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Optics in Health Care and Biomedical Optics XII 2022

作者： Song, Jiawei Yang, Huibin Zeng, Nan Ma, Hui Guangdong Research Center of Polarization Imaging and Measurement Engineering Technology Shenzhen Key Laboratory for Minimal Invasive Medical Technologies Tsinghua Shenzhen International Graduate School Tsinghua University Shenzhen518055 China Department of Physics Tsinghua University Beijing100084 China Shenzhen International Graduate School Tsinghua University Shenzhen China Center for Precision Medicine and Healthcare Tsinghua-Berkeley Shenzhen Institute Shenzhen518071 China

ISBN: (纸本)9781510657069

polarization imaging has shown the potential as a label-free tool in biomedical research due to its sensitivity to microstructures, especially the anisotropy analysis in pathological diagnosis. The digital pathology based on Mueller matrix systems has developed rapidly in recent years, and gradually progressed from qualitative to quantitative recognition. However, traditional critical illumination used in Mueller microscopes is likely to generate non-uniform projection accompanied by spatially varying irradiance, possibly due to unaligned optics, dust, nonuniform light sources, vignetting, etc. The non-uniform illumination results in artifacts in polarization images when stitching adjacent images to obtain a polarized image of the full sample, limiting the increase of the field of view (FOV). Therefore, a Mueller matrix microscope system with flat-field illumination and with motorized two-axis stage is proposed, we minimize the artifacts caused during splicing by uniform illumination, as well as increase the signal-to-noise (SNR) in the whole polarization images. The comparison of the real pathological sections under flat-field and wide-field illumination confirms the potential of large FOV imaging, which allows the structure of the sample to be presented more completely, laying the foundation for future pixel-level polarization digital pathology. © 2022 SPIE.

关键词： Light sources

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Super-resolution Reconstruction Algorithm for Depth Image Based on Fractional Calculus

Super-resolution Reconstruction Algorithm for Depth Image Ba...

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第35届中国控制与决策会议

作者： Tingsheng Huang Xinjian Wang Chunyang Wang Xuelian Liu Yanqing Yu Wenqian Qiu School of Electronic and Information Engineering Changchun University of Science and Technology Xi'an Key Laboratory of Active Photoelectric Imaging Detection Technology Xi'an Technological University College of Photonic and Electronic Engineering Fujian Normal University

This study presents a new method for superresolution of depth images by combining fractional calculus and inverse distance *** method improves edge recognition through fractional differential and solves the problem of missing data in traditional super-resolution algorithms for depth *** show that the proposed method outperforms classical interpolation algorithms,with improved PSNR by 3-10 *** method effectively solves the impact of depth image edge distance on interpolation results,and provides more texture information.

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Review of Geostationary Interferometric Infrared Sounder

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Chinese Optics Letters 2018年第11期16卷 47-57页

作者： Jianwen Hua Zhanhu Wang Juan Duan Libing Li Chenjun Zhang Xiaowei Wu Qing Fan Ren Chen Xiaojie Sun Lianwei Zhao Qian Guo Lei Ding Liwei Sun Changpei Han Xiangyang Li Nili Wang Haimei Gong Xiaoning Hu Qingjun Liao Dingquan Liu Tianyan Yu Yinong Wu Enguang Liu Zhijiang Zeng Center of Interferometer R＆D Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200082China Key Laboratory of Infrared System Detection and Imaging Technology Chinese Academy of SciencesShanghai 200082China Third Engineering Department Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200082China infrared Imaging Material and Device Laboratory Chinese Academy of SciencesShanghai 200082China Key Laboratory of Infrared Imaging Materials and Detectors Chinese Academy of SciencesShanghai 200082China Department of Optical Coatings and Materials Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200082China Space Cryocooler System Laboratory Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200082China State Key Laboratory of Transducer Technology Chinese Academy of SciencesShanghai 200082China Corresponding author：wuxiaowei@***

To measure the global atmospheric three-dimensional distribution and change of temperature and humidity is one of the key areas in atmospheric remote sensing detection; it is also a new research and development direction in the field of meteorological satellite application. As a main element of China second generation of geostationary meteorological satellite Fengyun 4 （FY-4）, which was launched on Dec. 11, 2016, the Geostationary Interferometric Infrared Sounder （GIIRS） is the first interferometric infrared sounder working on the international geostationary orbit. It is used for vertical atmospheric sounding and gains atmospheric temperature, humidity, and disturbances. The combination of Fourier transform spectrometer technology and infrared detectors makes GIIRS have high spectral resolution and large coverage over spatial areas. With this kind of instrument, meteoro- logical satellites can improve the capabilities for severe weather event monitoring and numerical weather prediction. Here a concise review of the GIIRS development project, including its history, missions and functions, technical design, key technologies, system integration, calibration and in-orbit operation status, etc., is presented.

关键词： Calibration Infrared detectors Remote sensing Temperature

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A simple Bessel module with tunable focal depth and constant resolution for commercial two-photon microscope

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Journal of Innovative Optical Health Sciences 2023年第4期16卷 150-159页

作者： Ting Mo Yiran Liu Fatao Bie Zimin Dai Jin Chang Hui Gong Wei Zhou Britton Chance Center and MoE Key Laboratory for Biomedical Photonics Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan P.R.China MoE Key Laboratory for Biomedical Photonics Collaborative Innovation Center for Biomedical Engineering School of Engineering Sciences Huazhong University of Science and Technology Wuhan Hubei 430074P.R.China Research Unit of Multimodal Cross Scale Neural Signal Detection and Imaging Chinese Academy of Medical Sciences HUST-Suzhou Institute for Brainsmatics JITRI Suzhou P.R.China

The volumetric imaging of two-photon microscopy expands the focal depth and improves the throughput,which has unparalleled superiority for three-dimension samples,especially in ***,emerging in volumetric imaging is still largely customized,which limits the integration with commercial two-photon ***,we analyzed the key parameters that modulate the focal depth and lateral resolution of polarized annular imaging and proposed a volumetric imaging module that can be directly integrated into commercial two-photon systems using conventional optical *** design incorporates the beam diameter adjustment settings of commercial two-photon systems,allowing flexibility to adjust the depth of focus while maintaining the same lateral ***,the depth range and lateral resolution of the design were verified,and the imaging throughput was demonstrated by an increase in the number of imaging neurons in the awake mouse cerebral cortex.

关键词： Volumetric imaging Bessel beam two-photon microscopy

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detection Algorithm of Infrared Dim Small Target Based on FPGA

Detection Algorithm of Infrared Dim Small Target Based on FP...

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Chinese Automation Congress (CAC)

作者： Yingyue Wu Huaicheng Yan Mengling Wang Key Laboratory of Infrared System Detection and Imaging Technology Shanghai Institute of Technical Physics Chinese Academy of Sciences Shanghai China School of Information Science and Engineering East China University of Science and Technology Shanghai China

ISBN: (数字)9781728176871

ISBN: (纸本)9781728176888

The traditional infrared dim and small target detection algorithm is generally implemented by DSP (Digital Signal Processing) processor, which is complex and has poor real-time performance. In this paper, a FAST (Features from Accelerated Segment Test) algorithm of adaptive threshold based on FPGA (Field Programmable Gate Array) is proposed to detect infrared dim and small target. Based on the characteristics of FPGA parallel processing, the hardware acceleration of algorithm is realized by pipeline design. The improved adaptive threshold method can generate appropriate thresholds according to different environments, and avoid the loss or redundancy of dim and small infrared targets due to improper threshold selection. At last, two different groups of infrared images are used for experiment, the results show that the algorithm can detect the dim and small targets in the infrared image in real time, and can achieve high detection rate and low false alarm rate, which meets the requirements of real-time and effectiveness.

关键词： Signal processing algorithms Real-time systems Information science Field programmable gate arrays Digital signal processing Redundancy Pipelines

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polarization imaging of biological samples with spatial filtering 12

Polarization imaging of biological samples with spatial filt...

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Optics in Health Care and Biomedical Optics XII 2022

作者： Liu, Zhidi Zeng, Nan Song, Jiawei Ma, Hui Guangdong Research Center of Polarization Imaging and Measurement Engineering Technology Shenzhen Key Laboratory for Minimal Invasive Medical Technologies Graduate School at Shenzhen Tsinghua Shenzhen International Graduate School Shenzhen518055 China Tsinghua Shenzhen International Graduate School Tsinghua University Beijing100084 China Department of Physics Tsinghua University Beijing100084 China Center for Precision Medicine and Healthcare Tsinghua-Berkeley Shenzhen Institute Shenzhen China

ISBN: (纸本)9781510657069

polarization measurement technology can detect the microscopic structure information from biological samples. However, for biological samples with weak scattering effect, the optical signal obtained by the detector will contain a large amount of zero-frequency light without scattering, which makes it difficult to effectively extract the polarization information of the samples with weak scattering effect. Therefore, in this study, we introduce spatial filtering technique into polarization measurement. In the experimental setup, a spatial filter is placed in the rear focal plane of the objective lens to block the zero-frequency light, so as to realize the selection of scattered photons. A red LED with the wavelength of 633nm was used as the lighting source. The measurement of polarization information is based on the dual-rotating quarter-wave plate method. Considering the widespread presence of spherical and columnar scatterers in biological systems, Hacat cells and biological fibers were selected for the experiment. By comparing with the polarization data without spatial filtering, we found that the polarization parameter obtained after the high pass filtering measurement can better characterize the samples. © 2022 SPIE.

关键词： High pass filters

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Advances in nuclear detection and readout techniques

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Nuclear Science and Techniques 2023年第12期34卷 281-358页

作者： Rui He Xiao‑Yang Niu Yi Wang Hong‑Wei Liang Hong‑Bang Liu Ye Tian Hong‑Lin Zhang Chao‑Jie Zou Zhi‑Yi Liu Yun‑Long Zhang Hai‑Bo Yang Ju Huang Hong‑Kai Wang Wei‑Jia Han Bei Cao Gang Chen Cong Dai Li‑Min Duan Rui‑Rui Fan Fang‑Fa Fu Jian‑Hua Guo Dong Han Wei Jiang Xian‑Qin Li Xin Li Zhuo‑Dai Li Yu‑Tie Liang Shun Liao De‑Xu Lin Cheng‑Ming Liu Guo‑Rui Liu Jun‑Tao Liu Ze Long Meng‑Chen Niu Hao Qiu Hu Ran Xiang‑Ming Sun Bo‑Tan Wang Jia Wang Jin‑Xiang Wang Qi‑Lin Wang Yong‑Sheng Wang Xiao‑Chuan Xia Hao‑Qing Xie He‑Run Yang Hong Yin Hong Yuan Chun‑Hui Zhang Rui‑Guang Zhao Ran Zheng Cheng‑Xin Zhao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China Key Laboratory of Particle and Radiation Imaging Department of Engineering PhysicsTsinghua UniversityBeijing 100084China School of Integrated Circuits Dalian University of TechnologyDalian 116020China Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Electronic Engineering School Heilongjiang UniversityHarbin 150080China Spallation Neutron Source Science Center Dongguan 523803China Micro‑electronic Department Harbin Institute of TechnologyHarbin 150001China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210034China Liaoning Academy of Materials Shenyang 110167China Istituto Nazionale di Fisica Nucleare Sezione di PerugiaPerugiaItaly School of Mathematics and Physics Chengdu University of TechnologyChengdu 620035China PLAC Key Laboratory of Quark and Lepton Physics(MOE)Central China Normal UniversityWuhan 430079China School of Electronics and Information Northwestern Polytechnical UniversityXi’an 710129China State Key Lab of Superhard Materials College of PhysicsJilin UniversityChangchun 130012China School of Computer Science Northwestern Polytechnical UniversityXi’an 710129China

“A Craftsman Must Sharpen His Tools to Do His Job,”said *** detection and readout techniques are the foundation of particle physics,nuclear physics,and particle astrophysics to reveal the nature of the ***,they are being increasingly used in other disciplines like nuclear power generation,life sciences,environmental sciences,medical sciences,*** article reviews the short history,recent development,and trend of nuclear detection and readout techniques,covering Semiconductor Detector,Gaseous Detector,Scintillation Detector,Cherenkov Detector,Transition Radiation Detector,and Readout *** explaining the principle and using examples,we hope to help the interested reader underst and this research field and bring exciting information to the community.

关键词： Silicon detector Wide bandgap detector Time projection chamber(TPC) Multigap resistive plate chamber detector(MRPC) Scintillation detector Calorimeters Cherenkov detector Transition radiation detector Artificial intelligence Trigger-less readout

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Infrared polarization Image Fusion and detection System for Ship Target

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Journal of Physics: Conference Series 2021年第2期1802卷

作者： Haonan Tuo Guochuan Shi Xiaolin Luo Army Artillery and Air Defense Academy Heifei China Anhui province Key Laboratory of Polarization Imaging Detection Technology Hefei China

In order to realize the fusion and detection of ship targets, infrared polarization image fusion and detection technology is adopted in this paper, and a design scheme of infrared polarization image fusion and detection system based on ship targets is proposed, which solves the key technologies such as processing system and fusion and detection algorithm, and the image detection rate is high. The proposed system can be used as a laboratory standby system.

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A quantitative and non-contact technique to detect skin water content based on Mueller matrix polarimetry

A quantitative and non-contact technique to detect skin wate...

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Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2021

作者： Zhai, Haoyu Huang, Rongrong Shao, Conghui He, Honghui Ma, Hui Guangdong Research Center of Polarization Imaging and Measurement Engineering Technology Shenzhen Key Laboratory for Minimal Invasive Medical Technologies Institute of Optical Imaging and Sensing Tsinghua Shenzhen International Graduate School Tsinghua University Shenzhen518055 China Department of Biomedical Engineering Tsinghua University Beijing100084 China Department of Physics Tsinghua University Beijing100084 China Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate School Tsinghua University Shenzhen518055 China Tsinghua-Berkeley Shenzhen Institute Tsinghua University Shenzhen518071 China

ISBN: (数字)9781510641280

ISBN: (纸本)9781510641273

Water content of stratum corneum has one of the most important biological effects on the physiological function of the skin. Measuring and adjusting the water content can be helpful to understand the physiological state of skin and delay skin aging. However, most existing skin water content analyzers have to contact the skin and the results may be affected by personal usage habits prominently. Mueller matrix polarimetry is sensitive to structural features of tissues. Parameters derived from Mueller matrix can provide the microstructural information quantitatively, such as the sizes of scatterers, the distribution of collagen fibers and so on. In this study, we demonstrate a novel, quantitative, non-contact and in situ technique based on Mueller matrix polarimetry for monitoring the microstructural changes of skin tissues during the process of skin water content reduction. We measure the Mueller matrices of rat skin samples and porcine abdominal skin samples, then analyze the Mueller matrix derived parameters to indicate microstructural changes during the skin water content reduction processes. Comparison between the rat skin samples applied with and without moisturizing cream show that the Mueller matrix derived parameters are potential indicators to reflect the water content of the skin quantitatively. This technique can provide a non-contact detection method and be used to evaluate the change of skin water content when different skin-care cosmetics are used on the skin. © 2021 SPIE

关键词： Polarimeters

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Comparative study of influence of imaging resolution on Mueller matrix derived parameters 18

Comparative study of influence of imaging resolution on Muel...

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Dynamics and Fluctuations in Biomedical Photonics XVIII 2021

作者： Huang, Rongrong Shen, Yuanxing He, Honghui Ma, Hui Guangdong Research Center of Polarization Imaging and Measurement Engineering Technology Shenzhen Key Laboratory for Minimal Invasive Medical Technologies Institute of Optical Imaging and Sensing Tsinghua Shenzhen International Graduate School Tsinghua University Shenzhen518055 China Department of Biomedical Engineering Tsinghua University Beijing100084 China Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate School Tsinghua University Shenzhen518055 China Tsinghua-Berkeley Shenzhen Institute Tsinghua University Shenzhen518071 China Department of Physics Tsinghua University Beijing100084 China

ISBN: (数字)9781510641181

ISBN: (纸本)9781510641174

Mueller matrix polarimetry has been applied to assist the diagnosis of several different types of diseases. The improvement of imaging resolution using objective with high numerical aperture (NA) is important for traditional optical microscope. However, imaging using a high NA objective entails a problem, namely, the field of view (FOV) is smaller and imaging speed is slower. Our previous work found that when using Mueller matrix microscope to obtain the structural features of tissue samples, some information of anisotropic structures, such as the density and orientation distribution of fibers can be revealed by polarization parameters images with relatively low resolution. In this study, we use objectives with different numerical aperture to measure the microscopic Mueller matrix of human healthy breast duct tissues and ductal carcinoma in situ (DCIS) tissues, which have distinct typical fibrous structures. Then a group of image texture feature parameters of Mueller matrix derived parameters images under high and low imaging resolutions are quantitatively compared. The results demonstrate that with the decline of imaging resolution, the fibers density information contained in the texture features of linear retardance δ parameter image are preserved well. While for the azimuthal orientation parameter θ which is closely related to the spatial location, the high imaging resolution to obtain quantitative structural information is still needed. The study provides an important criterion to decide which information of fibrous structures can be extracted accurately using transmission Mueller matrix microscope with low numerical aperture objectives to assist diagnose clinically such as breast ductal carcinoma. © 2021 SPIE.

关键词： Polarimeters

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