratory Zhejiang University Hangzhou 311121 China School of Acupuncture-Moxibustion and Tuina Tianjin University of Traditional Chinese Medicine Tianjin 301617 China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300381 China School of Chemistry and Chemical Engineering New Cornerstone Science Laboratory Frontiers Science Center for Transformative Molecules Zhangjiang Institute for Advanced Study and National Center for Translational Medicine Shanghai Jiao Tong University Shanghai 200240 China Institute of Molecular Medicine Shanghai Key Laboratory for Nucleic Acids Chemistry and Nanomedicine Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China

Acupuncture has been widely employed for treating chronic illnesses. In this work, a thumbtack needle patch is engineered with medication for transdermal drug delivery and sustained transdermal stimulation, augmenting the therapeutic effect of acupuncture therapy. The surface of the titanium needle is modified with porous nanotubes and/or assembled coatings to achieve sufficient loading of liraglutide (LRT) and diclofenac diethylamine (DDA), respectively. The LRT-loaded thumbtack needle declines the plasma glucose levels of type 2 diabetic mice to normoglycemia and reduces the insulin resistance index to ∼48.5 after daily treatment for 5 weeks, showing a significant improvement in efficiency compared with daily subcutaneously LRT injected group (∼117.6). Moreover, in an osteoarthritis (OA) rat model, the thumbtack needle loaded with DDA effectively alleviates pain hypersensitivity and reduces joint inflammation during 4 weeks of treatment. Both customized thumbtack needles have demonstrated pronounced therapeutic effects and desired biological safety in animal disease models.

关键词： drug delivery transdermal stimulation thumbtack needle chronic diseases

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The rheological behavior of carbon black filled natural rubber

The rheological behavior of carbon black filled natural rubb...

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中国化学会第12届复杂流体流变学学术研讨会

作者： Zhongjia Xu YH Song Qiang Zheng MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang University

The research on the mechanisms of reinforcement and nonlinear viscoelastic responses is an important foundation for China's rubber industry to move towards high-end and fine ***,the reinforcement mechanism has been in great dispute *** researchers tend to pay more attention to influence of filler network and interface effect on viscoelastic behavior of filled vulcanizates,the contribution of the rubber phase especially its filler loading-interfered viscoelasticity to the reinforcement and nonlinearity is usually *** the same time,the relationship between the matrix relaxation and the rheological behavior of the vulcanizates is still lack of a systematic *** herein prepare a series of carbon black filled natural rubber(CB/NR) vulcanizates with varying CB concentrations and crosslinking densities to investigate the *** results show that the vulcanizates have good modulus recovery properties while increasing CB concentration and crosslinking density tend to shorten the strain amplitude of the linear viscoelasticity ***,the CB concentration and crosslinking density have a synergistic effect on rubber reinforcement.

关键词： carbon black filled nature rubber vulcanizates nonlinear viscoelasticity

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CO2-BASED FLUORESCENT POLYMERS

CO2-BASED FLUORESCENT POLYMERS

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第八届高分子化学国际学术研讨会

作者： Xing-Hong Zhang Department of Polymer Science and Engineering MOE Key Laboratory of Macromolecular Synthesis and Functionalization Zhejiang University

The carbon dioxide（CO）is an abundant,low-cost,and renewable one-carbon（C1）*** CO into polymer is a promising path to green and sustainable *** copolymerization and coupling reaction of CO with epoxide are the comm... 详细信息

关键词： CO2-BASED FLUORESCENT POLYMERS

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Donor-acceptor(D-A)terpolymers based on alkyl-DPP and t-BocDPP moieties for polymer solar cells

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Chinese Chemical Letters 2017年第12期28卷 2223-2226页

作者： Fateh Ullah Sun Qian Weitao Yang Muhammad Naeem Shah Zhongqiang Zhang Hongzheng Chen Chang-Zhi Li MOE Key Laboratory of Macromolecular Synthesis and Functionalization State Key Laboratory of Silicon MaterialsDepartment of Polymer Science andEngineeringZhejiang UniversityHangzhou 310027China

A series of low band gap terpolymers based on 4,8-bis（5-（2-ethylhexyl）thiophen-2-yl）benzo[l,2-b：4,5- b＇]dithiophene （BDTr） and diketopyrrolopyrrole （DPP） with varied solubilizing groups （i.e., tert- butoxycarbonyl, t-Boc and 2-octyldodecyl） are developed as electron donors for bulk heterojunction （BHJ） polymer solar cells （PSCs）. The results reveal that the one with 50% t-Boc concentration （P3） performs better than the other terpolymers used in this study in conventional PSC devices with a power conversion efficiency of 2.92%.

关键词： Conjugated polymerOrganic semiconductorPolymer solar cellsBulk heterojunctionDiketopyrrolopyrrole

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In situ assembly of fibrinogen/hyaluronic acid hydrogel via knob-hole interaction for 3D cellular engineering

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Bioactive Materials 2017年第4期2卷 253-259页

作者： Shengjie Huang Chunfen Wang Jingwei Xu Lie Ma Changyou Gao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China

Hyaluronic acid(HA)-based hydrogels have applied widely for biomedical applications due to its biocompatibility and ***,the use of initiators or crosslinkers during the hydrogel formation may cause cytotoxicity and thereby impair the *** by the crosslinking mechanism of fibrin gel,a novel HA-based hydrogel was developed via the in situ supramolecular assembly based on knob-hole interactions between fibrinogen and knob-grafted HA(knob-g-HA)in this *** knob-grafted HA was synthesized by coupling knob peptides(GPRPAAC,a mimic peptide of fibrin knob A)to HA via Michael *** the translucent fibrinogen/knob-g-HA hydrogels were prepared by simply mixing the solutions of knob-g-HA and fibrinogen at the knob/hole ratio of *** rheological behaviors of the fibrinogen/knob-g-HA hydrogels with the fibrinogen concentrations of 50,100 and 200 mg/mL were evaluated,and it was found that the dynamic storage moduli(G0)were higher than the loss moduli(G00)over the whole frequency range for all the *** SEM results showed that fibrinogen/knob-g-HA hydrogels presented the heterogeneous mesh-like structures which were different from the honeycomb-like structures of fibrinogen/MA-HA ***,a higher swelling ratio was obtained in the groups of fibrinogen/knob-g-HA ***,the cytocompatibility of fibrinogen/knob-g-HA hydrogels was proved by live/dead stainings and MTT assays in the 293T cells encapsulation *** these results highlight the biological potential of the fibrinogen/knob-g-HA hydrogels for 3D cellular engineering.

关键词： Fibrinogen Knob-hole interactions Hyaluronic acid In situ assembly Cell encapsulation

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Author Correction: Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases

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Nature communications 2024年第1期15卷 9624页

作者： Tengfei Liu Bowen Xiao Fei Xiang Jianglin Tan Zhuo Chen Xiaorong Zhang Chengzhou Wu Zhengwei Mao Gaoxing Luo Xiaoyuan Chen Jun Deng Institute of Burn Research Southwest Hospital State Key Lab of Trauma Burn and Combined Injury Chongqing Key Laboratory for Disease Proteomics Third Military Medical University (Army Medical University) 400038 Chongqing China. Department of Endocrinology Southwest Hospital Third Military Medical University (Army Medical University) 400038 Chongqing China. Department of Respiratory Care Wuxi County People's Hospital 405800 Chongqing China. Institute of Burn Research Southwest Hospital State Key Lab of Trauma Burn and Combined Injury Chongqing Key Laboratory for Disease Proteomics Third Military Medical University (Army Medical University) 400038 Chongqing China. zwmao@***. MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University 310027 Hangzhou China. zwmao@***. Institute of Burn Research Southwest Hospital State Key Lab of Trauma Burn and Combined Injury Chongqing Key Laboratory for Disease Proteomics Third Military Medical University (Army Medical University) 400038 Chongqing China. logxw@***. Laboratory of Molecular Imaging and Nanomedicine National Institute of Biomedical Imaging and Bioengineering National Institutes of Health Bethesda MD 20892 USA. shawn.chen@nih.gov. Institute of Burn Research Southwest Hospital State Key Lab of Trauma Burn and Combined Injury Chongqing Key Laboratory for Disease Proteomics Third Military Medical University (Army Medical University) 400038 Chongqing China. djun.123@***.

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Tough Polyion Complex Hydrogel Films of Natural Polysaccharides

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Chinese Journal of Polymer Science 2017年第10期35卷 1276-1285页

作者： Feng-bo Zhu Hai-chao Yu Wen-xi Lei Ke-feng Ren Jin Qian 吴子良 Qiang Zheng Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Department of Engineering Mechanics Zhejiang University Ministry of Education Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University

The developments of tough hydrogels in recent years have greatly expanded the applications of hydrogels as structural materials. However, most of the tough hydrogels are made of synthetic polymers. To develop biopolymer-based tough hydrogels has both fundamental and practical significances. Here we report a series of polysaccharides-based tough hydrogel films prepared by polyion complexation and solvent evaporation of chondroitin sulfate（CS） and protonated chitosan（CHT） solutions with different weight ratios. The obtained CS/CHT gel films with thickness of 40-80 μm and water content of 66 wt%-81 wt% possess excellent mechanical properties, with tensile breaking stress and breaking strain being 0.4-3 MPa and 160%-320%, respectively. We found that in the mixture solutions there are large amounts of excess CHT in terms of charges; after swelling the films in water, the acetic acid, which is used to protonate the amino groups of CHT, diffuses out of the gel matrix, enhancing the intermolecular interactions between CHT molecules and thus improving the mechanical properties of gel films, besides the ionic bonds between CS and CHT. Antimicrobial tests also showed that the gel films with low weight ratio of CS to CHT, corresponding to the case with excess CHT, have evident antimicrobial effect. These CS/CHT gel films with good mechanical properties and antimicrobial effect should extend the applications of hydrogels in biomedical fields.

关键词： responsive polymerization methacrylate acrylamide hydrophilic reversible dissipation AMPS toughness swelling

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A Hybrid Supramolecular Polymeric Nanomedicine for Cascade-Amplified Synergetic Cancer Therapy

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Angewandte Chemie 2022年第27期134卷

作者： Kai Yang Dr. Shaolong Qi Dr. Xinyang Yu Dr. Bing Bai Xueyan Zhang Prof. Dr. Zhengwei Mao Prof. Dr. Feihe Huang Prof. Dr. Guocan Yu Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology Department of Chemistry Tsinghua University Beijing 100084 P. R. China State Key Laboratory of Chemical Engineering Stoddart Institute of Molecular Science Department of Chemistry Zhejiang University Hangzhou 310027 P. R. China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 311215 P. R. China Green Catalysis Center and College of Chemistry Zhengzhou University Zhengzhou 450001 P. R. China Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province the Second Affiliated Hospital School of Medicine MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou Zhejiang 310027 P. R. China

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Visualizing the toughening origins of gel-grown calcite single-crystal composites

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Chinese Chemical Letters 2018年第11期29卷 1666-1670页

作者： Yujing Liu Kai He Wentao Yuan Xinyi Jin Tao Liang Yong Wang Huolin L. Xin Hongzheng Chen Chao Gao Hanying Li MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China Center for Functional Nanomaterials Brookhaven National Laboratory Upton NY 11973 United States State Key Laboratory of Silicon Materials Zhejiang University Hangzhou 310027 China Center of Electron Microscopy Department of Materials Science and Engineering Zhejiang University Hangzhou 310027 China Department of Materials Science and Engineering，Northwestern University，Evanston 60208，United States

Biogenic single crystals have been widely demonstrated to incorporate macromolecules to achieve extra damage tolerance, spurring investigations on their synthetic analogs with enhanced mechanical properties as well as the enhancement mechanism（s） behind. And the investigations rely on both rational design of the single-crystal composites and, equally importantly, nanoscale and in-situ characterization strategy. Here, composite structures are constructed inside the calcite single-crystal host by incorporating guest materials of agarose fibers, multi-walled carbon nanotubes （MWCNTs）, and graphene oxide （GO）, through crystallization in agarose gel media. Further, transmission electron microscopy-scanning probe microscopy （TEM-SPM） method, coupling compression measurements with nanoscale imaging, shows that the obtained single-crystal composites exhibit improved toughness, compared to the solution-grown pure single crystals. Particularly, the rupture time increases by 1.25 times after the gel-networks and MWCNTs are incorporated. More importantly, the in-situ observation of the crystal deformation suggests that the guest incorporation toughens the single-crystal host by the shielding effect of nanofiber on crack-bridging at nanoscale. As such, this work may have implications for understanding the damage tolerance of biominerals as well as towards the development of new mechanically reinforced single-crystal composite materials.

关键词： Biomineralization Composite single-crystal Gel-grown Calcite Carbon nanotube Graphene oxide Toughening

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Understanding the Reinforcement and Dissipation of Natural Rubber Compounds Filled with Hybrid Filler Composed of Carbon Black and Silica

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Chinese Journal of Polymer Science 2017年第11期35卷 1436-1446页

作者：宋义虎 Ling-bin Zeng Qiang Zheng Ministry of Education Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Key Laboratory of Adsorption and Separation Materials & Technologies of Zhejiang ProvinceZhejiang University Shanghai Aerospace System Engineering Institute

The performance of reinforced rubber compounds depends on the filler composition while the reinforcement and dissipation mechanisms still remain unclear. Herein linear and nonlinear dynamic rheological responses of carbon black/silica hybrid filler filling nature rubber compounds are investigated. The rheological contributions of dynamically retarded bulk phase and filler network are revealed to be crucial at high and low frequencies, respectively, and the bulk phase is shown to be of vital importance for the occurrence of nonlinear Payne effect at mediate frequencies. A framework for simultaneously solving reinforcement and dissipation varying with filler composition and content is suggested, providing a new perspective in understanding the filling effect for manufacturing high-performance rubber materials.

关键词： Filling Reinforcement Dissipation Rubber compounds Time-concentration superpositioning principle

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