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Advancement in modulation of brain extracellular space and unlocking its potential for intervention of neurological diseases

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Med-X 2024年第1期2卷 70-102页

作者： Yu Yong Yicong Cai Jiawei Lin Lin Ma HongBin Han Fenfang Li Institute of Biomedical Engineering Shenzhen Bay LaboratoryShenzhenChina School of Physics and Optoelectronic Engineering Guangdong University of TechnologyGuangzhouChina Beijing Key Laboratory of Magnetic Resonance Imaging Devices and Technology Peking University Third HospitalPeking UniversityBeijingChina

Cells in the brain are surrounded by extracellular space (ECS), which forms porous nets and interconnected routes for molecule transportation. Our view of brain ECS has changed from a largely static compartment to dynamic and diverse structures that actively regulate neural activity and brain states. Emerging evidence supports that dysregulation of brain ECS contributes to the pathogenesis and development of many neurological disorders, highlighting the importance of therapeutic modulation of brain ECS function. Here, we aim to provide an overview of the regulation and dysfunction of ECS in healthy and pathological brains, as well as advanced tools to investigate properties of brain ECS. This review emphasizes modulation methods to manipulate ECS with implications to restore their function in brain diseases.

关键词： Brain extracellular space Regulation Brain dysfunction Advanced tools Modulation Neurological diseases

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Molecular design of efficient blue light-emitting polymers based on dibenzothiophene-S,S-dioxide

Molecular design of efficient blue light-emitting polymers b...

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International Conference on Display technology, ICDT 2021

作者： Ying, Lei Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and Devices South China University of Technology Guangzhou510640 China

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Standing Spin Waves in Finite Quantum Spin Spiral Chains

SSRN

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SSRN 2023年

作者： Wieser, Robert School of Physics and Optoelectronic Engineering Nanjing University of Information Science and Technology Nanjing210044 China Jiangsu Key Laboratory for Optoelectronic Detection of Atmosphere and Ocean Nanjing University of Information Science and Technology Nanjing210044 China

Standing spin waves in quantum spin-spiral chains are investigated using the local Pn and totalabsorbed power P. This method allows the investigation of the spin wave pattern and dispersioneven if the quantum mechanical spin system initially has no magnetic order due to quantum *** addition, the spin dynamics during resonance were examined more closely. Withouttaking damping into account, a multi-spin Rabi oscillation can be observed. The Rabi Oscillationdisappears when damping is taken into account. The cause of this behavior becomes apparent whenlooking at the spin wave excitation in the semi-classical description. In the semi-classical description,also a Rabi oscillation occurs, which will be prevented by damping. The cause of the semi-classicalRabi oscillation is to be found in the effective field, which periodically drives the spins out of theequilibrium position or brings them in. The damping creates a spin torque directed against theeffective field’s spin torque which results in small spin oscillations around its equilibrium position. © 2023, The Authors. All rights reserved.

关键词： Damping

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The 3,6-Dimethoxythieno[3,2-B]Thiophene-Based Bifunctional Electrodes for High-Performance Electrochromic Supercapacitors Prepared by One-Step Electrodeposition

SSRN

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SSRN 2024年

作者： Yu, Zhixuan Wang, Rui Tang, Huayu Zheng, Ding Yu, Junsheng State Key Laboratory of Electronic Thin Films and Integrated Devices School of Optoelectronic Science and Engineering University of Electronic Science and Technology of China Chengdu610054 China

An integrated visual energy system consisting of conjugated polymer electrodes is promising for combining electrochromism with energy storage. In this work, we obtained copolymer bifunctional electrodes poly(3,6-dimethoxythieno[3,2-b]thiophene-co-2,3-dihydrothieno[3,4-b][1,4]dioxin-3-ylmethanol)(P(TT-OMe-co-EDTM)) by one-step electrochemical copolymerization, which exhibits favorable electrochromic and capacitive energy storage properties. Owing to the synergistic effect of PTT-OMe and PEDTM, the prepared copolymers show better flexibility. In addition, the morphology and electrochemical properties of the copolymers could be tuned by depositing different molar ratios of 3,6-dimethoxythieno[3,2-b]thiophene (TT-OMe) and 2,3-dihydrothieno[3,4-b][1,4] dioxin-3-ylmethanol (EDTM). The resulted P(TT-OMe-co-EDTM) electrodes achieved high specific capacitance (190 F/g at 5 mV/s), recognizable and tunable color conversion. This work provides a novel and simple pathway to synergistically improve electrochromic and energy storage properties and develop thiophene-based conducting polymers for electrochromic energy storage devices. © 2024, The Authors. All rights reserved.

关键词： Electrochromism

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Trilayer multi-orbital models of La4Ni3O10

arXiv

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arXiv 2024年

作者： Chen, Cui-Qun Luo, Zhihui Wang, Meng Wú, Wéi Yao, Dao-Xin Center for Neutron Science and Technology Guangdong Provincial Key Laboratory of Magnetoelectric Physics and Devices State Key Laboratory of Optoelectronic Materials and Technologies School of Physics Sun Yat-Sen University Guangzhou510275 China

Recently, the discovery of superconductivity in Ruddlesden-Popper (RP) La4Ni3O10 under pressure has further expanded the realm of nickelate-based superconductor family. In this paper, we performed a first-principle study of La4Ni3O10 for both P21/a phase at ambient pressure and I4/mmm phase at high pressure, with U=0, 3.5 eV. Our results confirmed the characteristic upward shift of Ni-dz2 bonding band under pressure. Moreover, our analysis of electronic spectrum and orbital occupancy unveil the dynamic mechanism of electronic reconstructions under pressure, embedded in a critical dual effect. Based on our results, we further proposed a trilayer two-orbital model by performing Wannier downfolding on Ni-eg orbitals. Our model reveals four Fermi surface sheets with α, β, β′, γ pockets, bearing resemblance to that of bilayer La3Ni2O7. According to the model, our calculated spin susceptibility under random phase approximation shows that dx2−y2 orbital is also important for the magnetic fluctuation in RP series. Finally, a high energy sixteen-orbital model with direct dp, pp hoppings is proposed, which implies that La4Ni3O10 also lies in charge-transfer picture within Zaanen-Sawatzky-Allen scheme. Our exposition of electronic reconstructions and multi-orbital models shed light on theoretical electronic correlation study and experimental exploration of lower pressure superconductor in RP series. © 2024, CC0.

关键词： Nickel compounds

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Integrated indoor positioning and tracking system based on a single WiFi CSI image

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optoelectronics Letters 2025年

作者： ZHAI Yuefeng ZHOU Ruiyang MENG Fanchen XUE Mingming YANG Haixiao WU Hong College of Electronic Information and Optical Engineering， Nankai University Beijing Institute of Aerospace Control Devices Tianjin Key Laboratory of Optoelectronic Sensor and Sensing Network Technology Ministry of Education， Engineering Research Center of Thin Film Optoelectronics Technology， Nankai University

In recent years， with the increasing demand for indoor positioning， the indoor devic-less passive positioning technology based on WiFi channel state image information has developed rapidly. we propose TR-KWNN positioning algorithm. The positioning algorithm based on Time Reversal technology (TR) equalized the reverse channel to a matched filter， and used the spatio-temporal focusing characteristics of the signal to achieve high-precision position matching， so that the minimum average positioning error was 0.678m using all link information. The positioning error is below 0.78m with 80% probability， which realizes high-precision device-free positioning of static targets in indoor environment. At the same time， in order to extend the ability of positioning technology and realize the continuous positioning of indoor personnel， a variable-length continuous fingerprint separation method that is more in line with actual application scenarios is designed. It greatly reduces the cost of fingerprint database *** method introduces the voice signal endpoint detection algorithm into the WiFi positioning field by continuously sampling the target position information， and completes fingerprint separation by marking the movement time of personnel. The proposed method can effectively solve the complex problem of offline fingerprint database acquisition， and the average positioning accuracy of all the separated fingerprint data is 0.796m. Finally， the integrated system of indoor passive positioning and tracking with low complexity and continuous stability is realized.

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Magnetic phase transitions in the triangular-lattice spin-1 dimer compound K2Ni2(SeO3)3

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Physical Review B 2024年第21期109卷 214430-214430页

作者： Lei Yue Ziyou Lu Kun Yan Le Wang Shu Guo Ruixin Guo Peng Chen Xiaobin Chen Jia-Wei Mei Department of Physics School of Science and State Key Laboratory on Tunable Laser Technology and Ministry of Industry and Information Technology Key Lab of Micro-Nano Optoelectronic Information System Shenzhen Institute for Quantum Science and Engineering International Quantum Academy Shenzhen 518048 China Dongguan Guangdong 523808 China Shenzhen Key Laboratory of Advanced Quantum Functional Materials and Devices

In our study, we conduct magnetization and heat capacity measurements to investigate field-induced magnetic phase transitions within the newly synthesized compound K2Ni2(SeO3)3, a spin-1 dimer system arranged on a triangular lattice. From our first-principles simulations, we determine that the spin system in K2Ni2(SeO3)3 can be represented as a two-dimensional triangular-lattice spin-1 dimer model, including an intra-dimer exchange of J1=0.32meV, an inter-dimer exchange of J2=0.79meV, and an easy-axis anisotropy of D=0.14meV. The presence of easy-axis magnetic anisotropy explains the distinct magnetic phase diagrams observed under c-axis directional and in-plane magnetic fields. Notably, our investigation unveils a two-step phase transition with the magnetic field aligned with the c direction. Our findings yield valuable insights into the magnetic phase transitions inherent to geometrically frustrated magnetic systems featuring dimer structures.

关键词： Frustrated magnetism Magnetic phase transitions Triangular lattice Magnetization measurements Specific heat measurements X-ray diffraction

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CMOS Compatible Spike Vision Sensor

CMOS Compatible Spike Vision Sensor

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IEEE Electron devices technology and Manufacturing Conference (EDTM)

作者： Xiaolin Liu Chao Gao Bowei Jiang Xin Jin Zhou Zhou Yihong Qi Kai Wang Guangdong Province Key Laboratory of Display Material and Technology State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information Technology Sun Yat-sen University Guangzhou China National Innovation Center for Advanced Medical Devices Shenzhen China

ISBN: (数字)9798331504168

ISBN: (纸本)9798331504175

Intelligent vision systems hold a unique position in the era of big data due to their high efficiency and low power consumption. Conventional intelligent vision systems with traditional image sensors are reaching the limit and not smart enough to address rapidly-growing computer vision applications. Energy-efficient vision sensors are therefore urgently needed for the next-generation vision systems. Spike vision sensors, possessing the ability to realize in-sensing computing with low power consumption, are one of promising candidates for the future intelligent vision systems.

关键词： Image sensors Visualization Semiconductor device measurement Power demand Neuromorphic engineering Machine vision Spiking neural networks Vision sensors Topology Substrates

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A solution-processed nanoscale COF-like material towards optoelectronic applications

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Science China Chemistry 2021年第1期64卷 82-91页

作者： Qiang Fu Ting Wang Yanna Sun Nan Zheng Zengqi Xie Di Lu Zhiyuan Xu Xiangjian Wan Yamin Zhang Yongsheng Liu The Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer Materials Institute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin 300071China Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhou 510640China State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000China Renewable Energy Conversion and Storage Center Nankai UniversityTianjin 300071China

Two-dimensional(2 D)covalent organic frameworks(COFs)with periodic functionalπ-electron systems are an emerging class of optoelectronic ***,almost all conjugated COFs so far are insoluble and hard to process,which hampers severely their optoelectronic ***,a solution-processable,nanoscale and sp2 carbon-conjugated COF-like material,PDPP-C20 was successfully designed and *** solution-processed PDPP-C20 films exhibit high crystallinity and excellent charge transport properties along out-of-plane directions,combined with the highest occupied molecular orbital(HOMO)/lowest unoccupied molecular orbital(LUMO)levels of-5.36/-3.75 e V,making PDPP-C20 suitable for electronic device *** efficiency as high as 21.92%has been demonstrated when it was used as a functional interfacial layer in perovskite solar cells,coupled with dramatically improved stability in comparison with the control device due to the superior hydrophobicity of PDPP-C20 layer as well as its passivation effect on perovskite ***,the soluble PDPP-C20 could also be used as donor in bulk-heterojunction organic solar cells and an initial efficiency of 2.46%has been *** results indicate that this new class of soluble and nanoscale COF-like materials should offer a new arena of functional materials for optoelectronic devices.

关键词： solution-processable covalent organic frameworks perovskite solar cells mobility passivation

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A High-Sensitivity and Wide-Dynamic-Range Image Sensor with Extended-Silicon Responsive Spectrum from 254 nm to 1310 nm

A High-Sensitivity and Wide-Dynamic-Range Image Sensor with ...

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IEEE International Symposium on Circuits and Systems (ISCAS)

作者： Tao Ma Xiaoliu Liu Xin Jin Chao Gao Zhou Zhou Kai Wang Yihong Qi Guangdong Province Key Laboratory of Display Material and Technology State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information Technology Sun Yat-sen University Guangzhou China National Innovation Center for Advanced Medical Devices Shenzhen China

ISBN: (数字)9798350356830

ISBN: (纸本)9798350356847

The spectral response of silicon-based CMOS image sensors has been limited from 300 nm (UVB) to 1100 nm (NIR) with a non-uniform external quantum efficiency (EQE). Breaking through this limitation can push Si-based image sensors towards broader-band applications such as secure surveillance and scientific instrumentation. Here, we propose a silicon-based image sensor with a five-transistor active pixel sensor (5T-APS) design that is based upon an embedded photodiode-body-biased MOSFET (PD-MOS), achieving an EQE of 639 % at 254 nm and 154 % at 1310 nm, and a wide dynamic range of over 120 dB. Furthermore, we have developed a readout circuit, and a compact hardware system that works for the 5T-APS pixel arrays.

关键词： MOSFET Circuits and systems Surveillance Instruments Active pixel sensors CMOS image sensors Hardware High dynamic range

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