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Investigation of conformational changes of cathepsin B as a feasibility assessment for NaCl reduction in Jinhua ham

Food science and Human Wellness 2025年第2期14卷 429-438页

作者： Shiqi Hu Guanghong Zhou Xinglian Xu Wangang Zhang Chunbao Li Key Laboratory of Meat Processing and Quality Control Ministry of EducationKey Laboratory of Meat ProcessingMinistry of Agriculture and Rural AffairsJiangsu Synergetic Innovation Center of Meat Processing and Quality ControlCollege of Food Science and TechnologyNanjing Agricultural UniversityNanjing 210095China School of Life Science and Food Engineering Huaiyin Institute of TechnologyHuai’an 223003China

To regulate the sodium chloride content in Jinhua ham,the impact of NaCl on the activity and conformation of cathepsin B was investigated using spectroscopy and computational *** results showed that the activity of cathepsin B decreased with an increase in Na^(+)cation content and ***,decreasedα-helix content and increasedβ-sheet content were *** increase in sulfhydryl group content was attributed to the breaking of original disulfide bonds in the molecular structure or the release of embedded ***,the surface hydrophobicity gradually declined,which was consistent with the analysis of endogenous fluorescence *** the molecular level,the number of hydrogen bonds formed in NaCl-treated samples decreased,and the interactions between the hydrogen bonding were less powerful,which caused instability in the binding of the protein and *** conformation of cathepsin B accurately characterized its activity,and the structural changes had a macroscopic effect on the decrease in protease activity.

关键词： Protein conformation Cathepsin B activity Jinhua ham Molecular docking Molecular dynamics

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Application of Oriented Molecular Imprinting Biosensors in Biomarker Detection

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Journal of Analysis and Testing 2024年第4期8卷 553-568页

作者： Tianjian Lv Tiantong Chen Ziyu Zhu Ruilin Haotian Aiqin Luo Axin Liang Key Laboratory of Molecular Medicine and Biotherapy The Ministry of Industry and Information TechnologySchool of Life ScienceBeijing Institute of TechnologyBeijing100081China Department of Biomedical Engineering Chinese PLA General HospitalBeijing100853China

With the rapid development of nanomaterials,the interdisciplinary cross-linking between nanomaterials and biomedical detection is *** based on novel molecular recognition mechanisms are expected to achieve higher molecular recognition specificity and *** them,oriented molecular imprinting biosensors have recently become a research *** molecular imprinting biosensors are biosensors that can be used for specific *** are constructed by modifying template molecules with specific groups to form molecular imprinting microcavities with templateoriented recognition *** with general biosensors,oriented molecular imprinting biosensors have more directional recognition sites and fewer non-specific recognition *** unique advantage provides a higher signal-to-noise ratio for these sensors,which contributes to establishing a clear and intuitive relationship of light,electricity and other detection signals with the content of substances to be measured and has been widely used in biomarker *** this review,the types,principles and synthesis methods of oriented molecular imprinting technology are briefly *** application of oriented molecular imprinting biosensors in biomarker detection is ***,the technical bottleneck and future development trend of oriented molecular imprinting technology in the field of biosensors are discussed and summarized.

关键词： Oriented imprinting Biosensors Biomarker Detection

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Endomembrane-biased dimerization of ABCG16 and ABCG25 transporters determines their substrate selectivity in ABA-regulated plant growth and stress responses

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Molecular Plant 2024年第3期17卷 478-495页

作者： Yeling Zhou Yuzhu Wang Dong Zhang Jiansheng Liang institute of Plant and Food Science Department of BiologySchool of Life SciencesSouthern University of Science and Technology(SUSTech)Shenzhen 518055China Key Laboratory of Molecular Design for Plant Cell Factory of Guangdong Higher Education Institutes Southern University of Science and Technology(SUSTech)Shenzhen 518055China jiangsu Key Laboratory of Crop Genetics and Physiology/Co-lnnovation Center for Modern Production Technology of Grain Crops Key Laboratory of Plant Functional Genomics of the Ministry of EducationYangzhou UniversityYangzhou 225009China

ATP-binding cassette(ABC)transporters are integral membrane proteins that have evolved diverse func-tions fulfilled via the transport of various *** Arabidopsis,the G subfamily of ABC proteins is particularly abundant and participates in multiple signaling pathways during plant development and stress *** this study,we revealed that two Arabidopsis ABCG transporters,ABCG16 and ABCG25,engage in ABA-mediated stress responses and early plant growth through endomembrane-specific dimerization-coupled transport of ABA and ABA-glucosyl ester(ABA-GE),*** first revealed that ABCG16 contributes to osmotic stress tolerance via ABA *** specifically,ABCG16 induces cellular ABA efflux in both yeast and plant *** FRET analysis,we showed that ABCG16 forms oblig-atory homodimers for ABA export activity and that the plasma membrane-resident ABCG16 homodimers specifically respond to ABA,undergoing notable conformational ***,we demonstrated that ABCG16 heterodimerizes with ABCG25 at the endoplasmic reticulum(ER)membrane and facilitates the ER entry of ABA-GE in both Arabidopsis and tobacco *** specific responsiveness of the ABCG16-ABCG25 heterodimer to ABA-GE and the superior growth of their double mutant support an inhib-itory role of these twoABCGs in early seedling establishment via regulation of ABA-GE translocation across the ER *** endomembrane-specific analysis of the FRET signals derived from the homo-or heterodimerized ABcG complexes allowed us to link endomembrane-biased dimerization to the transloca-tion of distinct substrates by ABcG transporters,providing a prototypic framework for understanding the omnipotence of ABcG transporters in plant development and stress responses.

关键词： abscisic acid ABCG transporter dimerization endomembrane substrate selectivity

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Coupling Co-Ni phosphides for energy-saving alkaline seawater splitting

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Nano Research 2024年第6期17卷 4797-4806页

作者： Weijia Liu Wenxian Liu Tong Hou Junyang Ding Zhigui Wang Ruilian Yin Xingyuan San Ligang Feng Jun Luo Xijun Liu State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures Guangxi Key Laboratory of Processing for Nonferrous Metals and Featured MaterialsMOE Key Laboratory of New Processing Technology for Nonferrous Metals and MaterialsSchool of ResourcesEnvironment and MaterialsGuangxi UniversityNanning 530004China College of Materials Science and Engineering Zhejiang University of TechnologyHangzhou 310014China Hebei Key Laboratory of Optic-electronic Information and Materials the College of Physics Science and TechnologyHebei UniversityBaoding 071002China School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China ShenSi Lab Shenzhen Institute for Advanced StudyUniversity of Electronic Science and Technology of ChinaShenzhen 518110China

The coupling of energy-saving small molecule conversion reactions and hydrogen evolution reaction(HER)in seawater electrolytes can reduce the energy consumption of seawater electrolysis and mitigate chlorine corrosion ***,the fabrication of efficient multifunctional catalysts for this promising technology is of great ***,a heterostructured catalyst comprising CoP and Ni_(2)P on nickel foam(CoP/Ni_(2)P@NF)is reported for hydrazine oxidation(HzOR)-assisted alkaline seawater *** coupling of CoP and Ni_(2)P optimizes the electronic structure of the active sites and endows excellent electrocatalytic performance for HzOR and ***,the two-electrode HzOR-assisted alkaline seawater splitting(OHzS)cell based on the CoP/Ni_(2)P@NF required only 0.108 V to deliver 100 mA·cm^(−2),much lower than 1.695 V for alkaline seawater electrolysis ***,the OHzS cell exhibits satisfactory stability over 48 h at a high current density of 500 mA·cm^(−2).Furthermore,the CoP/Ni_(2)P@NF heterostructured catalyst also efficiently catalyzed glucose oxidation,methanol oxidation,and urea oxidation in alkaline seawater *** work paves a path for high-performance heterostructured catalyst preparation for energy-saving seawater electrolysis for H_(2) production.

关键词： seawater splitting heterostructure electrocatalysis hydrazine oxidation reaction hydrogen evolution reaction

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A covalently integrated ZIF-8/polyamide acid mixed matrix membrane with superior gas separation performance

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Chinese Journal of Chemical Engineering 2024年第12期76卷 30-41页

作者： Guozhen Li Shiqi Ling Yuhui Cui Shilong Dong Tianyin Liu Ting Li Siyu Pang Peiyong Qin National Energy Research and Development Center for Biorefinery College of Life Science and TechnologyBeijing University of Chemical TechnologyBeijing 100029China State Key Laboratory of Bio-Based Fiber Manufacturing Technology China Textile AcademyBeijing 100025China Paris Curie Engineer School Beijing University of Chemical TechnologyBeijing 100029China

Zeolitic imidazolate framework-8(ZIF-8)is a typical filler used to fabricate mixed matrix membranes(MMMs)on account of its attractive advantage of high selective permeability for gas ***,the performance is usually affected by filler aggregation due to strong interactions among fillers and weak interactions between the polymer and fillers,However,the performance is usually affected by filler aggregation due to strong interactions among fillers and weak interactions between the polymer and fillers,which will lead to a decrease of selectivity and the performance of gas separation will be strongly ***,we modified ZIF-8 with 3-amino-1,2,4-triazole to obtain ZIF-8-NH_(2),Kapton polyamide acid was selected as the polymer *** showed that the ZIF-8-NH_(2)/Kapton MMMs has a good compatibility interface between ZIF-8 and Kapton because of the covalent bridging,even the filler loading up to 45%(mass).The 45%(mass)of ZIF-8-NH_(2)/Kapton membrane showed 297 barrer(1 barrer=10^(-10)10 cm^(3)·cm·cm^(-2)·s^(-1)·cmHg^(-1),1 cmHg=1333.22 Pa,standard temperature and pressure)of the permeability of H_(2)and 43.9 and 62.2 of selectivities for H_(2)/N_(2)and for H_(2)/CH_(4),respectively,which are beyond the upper limit of Robeson 2008.

关键词： Polyamide acid ZIF-8 Mixed matrix membrane Gas separation

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Effect of traveling-wave magnetic field on dendrite growth of high-strength steel slab: Industrial trials and numerical simulation

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International Journal of Minerals,Metallurgy and Materials 2023年第9期30卷 1716-1728页

作者： Cheng Yao Min Wang Youjin Ni Dazhi Wang Haibo Zhang Lidong Xing Jian Gong Yanping Bao State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China Technical Support Center for Prevention and Control of Disastrous Accidents in Metal Smelting University of Science and Technology BeijingBeijing 100083China Qianshun Technology Center Shougang Qian’an Iron and Steel CompanyQian’an 064404China

The dendrite growth behavior of high-strength steel during slab continuous casting with a traveling-wave magnetic field was studied in this paper. The morphology of the solidification structure and composition distribution were analyzed. Results showed that the columnar crystals could deflect and break when the traveling-wave magnetic field had low current intensity. With the increase in current intensity, the secondary dendrite arm spacing and solute permeability decreased, and the columnar crystal transformed into an equiaxed crystal. The electromagnetic force caused by the traveling-wave magnetic field changed the temperature gradient and velocity magnitude and promoted the breaking and fusing of dendrites. Dendrite compactness and composition uniformity were arranged in descending order as follows:columnar-toequiaxed transition (high current intensity), columnar crystal zone (low current intensity), columnar-to-equiaxed transition (low current intensity), and equiaxed crystal zone (high current intensity). Verified numerical simulation results combined with the boundary layer theory of solidification front and dendrite breaking–fusing model revealed the dendrite deflection mechanism and growth process. When thermal stress is not considered, and no narrow segment can be found in the dendrite, the velocity magnitude on the solidification front of liquid steel can reach up to 0.041 m/s before the dendrites break.

关键词： high-strength steel traveling-wave magnetic field dendrite growth numerical simulation

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Boosting Adversarial Training with Learnable Distribution

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Computers, Materials & Continua 2024年第3期78卷 3247-3265页

作者： Kai Chen Jinwei Wang James Msughter Adeke Guangjie Liu Yuewei Dai School of Electronics and Information Engineering Nanjing University of Information Science and TechnologyNanjing210044China Key Laboratory of Intelligent Support Technology for Complex Environments Ministry of EducationNanjing210044China School of Computer and Software Nanjing University of Information Science and TechnologyNanjing210044China Nanjing Center for Applied Mathematics Nanjing211135China

In recent years,various adversarial defense methods have been proposed to improve the robustness of deep neural *** training is one of the most potent methods to defend against adversarial ***,the difference in the feature space between natural and adversarial examples hinders the accuracy and robustness of the model in adversarial *** paper proposes a learnable distribution adversarial training method,aiming to construct the same distribution for training data utilizing the Gaussian mixture *** distribution centroid is built to classify samples and constrain the distribution of the sample *** natural and adversarial examples are pushed to the same distribution centroid to improve the accuracy and robustness of the *** proposed method generates adversarial examples to close the distribution gap between the natural and adversarial examples through an attack algorithm explicitly designed for adversarial *** algorithm gradually increases the accuracy and robustness of the model by scaling ***,the proposed method outputs the predicted labels and the distance between the sample and the distribution *** distribution characteristics of the samples can be utilized to detect adversarial cases that can potentially evade the model *** effectiveness of the proposed method is demonstrated through comprehensive experiments.

关键词： Adversarial training feature space learnable distribution distribution centroid

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Copper Ions Removal from Wastewater by Electrocoagulation Using Cement-based Cathode Plates

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Journal of Wuhan University of technology(Materials science) 2023年第2期38卷 387-393页

作者： YOU Song WU Jing WANG Shizhe WANG Wei LI Qiong ZAHNG Ganggang DING Qinjun WANG Luoxin College of Materials Science and Engineering State Key Laboratory of New Textile Materials&Advanced Processing TechnologyWuhan Textile UniversityWuhan430200China Department of Logistics Support Wuhan University of TechnologyWuhan430070China School of Materials Science and Engineering Wuhan University of TechnologyWuhan430070China

The present work uses PEO solution to well disperse carbon fiber and identifies percolation thresholds of carbon fiber and carbon black which are used as conductive *** resultant cathode plates have an average compressive strength of 27.3 MPa and flexural strength of 29.09 MPa,which demonstrate excellent mechanical *** Cu^(2+)removal efficiency was measured at different current densities in EC process with cement-based cathode plate,while the voltage changes were *** results showed that the cement-based cathode plate operated stably and achieved 99.7%removal of 1 L of simulated wastewater with a Cu^(2+)concentration of 200 ppm at a current density of 8 m A/cm^(2)for 1 *** of floc and tested cathode plates,SEM and EDS analyses,and repeatability testing of the tested plates demonstrate the reusability of the plates,proving that cement-based plates can effectively replace metal cathode plates,reduce the cost of EC and improve the applicability of EC devices.

关键词： electrocoagulation cathode plate cement-based conductive materials copper ions repeatability

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L-Ergothioneine ameliorates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease in C57BL/6J mice by activating DJ-1

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Food science and Human Wellness 2025年第3期14卷 1045-1061页

作者： Xianshe Meng Huawen Meng Shuzeng Hou Zequn Yin Xuerui Wang Ke Gong Feng Zhang Qingshan Li Shuang Zhang Yuanli Chen Xiaoxiao Yang Zhiwei Zhao Chenzhong Liao Yajun Duan Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes College of Food and Biological EngineeringHefei University of TechnologyHefei 230009China Department of Cardiology The First Affi liated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China

Parkinson's disease(PD)is one of the most common neurodegenerative *** loss of dopaminergic(DAergic)neurons in the substantia nigra and the decrease of dopamine(DA)levels accelerate the process of PD.L-Ergothioneine(EGT)is a natural antioxidant derived from microorganisms,especially in edible *** can penetrate blood-brain barrier and its levels are significantly decreased in the plasma of PD ***,we speculated that EGT could ameliorate PD,and determined its effect on PD development by using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced PD mouse models and neurotoxin 1-methyl-4-phenylpyridinium(MPP^(+))-induced cell *** results show that EGT alleviated MPTP-induced behavioral dysfunction in ***,we innovatively revealed that EGT was a key regulator of *** restored DA levels by activating the DJ-1-nuclear receptor-related factor 1(Nurr1)***,it reduced reactive oxygen species(ROS)levels by regulating the DJ-1-nuclear factor erythroid 2-related factor 2(Nrf2)pathway,which inhibited oxidative stress-induced DAergic neuronal *** treatment with DJ-1-si RNA transfection revealed that blocking DJ-1 reversed EGT upregulated Nurr1 and Nrf2 expression in the nucleus,which significantly decreased the benefits of *** together,our study suggests that EGT can ameliorate PD and be considered as a strategy for PD treatment.

关键词： L-Ergothioneine 1-Methyl-4-phenyl-1 2 3 6-tetrahydropyridine Parkinson’s disease DJ-1 Dopaminergic neurons

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High-efficiency Fe(III)-doped ultrathin VO_(2)nanobelts boosted peroxydisulfate activation for actual antibiotics photodegradation

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Chinese Chemical Letters 2025年第3期36卷 199-205页

作者： Shukun Le Peng Wang Yuhao Liu Mutao Xu Quansheng Liu Qijie Jin Jie Miao Chengzhang Zhu Haitao Xu Inner Mongolia Key Laboratory of High-Value Functional Utilization of Low Rank Carbon Resources Chemical Engineering CollegeInner Mongolia University of TechnologyHohhot 010050China School of Environmental Science and Engineering Nanjing Tech UniversityNanjing 210009China Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science MOEQingdao University of Science and TechnologyQingdao 266042China

It has been challenging for Fe(III)regeneration in Fe-based photocatalysts for continuous peroxydisulfate(PDS)activation due to the lower ability to reduce Fe(III).In this work,Fe-doped ultrathin VO_(2)(Fe-VO_(2))nanobelts were synthesized for purifying metronidazole(MNZ)via PDS *** an efficient Fentonlike catalyst for PDS activation,2 wt%Fe-doped VO_(2)can remove 98%of MNZ within 40 min and exhibits impressive *** synergistic effect of Fe-VO_(2)and Fe(III)activated PDS boosted the photocatalytic ***,SO_(4)•^(−),h+,O_(2)•^(−),^(1)O_(2),and•OH were the main reactive *** effects of initial MNZ concentration,Fe-VO_(2),PDS dosage,and various anions/cations on MNZ removal by the Fe-VO_(2)/PDS/Vis system were *** intermediates of MNZ degradation and possible pathways were determined by density function theory(DFT)calculations and *** study provided a sustainable technology using Fe-doped ultrathin VO_(2)nanobelts for photocatalytic PDS activation and decontamination of pharmaceutical wastewater.

关键词： Fe-doped VO_(2)nanobelts Photodegradation Persulfate activation Antibiotics removal Bimetallic cycle

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