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Engineering Application Modeling Based on Mechanism Law for Hard Rock Disc Cutter Wear Evolution

Rock Mechanics and Rock Engineering 2025年 1-17页

作者： Wang, Lihui Kang, Yilan Zhang, Qian Li, Haipeng Delivery Equipment Support Department Army Military Transportation Academy Tianjin300161 China Key Laboratory of Modern Engineering Mechanics School of Mechanical Engineering Tianjin University Tianjin300072 China School of Materials Science and Engineering Hebei University of Technology Tianjin300130 China

Disc cutter wear and replacement significantly affect the construction efficiency and safety of hard rock tunnels. Disc cutter wear prediction has become a critical engineering problem. Based on the mechanical analysis, combined with experimental results, referring to numerical simulation analysis, this study developed a new method for predicting the wear evolution process of hard rock disc cutter. In this study, a theoretical equation of the disc cutter wear evolution is presented through the analysis on wear failure mechanism. The laws in the influence of rock joint direction angle and joint spacing on the tunnelling penetration rate are revealed based on the statistical analysis of field data and simulation data. And a new equation is proposed for calculating the contact stress. In addition, the internal relations among the disc cutter motion state, disc cutter load, rock friction performance are analyzed to propose a new equation for calculating relative slip distance. Thus, a new model was established to predict the disc cutter wear evolution, and the model was preliminarily validated using specific projects data collected from Yinsong Tunnel and Yintao Project #9 Tunnel. Owing to the comprehensive consideration of the effects of joint orientation and spacing in the hard rock mass, rock mechanics and performance characteristics, tunnelling parameters of the tunnel boring machine, cutter geometric properties, and cutter spacing on cutter wear evolution, this new model achieves real-time prediction, ensuring universality and accuracy. In further study, the laws in the influence of abnormal wear of disc cutters on TBM tunnelling loads will be analyzed to expand the prediction scope. © The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2025.

关键词： Rock mechanics

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Recent Advances in the Development of Indolizine Scaffolds:Synthetic Methodology and Mechanistic Insights

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Chinese Journal of Chemistry 2025年第3期43卷 315-348页

作者： Jiuzhong Huang Chunsheng Li Xiaoning Li Guangyu Li Ziyi Yang Yinke Yu Yanping Xie Hao Huang Fuchao Yu Zhihua He First Affiliated Hospital Gannan Medical UniversityGanzhouJiangxi341000 China Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine School of PharmacyGannan Medical UniversityGanzhouJiangxi341000 China School of Chemistry and Chemical Engineering Zhaoqing UniversityZhaoqingGuangdong526060 China Faculty of Life Science and Technology Kunming University of Science and TechnologyKunmingYunnan650500 China

Indolizine is a nitrogen-containing heterocycle with strong aromaticity,possessing a delocalized 10π-electron *** on the indolizine scaffolds,numerous molecules with biological activity and organic functional materials have been *** 2016,over 110 papers have been published on the synthesis of indolizine scaffolds,but the reviews on synthesizing indolizine scaffolds have been incomplete and not ***,from the perspective of the structure of indolizine with the combination of pyrrole and pyridine ring,we focus on the construction of indolizine scaffolds through the diversity of starting substrates,including pyridine derivatives(N1-substituted pyridinium salt derivatives,C2-substituted pyridine derivatives,N1-and C2-free substituted pyridine derivatives),pyrrole derivatives and unoriginal ring ***,the corresponding reaction mechanisms of synthetic methodologies are also ***,this review not only paves the way for indolizine synthesis but also provides insight into exploring new reaction modes for constructing nitrogen-containing heterocycles.

关键词： Indolizine scaffolds Synthetic methodology Mechanistic insights Pyridine derivatives Pyrrole derivatives Unoriginal ring substrates

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Enhancing biomass enzymatic hydrolysis performance by modified DES lignin

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Journal of Biotechnology 2025年 403卷 115-125页

作者： Yao, Lan Zhang, Zhe Chen, Guangyu Sun, Zhiyuan Chen, Xiong Yang, Haitao College of Life science and Health engineering Hubei University of Technology Wuhan430068 China Hubei Provincial Key Laboratory of Green Materials for Light Industry Hubei University of Technology Wuhan430068 China Department of Chemical and Biomolecular Engineering University of Tennessee Knoxville KnoxvilleTN37996-2200 United States

The enzymatic hydrolysis of lignocellulose continues to be encumbered by elevated production costs and diminished cellulase efficiency. In this work, modified DES recovered lignin was obtained by grafting acrylamide and acryloyl chloride to enhance glucose release. At a cellulase dosage of 5 FPU/g-cellulose and pH of 5.5, modified lignin promoted glucose yield of dilute-acid-pretreated wheat straw by 158 % compared with control. The mechanism by which modified lignin promotes enzymatic hydrolysis was further explored. The binding constant was reduced from (3.3510 ± 0.8361)* 104 to (2.7600 ± 0.6027)* 103 L•mol−1 after modification. Modified lignin could make α-helix content enhancement so that cellulase had a compact and stable spatial structure. Lignin binds within the catalytic tunnel of cellulase and that the modified lignin interacts with cellulase with increased hydrogen bonding, resulting in a more compact cellulase structure. The modified lignin might reduce the unproductive adsorption of cellulase, and increase stability and cellulose accessibility to reduce cellulase cost. © 2025 Elsevier B.V.

关键词： Enzymatic hydrolysis

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Molecular insights and rational engineering of a compact CRISPR-Cas effector Cas12h1 with a broad-spectrum PAM

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Signal Transduction and Targeted Therapy 2025年第3期10卷 1618-1629页

作者： Weiwei Zheng Hongyu Li Mengxi Liu Yuhang Wei Bo Liu Zekai Li Chenyang Xiong Shiqing Huang Chunyi Hu Songying Ouyang Key Laboratory of Microbial Pathogenesis and Interventions of Fujian Province University the Key Laboratory of Innate Immune Biology of Fujian ProvinceBiomedical Research Center of South ChinaKey Laboratory of OptoElectronic Science and Technology for Medicine of the Ministry of EducationCollege of Life SciencesFujian Normal UniversityFuzhou 350117China Department of Biological Sciences Faculty of Science/Department of BiochemistryPrecision Medicine Translational Research Programme(TRP)Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117557Singapore

Cas12h1 is a compact CRISPR-associated nuclease from functionally diverse type V CRISPR-Cas effectors and recognizes a purine-rich protospacer adjacent motif(PAM)distinct from that of other type V Cas ***,we report the nickase preference of Cas12h1,which predominantly cleaves the nontarget strand(NTS)of a double-stranded DNA(dsDNA)*** addition,Cas12h1 acts as a nickase in human *** further determined the cryo-EM structures of Cas12h1 in the surveillance,R-loop formation,and interference states,revealing the molecular mechanisms involved in the crRNA maturation,target recognition,R-loop formation,nuclease activation and target ***12h1 notably recognizes a broad 5’-DHR-3’PAM(D is A,G,or T;H is A,C,or T;R is A or G)both in vitro and in human *** addition,Cas12h1 utilizes a distinct activation mechanism that the lid motif undergoes a“flexible to stable”transition to expose the catalytic site to the substrate.A high-fidelity nucleic acid detector,Cas12h1hf,was developed through rational engineering,which distinguishes single-base mismatches and retains comparable on-target *** results shed light on the molecular mechanisms underlying Cas12h1 nickase,improve the understanding of type V Cas effectors,and expand the CRISPR toolbox for genome editing and molecular diagnosis.

关键词： nontarget strand nts cryo em structures broad spectrum pam high fidelity nucleic acid detector molecular mechanisms nickase preference genome editing rational engineering

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The discovery of tiny RNAs that have crucial roles

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science China(life sciences) 2025年第4期68卷 1183-1185页

作者： Shouhong Guang Mo-Fang Liu Department of Obstetrics and Gynecology The First Affiliated Hospital of USTCThe USTC RNA InstituteMinistry of Education Key Laboratory for Membraneless Organelles&Cellular DynamicsHefei National Research Center for Physical Sciences at the MicroscaleCenter for Advanced Interdisciplinary Science and Biomedicine of IHMSchool of Life SciencesDivision of Life Sciences and MedicineBiomedical Sciences and Health Laboratory of Anhui ProvinceUniversity of Science and Technology of ChinaHefei230027China New Cornerstone Science Laboratory Key Laboratory of Epigenetic Regulation and InterventionShanghai Key Laboratory of Molecular AndrologyCAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of Sciences-University of Chinese Academy of SciencesShanghai200031China

On October 7, the Nobel Assembly at Sweden's Karolinska Institute announced the awarding of the 2024 Nobel Prize in Physiology or Medicine to American scientists Victor Ambros and Gary Ruvkun for their discovery o... 详细信息

关键词： tiny RNAs microRNAs posttranscriptional gene regulation nobel assembly

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pH-responsive AIE nanogels for synergistic chemo-photodynamic cancer therapy with imaging guidance

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science China Chemistry 2025年第4期68卷 1445-1455页

作者： Yilin Zhu Liping Zhang Rongyuan Zhang Chenghan He Han Yang Yong Liu Ryan T.K.Kwok Jacky W.Y.Lam Jianwei Sun Jing Feng Zheng Zhao Cuiping Yao Ben Zhong Tang Institute of Biomedical Photonics and Sensing School of Life Science and TechnologyXi'an Jiaotong UniversityXi'an 710049China Clinical Translational Research Center of Aggregation-Induced Emission The Second Affiliated HospitalSchool of MedicineSchool of Science and EngineeringShenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Shenzhen 518172China Department of Urology Jining NO.1 People's Hospital Jining 27200China AIE Institute Guangzhou 510530China Department of Chemistry the Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionDivision of Life ScienceState Key Laboratory of Molecular Neuroscienceand Department of Biological and Chemical EngineeringThe Hong Kong University of Science and TechnologyHong Kong 999077China

Photodynamic therapy(PDT)is a promising cancer treatment that uses photosensitizers(PSs)to generate cytotoxic reactive oxygen species(ROS)under light;but improving its efficacy is crucial for clinical *** address this;we propose a smart nanoplatform(P@BAO-DOX)for synergistic chemo-photodynamic therapy;featuring efficient PDT;controllable drug release;and fluorescence imaging *** designed an aggregation-induced emission(AIE)-based PS(BAO)with effective ROS generation and NIR-II ***;BAO as a PS and doxorubicin(DOX)as a chemo drug were encapsulated in p H-responsive nanogels(PNA)to obtain P@BAO-DOX *** uptake by tumor cells;the nanogel releases drugs in acidic conditions;leading to cell *** light irradiation further triggers BAO to produce substantial ROS;enhancing phototoxicity and synergistic chemo-PDT cancer ***;P@BAO-DOX nanogels;as a smart nanoplatform;offer precise drug release and efficient ROS generation for imaging-guided chemo-PDT synergistic therapy;showing promise in advancing cancer treatment.

关键词： photodynamic therapy aggregation-induced emission pH-responsive nanogels imaging-guided synergistic cancer therapy

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Boosting with Omicron-specific mRNA vaccine or historical SARS-CoV-2 vaccines elicits discriminating immune responses against Omicron variants

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Acta Pharmaceutica Sinica B 2025年第2期15卷 947-962页

作者： Yi Wu Xiaoying Jia Namei Wu Xinghai Zhang Yan Wu Yang Liu Minmin Zhou Yanqiong Shen Entao Li Wei Wang Jiaming Lan Yucai Wang Sandra Chiu Department of Laboratory Medicine the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230031China School of Basic Medical Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430062China University of Chinese Academy of Sciences Beijing 100049China RNAlfa Biotech Hefei 230088China Core Unit of National Clinical Research Center for Laboratory Medicine Hefei 230031China Key Laboratory of Anhui Province for Emerging and Reemerging Infectious Diseases Hefei 230026China Shanghai Institute of Immunity and Infection Chinese Academy of SciencesShanghai 200031China

Booster vaccinations are highly recommended in combating the SARS-CoV-2 Omicron variant and its ***,the optimal booster vaccination strategies and related immune mechanisms with different prior vaccinations are *** this study,we systematically evaluated the immune responses in mice and hamsters with different prime-boost regimens before their protective efficacies against Omicron were *** found that boosting with Ad5-nCoV,S_(WT)-2P or SOmicron-6P induced significantly higher levels of neutralization activities against Omicron variants than CoronaVac and ZF2001 by eliciting stronger germinal center(GC)***,S_(Omicron)-6P induced even stronger antibody responses against Omicron variants in CoronaVac and Ad5-nCoV-primed animals than non-Omicron-specific vaccines but with limited differences as compared to Ad5-nCoV and *** addition,boosting with a specific vaccine has the potential to remodel the existing immune *** findings indicated that adenovirus-vectored vaccines and mRNA vaccines would be more effective than other types of vaccines as booster shots in combating Omicron ***,the protective efficacies of the vaccines in booster vaccinations are highly related to GC reactions in secondary lymphatic *** summary,these findings provide timely important information on prime-boost regimens and future vaccine design.

关键词： SARS-CoV-2 Omicron Subvariants Omicron-specific mRNA vaccine Commercial vaccines Booster vaccination Immune response

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Sustainably sourced p-coumaric acid-derived bio-based epoxy resins: Functionalized thermosetting epoxy materials with excellent flame retardancy, ultra-high strength, toughness, and transparency

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Journal of Industrial and Engineering Chemistry 2025年 148卷 809-820页

作者： Zhang, Chunhong Qi, Zhijie Ma, Zizheng Gong, Yuning Feng, Han Zang, Junbo Du, Weifeng Shang, Lei Jilin Province Key Laboratory of Carbon Fiber Development and Application JiLin Provincial Laboratory of Carbon Fiber and Composites College of Chemistry and Life Science Changchun University of Technology Changchun130012 China Zhejiang Baojing Carbon Material Co. Ltd. Shaoxing312073 China

Commercial epoxy resins are significantly limited in their applications in structural materials, packaging materials, and other fields due to inherent drawbacks such as the non-renewability of synthetic raw materials, high brittleness, and flammability. During the modification process, challenges related to the compatibility of additives and the "see-saw" issue between mechanical performance and flame retardancy persistently arise. This study presents the first synthesis of sustainable flame-retardant epoxy resins (p-CAIE) using biomass-derived p-coumaric acid (p-CA) and isophorone diisocyanate (IPDI) as raw materials. p-CAIE is utilized as a modifier for commercial epoxy resins, resulting in thermosetting materials (p-CAIE-E51/DDM) with excellent thermal stability, superior mechanical properties, and enhanced flame retardancy. The compatibility between the components is significantly improved, and the introduction of extensive hydrogen bonding within the crosslinked network leads to remarkable enhancements in performance. Specifically, the tensile strength and elongation at break of the 15 % p-CAIE-E51/DDM cured resin system increased by 119 % and 360 %, respectively, while the impact strength improved by 151 % compared to pure E51/DDM. The limiting oxygen index (LOI) reached 29.5 %, and the UL-94 test achieved a V-0 rating. Additionally, the peak heat release rate (PHRR), total heat release (THR), total smoke production (TSP), and carbon monoxide production (COP) were reduced by 54.2 %, 55.5 %, 53.6 %, and 40.5 %, respectively, effectively suppressing thermal and smoke release. The material also exhibited high transparency within the visible light range (400 nm-760 nm). Thus, this research provides an environmentally friendly strategy for the multifunctional manufacturing of bio-based epoxy resins, offering a promising solution for simultaneously enhancing the flame retardancy, toughness, and transparency of thermosetting epoxy materials. © 2025

关键词： Thermosets

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Impact of a new pesticide on rhizosphere microbes and plant health:Case study of Y17991 against sharp eyespot in wheat

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Journal of Integrative Agriculture 2025年第2期24卷 769-785页

作者： Xiangxia Yang Tingting Chen Libo Xiang Limin Liu Mi Wei School of Agriculture Shenzhen Campus of Sun Yat-Sen UniversityShenzhen 518107China Institute of Plant Protection and Soil Fertilizer Hubei Academy of Agricultural Sciences/Key Laboratory of Integrated Pest Management for Crops in the Central RegionMinistry of Agriculture and Rural Affairs/Hubei Key Laboratory of Crop Pest and Weed ControlWuhan 430079China Agricultural Technology Service Center of Yuxin Town Tianmen 433000China Key Laboratory for Quality Control of Characteristic Fruits and Vegetables of Hubei Province College of Life Science and TechnologyHubei Engineering UniversityXiaogan 432000China

Sharp eyespot(Rhizoctonia cerealis)is a widespread soil-borne fungal disease that poses a severe threat to wheat health,and it is one of the main obstacles to achieving stable and high-quality wheat yields in *** collaborative team has developed a novel,efficient,and low-toxicity fungicide named Y17991(N-(2-(2,4-bis-(trifluoromethyl)phenoxy)phenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide).Preliminary laboratory tests confirmed the significant inhibitory effect of this agent on ***-area field trials also demonstrated its efficacy,with a disease prevention index of 83.52%,which is 1.97%greater than that of the widely used thifluzamide,and it significantly increased the wheat ***,this study explored the impacts of Y17991 on the structure and function of the microbial community in wheat rhizosphere *** communities were more strongly affected than fungal communities.Y17991 significantly modulated key amino acid metabolic pathways and certain biosynthetic processes in diseased wheat rhizospheres,and it also enhanced certain biosynthetic pathways and metabolic activities in healthy wheat ***,the application of Y17991 regulated rhizosphere metabolites,thus exerting significant control over the microbial *** identified 15 microbial strains potentially involved in the prevention and treatment of ***,and Y17991 treatment promoted the growth of Pedobacter and Bacillus *** strains not only aid in plant growth but they also have the potential for disease *** summary,Y17991 application at a reasonable dose does not cause significant disruption to nontarget rhizosphere microbial *** future studies,we will continue to investigate the impacts of Y17991 on nonmicrobial components in soil ecosystems,such as protozoa and *** research provides a theoretical basis for the scientific application and promotion of new fungicides and offers a significant refere

关键词： pesticide sharp eyespot rhizosphere microbial community rhizosphere metabolites culturable microorganisms

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Power Allocation Based on Federated Multiagent Deep Reinforcement Learning for NOMA Maritime Networks

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IEEE Internet of Things Journal 2025年第9期12卷 12869-12884页

作者： He, Jiayi Liu, Zhiyong Zhang, Yakai Jin, Zihao Zhang, Qinyu School of Information Science and Engineering Shandong Weihai264209 China Shandong Provincial Key Laboratory of Marine Electronic Information and Intelligent Unmanned Systems Key Laboratory of Cross-Domain Synergy and Comprehensive Support for Unmanned Marine Systems of the Ministry of Industry and Information Technology Shandong Weihai264209 China Communication Engineering Research Center Guangdong Shenzhen518055 China Peng Cheng Laboratory Shenzhen518055 China

The absence of established communication infrastructures at sea presents a significant hurdle for the development of the Internet of Things (IoT) in maritime environments. In this article, we propose a novel solution: a nonorthogonal multiple access (NOMA) maritime network employing power allocation facilitated by federated multiagent deep reinforcement learning (DRL). Conventional single-agent DRL algorithms encounter challenges, such as dimensionality explosion in real-world scenarios. We address this issue by extending these algorithms to incorporate multiple agents. Furthermore, to mitigate risks associated with centralized training, such as data leakage and network attacks, we adopt a federated learning (FL) framework for distributed training across multiple agents. By uploading only select parameters during training and keeping data locally, FL not only enhances algorithm convergence speed but also bolsters data privacy. Specifically, we introduce the federated multiagent deep Q-network (FLMADQN) algorithm tailored for power allocation in NOMA maritime networks. Our algorithm aims to maximize system throughput, optimize data transfer rates, and expedite convergence. Through extensive computer simulations, we validate the efficacy of our proposed approach. Results demonstrate that the FLMADQN algorithm significantly outperforms the traditional DRL algorithm, DQN, in NOMA maritime environments, improving average system throughput by 20.12%, peak system throughput by 45.10%, and system spectral efficiency by 48.33%. Moreover, FLMADQN exhibits a twofold increase in convergence speed compared to MADQN without FL and is 2.5 times faster than DQN. Our findings underscore the potential of federated multiagent DRL in advancing communication systems for maritime IoT applications. © 2014 IEEE.

关键词： Federated learning

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