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Perfectly Alternating and Regioselective Copolymerization of Carbonyl Sulfide and Epoxides by Metal‐Free Lewis Pairs

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Angewandte Chemie 2017年第21期129卷

作者： Jia‐Liang Yang Hai‐Lin Wu Yang Li Xing‐Hong Zhang Donald J. Darensbourg Department of Polymer Science and Engineering MOE Key Laboratory of Macromolecular Synthesis and Functionalization Zhejiang University Hangzhou 310027 China Department of Chemistry Texas A&M University College Station TX 77843 USA

The preparation of perfectly alternating and regioslective copolymers derived from the copolymerization of carbonyl sulfide (COS) and epoxides by metal‐free Lewis pair catalysts composed of a Lewis base (amidine, guanidine, or quaternary onium salts) and a Lewis acid (triethyl borane) is described. Colorless and highly transparent copolymers of poly(monothiocarbonate) were successfully obtained with over 99 % tail‐to‐head content and high molecular weight (up to 92.5 kg mol −1 ). In most instances, oxygen–sulfur exchange reactions (O/S ERs), which would generate random thiocarbonate and carbonate units, were effectively suppressed. The turnover frequencies (TOF) of these Lewis pair catalyzed processes were as high as 119 h −1 at ambient temperature.

关键词： Epoxide Kohlenoxidsulfid Lewis-Paare Organokatalyse Poly(monothiocarbonate)

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干燥条件对聚乙烯醇/碳纳米管复合材料力学性能的影响

干燥条件对聚乙烯醇/碳纳米管复合材料力学性能的影响

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2012年全国高分子材料科学与工程研讨会

作者： SUN Lina 孙丽娜 GUO Honglei 郭宏磊 ZHU Zhongming 朱钟鸣 PEMG Mao 彭懋 MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science 浙江大学高分子科学与工程学系高分子合成与功能构造教育部重点实验室杭州 310027

本文通过调节干燥时间探究了水分对PVA膜及PVA/MWNTs复合膜力学性能的影响：干燥时间较短时，PVA膜的拉伸强度、模量较低，MWNTs的加入对其力学性能的增强效果显著。随着干燥时间的延长，膜中残留水分逐渐减少，此时PVA/MWNTs复合膜较PV... 详细信息

本文通过调节干燥时间探究了水分对PVA膜及PVA/MWNTs复合膜力学性能的影响：干燥时间较短时，PVA膜的拉伸强度、模量较低，MWNTs的加入对其力学性能的增强效果显著。随着干燥时间的延长，膜中残留水分逐渐减少，此时PVA/MWNTs复合膜较PVA膜力学性能无明显增强。水分作为增塑剂可显著降低PVA膜的Tg。

关键词：聚乙烯醇碳纳米管改性处理力学性能

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Preparation of Mn2+@PolyDOPA-b-polysarcosine micelle as MRI contrast agent with high longitudinal relaxivity

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Journal of macromolecular Science, Part A 2021年第3期58卷 175-181页

作者： Qingda Yan Xue Dong Rongze Xie Xiufang Xu Xiaoyan Wang Ke Zhang Jingya Xia Jun Ling Fei Zhou Jihong Sun a MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou China b Department of Radiology Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou China c Department of Radiology Jiulongpo People’s Hospital Chongqing China d Department of Medical Imagine Hangzhou Medical College Hangzhou China b Department of Radiology Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou Chinac Department of Radiology Jiulongpo People’s Hospital Chongqing Chinae Innovation Center for Minimally Invasive Techniques and Devices Zhejiang University Hangzhou China

Magnetic resonance imaging (MRI) is a promising technique widely used in clinical diagnose. Poly(α-amino acid)s are excellent carriers for MRI due to their excellent biocompatibility. PDOPA-b-PSar copolymers (defined as “DoS”) are synthesized by sequential polymerizations of 3,4-dihydroxy-L-phenylalanine N-thiocarboxyanhydride (DOPA-NTA) and sarcosine N-thiocarboxyanhydride (Sar-NTA) initiated by neopentylamine in tetramethylene sulfone. Mn2+@DoS micelles have been prepared as T1-weighted MRI contrast agents according to efficient coordination between catechol units and Mn2+cation. High longitudinal relaxivity (27.7 mM−1·s−1) of Mn2+@PDOPA12-b-PSar72was observed, and the aqueous micelle exhibits effective MRI contrast enhancementin vivoof nude mice. Mn2+@DoS shows potential clinical application in diagnostic radiology as a novel MRI contrast agent. Gd3+@DoS micelles are also investigated presenting a longitudinal relaxivity of 16.4 mM−1·s−1. Unfortunately, the Gd3+loading percentage is quite low as 19%.Preparation of Mn2+@PolyDOPA-b-polysarcosine micelle as MRI contrast agent with high longitudinal relaxivityAll authorsQingdaYan,XueDong,RongzeXie,XiufangXu,XiaoyanWang,KeZhang,JingyaXia,JunLing,FeiZhou&JihongSunhttps://***/10.1080/10601325.2020.1840918Published online:02 November 2020

关键词： Poly(α-amino acid)s polypeptides polypeptoids magnetic resonance imaging longitudinal relaxivity

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原位自由基聚合方法接枝改性碳纳米管和气相生长碳纤维

原位自由基聚合方法接枝改性碳纳米管和气相生长碳纤维

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2012年全国高分子材料科学与工程研讨会

作者： SUN Lina 孙丽娜 GUO Tanghua 郭唐华 ZHU Zhongming 朱钟鸣 PENG Mao 彭懋 MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science 浙江大学高分子科学与工程学系高分子合成与功能构造教育部重点实验室杭州310027

本文通过原位自由基聚合方法接枝改性MWNTs和VGCFs，比较不同物质接枝效果和接枝产物的分散稳定性，为复合材料的制备提供一定的依据。实验结果显示改性后MWNTs和VGCFs在特定的溶剂中分散稳定性得到一定的提高，同时使用相同的方法和相... 详细信息

本文通过原位自由基聚合方法接枝改性MWNTs和VGCFs，比较不同物质接枝效果和接枝产物的分散稳定性，为复合材料的制备提供一定的依据。实验结果显示改性后MWNTs和VGCFs在特定的溶剂中分散稳定性得到一定的提高，同时使用相同的方法和相同改性物质VGCFs的改性效果要明显低于MWNTs。

关键词：多壁碳纳米管气相生长碳纤维改性处理性能优化

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高分子复杂体系的结构演变与粘弹响应

高分子复杂体系的结构演变与粘弹响应

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2012年全国高分子材料科学与工程研讨会

作者： ZHENG Qiang 郑强 Key Laboratory of Macromolecular Synthesis and Functionalization Ministry of EducationDepartment o 高分子合成与功能构造教育部重点实验室浙江大学高分子科学与工程学系杭州 310027

共混改性对于获得优异综合性能的高分子材料、改善加工性能、降低生产成本，都具有重要的意义。正是由于学术研究和工业应用上的需要，大多数高分子材料不再均一(匀)体系，而是由共混得到的多相/多组分复杂体系。此类高分子体系的粘弹... 详细信息

共混改性对于获得优异综合性能的高分子材料、改善加工性能、降低生产成本，都具有重要的意义。正是由于学术研究和工业应用上的需要，大多数高分子材料不再均一(匀)体系，而是由共混得到的多相/多组分复杂体系。此类高分子体系的粘弹性与其组分间相互作用、相形态密切相关，其粘弹响应可准确反映形态结构的变化。由于非均相体系的粘弹行为的多样性、复杂性，近年来相行为、形态、结构与流变行为的关联成为多组分高分子研究领域的热点之一。尤其是，随着大量新型高分子材料的不断出现，对于材料粘弹响应与功能特性(例如热性能、电性能等)相关联的研究也已引起极大关注。
　　利用流变学方法，并围绕多相/多组分聚合物体系的形态结构，作者所在课题组已开展多方面的研究，其中包括：(1)填充体系的结构与粘弹行为，(2)导电高分子复合材料的粘弹响应，(3)聚电解质溶液的流变特性，(4)共混体系的相行为与流变行为等。研究表明，将高分子复杂体系的结构演变与其粘弹响应进行关联，运用流变学测试表征非均相高分子复杂体系的结构-性能关系是非常行之有效的方法。

关键词：高分子复杂体系结构演变粘弹响应流变学

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碳纤维-聚乙烯超疏水导电复合涂层的制备与研究

碳纤维-聚乙烯超疏水导电复合涂层的制备与研究

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2012年全国高分子材料科学与工程研讨会

作者： DING Hongliang 丁宏亮 WANG Wen 汪文 ZHANG Lei 张磊 SHEN Lie 沈烈 MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science 浙江大学高分子科学与工程学系高分子合成与功能构造教育部重点实验室杭州 310027

本文通过热压的方法，制备出兼具优异超疏水性能和导电性能的气相生长碳纤维-聚乙烯复合涂层。经研究表明，该复合涂层接触角为158°，滚动角约为3°，方块电阻为4.5±0.3Ω/sq。

关键词：导电材料制备工艺性能优化

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MOF负载Weel抑制剂实现p53突变胆囊癌的合成致死靶向治疗

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Science Bulletin 2024年第9期69卷 1286-1301页

作者：郦仕杰 Sarun Juengpanich Win Topatana 谢天傲侯丽丹朱怡远陈佳东单煜凯韩依纳陆子毅陈天恩 Charlie Topatana 张斌曹佳胜胡家豪严加费陈迎鑫顾臻俞计成蔡秀军陈鸣宇 Department of General Surgery Sir Run-Run Shaw HospitalZhejiang UniversityHangzhou 310016China School of Medicine Zhejiang UniversityHangzhou 310058China National Engineering Research Center of Innovation and Application of Minimally Invasive Instruments Sir Run-Run Shaw HospitalZhejiang UniversityHangzhou 310016China School of Materials Science and Engineering Zhejiang UniversityHangzhou 310058China Department of Chemistry Zhejiang UniversityHangzhou 310016China Department of Pathology Sir Run-Run Shaw HospitalZhejiang UniversityHangzhou 310016China International College Zhejiang UniversityHangzhou 310058China Institute of Advanced Magnetic Materials and International Research Center for EM Metamaterials College of Materials&Environmental EngineeringHangzhou Dianzi UniversityHangzhou 310018China Zhejiang Provincial Key Laboratory for Advanced Drug Delivery Systems College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Liangzhu Laboratory Zhejiang UniversityHangzhou 311121China Jinhua Institute of Zhejiang University Jinhua 321299China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

Adavosertib(ADA)is a WEE1 inhibitor that exhibits a synthetic lethal effect on p53-mutated gallbladder cancer(GBC).However,drug resistance due to DNA damage response compensation pathways and high toxicity limits further ***,estrone-targeted ADA-encapsulated metal–organic frameworks(ADA@MOF-EPL)for GBC synthetic lethal treatment by inducing conditional factors are *** high expression of estrogen receptors in GBC enables ADA@MOF-EPL to quickly enter and accumulate near the cell nucleus through estrone-mediated endocytosis and release ADA to inhibit WEE1 upon entering the acidic tumor *** irradiation induces ADA@MOF-EPL to generate reactive oxygen species(ROS),which leads to a further increase in DNA damage,resulting in a higher sensitivity of p53-mutated cancer cells to WEE1 inhibitor and promoting cell death via conditional synthetic *** conditional factor induced by ADA@MOF-EPL further enhances the antitumor efficacy while significantly reducing systemic ***,ADA@MOF-EPL demonstrates similar antitumor abilities in other p53-mutated solid tumors,revealing its potential as a broad-spectrum antitumor drug.

关键词： Synthetic lethality Nanomedicine Sonodynamic therapy Gallbladder cancer Metal-organic frameworks DNA damage response

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Efficient Ceo2/Zno Heterojunction for Enhanced Heterogenous Photocatalytic Application

SSRN

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SSRN 2024年

作者： Li, Honglin Wu, Rong Ji, Jun Liu, Yue Zhao, Jiahui Sahar, Shafaq Zeb, Akif College of Chemistry and Material Engineering Chao Hu University Hefei238000 China School of Energy Materials and Chemical Engineering Hefei University Hefei City230601 China Key Laboratory of Resource Comprehensive Utilization of Chaohu University Chaohu University Hefei238000 China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University 866 Yuhangtang Rd Hangzhou310058 China Hunan Joint International Laboratory of Advanced Materials and Technology for Clean Energy College of Materials Science and Engineering Hunan University Changsha410082 China Surface and Materials Technology Institute of Materials Engineering University of Siegen Paul-Bonatz-Straße 9-11 Siegen57076 Germany

Organic pollutants pose a significant challenge due to their toxicity and potential carcinogenicity, posing a severe threat to the environment and human health. Heterogeneous photocatalysts offer promising advantages over traditional water purification methods due to their tunable electronic properties such as bandgap, easy separation from the reaction solution and formidable nanostructures. Herein, we prepare a CeO2/ZnO heterostructure via simple hydrothermal synthesis. The electronic structure of this nanocomposite was tuned to achieve a band gap of ~2.94 eV, which was between the individual bandgaps of CeO2 and ZnO nanoparticles. In addition, the mixed valence character of Ce further enhanced the electronic properties of the CeO2/ZnO heterostructure. The photocatalytic performance of CeO2, ZnO and CeO2/ZnO heterostructure was evaluated and it was found that CeO2/ZnO heterostructure with a Zn/Ce ratio of 0.2 exhibited the highest photocatalytic activity and the degradation efficiency was 99.28% after irradiation for 60 min. It was mainly ascribed to the heterojunction structure of the CeO2/ZnO nanocomposite, leading to a higher separation efficiency of electron-hole pairs and generating more superoxide radicals, which in turn improved the photocatalytic activity effectively. © 2024, The Authors. All rights reserved.

关键词： II-VI semiconductors

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Actuators: Combining 3D Printing with Electrospinning for Rapid Response and Enhanced Designability of Hydrogel Actuators (Adv. Funct. Mater. 19/2018)

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Advanced Functional Materials 2018年第19期28卷

作者： Tingting Chen Hadi Bakhshi Li Liu Jian Ji Seema Agarwal MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Zheda Road 38 310027 Hangzhou China Macromolecular Chemistry II and Bayreuth Center for Colloids and Interfaces Universität Bayreuth Universitätsstraße 30 95440 Bayreuth Germany

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Hypoxia-Responsive Microgels Act as an Intra-Articular Lubricant and Inflammatory Inhibitor for Osteoarthritis Therapy

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SSRN 2024年

作者： Wang, Zhaoyi Yao, Shun-Yu Zhang, Yuxiang Li, Shifen Zhou, Tong Wang, Shuqin Guo, Dong-Sheng Gao, Changyou MOE Key Laboratory of Macromolecular Synthesis and Functionalization International Research Center for X Polymers Department of Polymer Science and Engineering Zhejiang University Hangzhou310027 China College of Chemistry Key Laboratory of Elemento-Organic Chemistry Key Laboratory of Functional Polymer Materials Ministry of Education Frontiers Science Center for New Organic Matter Collaborative Innovation Center of Chemical Science and Engineering Nankai University Tianjin300071 China Department of Plastic Surgery Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou310020 China Center for Healthcare Materials Shaoxing Institute Zhejiang University Shaoxing312035 China Dr. Li Dak Sum and Yip Yio Chin Center for Stem Cell and Regenerative Medicine Zhejiang University Hangzhou310058 China

The reduced oxygen concentration is a distinctive feature of osteoarthritic (OA) cartilage, whereas the mechanical friction also contributes to the inflammatory hypoxia microenvironment of OA. Herein, novel hypoxia-responsive methylprednisolone (MP) delivery microgels combining the capability of reactive oxygen species (ROS) depletion and lubrication were constructed for regulating the microenvironment of OA. Methacrylate-modified sulfonated azocalix[4]arene (MACA) loaded with MP, the copolymers consisting of bioinspired lubricant 2-methacryloxyethyl phosphorylcholine (MPC), and polyethylene glycol-modified ROS-responsive poly(thioketal) (PEG-4PTK) were crosslinked together to construct the microgels. The zwitterionic MPC offered a lubrication effect, while the ROS-elimination was contributed by the PTK segments and the phenol groups in MACA. The microgels responsively released cargos in inflammatory environment and decreased inflammation by inhibiting the production of ROS and regulating the expression of inflammatory cytokines, and showed the lowest hypoxia-inducible factor-1α (HIF-1α) positive area and presented more deposition of glycosaminoglycans and collagen II with a smoother and integrated cartilage structure in therapy of OA in rats in vivo. © 2024, The Authors. All rights reserved.

关键词： Lubrication

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