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Molecular architecture of mammalian pyruvate dehydrogenase complex

Protein & Cell 2025年第1期16卷 72-78页

作者： Maofei Chen Yutong Song Sensen Zhang Yitang Zhang Xudong Chen Minghui Zhang Meng Han Xin Gao Sai Li Maojun Yang Tsinghua-Peking Center for Life Sciences Beijing Frontier Research Center for Biological StructureSchool of Life SciencesTsinghua UniversityBeijing 100084China Ministry of Education Key Laboratory of Protein Science Tsinghua UniversityBeijing 100084China State Key Laboratory of Membrane Biology Tsinghua UniversityBeijing 100084China Department of Biochemistry and Molecular Biology School of Basic Medical SciencesShenzhen University Health Science CenterShenzhen 518060China Protein Research Technology Center Protein Chemistry and Omics PlatformSchool of Life SciencesTsinghua UniversityBeijing 100084China Computer Science Program ComputerElectrical and Mathematical Sciences and Engineering DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Kingdom of Saudi Arabia Computational Bioscience Research Center King Abdullah University of Science and TechnologyThuwal 23955-6900Kingdom of Saudi Arabia Cryo-EM Facility Center Southern University of Science and TechnologyShenzhen 518055China Beijing Life Science Academy Beijing 102209China

Dear Editor,Pyruvate dehydrogenase complex(PDHc) is a large multienzyme assembly(Mr = 4–10 million Daltons) consisting of three essential components: pyruvate dehydrogenase(E1p), dihydrolipoyl transacetylase(E2p), and dihydrolipoyl dehydrogenase(E3). These three enzymes perform distinct functions sequentially to catalyze the oxidative decarboxylation of pyruvate with formation of nicotinamide adenine dinucleotide(NADH) and acetyl-coenzyme A(Patel and Roche, 1990).

关键词： sequentially oxidative Dalton

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Dual‑Donor‑Induced Crystallinity Modulation Enables 19.23% Efficiency Organic Solar Cells

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Nano-Micro Letters 2025年第3期17卷 376-388页

作者： Anhai Liang Yuqing Sun Sein Chung Jiyeong Shin Kangbo Sun Chaofeng Zhu Jingjing Zhao Zhenmin Zhao Yufei Zhong Guangye Zhang Kilwon Cho Zhipeng Kan Center On Nanoenergy Research Institute of Science and Technology for Carbon Peak&NeutralitySchool of Physical Science&TechnologyGuangxi UniversityNanning 530004People’s Republic of China Department of Chemical Engineering Pohang University of Science and TechnologyPohang 37673South Korea College of New Materials and New Energies Shenzhen Technology UniversityShenzhen 518118People’s Republic of China Zhejiang Engineering Research Center for Fabrication and Application of Advanced Photovoltaic Materials School of Materials Science and EngineeringNingboTech UniversityNingbo 315100People’s Republic of China State Key Laboratory of Featured Metal Materials and Life-Cycle Safety for Composite Structures Nanning 530004People’s Republic of China

Trap-assisted charge recombination is one of the primary limitationsof restricting the performance of organic solar cells. However, effectivelyreducing the presence of traps in the photoactive layer remains ***, wide bandgap polymer donor PTzBI-dF is demonstrated as an effectivemodulator for enhancing the crystallinity of the bulk heterojunction active layerscomposed of D18 derivatives blended with Y6, leading to dense and orderedmolecular packings, and thus, improves photoluminescence quenching *** a result, the photovoltaic devices exhibit reduced trap-assisted charge recombinationlosses, achieving an optimized power conversion efficiency of over 19%.Besides the efficiency enhancement, the devices comprised of PTzBI-dF as athird component simultaneously attain decreased current leakage, improved chargecarrier mobilities, and suppressed bimolecular charge recombination, leading toreduced energy losses. The advanced crystalline structures induced by PTzBI-dFand its characteristics, such as well-aligned energy level, and complementaryabsorption spectra, are ascribed to the promising performance *** findings suggest that donor phase engineering is a feasible approach to tuning the molecular packings in the active layer, providingguidelines for designing effective morphology modulators for high-performance organic solar cells.

关键词： Trap-assisted charge recombination Photoluminescence Miscibility Current leakage Power conversion efficiency

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Drug discovery targeting thyroid hormone receptor b (THRb) for the treatment of liver diseases and other medical indications

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Acta Pharmaceutica Sinica B 2025年第1期15卷 35-51页

作者： Kean Wang Feiyang Chen Jiang Wang Hong Liu School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Lingang Laboratory Shanghai 200031China School of Life Science and Technology Shanghai Tech UniversityShanghai 200031China

Thyroid hormone receptors(THRs),a crucial nuclear receptor protein family,primarily consist of two categories:a receptors and b *** them,THRb is the primary subtype of thyroid hormone that confers benefits to the *** the last two decades,there have been efforts to develop THRb agonists that selectively yield beneficial effects on the liver,such as lowering triglycerides and cholesterol,while reducing adverse effects on the heart,muscle,and *** paper systematically reviews strategies to enhance the safety of THRb agonists for the treatment of MASH,with a focus on improving the selectivity of THRa and increasing the distribution of the drug in the ***,we explore the potential application of this target in addressing other medical indications.

关键词： Thyroid hormone Thyroid hormoneβreceptor MASLD MASH THRβagonist

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Uniform Ag_(6)Mo_(10)O_(33) meso/nanowires:High-efficient fabrication,novel growth mechanism,and reversibly high-energy sodium-ion battery

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Nano Research 2025年第4期18卷 189-198页

作者： Yuqing Yang Juan Liu Meiqi Zhang Qing Wang Ziqing Gui Xucheng Gu Chunsheng Li Yan Sun Yuxuan Sun Lianghuan Qin Yuzhen Zhao Wanzheng Lu Xiaofang Xu Xufeng Wang Key Laboratory of Advanced Electrode Materials for Novel Solar Cells for Petroleum and Chemical Industry of China School of Chemistry and Life SciencesSuzhou University of Science and TechnologySuzhou 215009China Xi’an Key Laboratory of Advanced Photo-electronics Materials and Energy Conversion Device School of Electronic InformationXijing UniversityXi’an 710123China School of Safety Science and Engineering Changzhou UniversityChangzhou 213164China Suzhou Key Laboratory of Biophotonics School of Optical and Electronic InformationSuzhou City UniversitySuzhou 215104China State Key Laboratory of Advanced Chemical Power Sources Guizhou Meiling Power Sources Co.LtdZunyi 563003China

Silver molybdate(Ag_(6)Mo_(10)O_(33))exhibits excellent catalytic properties and photocatalytic degradation owing to its unique chemical and structural characteristics,but its prospective applications in electrochemistry energy storage have not received sufficient ***,the Ag_(6)Mo_(10)O_(33) meso/nanowires with superior morphological characteristics are fabricated employing a high-efficient microwave irradiation ***,the novel synthesizing mechanism of ultralong Ag_(6)Mo_(10)O_(33) mesowires is also proved to be a“self-assembly-dissolution-recrystallization-Ostwald-ripening”process,by exploring through the parallel experiments on the dramatic alterations in topology and size of Ag_(6)Mo_(10)O_(33) at continuous reaction ***,the properties of the ultralong uniform Ag_(6)Mo_(10)O_(33) mesowires for the sodium storage are investigated via cyclic voltammetry,electrochemical impedance spectroscopy and galvanostatic ***,these as-obtained Ag_(6)Mo_(10)O_(33) mesowires exhibit an outstanding initial capacity(1587.9 mAh·g^(-1)),a remarkable specific capacity for the second cycle(817.9 mAh·g^(-1)),and an excellent reversible capacity(551.5 mAh·g^(-1) after 30 cycles).The superior electrochemical properties of the nanoscaled silver molybdate are ascribed to the lower charge transfer resistance due to the microstructure of the smallest size Ag_(6)Mo_(10)O_(33) nanosheets that exhibit a thickness of around 5 nm,which can provide a great contact with the electrolyte,facilitating the rapid diffusion of sodium ions at the electrode/electrolyte interface and the rapid transport of sodium ions within the electrode ***,the proposed synthetic strategy and achieved deep insights will stimulate the development of Ag_(6)Mo_(10)O_(33) for high-safety and long-life sodium ion batteries.

关键词： sodium-ion batteries self-assembly-dissolution-recrystallization-Ostwald-ripening fabricating mechanism microwave irradiation fabrication Ag_(6)Mo_(10)O_(33)meso/nanowires energy storage and conversion

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UAV-Aided Multi-antenna Relay Systems with Wireless Power Transfer for Maritime Communications 14th

UAV-Aided Multi-antenna Relay Systems with Wireless Power T...

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14th EAI International Conference on Wireless and Satellite Systems, WiSATS 2024

作者： Li, Yuheng Zhou, Zhiquan Wang, Jinlong Wang, Lina Wang, Chenxu School of Information Science and Engineering Harbin Institute of Technology Weihai264209 China Shandong Provincial Key Laboratory of Marine Electronic Information and Intelligent Unmanned Systems Weihai264209 China Key Laboratory of Cross-Domain Synergy and Comprehensive Support for Unmanned Marine Systems Ministry of Industry and Information Technology Weihai264209 China

ISBN: (纸本)9783031862021

With the increase in maritime activities, traditional communication methods can no longer meet the needs of today’s maritime work, and the use of unmanned aerial vehicle(UAV) relay communications in marine scenarios has attracted more and more attention. In this paper, A long-distance three-node two-hop UAV relay system for maritime users is investigated. The UAV aerial relay node first transmits an energy-carrying radio frequency (RF) signal to the maritime user node, which then harvests energy and sends data information back to the UAV aerial relay node, which in turn forwards it to the land node. Considering the peculiarities of maritime communication channels, a novel land-air-maritime communication channel model is proposed. Utilizing Zero-Forcing/Zero-Transmission (ZFR/ZFT) technology, a precoding matrix for the aerial relay node is designed, followed by simulation and emulation, the performance of the channel is tested in the case of different transmission power of relay nodes or different number of antennas of relay nodes. © ICST Institute for Computer sciences, Social Informatics and Telecommunications Engineering 2025.

关键词： Unmanned aerial vehicles (UAV)

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Pyrite-based materials for heavy metals wastewater remediation:progress and challenges

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Frontiers of Environmental science & Engineering 2025年第3期19卷 229-244页

作者： Kaixuan Zheng Fuli Li Kuang He Xiangrui Kong Wei Wang Yanzhi Chen Renli Yin Na Liu Yong Wen Hongtao Wang State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment South China Institute of Environmental ScienceMinistry of Ecological EnvironmentGuangzhou 510655China College of Life Science and Technology Jinan UniversityGuangzhou 510632China Guangdong Laboratory for Lingnan Modern Agriculture Guangdong Provincial Key Laboratory of Agricultural&Rural Pollution Abatement and Environmental SafetyCollege of Natural Resources and EnvironmentSouth China Agricultural UniversityGuangzhou 510642China School of Environment Tsinghua UniversityBeijing 100084China

The heavy metal pollution in water,largely driven by human activities,has become a significant concern in *** has gained attention for treating heavy metal wastewater due to its excellent adsorptive and redox properties,affordability,and environmental ***,the inherent limitations of natural pyrite,such as its small specific surface area,inadequate active sites,and tendency to agglomerate,hinder its effectiveness in removing heavy metal *** address these shortcomings and optimize pyrite’s performance in practical applications,various modification strategies have been *** this paper,the oxidation,reduction,and adsorption capabilities of pyrite with respect to different heavy metal ions have been systematically reviewed by the comparison of the underlying *** also discussed pyrite modification strategies and their corresponding enhancement ***,the paper systematically reviews the current application status and future research trends of pyrite and its modified composites in heavy metal wastewater ***,this work provides a systematic review on pyrite-based materials for heavy metal removal,from theoretical insights to practical applications and future modification strategies.

关键词： Pyrite Modification Heavy metal Redox Adsorption

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Hox-determined appendage regeneration restores cockroach courtship rituals

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science China(life sciences) 2025年第3期68卷 874-876页

作者： Xingmei Mai Mingtao Liao Fangming Zhao Ethan Yihao Li Fangzheng Liu Renaguli Aisa Sichen Wu Nan Chen Sheng Li Chonghua Ren Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology Guangzhou Key Laboratory of Insect Development Regulation and Application ResearchInstitute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhou 510631China Guangmeiyuan R&D Center Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied TechnologySouth China Normal UniversityMeizhou 514779China High School Affiliated to South China Normal University Guangzhou 510631China Xinyang Aviation Vocational College Xinyang 464006China

Dear Editor,The German cockroach,Blattella germanica(Insecta,Blattodea),is one of the most synanthropic cosmopolitan pests affecting public health,which is often described as“little mighty”because of its extreme vitality and *** characterization in cockroaches is primarily due to two crucial biological traits,strong regenerative capacity and excellent fecundity(Ren et al.,2023),but nothing is known about the underlying relationship between these two traits in terms of physiology and *** have evolved diverse appendages(***,labial palp,maxillary palp,leg,wing,and cercus)that are used for locomotion,feeding,communication,and other vital functions(Chen et al.,2022;Li et al.,2024).As a crucial adaptive strategy,appendage regeneration enables animals to restore injured body parts and their associated functions(Tanaka,2016),significantly enhancing survival ability and ecological adaptation(Zhong et al.,2023).Moreover,cockroaches exhibit extremely prominent capacity of leg regeneration in the insect kingdom(Li et al.,2018;Ren et al.,2024;Zhang et al.,2024).

关键词： traits antenna regeneration

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Normative structural connectome constrains spreading transient brain activity in generalized epilepsy

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BMC Medicine 2025年第1期23卷 1-16页

作者： Xia, Jie Yang, Siqi Li, Jiao Meng, Yao Niu, Jinpeng Chen, Huafu Zhang, Zhiqiang Liao, Wei The Clinical Hospital of Chengdu Brain Science Institute School of Life Science and Technology University of Electronic Science and Technology of China Chengdu 611731 China MOE Key Lab for Neuroinformation High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province University of Electronic Science and Technology of China Chengdu 611731 China School of Cybersecurity Chengdu University of Information Technology Chengdu 610225 China Department of Medical Imaging Jinling Hospital Nanjing University School of Medicine Nanjing 210002 China

Background: Genetic generalized epilepsy is characterized by transient episodes of spontaneous abnormal neural activity in anatomically distributed brain regions that ultimately propagate to wider areas. However, the connectome-based mechanisms shaping these abnormalities remain largely unknown. We aimed to investigate how the normative structural connectome constrains abnormal brain activity spread in genetic generalized epilepsy with generalized tonic–clonic seizure (GGE-GTCS). Methods: Abnormal transient activity patterns between individuals with GGE-GTCS (n = 97) and healthy controls (n = 141) were estimated from the amplitude of low-frequency fluctuations measured by resting-state functional MRI. The normative structural connectome was derived from diffusion-weighted images acquired in an independent cohort of healthy adults (n = 326). Structural neighborhood analysis was applied to assess the degree of constraints between activity vulnerability and structural connectome. Dominance analysis was used to determine the potential molecular underpinnings of these constraints. Furthermore, a network-based diffusion model was utilized to simulate the spread of pathology and identify potential disease epicenters. Results: Brain activity abnormalities among patients with GGE-GTCS were primarily located in the temporal, cingulate, prefrontal, and parietal cortices. The collective abnormality of structurally connected neighbors significantly predicted regional activity abnormality, indicating that white matter network architecture constrains aberrant activity patterns. Molecular fingerprints, particularly laminar differentiation and neurotransmitter receptor profiles, constituted key predictors of these connectome-constrained activity abnormalities. Network-based diffusion modeling effectively replicated transient pathological activity spreading patterns, identifying the limbic-temporal, dorsolateral prefrontal, and occipital cortices as putative disease epicenters. These

关键词： Disease epicenter Generalized epilepsy Network spreading Structural connectome Transient brain activity

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Glibenclamide targets MDH2 to relieve aging phenotypes through metabolism-regulated epigenetic modification

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Signal Transduction and Targeted Therapy 2025年第3期10卷 1652-1666页

作者： Zhifan Mao Wenwen Liu Rong Zou Ling Sun Shuman Huang Lingyu Wu Liru Chen Jiale Wu Shijie Lu Zhouzhi Song Xie Li Yunyuan Huang Yong Rao Yi-You Huang Baoli Li Zelan Hu Jian Li State Key Laboratory of Bioreactor Engineering Shanghai Frontiers Science Center of Optogenetic Techniques for Cell MetabolismFrontiers Science Center for Materialbiology and Dynamic ChemistryShanghai Key Laboratory of New Drug DesignSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China Key Laboratory of Tropical Biological Resources of Ministry of Education and Hainan Engineering Research Center for Drug Screening and EvaluationSchool of Pharmaceutical SciencesHainan UniversityHaikou 570228China Hubei Key Laboratory of Genetic Regulation and Integrative Biology School of Life SciencesCentral China Normal UniversityWuhanChina Key Laboratory of Xinjiang Phytomedicine Resource and Utilization Ministry of EducationSchool of PharmacyShihezi UniversityShihezi 832003China

Mitochondrial metabolism-regulated epigenetic modification is a driving force of aging and a promising target for therapeutic *** malate dehydrogenase(MDH2),an enzyme in the TCA cycle,was identified as an anti-aging target through activity-based protein profiling in present *** expression level of MDH2 was positively correlated with the cellular senescence in Mdh2 knockdown or overexpression ***(Gli),a classic anti-glycemic drug,was found to inhibit the activity of MDH2 and relieve fibroblast senescence in an MDH2-dependent *** anti-aging effects of Gli were also further validated in vivo,as it extended the lifespan and reduced the frailty index of naturally aged *** specific Mdh2 knockdown eliminated Gli’s beneficial effects in naturally aged mice,reducing p^(16INK4a) expression and hepatic ***,MDH2 inhibition or knockdown disrupted central carbon metabolism,then enhanced the methionine cycle flux,and subsequently promoted histone ***,the tri-methylation of H3K27,identified as a crucial methylation site in reversing cellular senescence,was significantly elevated in hepatic tissues of naturally aged mice with Mdh2 *** together,these findings reveal that MDH2 inhibition or knockdown delays the aging process through metabolic-epigenetic *** research not only identified MDH2 as a potential therapeutic target and Gli as a lead compound for anti-aging drug development,but also shed light on the intricate interplay of metabolism and epigenetic modifications in aging.

关键词： metabolism glibenclamide cellular senescence MDH therapeutic interventionmitochondrial malate dehydrogenase mdh epigenetic modification aging inhibit activ

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Aggregation of thermally activated delayed fluorescence molecules to boost solid electrochemiluminescence efficiency for biosensing of protein-specific glycoforms

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science China Chemistry 2025年

作者： Chao Wang Zhiwei Tang Yiran Li Mengjiao Li Haijiao Xie Huangxian Ju State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical Engineering Nanjing University Hangzhou Yanqu Information Technology Co. Ltd.

Low quantum yield and insufficient exciton utilization of nanoemitters are great obstacles to achieving their practical electrochemiluminescence(ECL) applications. Here an aggregation strategy of thermally activated delayed fluorescence molecules was designed to reduce the energy gap between the lowest excited singlet and triplet states, and accelerate the reverse intersystem crossing of triplet excitons to the excited singlet state, which increased the exciton utilization, leading to longer delayed fluorescence lifetime and greatly boosted the quantum yield up to 87.5%, using a previously reported DMAC-TRZ as a *** aggregation could be conveniently performed by increasing the water content in the tetrahydrofuran solution of DMACTRZ. Benefiting from the high quantum yield, the solid ECL efficiency was broken through to 62.9%, much higher than the limit of 25%, and a sensitive ECL imaging method was thus proposed for simultaneous high-throughput detection of mucin1-specific sialic acid and fucose on cells by combining a ***-aided cleavage recycling to obtain the detection samples, and a DNA array to capture the detection samples and then recognize the ECL probes. This method showed good reliability and could be expanded to detect the glycans on different proteins by altering the protein aptamer sequence. This work charts a fresh course for exploiting highly efficient ECL emitters and extends their applications in ECL bioanalysis.

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