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A-DA’D-A Type Pentacyclic Small Molecule Acceptors to Exceed 16.5%Efficiency by Heteroatom Effect at the Outer Side Chain

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Chinese Journal of Chemistry 2023年第15期41卷 1815-1822页

作者： Shaofeng Zhu Changzhou Shi Qingya Wei Can Zhu Jie Ren Jianghua Li Lei Meng Yongfang Li Jun Yuan Yingping Zou State Key Laboratory of Powder Metallurgy College of Chemistry and Chemical EngineeringCentral South UniversityChangshaHunan 410083China Beiing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China. MOE Key Laboratory of Macromolecular Synthesis and Functionalization International Research Center for X PolymersDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhouZhejiang 310027China

Comprehensive Summary In this work,we adopt a“heteroatom side-chains”modification strategy to modify the thiophene units in A-DA'D-A(acceptor-donor-acceptor’-donor-acceptor)type pentacyclic SMAs(small molecule acceptors),that is,introducing branched alkyl chain at theβ-position of thiophene instead of straight alkyl chain,and then introducing oxygen atom at the third-position on the basis of branched *** new pentacyclic SMAs(BZ4F-EH and BZ4F-OEH)were synthesized,and the influence of the heteroatom side-chains on photoelectric properties of A-DA'D-A type pentacyclic SMAs was systematically *** with our previously reported BZ4F(Y26),BZ4F-EH shows slightly blue-shifted absorption,while BZ4F-OEH has obvious red-shifted *** a result,BZ4F-OEH-based binary device achieved a high power conversion efficiency(PCE)of 16.56%with a fill factor(FF)of 79.3%,which is the highest efficiency of pentacyclic SMAs to date.

关键词： Organic solar cells Small molecule acceptors A-DA'D-A type structure Heteroatom side chains Substituent effects

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C-176 loaded Ce DNase nanoparticles synergistically inhibit the cGAS-STING pathway for ischemic stroke treatment

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Bioactive Materials 2023年第11期29卷 230-240页

作者： Zhixin Zhu Haipeng Lu Lulu Jin Yong Gao Zhefeng Qian Pan Lu Weijun Tong Pik Kwan Lo Zhengwei Mao Haifei Shi Department of Orthopedics 1st Affiliated Hospital of Zhejiang University School of MedicineQingchun Road 79Hangzhou31000China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China Department of Chemistry and State Key Laboratory of Marine Pollution City University of Hong KongTat Chee AvenueKowloonHong Kong

The neuroinflammatory responses following ischemic stroke cause irreversible nerve cell *** free-double strand DNA(dsDNA)segments from ischemic tissue debris are engulfed by microglia and sensed by their cyclic GMP-AMP synthase(cGAS),which triggers robust activation of the innate immune stimulator of interferon genes(STING)pathway and initiate the chronic inflammatory *** decomposition of immunogenic dsDNA and inhibition of the innate immune STING are synergistic immunologic targets for ameliorating *** combine the anti-inflammatory strategies of STING inhibition and dsDNA elimination,we constructed a DNase-mimetic artificial enzyme loaded with *** are self-assembled by amphiphilic copolymers(P[CL35-b-(OEGMA20.7-co-NTAMA14.3)]),C-176,and Ce^(4+)which is coordinated with nitrilotriacetic acid(NTA)group to form corresponding catalytic *** work developed a new nano-drug that balances the cGAS-STING axis to enhance the therapeutic impact of stroke by combining the DNase-memetic Ce^(4+)enzyme and STING inhibitor *** conclusion,it is a novel approach to modulating central nervus system(CNS)inflammatory signaling pathways and improving stroke prognosis.

关键词： Ischemic stroke Ce-based nano-nuclease The cGAS-STING signaling pathway Anti-inflammation

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Light-driven Self-sustained Rolling of Cylinder Hydrogels with Fast and Anisotropic Responses

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Chinese Journal of Polymer Science 2025年第4期43卷 548-555页

作者： Qing-Li Zhu Han-Lei Cheng Wei-Xuan Liu Yin-Bin Xiao Xin-Lei Wu Josef Breu Wei Hong Zhi-Jian Wang Qiang Zheng Zi-Liang Wu Ministry of Education Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310058China Department of Mechanics and Aerospace Engineering Southern University of Science and TechnologyShenzhen518055China Bavarian Polymer Institute and Department of Chemistry University of BayreuthUniversitätsstrasse 3095440BayreuthGermany Institute for Chemical Reaction Design and Discovery Hokkaido UniversitySapporo001-0021Japan

Achieving continuous motions typically requires dynamic external stimuli for cyclic deformation,or crafted geometries with intricate modules to form a self-regulated feedback loop upon static *** is still a grand challenge to realize self-sustained motion in soft robots subject to unchanging environment,without complex geometry or a control *** this work,we report soft robots based on an anisotropic cylindrical hydrogel showing self-regulated,continuous rolling motions under constant light *** robots are animated by mirror-symmetry-breaking induced by photothermal strain *** self-sustained motion is attributed to the fast and reversible deformation of the gel and the autonomous refresh of the irradiated region during the rolling *** hydrogel robots can reach a rolling speed of 1.27 mm·s^(-1)on a horizonal surface and even climb a ramp of 18°at a speed of 0.57 mm·s^(-1)in an aqueous ***,the hydrogel robots can overcome an obstacle,with rolling direction controllable through irradiation angle of the light and local irradiation on selective *** work suggests a facile strategy to develop hydrogel robots and may provide unforeseen inspirations for the design of self-regulated soft robots by using other intelligent materials.

关键词： Self-sustained motions Light-driven Rolling Anisotropic hydrogels Soft robots

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A tough,antibacterial and antioxidant hydrogel dressing accelerates wound healing and suppresses hypertrophic scar formation in infected wounds

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Bioactive Materials 2024年第4期34卷 269-281页

作者： Xiaoqing Liu Yiming Sun Jie Wang Yongyuan Kang Zhaolong Wang Wangbei Cao Juan Ye Changyou Gao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310058China Eye Center The Second Affiliated Hospital of Zhejiang UniversitySchool of MedicineHangzhou310009China Center for Healthcare Materials Shaoxing InstituteZhejiang UniversityShaoxing312099China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan030000China

Wound management is an important issue that places enormous pressure on the physical and mental health of patients,especially in cases of infection,where the increased inflammatory response could lead to severe hypertrophic scars(HSs).In this study,a hydrogel dressing was developed by combining the high strength and toughness,swelling resistance,antibacterial and antioxidant *** hydrogel matrix was composed of a double network of polyvinyl alcohol(PVA)and agarose with excellent mechanical *** polylysine(HBPL),a highly effective antibacterial cationic polymer,and tannic acid(TA),a strong antioxidant molecule,were added to the hydrogel as functional *** of antibacterial and antioxidant properties of the hydrogel confirmed the full play of the efficacy of HBPL and *** the in vivo studies of methicillin-resistant Staphylococcus aureus(MRSA)infection,the hydrogel had shown obvious promotion of wound healing,and more profoundly,significant suppression of scar *** to the common raw materials and simple preparation methods,this hydrogel can be mass produced and used for accelerating wound healing while preventing HSs in infected wounds.

关键词： Hydrogel dressing Hypertrophic scars Wound healing Bacterial infection ROS-scavenging

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Plastic‑Swelling Preparation of Functional Graphene Aerogel Fiber Textiles

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Advanced Fiber Materials 2023年第6期5卷 2016-2027页

作者： Yuxiang Qi Yuxing Xia Peng Li Ziqiu Wang Xin Ming Bo Wang Kai Shen Gangfeng Cai Kaiwen Li Yue Gao Yingjun Liu Chao Gao Zhen Xu MOE Key Laboratory of Macromolecular Synthesis and Functionalization International Research Centre for X PolymersDepartment of Polymer Science and EngineeringZhejiang University38 Zheda RoadHangzhou 310027People’s Republic of China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030032People’s Republic of China

Graphene aerogel fibers(GAFs)combine the advantages of lightweight,high specific strength and conductivity of graphene,showing great potential in multifunctional wearable ***,the fabrication and application of GAF textiles are considerably limited by the low structural robustness of ***,we report a plastic-swelling method to fabricate GAF textiles with high performance and *** textiles were achieved by plastic-swelling,the prewoven graphene oxide fiber(GOF)tow *** near-solid plastic-swelling process allows GAFs in textiles to maintain high structural order and controllable density,and exhibit record-high tensile strength up to 103 MPa and electrical conductivity up to 1.06.104 S m−1 at the density of 0.4 g cm−*** textiles exhibit high strength of 113 MPa,multiple electrical and thermal functions,and high porosity to serve as host materials for more functional *** plastic-swelling provides a general strategy to fabricate diverse aerogel fiber textiles,paving the road for their realistic application.

关键词： Aerogel fiber Plastic-swelling Smart textiles Graphene

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Alkaline phosphatase-responsive lipid-like polyphosphonitrile nanovesicles to enhance immunotherapy and inhibit metastasis of triple-negative breast cancer

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Chemical Engineering Journal 2025年 515卷

作者： Zhao, Xinchen Qiu, Liyan Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou310058 China

Triple-negative breast cancer (TNBC) is associated with high invasiveness and mortality, with current immunotherapies offering limited clinical benefits. Reduced tumor immunogenicity and dendritic cell (DC) dysfunction are major contributors to tumor immune evasion. Herein, an alkaline phosphatase (ALP)-responsive nanovesicle system (P-DOX/IFN-γ), based on lipid-like polyphosphonitrile (PEBP), was developed for the co-delivery of doxorubicin hydrochloride (DOX) and interferon-γ (IFN-γ), aiming to enhance the therapeutic efficacy against TNBC. The phosphate ester structure facilitates nanovesicle formation and enables multiple interactions with both drugs, thereby efficiently achieving the synchronous encapsulation of DOX within the membrane and IFN-γ in the aqueous cavity. P-DOX/IFN-γ exhibits enhanced tumor targeting and ALP-responsive drug release within the tumor microenvironment. Mechanistically, DOX induces immunogenic cell death in tumor cells, while IFN-γ induces cell cycle arrest and upregulates major histocompatibility complex class I (MHC I) expression, synergistically enhancing tumor immunogenicity and promoting DC activation. As a result, P-DOX/IFN-γ significantly amplifies antitumor immunity and reduces long-term postoperative metastasis in the orthotopic 4T1 tumor model. Overall, this study provides a versatile nanoplatform and a promising immunotherapeutic strategy for TNBC and other poorly immunogenic tumors. © 2025 Elsevier B.V.

关键词： Targeted drug delivery

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Design of Flexible Piezoelectric Nanocomposite for Energy Harvesters:A Review

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Energy Material Advances 2023年第1期4卷 377-392页

作者： Fu Lv Zijian Hong Zeeshan Ahmad Hanying Li Yongjun Wu Yuhui Huang School of Materials Science and Engineering Zhejiang UniversityHangzhouZhejiang 310027China State Key Laboratory of Silicon and Advanced Semiconductor Materials Zhejiang UniversityHangzhouZhejiang 310027China Department of Mechanical Engineering Texas Tech UniversityLubbockTXUSA MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhouZhejiang 310027China

Piezoelectric materials that can effectively convert natural mechanical energy into electrical energy without time and space constraints have been widely applied for energy harvesting and *** piezocomposites with high piezoelectricity and flexibility have shown great promise for renewable electric energy generation that can power implantable and wearable *** minireview aims to summarize the recent progress of the piezocomposites with different composite structures,as well as the role of the theoretical understandings and designs in the development of new piezoelectric nanogenerator ***,the most common composite structural types(0-3,1-3,and 3-3)have been discussed *** strategies for high output performance of piezocomposites are also proposed on the basis of current experimental and simulation ***,the review concludes with perspectives on the future design of flexible piezoelectric nanocomposites for energy harvesters.

关键词： composite piezoelectric harvesting

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synthesis of Well-defined Poly(tetrahydrofuran)-b-Poly(a-amino acid)s via Cationic Ring-opening Polymerization (ROP) of Tetrahydrofuran and Nucleophilic ROP of N-thiocarboxyanhydrides

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Chinese Journal of Polymer Science 2021年第6期39卷 702-708,I0006页

作者： Peng Zhou Xuan-Geng Dai Jie Kong Jun Ling Ministry of Education Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi'an 710072China

The synthesis of block copolymers of poly(tetrahydrofuran)-b-poly(α-amino acid)(PTHF-b-PAA)is challenging since it is difficult to combine the two blocks produced via different/conflicting ring-opening polymerization(ROP)*** this contribution,the cationic ROP of THF is catalyzed by rare-earth triflate[RE(OTf)3]and terminated by 2-(t-butyloxycarbonyl-amino)ethanol(BAE).After the deprotection of t-butyloxycarbonyl(Boc)group,the chain end of PTHF is quantitatively changed to amino group which thereafter initiates the nucleophilic ROP ofα-amino acid N-thiocarboxyanhydrides(NTAs).Both polymerizations are well controlled,generating PTHF and PAA segments with designable molecular weights(MWs).PTHF-b-polylysine(PTHF-b-PLys)and PTHF-b-polysarcosine(PTHF-b-PSar)are obtained with MWs between 8.6 and 28.7 kg/*** above amphiphilic diblock copolymers form micelles in ***40-b-PSar32 acts as a surfactant to stabilize oil-in-water *** segments of PTHF-b-PAA are biocompatible and promising in the biomedical application.

关键词： anhydride polymerization carbonyl

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Non-linear Radical Additions-Coupling Polymerization of Monovinyl Monomers towards Polymer Networks: Theory, Tunability and Heritable Architecture

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Chinese Journal of Polymer Science 2022年第12期40卷 1623-1630,I0008页

作者： Li-Mei Ren Cheng-Lin Li Qi Wang MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science&Engineering Zhejiang UniversityHangzhou 310027China Current address:Zhejiang University-University of Edinburgh Institute Zhejiang University School of Medicineand Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang ProvinceZhejiang University School of MedicineHangzhou 310027China

Exploring new polymerization strategy for current available monomers is a big challenge in polymer science. Here we re-investigate radical polymerization of monovinyl monomer(MVM) initiated by uniform branched polyfunctional initiator(PFI), which is termed non-linear radical additions-coupling polymerization(NLRAs CP). In NLRAs CP, both addition and coupling reactions of radical contribute to the construction of the polymer chains, which leads to continuous growth of branch topology. Theoretical analysis of NLRAs CP predicts that the gelation is determined by the functionality of PFI(a), the extent of initiation of the PFI(q) and the termination factor of radical(φ). NLRAs CPs of styrene and methyl methacrylate promoted by Cu(0)/MeTREN or Mn_(2)(CO)_(10)/visible light were conducted. After the cleavage of incorporated PFI fragment or junctions in the network, the network was transformed to linear chains having almost the same structure as segmental chains in the precursor network. This allows the reverse deducing the network structure from its cleaved products. It has been proven that NLRAs CP includes stepwise initiation of PFI, chain-growth of segmental chains and successive endlinking of macroradicals derived from PFI. The three parameters related to the gelation process, a, q and φ, were adjusted via binary PFI, the feed ratio of [Mn_(2)(CO)_(10)]/[PFI] and addition of non-homopolymerizable comonomer respectively. The minimum values of a and q, and the minimum amount of comonomer required for gelation were determined,which can be applied to estimate φ of various macroradicals. NLRAs CP opens a general and facile strategy for synthesis of a variety of polymer networks with heritable architecture by one-pot polymerization of various MVMs.

关键词： Non-linear radical additions-coupling polymerization Monovinyl monomer Polyfunctional initiator Polymer network Theory

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Hydrogen bonding-induced oxygen clusters and long-lived room temperature phosphorescence from amorphous polyols

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Chinese Chemical Letters 2023年第1期34卷 187-191页

作者： Ya-Ling Wang Kang Chen Hai-Ru Li Bo Chu Zishan Yan Hao-Ke Zhang Bin Liu Shengliang Hu Yongzhen Yang School of Energy and Power Engineering North University of ChinaTaiyuan 030051China MOE Key Laboratory of Interface Science and Engineering in Advanced Materials Taiyuan University of TechnologyTaiyuan 030024China Department of Polymer Science and Engineering MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationZhejiang UniversityHangzhou 310027China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030032China

Developing non-conjugated luminescent polymers(NCLPs)with fluorescence and long-lived roomtemperature phosphorescence is of great significance for revealing the essence of NCLPs luminescence,which has gradually attracted the attention of researchers in recent ***,polymethylol(PMO)and poly(3-butene-1,2-diol)(PBD)with polyhydroxy structures were prepared and their luminescence behaviors were investigated to reveal the clusteroluminescence(CL)*** with polyvinyl alcohol with non-luminescent behavior,PMO and PBD exhibit cyan-blue fluorescence with quantum yields of ca.12%and green room-temperature phosphorescence with lifetimes of ca.89 ms in the solid *** fluorescence and phosphorescence exhibit typical excitation-dependent CL *** and theoretical analyses show that the strong hydrogen-bonding interaction of PMO and PBD greatly promotes the formation of oxygen clusters and the through-space n-n interaction of oxygen atoms,enabling fluorescence and phosphorescence *** results have enormous implications for understanding the CL mechanism of NCLPs and provide a new polymer design strategy for the rational design of novel NCLPs materials.

关键词： Clusteroluminescence Through-space interactions Polymethylol Poly(3-butene-1,2-diol) Hydrogen bonding Polymerization

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