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technology for Subsurface Damage detection of Optical Components Based on Various Fluorescent Material

Technology for Subsurface Damage Detection of Optical Compon...

2022 Applied Optics and Photonics China: Novel Optical Design;and Optics Ultra Precision Manufacturing and Testing, AOPC 2022

作者： Cui, Yana Wang, Chunyang Liu, Xuelian Gao, Rongting Li, Tiantian School of Electronic and Information Engineering Changchun University of Science and Technology Changchun130022 China Xi'an Key Laboratory of Active Photoelectric Imaging Detection Technology Xi'an Technological University Xi'an710021 China

ISBN: (纸本)9781510662322

The technique of tagging lapping and polishing slurries with fluorescent material is a promising subsurface damage (SSD) detection method for detecting SSD of optical component and perceiving its formation. However, currently only CdSe/ZnS QDs, CdSSe/ZnS QDs and Rhodamine 6G (R6G) were used to detect SSD, the feasibility of other types of QDs for SSD detection is not been analyzed in detail. And compared with QDs, R6G have a lower fluorescence intensity and is prone to photobleaching. Therefore, in this paper, we not only investigated the feasibility of various types of QDs for SSD detection theoretically and experimentally, but also used the anti-fluorescence quenching agent to enhance the fluorescence of R6G solution, and further studied the influence of anti-fluorescence quenching agent on the fluorescence of SSD tagged by R6G. It is found that (1) no matter how excitation intensity changes, the InP/ZnS QDs, CuInS2/ZnS QDs, R6G, R6G containing anti-fluorescence quenching agent and C QDs can be used to detect SSD;(2)CdSe/ZnS QDs can be used to detect SSD when the excitation intensity is higher than 33 mW;(3)Si QDs, Perovskite QDs, CdSe QDs, and InP QDs can’t be used to detect SSD;(4) The influence of anti-fluorescence quenching agent on the fluorescence of R6G in SSD is related to excitation intensity. This study lays a foundation for detecting the distribution and depth of SSD and perceiving the formation mechanism of SSD in brittle optical materials. © 2023 SPIE.

关键词： Semiconductor quantum dots

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Design and implementation of high reliable spaceborne reconfiguration system

Design and implementation of high reliable spaceborne reconf...

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International Conference on Electronics Information and Emergency Communication

作者： Changpei Han Lei Zhang Yaopu Zou Minzhu Yang Key Laboratory of Infrared System Detection and Imaging Technology Shanghai China University of Chinese Academy of Sciences Key Laboratory of Infrared System Detection and Imaging Technology Shanghai China

ISBN: (纸本)9781509019984

As the improvement of the SRAM-based FPGA's production technology, the number of gates has reached 10 million-scale, it becomes more powerful, increasingly used in the space field. Due to the impact of space radiation, SRAM FPGA couldn't always be stable for space applications, it needs to strengthen reliability. High reliable spaceborne reconfiguration system is designed to ensure correct operation of the SRAM FPGA onboard. The system can achieve three functions: first, reconfiguring SRAM FPGA using external PROM or E 2 PROM memory; second, accepting the ground configuration file and coding it in Hamming method, then storing it in E 2 PROM; last, operating EDAC during idle time. The system can reduce the impact of SEU on SRAM FPGA, store different programs in E 2 PROM, realizing multiple functions in a single FPGA in different time. The cyclic EDAC function, not only guarantees configuration data correct in the E2PROM, but also achieves statistics of single event effect occurrence probability in external memory device, such as E2PROM.

关键词： Field programmable gate arrays Random access memory Single event upsets PROM Loading Reliability engineering

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Simulation Research on Laser Transmission Characteristics in Inclined Turbulent Atmosphere 2

Simulation Research on Laser Transmission Characteristics in...

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2nd International Conference on Laser, Optics and Optoelectronic technology, LOPET 2022

作者： Yang, Xiaoce Wang, Chunyang Xi＇an Key Laboratory of Active Photoelectric Imaging Detection Technology Xi'an Technological University Xi'an710021 China School of Optoelectronic Engineering Xi'an Technological University Xi'an710021 China

ISBN: (纸本)9781510657588

In this paper, a simulation experiment is done to study the influence of atmospheric turbulence on the laser beam in the process of oblique transmission. The horizontal random atmospheric turbulence phase screen group is generated by using the power spectrum inversion method plus sub-harmonic compensation method, and the position distribution of the phase screen on the inclined transmission path is corrected by combining the atmospheric refractive index structure parameters that vary with height. Atmospheric turbulence phase screen set suitable for simulating slant laser transmission. Through simulation, the far-field light intensity distribution of the inclined transmission phase screen group and the horizontal transmission phase screen group is compared. The results show that, compared with the horizontal atmospheric turbulence phase screen group that does not consider the atmospheric refractive index structure parameter changing with height, the far-field light spot of the laser beam after passing through the oblique transmission phase screen group is more obvious, and the light intensity attenuation is more serious. The modified slope phase screen group is more accurate in simulating the effect of atmospheric turbulence on the laser beam. © 2022 SPIE.

关键词： Atmospheric turbulence

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Effect of hematoxylin and eosin staining on tissue linear birefringence imaging: a case study

Effect of hematoxylin and eosin staining on tissue linear bi...

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Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2024

作者： Zheng, Haohan Deng, Liangyu He, Honghui Ma, Hui Guangdong Research Center of Polarization Imaging and Measurement Engineering Technology Shenzhen Key Laboratory for Minimal Invasive Medical Technologies Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate School Tsinghua University Shenzhen518055 China

ISBN: (纸本)9781510669499

Hematoxylin-eosin staining is the gold standard for anatomic pathology as the general stain for histological examination of human tissue. Birefringent property is a valuable and commonly used metric for characterizing the anisotropic structure of tissue. When assessing the birefringent property of tissue slices, unstained slice is often preferred to avoid the potential effects of staining dyes. However, obtaining high-quality adjacent tissue samples is often difficult due to possible distortion, rotation, and uneven thickness of the tissue slices during sample preparation. In this study, we measure the Mueller matrix images of the unstained, hematoxylin stained, eosin stained, and hematoxylin-eosin stained tissue slices using the transmission Mueller matrix microscope developed in our previous study. Then the Mueller matrix polar decomposition parameter of linear phase retardance is calculated to describe the linear birefringent property of tissue. It is shown that the linear birefringent property is enhanced by the combination of dye molecules and birefringent structures, which may be due to the parallel attachment of the dye molecules to the fibers. To evaluate in detail the contrast consistency of tissue linear birefringence imaging from differently stained slices, we perform a similarity analysis using the Bhattacharyya coefficient, which demonstrated that hematoxylin, eosin, and hematoxylin-eosin staining do not generate linear birefringent property on region of tissue samples without birefringent structures. Therefore, it can be acceptable to prepare hematoxylin-eosin stained slice to obtain both bright field image and linear phase retardance image simultaneously for digital pathologic diagnosis. © 2024 SPIE.

关键词： Pathology

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Microfluidics-based strategies for molecular diagnostics of infectious diseases

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Military Medical Research 2022年第6期9卷 727-753页

作者： Xin Wang Xian-Zhe Hong Yi-Wei Li Ying Li Jie Wang Peng Chen Bi-Feng Liu The Key Laboratory for Biomedical Photonics of MOE at Wuhan National Laboratory for Optoelectronics-Hubei Bioinformatics&Molecular Imaging Key Laboratory Systems Biology ThemeDepartment of Biomedical EngineeringCollegeof Life Science and TechnologyHuazhong University of Scienceand TechnologyWuhan 430074China State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics Wuhan National Laboratory for OptoelectronicsNational Centre for Magnetic Resonancein WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences-Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430071China Department of Radiology Canary Center at Stanford for Cancer Early DetectionSchool of MedicineStanford UniversityPalo AltoCA 94304USA

Traditional diagnostic strategies for infectious disease detection require benchtop instruments that are inappropriate for point-of-care testing(POCT). Emerging microfluidics, a highly miniaturized, automatic, and integrated technology,are a potential substitute for traditional methods in performing rapid, low-cost, accurate, and on-site *** diagnostics are widely used in microfluidic devices as the most effective approaches for pathogen *** review summarizes the latest advances in microfluidics-based molecular diagnostics for infectious diseases from academic perspectives and industrial outlooks. First, we introduce the typical on-chip nucleic acid processes,including sample preprocessing, amplification, and signal read-out. Then, four categories of microfluidic platforms are compared with respect to features, merits, and demerits. We further discuss application of the digital assay in absolute nucleic acid quantification. Both the classic and recent microfluidics-based commercial molecular diagnostic devices are summarized as proof of the current market status. Finally, we propose future directions for microfluidics-based infectious disease diagnosis.

关键词： Microfluidics Molecular diagnostics Infectious disease Point-of-care testing(POCT) Digital assay

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Automatic multi-spectral image registration for Tiangong-2 wide-band imaging spectrometer

Automatic multi-spectral image registration for Tiangong-2 w...

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Tiangong-2 Remote Sensing Application Conference on technology, Method and Application

作者： Li, Liangji Liu, Xiaohua Huang, Xiaoxian Tang, Yuyu University of Chinese Academy of Sciences Beijing100049 China Key Laboratory of Infrared System Detection and Imaging Technology Shanghai Institute of Technical Physics of the Chinese Academy of Sciences Shanghai200083 China

ISBN: (纸本)9789811335006

Automatic multi-spectral image registration can improve the application efficiency and ability of remote sensing images while this technology is yet to be improved. Based on the remote sensing data of Tiangong-2 wide-band imaging spectrometer, the differences and similarities between multi-spectral images were analyzed in this paper. An edge extraction method with edge symmetry and non-directionality was proposed according to the neighborhood structure of image pixels. Using the edge information images, multi-spectral image registration was achieved through the measurement of mutual information. A contrast experiment was also set up to compare the effects of the proposed edge extraction method with those of several traditional edge extraction methods in image registration. The results showed that the registration precision of this method is higher, indicating that the extracted edge features were more stable among multi-spectral images. © Springer Nature Singapore Pte Ltd. 2019.

关键词： Image registration

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Real Aperture and Synthetic Aperture Joint imaging Approach for Vehicle-mounted Forward Look Radar 6

Real Aperture and Synthetic Aperture Joint Imaging Approach ...

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6th International Conference on Signal and Image Processing, ICSIP 2021

作者： Liu, Huixin Gao, Lili Shi, Tianyue Mao, Xinhua Nanjing University of Aeronautics and Astronautics Key Laboratory of Radar Imaging and Microwave Photonics Ministry of Education Nanjing China Beijing Institute of Control and Electronic Technology RandD Center For Artificial Intelligence and Detection Technology Beijing China

ISBN: (纸本)9780738133737

The vehicle-mounted millimeter-wave forward-looking imaging is a research hotspot in the radar field recently. If imaging is done only through the real aperture, the azimuth resolution of the radar will be still greatly restricted for the limitation of the aperture size. Considering the movement of the car itself, the synthetic aperture principle can be used to improve the azimuth resolution. However, synthetic aperture radar cannot completely solve the problem due to the blind area and left-right blurring of forward-looking area imaging (a small angular range directly in front). To this end, a new real aperture synthetic aperture joint imaging method is proposed, in which the real aperture can solve the problem of radar left and right blur, and can image at the forward-looking area. For the squint area, the length of the synthetic aperture is often longer than the real aperture, so higher resolution can be obtained by using synthetic aperture processing. Finally, the simulation results demonstrate the correctness of the back projection algorithm used in this vehicle-mounted forward look radar. © 2021 IEEE.

关键词： Vehicles

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Analysis and correction of backscattering polarimetric aberration induced by tissue surface geometry: a pilot ex-vivo study

Analysis and correction of backscattering polarimetric aberr...

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Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2024

作者： Jiao, Wei Zhang, Zheng He, Honghui Ma, Hui Guangdong Research Center of Polarization Imaging and Measurement Engineering Technology Shenzhen Key Laboratory for Minimal Invasive Medical Technologies Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate School Tsinghua University Shenzhen518055 China

ISBN: (纸本)9781510669499

polarization imaging techniques have been extensively employed in biomedical studies and clinical applications. As a comprehensive polarization representation, the Mueller matrix (MM) can provide abundant polarization-related information of biomedical samples. For quantitative information acquisition, groups of polarization basic parameters (PBPs) have been obtained through MM analysis and demonstrated as effective structural characterization tools of tissue samples. Recently, MM polarimetric endoscopy has shown great clinical diagnostic potential. For in-vivo polarimetry such as gastrointestinal MM endoscopy of human internal organ cavities, the complicated undulating tissue surface geometry delivers an inescapable occurrence of oblique incidence, which induces a prominent aberration to backscattering tissue polarimetry. Thus, quantitatively analyzing and reducing the polarimetric aberration induced by oblique incidence are crucial for in-vivo precision MM endoscopy. In this study, we quantitatively analyze the polarimetric aberration induced by tissue surface geometry on PBPs. A correlation heatmap is obtained as applicable criteria to select appropriate incident angle for different PBPs. Based on the analyzing results, we propose two aberration correction strategies of parameter selection and azimuth rotation, which are suitable for tissue samples with randomly and well-aligned fiber textures, respectively. Both strategies are demonstrated to be effective in the ex-vivo human gastric muscularis tissue experiment. The findings presented in this study can be useful to provide accurate polarization imaging results, widely applied on in-vivo polarimetric endoscopy for tissues with complicated surface topography. © 2024 SPIE.

关键词： polarization

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PSIG-GAN: a polarization structure information guided generative adversarial network for stain transformation 15

PSIG-GAN: a polarization structure information guided genera...

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15th International Conference on Information Optics and Photonics, CIOP 2024

作者： Fan, Jiahao He, Honghui Ma, Hui Guangdong Research Center of Polarization Imaging and Measurement Engineering Technology Shenzhen Key Laboratory for Minimal Invasive Medical Technologies Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate School Tsinghua University Shenzhen518055 China

ISBN: (数字)9781510686175

ISBN: (纸本)9781510686168

Histopathological examination is one of the important methods in clinical pathology diagnosis, traditionally involving the observation and analysis of stained tissue slices under a microscope. However, the staining process for tissue slices is typically time-consuming and resource-intensive. Therefore, with the advancement of deep learning, virtual staining technique has been proposed to address this issue. This technique aims to achieve rapid pathological diagnosis by bypassing the conventional chemical staining process. The implementation of virtual staining often relies on generative adversarial network trained on non-paired data. However, due to the lack of effective constraint information, the network often fails to achieve accurate virtual staining. Thus, our study proposes a virtual staining paradigm guided by Mueller matrix polarization information to address this issue. By introducing additional polarization information, the model can effectively learn the mapping relationship between different stained images to achieve accurate staining effects. In this study, we use CycleGAN as an example to analyze the shortcomings of generative adversarial learning based on non-paired data. Additionally, by studying the transformation between H&E-stained images and Masson trichrome (MT) stained images, we propose a polarization structure information guided generative adversarial network (PSIG-GAN). Experimental results demonstrate that by incorporating polarization information into the generative network, the model can effectively produce highly accurate virtual stained images. © 2024 SPIE.

关键词： Generative adversarial networks

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Nonlinear Correction Approach for FMCW Radar based on Spectrum Recovery 6

Nonlinear Correction Approach for FMCW Radar based on Spectr...

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6th International Conference on Signal and Image Processing, ICSIP 2021

作者： Liu, Yanqi Gao, Lili Shi, Tianyue Mao, Xinhua Nanjing University of Aeronautics and Astronautics Key Laboratory of Radar Imaging and Microwave Photonics Ministry of Education Nanjing China Beijing Institute of Control and Electronic Technology RandD Center For Artificial Intelligence and Detection Technology Beijing China

ISBN: (纸本)9780738133737

There are two basic approaches for LFM (linear frequency modulation) signal pulse compression - matched filtering and Dechrip. For high-resolution imaging of small scenes, Dechirp is much more popular because it requires a lower sampling rate. However, the transmission signal of demodulation needs to be an ideal chirped signal for Dechirp. When linear modulation cannot be guaranteed accurately, the compression result will be spatially defocused, which causes the compensation complicated. This paper first derives the equivalence of matched filtering and Dechirp processing. Then, for the Dechirp received signal, this paper proposes a pulse compression method for nonlinear FM signals based on matched filtering without upsampling. Finally, the feasibility of the method was verified through experiments. © 2021 IEEE.

关键词： Frequency modulation

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