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Applications of artificial intelligence to lipid nanoparticle delivery

Particuology 2024年第7期90卷 88-97页

作者： Ye Yuan Yuqi Wu Jiabei Cheng Kaiyuan Yang Yilin Xia Hongguang Wu Xiaoyong Pan Institute of Image Processing and Pattern Recognition Shanghai Jiao Tong UniversityKey Laboratory of System Control and Information ProcessingMinistry of Education of ChinaChina Songjiang Research Institute Songjiang District Central HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Lipid nanoparticles(LNPs)are nanocarriers composed of four lipid components and can be used for gene therapy,protein replacement,and vaccine ***,LNPs also face several challenges,such as toxicity,immune activation,and low delivery *** overcome these challenges,artificial intelligence can be used to optimize the design and formulation of LNPs,as well as to predict their properties and ***,antibody-targeted conjugation can be used to enhance the specificity and selectivity of LNPs by attaching an antibody that recognizes a specific antigen on the cell surface to LNPs.

关键词： Artificial intelligence Lipid nanoparticles Antibody Targeted conjugation

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Study of the 6.x nm short wavelength radiation spectra of laser-produced erbium plasmas for BEUV lithography

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Plasma Science and Technology 2023年第6期25卷 41-51页

作者：吴涛王倩陈柳安陆培祥 Hubei Key Laboratory of Optical Information and Pattern Recognition School of Optical Information and Energy EngineeringWuhan Institute of TechnologyWuhan 430205People's Republic of China Guangdong Intelligent Robotics Institute Dongguan 523808People's Republic of China

Beyond extreme ultraviolet(BEUV)radiation with a wavelength of 6.x nm for lithography is responsible for reducing the source wavelength to enable continued miniaturization of semiconductor *** this work,the Required BEUV light at 6.x nm wavelength was generated in dense and hot Nd:YAG laser-produced Er *** spectral contributions from the 4p–4d and 4d–4f transitions of singly,doubly and triply excited states of Er XXIV–Er XXXII in the BEUV band were calculated using Cowan and the Flexible Atomic *** was also found that the radiative transitions between multiply excited states dominate the narrow wavelength window around 6.x *** the assumption of collisional radiative equilibrium of the laser-produced Er plasmas,the relative ion abundance in the experiment was *** the Boltzmann quantum state energy level distribution and Gram–Charlier fitting function of unresolved transition arrays(UTAs),the synthetic spectrum around 6.x nm was finally obtained and compared with the experimental *** spatio-temporal distributions of electron density and electron temperature were calculated based on radiation hydrodynamic simulation in order to identify the contributions of various ionic states to the UTAs arising from the Er plasmas near 6.x nm.

关键词： laser-produced plasmas unresolved transition array collisional radiative equilibrium

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A new RCNN-RF for efficient and robust parking lot available detection 16

A new RCNN-RF for efficient and robust parking lot available...

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16th International Conference on Digital Image Processing, ICDIP 2024

作者： Zhang, Qian Ran, Yaqin Luo, Di Xu, Kaili Shi, Jilaing School of Data Science and Information Engineering GuiZhou MinZu University Guiyang550025 China Guizhou Key Laboratory of Pattern Recognition and Intelligent System Guiyang550025 China

ISBN: (数字)9781510682917

ISBN: (纸本)9781510682900

It's very meaningful to conduct the driver to the parking space available in the parking lot clearly and accurately by computer vision and computational intelligence. While it is an extremely difficult task, because of the scene complexity in the parking lot. In this paper, a new computational intelligence technology is proposed to detect parking spaces available in the parking lot outdoor based on fusing of Region Convolution Neural Network (RCNN) and random forests (RF), and we called it as RCNN-RF. Within the RCNN-RF, a new activation function is design. And with the help of random forests, RCNN-RF overcomes scene complexity includes illumination, weather, and slight occlusion successfully. Extensive experimental results on the benchmark dataset named PKLot and the self-built dataset named GZMU-LOT outperform those of the state-of-the-art, and it shows the superiority of our proposed RCNN-RF method. © 2024 SPIE.

关键词： Random forests

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Research on the Detection of Abnormal Cervical Cells Based on Improved YOLOv7 9

Research on the Detection of Abnormal Cervical Cells Based o...

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9th International Conference on intelligent Computing and Signal Processing, ICSP 2024

作者： Wang, Xuewei Yuan, Shuang Yang, Lidong Niu, Dawei Inner Mongolia University of Science and Technology School of Digtial and Intelligence Industry Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing Inner Mongolia China

ISBN: (纸本)9798350376548

Cervical cytologic screening is clinically important for the prevention and diagnosis of cervical cancer. Aiming at the many challenges in the detection of abnormal cervical cells, including the difficult detection of small targets of abnormal cervical cells, complex backgrounds, and uneven cell morphology, a detection algorithm for abnormal cervical cells based on improved YOLOv7 was proposed. The algorithm utilizes Deformable Convolutional Networks v2 (DCNv2) that adaptively de-tunes the scale and receptive field size to more effectively cope with the complexity and diversity of cervical cell images. The experimental results show that the improved YOLOv7 algorithm mAP achieves 57.26%, up to 73.88% accuracy, and 46.90% recall on the cervical abnormal cell dataset. Compared with the benchmark model, they increased by 4.07%, 3.39%, and 5.69%, respectively. © 2024 IEEE.

关键词： Convolution

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Size and Defect Detection of Valve Based on Computer Vision

Size and Defect Detection of Valve Based on Computer Vision

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2022 International Conference on Computer Graphics, Artificial Intelligence, and Data Processing, ICCAID 2022

作者： Yan, Xiaobo Feng, Le Tan, Mian Yang, Yuan Zhang, Yu Wang, Lin Guizhou Key Laboratory of Pattern Recognition and Intelligent System China Guizhou Minzu University Guiyang550025 China Guiyang Fusheng Intelligent Technology Co. Ltd China

ISBN: (纸本)9781510663350

Engine valve is the core component of the engine, and its quality determines the performance of the engine. In industrial production quality inspection, it is necessary to detect the size of the valve and whether there are defects on the surface. Usually, the quality of the valve is determined by comparing the image of the valve surface with the standard image. However, the existing surface defect detection technology cannot detect the curved surface device. In order to solve this problem, this paper designs a valve size and defect detection method based on computer vision. The experimental results show that the method can quickly and accurately detect the rod diameter, groove radius and surface defects of the valve. The method is practical, robust and real-time. © 2023 SPIE.

关键词： Computer vision

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Facial expression recognition under occlusion conditions based on multi-feature cross-attention

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Journal of intelligent and Fuzzy Systems 2024年第4期46卷 9841-9856页

作者： Guo, Sheng Tan, Mian Cai, Shan Zhang, Zaijun Liang, Yihui Feng, Hongxi Zou, Xue Wang, Lin School of Data Science and Information Engineering Guizhou Key Laboratory of Pattern Recognition and Intelligent System Guizhou Minzu University Guiyang China School of Mathematics and Statistics Qiannan Normal University for Nationalities Key Laboratory of Complex Systems and Intelligent Optimization of Guizhou Province Duyun China Zhongshan Institute University of Electronic Science and Technology of China Zhongshan China Guizhou Aerospace Tianma Electromechanical Technology Co LTD Zunyi China

Although facial expression recognition (FER) has a wide range of applications, it may be difficult to achieve under local occlusion conditions which may result in the loss of valuable expression features. This issue has motivated the present study, as a part of which an effective multi-feature cross-attention network (MFCA-Net) is proposed. The MFCA-Net consists of a two-branch network comprising a multi-feature convolution module and a local cross-attention module. Thus, it enables decomposition of facial features into multiple sub-features by the multi-feature convolution module to reduce the impact of local occlusion on facial expression feature extraction. In the next step, the local cross-attention module distinguishes between occluded and unoccluded sub-features and focuses on the latter to facilitate FER. When the MFCA-Net performance is evaluated by applying it to three public large-scale datasets (RAF-DB, FERPlus, and AffectNet), the experimental results confirm its good robustness. Further validation is performed on a real FER dataset with local occlusion of the face. © 2024 – IOS Press.

关键词： Convolution

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Multi-Level Cross-Modal Alignment for Speech Relation Extraction

Multi-Level Cross-Modal Alignment for Speech Relation Extrac...

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2024 Conference on Empirical Methods in Natural Language Processing, EMNLP 2024

作者： Zhang, Liang Yang, Zhen Fu, Biao Lu, Ziyao Shao, Liangying Liu, Shiyu Meng, Fandong Zhou, Jie Wang, Xiaoli Su, Jinsong School of Informatics Xiamen University China Xiamen Key Laboratory of Intelligent Storage and Computing School of Informatics Xiamen University China Pattern Recognition Center WeChat AI Tencent Inc. China

ISBN: (纸本)9798891761643

Speech Relation Extraction (SpeechRE) aims to extract relation triplets from speech data. However, existing studies usually use synthetic speech to train and evaluate SpeechRE models, hindering the further development of SpeechRE due to the disparity between synthetic and real speech. Meanwhile, the modality gap issue, unexplored in SpeechRE, limits the performance of existing models. In this paper, we construct two real SpeechRE datasets to facilitate subsequent researches and propose a Multi-level Cross-modal Alignment Model (MCAM) for SpeechRE. Our model consists of three components: 1) a speech encoder, extracting speech features from the input speech;2) an alignment adapter, mapping these speech features into a suitable semantic space for the text decoder;and 3) a text decoder, autoregressively generating relation triplets based on the speech features. During training, we first additionally introduce a text encoder to serve as a semantic bridge between the speech encoder and the text decoder, and then train the alignment adapter to align the output features of speech and text encoders at multiple levels. In this way, we can effectively train the alignment adapter to bridge the modality gap between the speech encoder and the text decoder. Experimental results and in-depth analysis on our datasets strongly demonstrate the efficacy of our method. Our source code is available at https://***/DeepLearnXMU/SpeechRE-MCAM. © 2024 Association for Computational Linguistics.

关键词： Semantics

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Feature Decoupled of Deep Mutual Information Maximization 2

Feature Decoupled of Deep Mutual Information Maximization

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2nd International Conference on Automation, Robotics and Computer Engineering, ICARCE 2023

作者： He, Xing Peng, Changgen Wang, Lin Tan, Weijie Wang, Zifan State Key Laboratory of Public Big Data College of Computer Science and Technology Guizhou University Guizhou Key Laboratory of Pattern Recognition and Intelligent System Guizhou Minzu University Guiyang China Guizhou Big Data Academy Guizhou University Guiyang China Guizhou Minzu University Guizhou Key Laboratory of Pattern Recognition and Intelligent System Guiyang China Institute of Guizhou Aerospace Measuring and Testing Technology Guiyang China

ISBN: (纸本)9798350308341

In deep learning, supervised learning techniques usually require a large amount of expensive labeled data to train the network, and the feature representations extracted by the model usually mix multiple attributes, resulting in feature representations that are difficult to decouple and are non-interpretable, which restricts the application and development of deep learning techniques, and for this reason, it is particularly important to study decoupled feature representation methods for unsupervised learning. Although the Learning deep representations by mutual information estimation and maximization (DIM) method achieves excellent results in unsupervised learning, the feature representations learned by the DIM method still suffer from the problem of difficult decoupling. decoupling problem. To address this problem, we minimize the mutual information between the intermediate layer feature representations learned by the hidden layer of the encoder during the encoder training process, so that the features learned by each filter are as uncorrelated as possible, thus realizing feature decoupling, and our method is called FP-DIM. Finally, the effectiveness of the FP-DIM method is verified on the CIFAR-10, STL-10, and Fashion-MNIST datasets. The experiments show that our proposed FP-DIM method is more significant for the learned decouplable middle layer feature representation. Finally, we also propose a reflection of future research for the FP-DIM method, aiming to provide a research idea and direction for solving unsupervised interpretable machine learning and to lay a solid theoretical and application foundation for machine learning fields such as image classification and migration learning. © 2023 IEEE.

关键词： Unsupervised learning

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Gait Planning and Motion control Based on Vrep Simulation for Quadruped Robot 5

Gait Planning and Motion Control Based on Vrep Simulation fo...

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5th World Robot Conference Symposium on Advanced Robotics and Automation, WRC SARA 2023

作者： Zhou, Linqi Chen, Zhihua Liu, Jun Liu, Zhi Chen, Yumeng Zhang, Liting Nanchang Hangkong University Key Laboratory of Jiangxi Province for Image Processing and Pattern Recognition Moe Key Lab of Nondestructive Testing Technology Nanchang330063 China Beijing Institute of Technology State Key Laboratory of Intelligent Control and Decision of Complex Systems School of Automation Beijing100081 China

ISBN: (纸本)9798350307320

Gait planning of quadruped robots plays an important role in achieving less walking, including dynamic and static gait. In this article, a static and dynamic gait control method based on center of gravity stability margin is proposed. Firstly, the robot model and kinematics modeling are introduced. Secondly, the robot's foot static and dynamic gait were planned and the foot trajectory was designed. Finally, two types of gait of the robot were simulated using Vrep simulation software, and the differences in stability and speed between the coordinated gait with speed and stability in the static and dynamic gait of a 12 degree of freedom robot were analyzed, verifying the effectiveness of the gait control method proposed in this paper. © 2023 IEEE.

关键词： Robot programming

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A cross-domain person re-identification algorithm based on distribution-consistency and multi-label collaborative learning

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Multimedia Tools and Applications 2024年第38期83卷 85939-85962页

作者： Zhang, Baohua Hao, Chen Lv, Xiaoqi Gu, Yu Wang, Yueming Liu, Xin Ren, Yan Li, Jianjun School of Information Engineering Inner Mongolia University of Science and Technology Inner Mongolia Baotou014010 China School of Information Engineering Mongolia Industrial University Inner Mongolia Huhehaote010051 China Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing Inner Mongolia Baotou014010 China

To decrease domain shift in cross-domain person re-identification, existing methods generate pseudo labels for training models, however, the inherent distribution between source domain data and the hard quantization loss is ignored. Therefore, a cross-domain person re-identification method based on distribution consistency and multi-label collaborative learning is proposed. Firstly, a soft binary cross-entropy loss function is constructed to constrain the inter-sample relationship of cross-domain transformation, which can ensure the consistency of appearance features and sample distribution, and achieving feature cross-domain alignment. On this basis, in order to suppress the noise of hard pseudo labels, a multi-label collaborative learning network is constructed. The soft pseudo labels are generated by using the collaborative foreground features and global features to guide the network training, making the model adapt to the target domain. The experimental results show that the proposed method has better performance than that of recent representative methods. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.

关键词： Federated learning

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