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Amino-Functionalized Ce-Mof Synthesized by Micro-Plasma: As a Dual-Mode Colorimetric/Fluorescence Sensor for On-Site analysis of Doxycycline

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SSRN 2025年

作者： Xia, Yi Yang, Lin Hu, Miao Zhang, Jun Tan, Chao Yan, Yiting Yang, Congling Xiao, Yaoyu Jiang, Zhi-Chao Huang, Ke Xiong, Xiaoli Jiang, Xue Key Laboratory of Land Resources Evaluation and Monitoring in Southwest Ministry of Education College of Chemistry and Materials Science Sichuan Normal University Chengdu610068 China Key Lab of Process Analysis and Control of Sichuan Universities Yibin University Sichuan Yibin644000 China School of Mechanical Engineering Sichuan University Chengdu610065 China State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu610065 China

The improper and excessive use of doxycycline (DOX) poses a significant risk to public health through food residues and soil/water contamination, however on-site and accurately distinguish DOX from complex substrates (especially other tetracycline antibiotics which with similar molecular structures) remains a significant challenge for field analysis. In this work, an amino-functionalized cerium-based metal-organic framework (NH2-Ce-MOF) with high peroxidase activity was one-step synthesized by dielectric barrier discharge microplasma. The DOX adsorbs more readily on the (001) crystal faces of NH2-Ce-MOF compared with other tetracyclines, thus facilitating its distinct recognition. Based on the inward filtration effect (IFE) and selective adsorption between NH2-Ce-MOF and TMB, a high effective dual-mode colorimetric/fluorescent DOX sensor was developed and applied for on-site analyzing really pharmaceutical and livestock sewage samples by smartphone assisted visualization, with a concentration range of 0.1-150 μM and a low limit of detection (LOD) of 79 nM with recoveries ranging from 96.56%-107.22%. © 2025, The Authors. All rights reserved.

关键词： Dielectric barrier discharge

Targeted modulation of dual-metal ion homeostasis to induce ER stress and cuproptosis for synergistic breast tumor suppression

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Chemical Engineering Journal 2025年 515卷

作者： Zhang, Xiaoxian Zhang, Xuequan Zhu, Jiahui Li, Tinghua Yang, Lianyi Lei, Lei Wu, Fang He, Bin Cao, Jun National Engineering Research Center for Biomaterials College of Biomedical Engineering Sichuan University Chengdu610065 China Key Lab of Process Analysis and Control of Sichuan Universities Faculty of Materials and Chemical Engineering Yibin University Yibin644000 China

Targeted modulation of metal ion homeostasis in tumor cells has emerged as a promising method for cancer therapy. However, the coordination efficiency and stability of different metal ions posed significant challenges for current multi-metal ions delivery systems. In this study, we presented an innovative strategy that utilized a single-metal ion nanoregulator capable of precisely modulating intracellular dual-metal ion homeostasis. This nanoregulator induced endoplasmic reticulum (ER) stress and cuproptosis, which worked synergistically to inhibit tumor growth. Specifically, a calcium-selective chelator, BAPTA (BA), formed a metal coordination complex with copper ions (Cu2+), which remained stable in the physiological environment but disassembled upon internalized by tumor cells. Once inside, the released BA selectively chelated intracellular calcium ions (Ca2+), depleting ER Ca2+ stores and triggering ER stress. This stress activated the PERK/p-eIF2α/ATF4/CHOP apoptotic pathway, leading to tumor cell apoptosis. Meanwhile, Cu2+ induced cuproptosis and was reduced to Cu+ in the cytosol, where it consumed hydrogen peroxide and generated cytotoxic hydroxyl radicals. These radicals induced oxidative stress, which, combined with glutathione depletion, further amplified ER stress and promoted tumor cell apoptosis. Both in vitro and in vivo experiments exhibited that the nanoregulator effectively suppressed tumor growth through apoptosis and cuproptosis pathways, with favorable biocompatibility. This study highlighted the synergistic roles of copper and calcium ions in tumor therapy and introduced a novel strategy for modulating intracellular dual-metal ion homeostasis, offering more efficient and low toxicity anti-cancer treatments. © 2025 Elsevier B.V.

关键词： Stress analysis

One Pot Facile Visible-Light Promoted Synthesis of Quinazolinones Via Csp3-H Oxidation in Aqueous Media

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SSRN 2023年

作者： Chen, Taiping Yang, Huan Li, Shuangjun Xie, Jiangping Wei, Lingyu Yang, Li Key Lab of Process Analysis and Control of Sichuan Universities Yibin University Sichuan Yibin644000 China Party Working Committee of Yibin Campus Xihua University Sichuan Yibin644000 China College of Science Xihua University Sichuan Chengdu610039 China

The utilization of biocompatible catalysts for the synthesis of biologically significant molecules in aqueous environments represents a pivotal and challenging aspect within the realm of green and sustainable chemistry. Herein, a KI-mediated Csp3-H oxidation reaction to synthesis heterogeneously of quinazolinones is reported in this study. Alcohol-oxidized aldehydes attack amides and cyclize to obtain various quinazolinones efficiently only under sunlight, in aqueous media. The utilization of solar energy significantly reduces experimental costs and minimizes the occurrence of toxic effects. This approach proceeded smoothly to afford quniazolinones in high to excellent yields with a wide substrate scope © 2023, The Authors. All rights reserved.

关键词： Synthesis (chemical)

Fabrication of Porous Hematite Nanoparticles by Recycling of Waste Ferrous Sulfate with Microwave-Assisted Reduction Technique

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SSRN 2023年

作者： Ren, Genkuan Zhang, Zhengan Wang, Xinlong Yang, Xiushan Zhu, Denglei Chen, Aijun Xin, Luo He, Xuemei Key Lab of Process Analysis and Control Sichuan Universities Yibin University Yibin64000 China School of Chemical Engineering Sichuan University Chengdu610065 China Department of Materials and Chemical Engineering Yibin College Yibin64000 China

Massive ferrous sulfate heptahydrate put aside without being utilized not merely resulted in serious environment pollution, but also caused resource waste in China. To alleviate environmental pressures and increase resource utilization, a novel solution is proposed to fabricate porous hematite nanoparticles using waste ferrous sulfate as the starting material via microwave-assisted reduction technique in nitrogen protection. Physicochemical properties of the synthesized porous α-HNPs were separately analyzed by X-ray diffraction (XRD), Fourier transform infrared spectrum (FTIR), Raman spectroscopy (RM), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and Brunauer–Emmett–Teller (BET) method. Fabrication of α-HNPs with spherical-like microscopy was certified by using XRD, FTIR, RM and XPS. SEM and TEM images indicated that the porous α-HNPs with the size of 35~75 nm were formed by microwave-assisted reduction technique. Special surface area, pore volume and pore size of α-HNPs were evaluated to be ca. 20.999 m2/g, ca. 0.111 cm3/g and ca. 0.892 nm. The novel synthesis technique of α-HNPs provides an effective way for utilizing ferrous sulfate heptahydrate from titanium dioxide production and easing environmental pressures, which is in line with the idea of recycling economy and meets the requirements for cleaner utilization. © 2023, The Authors. All rights reserved.

关键词： Sulfur compounds

Prediction of Residual Life of High Temperature and High Pressure Vessels Based on Digital Twin

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Science Technology and Engineering 2024年第15期24卷 6320-6328页

作者： Xue, Xiang-Dong Hu, Guang-Zhong Wang, Ping Qu, Zhao-Yang School of Mechanical Engineering Sichuan University of Science & Engineering Yibin644000 China Key Laboratory of Process Equipment and Control Engineering in Sichuan Province Universities Yibin644000 China

In order to solve the difficult problem of online prediction of the remaining life of high-temperature and high-pressure vessel, a method of constructing the remaining life prediction model of high-temperature and high-pressure vessel based on digital twin was proposed. The method was based on real-time working conditions, using ANSYS simulation model for coupled simulation, obtaining a certain time-domain physical field of high-temperature and high-pressure vessel, establishing a sample dataset of remaining life prediction of high-temperature and high-pressure vessel through the multiaxial creep damage model, and using BP (back propagation) neural network algorithm optimized by Tent-SSA for training prediction, to establish a digital twin high-temperature and high-pressure vessel life prediction model driven by the fusion of the mechanism model and machine learning. Finally, the tube plate, which is a key component of a certain sodium-cooled fast reactor steam generator, was used as an object, and the experimental results show that the overall mean square error of the prediction model is reduced from 3. 219 7 × 10 - 2 before optimization to 7. 744 9 × 10 - 3, and the model is more stable, robust, and fast converging. © 2024 Beijing Kexue Jishu yu Gongcheng Zazhishe. All rights reserved.

关键词： Backpropagation

Formation of Hematite Nanoparticles By Recycling Waste Ferrous Sulfate Using Microwave-Assisted Reduction Technology

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SSRN 2023年

作者： He, Xuemei Zhang, Min Wang, Xinlong Yang, Xiushan Zhu, Denglei Zhang, Zhengan Ren, Genkuan Chen, Aijun Key Lab of Process Analysis and Control of Sichuan Universities Yibin University Yibin64000 China International Institute of Applied Technology Yibin University Yibin64000 China Department of Materials and Chemical Engineering Yibin University Yibin64000 China Chemical Science and Engineering College Sichuan University Chengdu610065 China Sichuan University China Yibin University China

Massive waste ferrous sulfate heptahydrate without being properly treated not only caused serious environment pollution but also enormous resource waste. To relieve environmental pressures and enhance resource utilization, a novel solution is proposed to fabricate hematite nanoparticles (α-HNPs) using waste ferrous sulfate as raw material by microwave- assisted reduction technology under nitrogen protection. Physicochemical properties of the synthesized α-HNPs were investigated by X-ray diffraction (XRD), Fourier transform infrared spectrum (FTIR), Raman spectroscopy (RM), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and Brunauer–Emmett–Teller (BET) method. The obtained conditions for fabrication of α-HNPs are at 550 ℃ for 6 min at the ratio of 14:1 (waste ferrous sulfate /pyrite). Fabrication of α-HNPs with spherical-like shape was analyzed by using XRD, FTIR, RM and XPS. Results indicated that the α-HNPs with the mean particle diameter of 45 nm were obtained by microwave-assisted reduction technique. Special surface area, pore volume and pore size of α-HNPs were evaluated to be ca. 20.999 m2/g, ca. 0.111 cm3/g and ca. 0.892 nm. The novel synthesis technique of α-HNPs provides an effective way for utilizing waste ferrous sulfate from titanium dioxide production and easing environmental pressures, which is in line with the idea of recycling economy and meets the requirements for cleaner utilization. © 2023, The Authors. All rights reserved.

关键词： Sulfur compounds

Improvement of Hot Air Drying on Quality of Xiaocaoba Gastrodia Elata in China 9th

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Improvement of Hot Air Drying on Quality of Xiaocaoba Gastro...

9th International Workshop of Advanced Manufacturing and Automation, IWAMA 2019

作者： Tang, Xiuying Tan, Chao Cheng, Bin Leng, Xuemei Feng, Xiangcai Luo, Yinhua College of Mechanical and Electrical Engineering Yunnan Agricultural University Kunming China Key Lab of Process Analysis and Control of Sichuan Universities Yibin University Yuban China College of Mechanics and Transportation Southwest Forestry University Kunming China

ISBN: (纸本)9789811523403

As a perennial herb, gastrodia elata is distributed in most parts of China. Its tuber is a valuable Chinese herbal medicine, and controlling its dryness is the most critical factor to ensure the quality of storing gastrodia elata. This paper takes Gastrodia tuber drying as the research object, and attempts to improve the local processing method which is hot air drying by coal heated. Our team use electricity instead of coal as the energy for hot air drying and takes 50 °C for drying under constant temperature. Experimental results show the appearance and the polysaccharide content of gastrodia elata are not improved, however, that the processing time has been reduced by one third, and the gastrodin content in boiled gastrodia elata is significantly higher compared to local drying method. © Springer Nature Singapore Pte Ltd 2020.

关键词： Drying

Single-Cu-atom anchoring on covalent organic framework as a wearable flexible electrochemical sensor for acetaminophen

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Microchemical Journal 2025年 214卷

作者： Liu, Zihan Xu, Yao Heng, Yuxin Liu, Fanghua Tan, Chao Wen, Guijiao Xu, Fujian He, Juan Huang, Ke Xiong, Xiaoli Jiang, Xue Key Laboratory of Land Resources Evaluation and Monitoring in Southwest Ministry of Education College of Chemistry and Materials Science Sichuan Normal University Chengdu 610068 China Key Lab of Process Analysis and Control of Sichuan Universities Yibin University Sichuan Yibin 644000 China Analytical & Testing Center Sichuan University Sichuan Chengdu 610064 China School of Chemistry and Environment Southwest Minzu University Chengdu 610041 China

In this paper, a wearable flexible patch featuring a non-enzymatic electrochemical sensor based on Cu single-atom catalysts (SACs) anchored on bipyridine-covalent organic framework (COF) electrode was proposed for specific detection of acetaminophen (AP) in human sweat. The electrode modified material is Cu single atom catalytic material (Cu-TpBpy). The bifunctional TpBpy acts as a support for binding individual Cu atoms through abundant and well-organized N-N chelating sites, while simultaneously serving as an active host for specific recognition/adsorption of AP due to its porous structure and active N sites. The resulting Cu-TpBpy with atomically dispersed Cu sites demonstrated high electrochemical activity for AP, attributed to enhanced electron transfer efficiency and reduced binding and adsorption energies. Density functional theory calculations further reveal that the Cu single-atom anchoring on TpBpy provides superior adsorption of AP than TpBpy alone, resulting in lower binding energy, and higher selectivity and sensitivity. The wearable flexible patch, based on Cu-TpBpy, enabled real-time and accurate detection of AP in human sweat and achieved a linear range of 0.3 µM-5 µM and a limit of detection of 13 nM, with satisfied stability and repeatability. This work developed a highly sensitive non-enzymatic sensing method for wearable flexible patches. © 2025

关键词： Acetaminophen COF Flexible patch Non-enzymatic sensor SACs

New Tocopherol and Acylphloroglucinol Derivatives from Dryopteris Crassirhizoma and Their Antimicrobial Activities

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SSRN 2022年

作者： Hai, Ping He, Yunqing Wang, Ruirui Gao, Yuan Wu, Xudong Li, Xianyan Yang, Jin Yang, Jian Li, Rongtao Faculty of Life Science and Technology Kunming University of Science and Technology Kunming650500 China Key Lab of Process Analysis and Control of Sichuan Universities Faculty of Materials and Chemical Engineering Yibin University Yibin644000 China School of Pharmaceutical Sciences Yunnan University of Chinese Medicine Kunming650500 China State Key Laboratory Breeding Base of Dao-di Herbs National Resource Center for Chinese Materia Medical China Academy of Chinese Medical Sciences Beijing100700 China

Nine previously undescribed compounds including six tocopherol derivatives (1–6) and three acylphloroglucinol derivatives (7–9) were isolated and characterized from the plants of Dryopteris crassirhizoma. Their structures with absolute configurations were determined by extensive spectroscopic analyses, including IR, HRESIMS, NMR, and calculated electronic circular dichroism (ECD). Compounds 1 and 2 are the first tocopheroid derivatives possessing unique 2,5-dimethylcyclopent-4-ene-1,3-dione carbon skeleton, and compounds 3–6 were new 5a-norcyclopentenones having a spirofused bicyclic carbon skeleton. The biosynthetic pathway of compounds 1–6 was postulated. When combined with fluconazole (FLC), compound 3 showed significant antifungal activity against standard Candida albicans with MIC50 value of 1.19 μg/mL (FLC: 3.41 μg/mL). Furthermore, the anti-plant pathogenic fungi and bacterial activities have been evaluated in vitro, compounds 5 and 8 showed anti-Verticillium dahlia and Sclerotinia sclerotiorum with MIC value of 50 μg/mL, respectively. Compounds 1 and 5 exhibited moderate antibacterial activities against Micrococcus luteus with MIC value of 50 μg/mL, respectively. © 2022, The Authors. All rights reserved.

关键词： Spectroscopic analysis