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TIP60 acetylation of Bub1 regulates centromeric H2AT120 phosphorylation for faithful chromosome segregation

science China(life sciences) 2024年第9期67卷 1957-1969页

作者： Mengjie Sun Biying Yang Guangwei Xin Yao Wang Jia Luo Qing Jiang Chuanmao Zhang The Academy for Cell and Life Health Faculty of Life Science and TechnologyKunming University of Science and TechnologyKunming 650500China The Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education College of Life SciencesPeking UniversityBeijing 100871China

Proper function of the centromeres ensures correct attachment of kinetochores to spindle microtubules and faithful chromosome segregation in *** in the integrity and function of centromeres can result in chromosome missegregation and genomic ***1 is essential for the mitotic centromere dynamics,yet the underlying molecular mechanisms remain largely ***,we demonstrate that TIP60 acetylates Bub1 at K424 and K431 on kinetochores in early *** acetylation increases the kinase activity of Bub1 to phosphorylate centromeric histone H2A at T120(H2Ap T120),which recruits Aurora B and Shugoshin 1(Sgo1)to regulate centromere integrity,protect centromeric cohesion,and ensure the subsequent faithful chromosome *** of the nonacetylated Bub1 mutant reduces its kinase activity,decreases the level of H2Ap T120,and disrupts the recruitment of centromere proteins and chromosome congression,leading to genomic instability of daughter *** cells exit mitosis,HDAC1-regulated deacetylation of Bub1 decreases H2Ap T120 levels and thereby promotes the departure of centromeric CPC and Sgo1,ensuring timely centromeres ***,our results reveal a molecular mechanism by which the acetylation and deacetylation cycle of Bub1 modulates the phosphorylation of H2A at T120 for recruitment of Aurora B and Sgo1 to the centromeres,ensuring faithful chromosome segregation during mitosis.

关键词： acetylation Bub1 TIP60 H2ApT120 chromosome segregation

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Molecular regulation of metal-organic frameworks for rapid and efficient extraction of uranium from seawater

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science China Chemistry 2025年第5期68卷 1906-1915页

作者： Jie Luo Xiao Luo Mo Xie Jia-Tong Lin Jie Pang Na Yin Yan-Yan Li Guo-Hong Ning Dan Li College of Chemistry and Materials Science Guangdong Provincial Key Laboratory of Supramolecular Coordination ChemistryJinan University Department of Biomedical Engineering College of Life Science and TechnologyJinan University

The development of novel metal-organic frameworks（MOFs） as solid adsorbents for rapid and efficient extraction of uranium from natural seawater is a long-term pursuit, yet remains challenging. In this work, we have prepared four two-dimensional（2D）vinylene-linked cyclic trinuclear units（CTUs） based MOFs. The metal nodes in the skeleton can be regulated, resulting in two Ag-CTU and two Cu-CTU-based MOFs with similar 2D hexagonal structures. These MOFs exhibit not only good stability in acid/base, γ-ray irradiation and natural seawater but also feature excellent anti-biofouling properties against five marine bacteria with inhibition rates as high as ～99%. Interestingly, the alteration of Ag（I） to Cu（I） remarkably enhances the uranium sorption capacity due to the reduction of soluble U（VI） to insoluble U（IV） triggered by the chemical and photo-redox reaction of *** to the multiple functions, the Cu-CTU-based MOF delivers the best overall performance for uranium extraction from natural seawater with a high adsorption capacity of 7.96 mg g-1and adsorption rate of ～1.00 mg g-1day-1, which is much higher than most of reported representative solid adsorbents. Our work paves a new way for rationally designing synergistic MOFs with superior performance for extracting uranium from natural seawater.

关键词： metal-organic frameworks uranium extraction photocatalytic reduction seawater

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SegNet4D: Efficient Instance-Aware 4D Semantic Segmentation for LiDAR Point Cloud

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IEEE Transactions on Automation science and Engineering 2025年 22卷 15339-15350页

作者： Wang, Neng Guo, Ruibin Shi, Chenghao Wang, Ziyue Zhang, Hui Lu, Huimin Zheng, Zhiqiang Chen, Xieyuanli National University of Defense Technology College of Intelligence Science and Technology National Key Laboratory of Equipment State Sensing and Smart Support Changsha410073 China

4D LiDAR semantic segmentation classifies the semantic category of each LiDAR point and detects whether it is dynamic, a critical ability for tasks like obstacle avoidance and autonomous navigation. Existing approaches often rely on computationally heavy 4D convolutions or recursive networks, which result in poor real-time performance. In this paper, we introduce SegNet4D, a novel real-time 4D semantic segmentation network, offering both efficiency and strong semantic understanding. SegNet4D addresses 4D segmentation as two tasks: single-scan semantic segmentation and moving object segmentation, each tackled by a separate network head. Both results are combined in a motion-semantic fusion module to achieve comprehensive 4D segmentation. Additionally, instance information is extracted from the current scan and exploited for instance-wise segmentation consistency. Extensive experiments on the SemanticKITTI and nuScenes datasets demonstrate that our method outperforms the state-of-the-art in both 4D semantic segmentation and moving object segmentation. Through detailed runtime analysis, our method shows greater efficiency, enabling real-time operation. Besides, its effectiveness and efficiency have also been validated on a real-world robotic platform. © 2004-2012 IEEE.

关键词： Semantic Segmentation

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Nonlinear dynamics of Nishimura model-based fractional-order vibration isolation system under the synergistic effect of aerodynamic lift and harmonic excitation

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Nonlinear Dynamics 2025年第11期113卷 12693-12717页

作者： Qu, Minghe Wang, Lianchun Jin, Qiduo Zhou, Danfeng Li, Jie College of Intelligence Science and Technology National University of Defense Technology Changsha410073 China National Key Laboratory of Equipment State Sensing and Smart Support National University of Defense Technology Changsha410073 China

The electromagnetic sled test platform exhibits complex nonlinear vibration characteristics under the excitation of synergistic effects due to the influence of self-excited vibration and aerodynamic lift from the test model. Metal plate and rubber combined structure vibration isolator are anticipated to deliver superior vibration attenuation performance for sled. However, the complex constitutive relation of rubber is always challenging to the change of excitation source. In this study, the nonlinear dynamics of metal-rubber-vibration subsystem is studied, and the dynamic characteristics under the synergistic effect of aerodynamic lift and harmonic excitation are emphatically discussed. A nonlinear Nishimura model-based on fractional-order is developed to describe the constitutive relationship of metal-rubber. The fractional order is defined by Caputo, the periodic solution is obtained by harmonic balance method, and the aperiodic response is numerically simulated. The amplitude-frequency characteristics of the system are obtained, and the complex nonlinear dynamic behavior of the system is verified by Poincaré mapping, phase diagram and spectrum diagram. The stability of dynamic response is further revealed by Lyapunov exponent and attraction basin. The multiplicity of amplitude-frequency response and the mechanism of periodic motion and chaotic transition are analyzed. The results show that the amplitude-frequency curve of the system exhibits a complex dynamic phenomenon with 5 coexisting solutions under combined excitation, and there are multiple types of bifurcations in the periodic motion and chaotic transition processes. The transition dynamics between periodic motion and chaos under varying excitation exhibit significant differences, and this transition process is inherently irreversible. The research in this paper provides theoretical guidance for the parameter design of metal-rubber vibration isolation system and its application in electromagnetic sled. © T

关键词： Lyapunov methods

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Tumor-repopulating cell-derived microparticles elicit cascade amplification of chemotherapy-induced antitumor immunity to boost anti-PD-1 therapy

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5539-5555页

作者： Nana Bie Tuying Yong Zhaohan Wei Qingle Liang Xiaoqiong Zhang Shiyu Li Xin Li Jianye Li Lu Gan Xiangliang Yang National Engineering Research Center for Nanomedicine College of Life Science and TechnologyHuazhong University of Science and Technology430074WuhanChina Key Laboratory of Molecular Biophysics of the Ministry of Education College of Life Science and TechnologyHuazhong University of Science and Technology430074WuhanChina Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica Huazhong University of Science and Technology430074WuhanChina

Immune checkpoint blockade(ICB)therapy,particularly antibodies targeting the programmed death receptor 1(PD-1)and its ligand(PD-L1),has revolutionized cancer ***,its efficacy as a standalone therapy remains *** ICB therapy in combination with chemotherapy shows promising therapeutic responses,the challenge lies in amplifying chemotherapy-induced antitumor immunity *** relies on efficient drug delivery to tumor cells and robust antigen presentation by dendritic cells(DCs).Here,we developed tumor-repopulating cell(TRC)-derived microparticles with exceptional tumor targeting to deliver doxorubicin(DOX@3D-MPs)for improve anti-PD-1 ***@3D-MPs effectively elicit immunogenic tumor cell death to release sufficient tumor *** shock protein 70(HSP70)overexpressed in DOX@3D-MPs contributes to capturing tumor antigens,promoting their phagocytosis by DCs,and facilitating DCs maturation,leading to the activation of CD8+T ***@3D-MPs significantly enhance the curative response of anti-PD-1 treatment in large subcutaneous H22 hepatoma,orthotopic 4T1 breast tumor and Panc02 pancreatic tumor *** results demonstrate that DOX@3D-MPs hold promise as agents to improve the response rate to ICB therapy and generate long-lasting immune memory to prevent tumor relapse.

关键词： immunity chemotherapy boost

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Structural design and controllable preparation of SiC NWs@Fe_(3)O_(4)@NC nanocomposites for electromagnetic wave absorption

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International Journal of Minerals,Metallurgy and Materials 2025年第3期32卷 520-533页

作者： Wenxin Zhao Meng Zhang Yukun Miao Chang Wang Anguo Cui Liying Yuan Zeqing Miao Xiaoqing Wang Zhibo Wang Haoyu Pang Alan Meng Zhenjiang Li Ting Wang College of Materials Science and Engineering Qingdao University of Science and TechnologyQingdao 266042China Shandong Engineering Laboratory for Preparation and Application of High-Performance Carbon-Materials College of Electromechanical EngineeringQingdao University of Science and TechnologyQingdao 266061China Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science MOEShandong Key Laboratory of Biochemical AnalysisCollege of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042China College of Chemical Engineering Qingdao University of Science and TechnologyQingdao 266042China

Using SiC nanowires(SiCNWs)as the substrate,reflux-annealing and electrodeposition-carbonization were sequentially applied to integrate SiC nanowires with magnetic Fe_(3)O_(4) nanoparticles and amorphous nitrogen-doped carbon(NC)for the fabrication of SiCNWs@Fe_(3)O_(4)@NC *** testing and characterization of this product provided valuable insights into the im-pact of structural and composition changes on its electromagnetic wave absorption *** optimized SiCNWs@Fe_(3)O_(4)@NC nanocomposite,which has 30wt%filler content and a corresponding thickness of 2.03 mm,demonstrates exceptional performance with the minimum reflection loss(RL_(min))of-53.69 dB at 11.04 GHz and effective absorption bandwidth(EAB)of 4.4 *** synergistic effects of the enhanced nanocomposite on electromagnetic wave absorption were thoroughly elucidated using the theories of multiple scattering,polarization relaxation,hysteresis loss,and eddy current ***,a multicomponent electromagnetic wave attenu-ation model was established,providing valuable insight into the design of novel absorbing materials and the enhancement of their absorp-tion *** research demonstrated the significant potential of the SiCNWs@Fe_(3)O_(4)@NC nanocomposite as a highly efficient electromagnetic wave-absorbing material with potential applications in various fields,such as stealth technology and microwave absorption.

关键词： electromagnetic attenuation mechanism multicomponent nanocomposite SiC nanowires structural design

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Advances in understanding the roles of actin scaffolding and membrane trafficking in dendrite development

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Journal of Genetics and Genomics 2024年第11期51卷 1151-1161页

作者： Wanting Wang Menglong Rui School of Life Science and Technology The Key Laboratory of Developmental Genes and Human DiseaseSoutheast UniversityNanjingJiangsu 210031China

Dendritic morphology is typically highly branched,and the branching and synaptic abundance of dendrites can enhance the receptive range of neurons and the diversity of information received,thus providing the basis for information processing in the nervous *** dendritic development is aberrantly compromised or damaged,it may lead to abnormal connectivity of the neural network,affecting the function and stability of the nervous system and ultimately triggering a series of neurological *** on the regulation of dendritic developmental processes has flourished,and much progress is now being made in its regulatory ***,dendrites are characterized by an extremely complex dendritic arborization that cannot be attributed to individual protein functions alone,requiring a systematic analysis of the intrinsic and extrinsic signals and the coordinated roles among *** cytoskeleton organization and membrane vesicle trafficking are required during dendrite development,with actin providing tracks for vesicles and vesicle trafficking in turn providing material for actin *** this review,we focus on these two basic biological processes and discuss the molecular mechanisms and their synergistic effects underlying the morphogenesis of neuronal *** also offer insights and discuss strategies for the potential preventive and therapeutic treatment of neuropsychiatric disorders.

关键词： Actin Membrane vesicle transport Exocyst complex Secretory pathway Dendrite development Neurological disease

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Copper-catalyzed C–H bond functionalization enabled by programmed alternating current

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science China Chemistry 2025年第1期68卷 10-11页

作者： Zhoumei Tan Kun Xu Chengchu Zeng Beijing Key Laboratory of Environmental and Viral Oncology College of Chemistry and Life ScienceBeijing University of TechnologyBeijing 100124China

Synthetic electrochemistry has been selected as one of the Top Ten Emerging Technologies in Chemistry in 2023 by International Union of Pure and Applied Chemistry(IUPAC)^([1]).It has emerged as a sustainable platform for organic synthesis and has exhibited a wide range of applications from academia to industry^([2]).However,electrosynthesis has been predominantly performed by using direct current(DC).

关键词： catalyzed Copper IUPAC

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Gelatinized starch as a low-cost and bifunctional binder enables shuttle-free aqueous zinc-iodine batteries

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Rare Metals 2024年第12期43卷 6351-6361页

作者： Zheng-Tai Yu Zong-Shuai Gong Rui-Hang Wen Ya-Jun Hou Zhi-Qiang Luo Zhi-Hao Yuan Ning Zhang School of Materials Science and Engineering Tianjin University of TechnologyTianjin300384China College of Chemistry and Materials Science Key Laboratory of Analytical Science and Technology of Hebei ProvinceInstitute of Life Science and Green DevelopmentHebei UniversityBaoding071002China

Rechargeable aqueous zinc-iodine(Zn-I_(2))batteries are widely regarded as a promising contender for energy-storage devices,due to their intrinsic safety,low cost,and high ***,the severe shuttle effect of polyiodides and the large volume change of I_(2)cathode induce severe capacity loss and poor electrochemical reversibility,hindering their commercial ***,we report that the low-cost gelatinized starch(Gstarch)can be used as a bifunctional binder for Zn-I_(2)batteries to circumvent the above problems *** on both calculation and experimental data,it is demonstrated that the double-helix structure of G-starch with bothα-1,4-andα-1,6-glycosidic bonds can strongly interact with polyiodides to suppress the shuttle ***,the G-starch with multiple hydrogen-bonded cross-linking networks exhibits a much-enhanced adhesion ability and can buffer the volume expansion of active *** contrast,the traditional carboxymethyl cellulose sodium-based aqueous binder lacks these *** a result,the G-starch binder enables the aqueous Zn-I_(2)battery to achieve a high reversible capacity of212.4 mAh·g^(-1)at 0.2 A·g^(-1)after 1000 cycles and ultralong-cycling life over 48,000 cycles with 135.4 mAh·g^(-1)and 89.6%capacity retention at 2 A·g^(-1).This work develops a simple yet efficient strategy to construct highperformance Zn-I_(2)batteries.

关键词： Zn-I_(2)batteries Gelatinized starch Binder Shuttle effect Aqueous Zn metal batteries

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Carbonation of Dicalcium Silicate Enhanced by Ammonia Bicarbonate and Its Mechanism

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Journal of Wuhan University of technology(Materials science) 2024年第1期39卷 69-74页

作者：周浩刘鹏 WANG Fazhou HU Chuanlin School of Chemistry Chemical Engineering and Life ScienceWuhan University of TechnologyWuhan 430070China State Key Laboratory of Silicate Materials for Architectures Wuhan University of TechnologyWuhan 430070China

The strength development law of γ-type dicalcium silicate (γ-C_(2)S) under different carbonation processes was investigated,and the carbonation mechanism of γ-C_(2)S under the action of NH_(4)HCO_(3) was clarified by using a wide range of test methods,including XRD and SEM.A method of saturated NH_(4)HCO_(3) solution as a curing agent was identified to improve the carbonation efficiency and enhance the carbonation degree of γ-C_(2)S,and then a high-strength carbonated specimen was *** analysis and SEM morphology analysis were conducted on the carbonised specimens obtained under atmospheric pressure carbonisation conditions using the curing *** was found that γ-C_(2)S could perform carbonisation well under atmospheric pressure,which promoted the carbonisation efficiency and decreased the carbonisation cost ***,a new carbonisation process solution was proposed for the rapid carbonisation of γ-C_(2)S.

关键词： type dicalcium silicate carbonization process curing agent atmospheric carbonization

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