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A Hybrid Supramolecular Polymeric Nanomedicine for Cascade-Amplified Synergetic Cancer Therapy

Angewandte Chemie 2022年第27期134卷

作者： Kai Yang Dr. Shaolong Qi Dr. Xinyang Yu Dr. Bing Bai Xueyan Zhang Prof. Dr. Zhengwei Mao Prof. Dr. Feihe Huang Prof. Dr. Guocan Yu Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology Department of Chemistry Tsinghua University Beijing 100084 P. R. China State Key Laboratory of Chemical Engineering Stoddart Institute of Molecular Science Department of Chemistry Zhejiang University Hangzhou 310027 P. R. China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 311215 P. R. China Green Catalysis Center and College of Chemistry Zhengzhou University Zhengzhou 450001 P. R. China Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province the Second Affiliated Hospital School of Medicine MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou Zhejiang 310027 P. R. China

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Wiring Covalent Organic Frameworks with Conducting Polymers

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Angewandte Chemie 2024年第45期136卷

作者： Yifan Gong Lejian Deng Xiaoyi Xu Dr. Ruoyang Liu Prof. Dr. Juan Li Prof. Dr. Ning Huang Prof. Dr. Donglin Jiang Integrative Sciences & Engineering NUS Graduate School National University of Singapore Singapore 119077 Singapore Department of Chemistry Faculty of Science National University of Singapore Singapore 117543 Singapore Joint School of National University of Singapore and Tianjin University International Campus of Tianjin University Binhai New City 350207 P. R. China. MOE Key Laboratory of Macromolecular Synthesis and Functionalization State Key Laboratory of Silicon Materials International Research Centre for X Polymers Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China Institute of Crystalline Materials Shanxi University Taiyuan 030006 China

Covalent organic frameworks are a class of crystalline porous polymers formed by linking organic units into periodically aligned skeletons and pores. Here we report a strategy for wiring these frameworks with conducting polymers via wall engineering and polymerization. We anchored each edge site with one pyrrole unit, which is densely packed along the z direction yet protruded from pore walls. This assembly enables the polymerization of pyrrole units to form polypyrrole and creates a new polypyrrole chain conformation. The resultant framework constitutes six single file polypyrrole chains in each pore and develop spatially segregated yet built-in single molecular wires with exceptional stable polarons. Hall effect measurements revealed that the materials are p -type semiconductors, increase conductivity by eight orders of magnitude compared to the pristine frameworks, and achieve a carrier mobility as large as 13.2 cm 2 V −1 s −1 . Our results open an avenue to π electronic frameworks by interlayer molecular wiring with conducting polymers.

关键词： Covalent organic frameworks Single file molecular wire Polymerization π Electronic property Carrier mobility

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Linker-Mediated Delocalized Excited States in Dimeric Acceptors Enable Efficient Exciton Dissociation with Negligible Energy-Level Offsets

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Angewandte Chemie 2024年第4期137卷

作者： Sheng-Yu Shi Chao Yang Xinjie Xu Zhi-Xi Liu Wanchun Duan Xing-Xing Chen Zhou Lu Hongping Zhou Zhi-Peng Yu Chang-Zhi Li Institutes of Physical Science and Information Technology School of Chemistry and Chemical Engineering Anhui University Hefei Anhui 230601 P. R. China School of Chemical and Environmental Engineering Anhui Polytechnic University Wuhu 241002 China Anhui Key Laboratory for Control and Applications of Optoelectronic Information Materials School of Physics and Electronic Information Anhui Normal University Wuhu 241002 China State Key Laboratory of Silicon Materials MOE Key Laboratory of Macromolecular Synthesis and Functionalization International Research Center for X Polymers Department of Polymer Science and Engineering Zhejiang University-Hangzhou Global Scientific and Technological Innovation Center Zhejiang University 310027 Hangzhou P. R. China Department of Materials Science and Engineering University of Science and Technology of China Hefei 230026 China

Efficient exciton dissociation at low energy offsets is key to overcoming voltage losses in organic solar cells. In this work, we developed two dimeric acceptors, i-YT and o-YT, by precisely controlling the position of an asymmetric electron-donating linker. It induced the foldamer conformation of i-YT with a para linkage (relative to the dicyano groups), while retaining the unfold conformation for o-YT. This subtle structural modification influenced the molecular assembly properties, enabled near-zero energy offset exciton dissociation and power conversion efficiencies exceeding 18 % for i-YT based organic solar cells. Detailed excitonic dynamics further revealed that the linker position critically influences three processes: the formation of delocalized singlet excited states, ultrafast charge transfer (~5 ps) in solid blends, and the suppression of exciton recombination. Additionally, devices based on i-YT demonstrated outstanding long-term stability, retaining 85 % of their initial efficiency after 1,400 hours of continuous illumination. These findings introduce a new class of dimeric acceptors that combine high efficiency with exceptional stability, offering a promising pathway toward low-energy-loss organic photovoltaics.

关键词： Organic Photovoltaics Dimeric Acceptor High Efficiency Stability Delocalized Excited State

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Correction: A miRNA stabilizing polydopamine nano-platform for intraocular delivery of miR-21-5p in glaucoma therapy

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Journal of materials chemistry. B 2021年第16期9卷 3595页

作者： Chen Tan Fan Jia Peng Zhang Xinghuai Sun Yunsheng Qiao Xueli Chen Youxiang Wang Junyi Chen Yuan Lei Department of Ophthalmology & Visual Science Eye & ENT Hospital Shanghai Medical College Fudan University Shanghai 200031 China. MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 P. R. China. Department of Ophthalmology & Visual Science Eye & ENT Hospital Shanghai Medical College Fudan University Shanghai 200031 China and NHC Key Laboratory of Myopia Chinese Academy of Medical Sciences and Shanghai Key Laboratory of Visual Impairment and Restoration (Fudan University) Shanghai 200031 China and State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain Science Fudan University Shanghai 200032 China. Department of Ophthalmology & Visual Science Eye & ENT Hospital Shanghai Medical College Fudan University Shanghai 200031 China and NHC Key Laboratory of Myopia Chinese Academy of Medical Sciences and Shanghai Key Laboratory of Visual Impairment and Restoration (Fudan University) Shanghai 200031 China.

Correction for 'A miRNA stabilizing polydopamine nano-platform for intraocular delivery of miR-21-5p in glaucoma therapy' by Chen Tan et al., J. Mater. Chem. B, 2021, DOI: 10.1039/d0tb02881a.

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Frontispiece: Platelet-Drug Conjugates Engineered via One-step Fusion Approach for Metastatic and Postoperative Cancer Treatment

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Angewandte Chemie International Edition 2024年第37期63卷

作者： Zhengjie Zhao Yinxian Yang Tao Sheng Yuhang Bao Ruixi Yu Xinmin Yu Shuangxu Jia Qing Wu Chaojie Zhu Xinyuan Shen Wentao Zhang Ziyi Lu Kangfan Ji Xiaofeng Chen Xinyun Jiang Prof. Yuqi Zhang Prof. Zhen Gu Prof. Jicheng Yu State Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang Provincial Key Laboratory for Advanced Drug Delivery Systems College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China Department of Hepatobiliary and Pancreatic Surgery the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China Liangzhu Laboratory Zhejiang University Hangzhou 311121 China Department of Burns and Wound Center Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China Jinhua Institute of Zhejiang University Jinhua 321299 China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China

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Membranes: Dopamine: Just the Right Medicine for Membranes (Adv. Funct. Mater. 8/2018)

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Advanced Functional Materials 2018年第8期28卷

作者： Hao‐Cheng Yang Ruben Z. Waldman Ming‐Bang Wu Jingwei Hou Lin Chen Seth B. Darling Zhi‐Kang Xu Nanoscience and Technology Division Argonne National Laboratory Lemont IL 60439 USA Institute for Molecular Engineering University of Chicago Chicago IL 60637 USA MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China UNESCO Centre for Membrane Science and Technology School of Chemical Engineering University of New South Wales Sydney 2052 Australia Department of Materials Science and Metallurgy University of Cambridge Cambridge CB3 0FS UK Energy Systems Division Argonne National Laboratory Lemont IL 60439 USA Institute for Molecular Engineering Argonne National Laboratory Lemont IL 60439 USA

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Platelet-Drug Conjugates Engineered via One-step Fusion Approach for Metastatic and Postoperative Cancer Treatment

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Angewandte Chemie 2024年第37期136卷

The exploration of cell-based drug delivery systems for cancer therapy has gained growing attention. Approaches to engineering therapeutic cells with multidrug loading in an effective, safe, and precise manner while preserving their inherent biological properties remain of great interest. Here, we report a strategy to simultaneously load multiple drugs in platelets in a one-step fusion process. We demonstrate doxorubicin (DOX)-encapsulated liposomes conjugated with interleukin-15 (IL-15) could fuse with platelets to achieve both cytoplasmic drug loading and surface cytokine modification with a loading efficiency of over 70 % within minutes. Due to their inherent targeting ability to metastatic cancers and postoperative bleeding sites, the engineered platelets demonstrated a synergistic therapeutic effect to suppress lung metastasis and postoperative recurrence in mouse B16F10 melanoma tumor models.

关键词： drug delivery platelet cancer immunotherapy liposome

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Frontispiz: Platelet-Drug Conjugates Engineered via One-step Fusion Approach for Metastatic and Postoperative Cancer Treatment

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Angewandte Chemie 2024年第37期136卷

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How the Length of Through-Space Conjugation Influences the Clusteroluminescence of Oligo(Phenylene Methylene)s

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Angewandte Chemie 2024年第8期136卷

作者： Dr. Lei Wang Zuping Xiong Prof. Jing Zhi Sun Prof. Feihe Huang Prof. Haoke Zhang Prof. Ben Zhong Tang MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310058 China Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials ZJU-Hangzhou Global Scientific and Technological Innovation Center Zhejiang University Hangzhou 311215 China Centre of Healthcare Materials Shaoxing Institute Zhejiang University Shaoxing 312000 China Stoddart Institute of Molecular Science Department of Chemistry Zhejiang University Hangzhou 310058 China School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong Kong Shenzhen (CUHK-Shenzhen) Guangdong 518172 China

The length and mode of conjugation directly affect the molecular electronic structure, which has been extensively studied in through-bond conjugation (TBC) systems. Corresponding research greatly promotes the development of TBC-based luminophores. However, how the length and mode of through-space conjugation (TSC), one kind of weak interaction, influence the photophysical properties of non-conjugated luminophores remains a relatively unexplored field. Here, we unveil a non-linear relationship between TSC length and emission characteristics in non-conjugated systems, in contrast to the reported proportional correlation in TBC systems. More specifically, oligo(phenylene methylene)s (OPM[4]-OPM[7]) exhibit stronger TSC and prominent blue clusteroluminescence (CL) (≈440 nm) compared to shorter counterparts (OPM[2] and OPM[3]). OPM[6] demonstrates the highest solid-state quantum yield (40 %), emphasizing the importance of balancing flexibility and rigidity. Further theoretical calculations confirmed that CL of these oligo(phenylene methylene)s was determined by stable TSC derived from the inner rigid Diphenylmethane (DPM) segments within the oligomers instead of the outer ones. This discovery challenges previous assumptions and adds a new dimension to the understanding of TSC-based luminophores in non-conjugated systems.

关键词： Aggregation-Induced Emission Clusteroluminescence Oligo(Phenylene Methylene)s Through-Space Conjugation

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Correction: Rapid kinetic evaluation of homogeneous single-site metallocene catalysts and cyclic diene: how do the catalytic activity, molecular weight, and diene incorporation rate of olefins affect each other?

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RSC advances 2021年第53期11卷 33301页

作者： Amjad Ali Muhammad Nadeem Jianwei Lu Jamile Mohammadi Moradian Tahir Rasheed Tariq Aziz Chanez Maouche Yintian Guo Muhammad Awais Fan Zhiqiang Li Guo Research School of Polymeric Materials Science & Engineering Jiangsu University Zhenjiang 212013 PR China liguo@***. Department of Environmental Engineering Wuhang University of Technology Wuhan 430223 PR China. Interdisciplinary Research Center for Advanced Materials King Fahd University of Petroleum and Minerals Dhahran 31261 Saudi Arabia. Research Center of Fluid Machinery Engineering and Technology Jiangsu University Zhenjiang 212013 PR China. MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 PR China.

[This corrects the article DOI: 10.1039/D1RA06243C.].

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