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Application of lipidomics in the study of traditional Chinese medicine

Journal of Pharmaceutical Analysis 2025年第2期15卷 304-316页

作者： Yang Yang Guangyi Yang Wenpeng Zhang Lingyi Xin Jing Zhu Hangtian Wang Baodong Feng Renyan Liu Shuya Zhang Yuanwu Cui Qinhua Chen Dean Guo Key Laboratory of TCM Clinical Pharmacy Shenzhen Bao'an Authentic TCM Therapy HospitalShenzhenGuangdong518000China Department of Pharmacy Shenzhen Hospital of Integrated Traditional Chinese and Western MedicineShenzhenGuangdong518000China State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentTsinghua UniversityBeijing100084China Laboratory for TCM Standardization Technology Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China

Lipidomics is an emerging discipline that systematically studies the various types,functions,and metabolic pathways of lipids within living *** field compares changes in diseases or drug impact,identifying biomarkers and molecular mechanisms present in lipid metabolic networks across different physiological or pathological *** employing analytical chemistry within the realm of lipidomics,researchers analyze traditional Chinese medicine(TCM).This analysis aids in uncovering potential mechanisms for treating diverse physiopathological conditions,assessing drug efficacy,understanding mechanisms of action and toxicity,and generating innovative ideas for disease prevention and *** manuscript assesses recent literature,summarizing existing lipidomics technologies and their applications in TCM *** delineates the efficacy,mechanisms,and toxicity research related to lipidomics in Chinese ***,it explores the utilization of lipidomics in quality control research for Chinese medicine,aiming to expand the application of lipidomics within this ***,this initiative seeks to foster the integration of traditional medicine theory with modern science and technology,promoting an organic fusion between the two domains.

关键词： Lipidomics Traditional Chinese medicine Mechanism Curative effect Toxicity Quality control

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Interface effect on superlattice quality and optical properties of InAs/GaSb type-Ⅱ superlattices grown by molecular beam epitaxy

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Chinese Physics B 2022年第12期31卷 671-676页

作者： Zhaojun Liu Lian-Qing Zhu Xian-Tong Zheng Yuan Liu Li-Dan Lu Dong-Liang Zhang The School of Opto-Electronic Engineering Changchun University of Science and TechnologyChangchun 130022China Key Laboratory of the Ministry of Education for Optoelectronic Measurement Technology and Instrument Beijing Information Science&Technology UniversityBeijing 100192China

We systematically investigate the influence of InSb interface(IF)engineering on the crystal quality and optical properties of strain-balanced InAs/GaSb type-Ⅱsuperlattices(T2SLs).The type-Ⅱsuperlattice structure is 120 periods InAs(8 ML)/GaSb(6 ML)with different thicknesses of InSb interface grown by molecular beam epitaxy(MBE).The highresolution x-ray diffraction(XRD)curves display sharp satellite peaks,and the narrow full width at half maximum(FWHM)of the 0th is only 30-39 *** high-resolution cross-sectional transmission electron microscopy(HRTEM)characterization,the InSb heterointerfaces and the clear spatial separation between the InAs and GaSb layers can be more intuitively *** the InSb interface thickness increases,the compressive strain increases,and the surface“bright spots”appear to be more apparent from the atomic force microscopy(AFM)***,photoluminescence(PL)measurements verify that,with the increase in the strain,the bandgap of the superlattice *** optimizing the InSb interface,a high-quality crystal with a well-defined surface and interface is obtained with a PL wavelength of 4.78μm,which can be used for mid-wave infrared(MWIR)detection.

关键词： InAs/GaSb type-Ⅱsuperlattice molecular beam epitaxy interface mid-wave infrared

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Single-pixel high-speed imaging through a multimode fiber

Single-pixel high-speed imaging through a multimode fiber

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CLEO: Science and Innovations, S and I 2022

作者： Liu, Zhoutian Li, Dan Yan, Ping Gong, Mali Xiao, Qirong State Key Laboratory of Precision Measurement Technology and Instruments Key Laboratory of Photonics Control Technology of the Ministry of Education Department of precision instrument Tsinghua University Beijing100084 China

While traditional high-speed cameras are generally bulky and based on pixel-array detectors, we propose a high-speed imaging scheme based on a multimode fiber using only one pixel. The frame rate of imaging reaches 60... 详细信息

ISBN: (纸本)9781557528209

关键词： Multimode fibers

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RESEARCH ON AUTONOMOUS INTERVAL MAINTENANCE IN COLLABORATIVE FLIGHT OF UNMANNED AERIAL VEHICLES 10

RESEARCH ON AUTONOMOUS INTERVAL MAINTENANCE IN COLLABORATIVE...

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10th International Symposium on Test Automation and instrumentation, ISTAI 2024

作者： Ling, Xing Wang, Weiye Li, Qing School of Automation Beijing Information Science & Technology University Beijing China Ministry of Education Key Laboratory of Modern Measurement & Control Technology Beijing China

ISBN: (纸本)9781837242672

This study investigates the use of the Vicsek model for maintaining autonomous intervals in the cooperative flight of unmanned aerial vehicles (UAVs). Although the Vicsek model effectively simulates group movement, it does not inherently maintain safe intervals between drones. To address this limitation, we propose an enhanced approach that incorporates a speed adaptive mechanism and a repulsive force mechanism. The speed adaptive mechanism dynamically adjusts the drone's speed based on its proximity to neighboring drones, slowing down when in close proximity and speeding up when further apart, thus preventing collisions. Additionally, the repulsive force mechanism ensures that drones maintain a safe distance from each other, even in high-density areas, thereby avoiding clustering and maintaining formation stability. Our simulation results indicate that drones equipped with these mechanisms achieve direction and speed consistency more rapidly, effectively avoid collisions in dense environments, and enhance overall movement speed and task execution efficiency. This approach provides a robust solution for autonomous interval maintenance in UAV swarms, ensuring safe and efficient collaborative operations in complex environments. The findings of this study contribute significantly to the field of UAV collaborative flight, offering practical implications for military reconnaissance, agricultural management, logistics, and disaster relief applications. © The Institution of Engineering & technology 2024.

关键词： Drones

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Analyzing the Effect of the Intra-Pixel Position of Small PSFs for Optimizing the PL of Optical Subpixel Localization

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Engineering 2023年第8期27卷 140-149页

作者： Haiyang Zhan Fei Xing Jingyu Bao Ting Sun Zhenzhen Chen Zheng You Li Yuan Department of Precision Instrument Tsinghua UniversityBeijing 100084China State Key Laboratory of Precision Measurement Technology and Instruments Tsinghua UniversityBeijing 100084China Beijing Advanced Innovation Center for Integrated Circuits Tsinghua UniversityBeijing 100084China Joint International Research Laboratory of Advanced Photonics and Electronics Beijing Information Science and Technology UniversityBeijing 100192China Beijing Institute of Control Engineering Beijing 100190Chin

Subpixel localization techniques for estimating the positions of point-like images captured by pixelated image sensors have been widely used in diverse optical measurement *** unavoidable imaging noise,there is a precision limit(PL)when estimating the target positions on image sensors,which depends on the detected photon count,noise,point spread function(PSF)radius,and PSF’s intra-pixel *** studies have clearly reported the effects of the first three parameters on the PL but have neglected the intra-pixel position ***,we develop a localization PL analysis framework for revealing the effect of the intra-pixel position of small *** accurately estimate the PL in practical applications,we provide effective PSF(e PSF)modeling approaches and apply the Cramér–Rao lower *** on the characteristics of small PSFs,we first derive simplified equations for finding the best PL and the best intra-pixel region for an arbitrary small PSF;we then verify these equations on real ***,we use the typical Gaussian PSF to perform a further analysis and find that the final optimum of the PL is achieved at the pixel boundaries when the Gaussian radius is as small as possible,indicating that the optimum is ultimately limited by light ***,we apply the maximum likelihood *** combination with e PSF modeling allows us to successfully reach the PL in experiments,making the above theoretical analysis *** work provides a new perspective on combining image sensor position control with PSF engineering to make full use of information theory,thereby paving the way for thoroughly understanding and achieving the final optimum of the PL in optical localization.

关键词： Optical measurement Subpixel localization Precision limit optimization Small point spread functions Centroiding Star sensors

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A 7DOF redundant manipulator inverse kinematic solution algorithm based on bald eagle search optimization algorithm

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Soft Computing 2024年第23期28卷 13681-13699页

作者： Zhao, Guojun Sun, Ying Jiang, Du Liu, Xin Tao, Bo Jiang, Guozhang Kong, Jianyi Yun, Juntong Liu, Ying Li, Gongfa Key Laboratory of Metallurgical Equipment and Control Technology of Ministry of Education Wuhan University of Science and Technology Wuhan430081 China Research Center for Biomimetic Robot and Intelligent Measurement and Control Wuhan University of Science and Technology Wuhan430081 China Hubei Key Laboratory of Mechanical Transmission and Manufacturing Engineering Wuhan University of Science and Technology Wuhan430081 China Precision Manufacturing Research Institute Wuhan University of Science and Technology Wuhan430081 China

Solving inverse kinematics (IK) is an excellent challenge for redundant manipulators due to their highly non-linear and complex coupling, which is not amenable to analytical solutions by conventional methods. In this paper, the conventional solution was replaced by the optimization process of a fitness function. The fitness function aims to obtain a set of solutions for the desired position of the end effector (EE). The function is based on forward kinematics;hence, this method can avoid singularities and be suitable for solving redundant manipulators. For solving this optimization problem, the bald eagle search (BES) optimization algorithm was chosen due to its easy principle and excellent performance. BES integrates the advantages of evolutionary and swarm techniques. On the one hand, BES maximizes the advantages offered by swarm intelligence (SI) in terms of searching within the best position in the swarm. On the other hand, BES capitalizes on the capability of evolutionary techniques to explore the search space frequently and avoid the local optimum. In this study, two 7-degree of freedom (DOF) manipulators were used to test the performance of BES. Meanwhile, several evolutionary and SI optimization algorithms were selected to compare with BES. The experimental results demonstrate that the BES optimization algorithm can efficiently and accurately solve the IK problem of 7DOF redundant manipulators. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.

关键词： Inverse kinematics

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Receiver-side Lookup-Table-Assisted Equalization for PAM4 IM/DD Transmission Systems

Receiver-side Lookup-Table-Assisted Equalization for PAM4 IM...

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2024 Asia Communications and Photonics Conference, ACP 2024 and International Conference on Information Photonics and Optical Communications, IPOC 2024

作者： Lu, Junde Sun, Yu Qin, Jun Tan, Junxiong Wang, Qian Shi, Jie Chen, Lanling Li, Yueqin Sun, Jian Key Laboratory of lnformation and Communication Systems Ministry of Information Industry Beijing Information Science and Technology University Beijing100192 China Key Laboratory of the Ministry of Education for Optoelectronic Measurement Technology and Instrument Beijing Information Science and Technology University Beijing100192 China

We experimentally demonstrate the performance of the receiver (Rx)-side lookup-table (LUT)-assisted equalization, which has not been previously explored in the receiver for 4-ary pulse amplitude modulation (PAM4) inte... 详细信息

ISBN: (纸本)9798350379266

关键词： Table lookup

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SHORT-TERM TRAFFIC FLOW FORECASTING USING ADAPTIVE ECHO STATE NETWORKS 10

SHORT-TERM TRAFFIC FLOW FORECASTING USING ADAPTIVE ECHO STAT...

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10th International Symposium on Test Automation and instrumentation, ISTAI 2024

作者： Li, Zhouyang Wang, Weiye Li, Qing School of Automation Beijing Information Science & Technology University Beijing China Ministry of Education Key Laboratory of Modern Measurement & Control Technology Beijing China

ISBN: (纸本)9781837242672

In recent years, with the increase in vehicle volume, the traffic system has been inconvenienced. Therefore, the timeliness and accuracy of traffic flow prediction are crucial to the overall efficiency of the traffic system. Echo state network (ESN) has attracted extensive attention in the field of time series and traffic flow prediction due to its simple concept, low computational cost and simplicity. However, the traditional ESN model has certain limitations in terms of prediction accuracy and stability when facing complex and changeable traffic flow data. In order to solve this problem, this paper proposes an ESN prediction model combined with adaptive optimization. The simulated annealing algorithm is used to optimize the configuration of several important parameters of ESN, thereby improving the prediction performance and stability of the model. The experimental results show that the optimized ESN model is significantly better than the traditional ESN method in terms of prediction accuracy and stability. The monthly mean absolute percentage error (MAPE) is reduced from 10.05% to 6.6%, and the average error of each detector is reduced from 9.5% to 6.61%. This study proposes a more efficient and reliable method for short-term traffic flow prediction, which shows potential value in practical applications. © The Institution of Engineering & technology 2024.

关键词： Simulated annealing

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Intracavity-dynamics-based optical phase amplifier with over tenfold amplification

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Photonics Research 2023年第11期11卷 1892-1901页

作者： MINGWANG TIAN YIDONG TAN The State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentTsinghua UniversityBeijing 100084China

The relative phase change between two light fields can be used as a fundamental parameter to measure the physical quantity causing this ***,amplifying the relative phase change becomes attractive to improve the measurement *** amplification using a many-body entangled state(NOON state)is a well-known method;nevertheless,the preparation process for a high-number NOON state is difficult and sensitive to optical ***,we propose and experimentally verify a concise phase amplification method with a tolerance of about five orders of magnitude for optical *** method is based on the optical-feedback-induced intracavity harmonics generation effect to amplify the phase change by 11 times,which is comparable to the highest level of about 10 experimentally reached in NOON ***,the 20th intracavity harmonic is generated when the reinjected photon number increases,indicating that 20 times phase amplification is *** proposed method has a prospect for precision measurement applications.

关键词： optical amplifier phase

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High-Speed PAM8 Silicon Photonics IM/DD System with Artificial Neural Network Equalization 13

High-Speed PAM8 Silicon Photonics IM/DD System with Artifici...

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Optoelectronic Devices and Integration XIII 2024

作者： Lu, Junde Sun, Yu Qin, Jun Tan, Junxiong Wang, Qian Li, Yueqin Sun, Jian Li, Zhensong Key Laboratory of Information and Communication Systems Ministry of Information Industry Beijing Information Science and Technology University Beijing100192 China Key Laboratory of the Ministry of Education for Optoelectronic Measurement Technology and Instrument Beijing Information Science and Technology University Beijing100192 China

ISBN: (纸本)9781510682009

The intensity modulation direct detection (IM/DD) system based on silicon photonic devices stands out as a leading contender for the next generation of short-reach optical communication due to its cost-effectiveness, low power consumption, and compact physical footprint. Nonetheless, its direct representation of digital information through amplitude variations renders them acutely susceptible to transmission impairments. To improve the signal quality at the receiver, digital signal processing (DSP) based equalization plays a pivotal role due to its programmability, flexibility and stability. Among different kinds of equalization methods, neural network (NN)-based equalization algorithms have attracted considerable attention, surpassing traditional algorithms such as feed-forward equalization (FFE), decision feedback equalization (DFE) and Volterra series-based nonlinear equalization (VNLE) et al. This increased attention is attributed to their robust capability for modeling both linear and nonlinear systems. In this paper, by employing a novel NN-based equalization with eight saturation regions activation function, we successfully transmit a 60 GBaud 8-ary pulse amplitude modulation (PAM8) signal with the bit error rate (BER) below high-definition forward error correction (HD-FEC) threshold of 3.8×10-3 and a 70 GBaud PAM8 signal with BER below soft-decision forward error correction (SD-FEC) threshold 2×10-2 using a 4-layer network architecture. Compared to the traditional activation function such as sigmoid and tanh, 1∼3 orders of magnitude of BER can be decreased. The results show that the proposed innovative NNbased equalization has the potential to significantly enhance the performance of the next generation silicon photonics based short-range optical communication systems. © 2024 SPIE. All rights reserved.

关键词： Silicon photonics

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