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15th IEEE Global Reliability and Prognostics and Health Management Conference, PHM-Beijing 2024

作者： Yang, Dingxin Liu, Xiaorong National Key Laboratory of Equipment State Sensing and Smart Support College of Intelligence Science and Technology National University of Defense Technology Changsha China

ISBN: (纸本)9798350354010

With the purpose of improving the wear state classification accuracy of bearing based on combined online oil and vibration monitoring data, this paper proposes a new method to classify the wear state of bearing based on the K-means clustering and deep belief network (DBN). First, we carried out several groups of full life test for bearings on a bearing life test bench to obtain the online oil parameters such as wear metal debris, oil viscosity, temperature, density, and permittivity and vibration data during the whole test. The data are pretreated and normalized to form the wear state classification input data. Then, K-means method is used to cluster the input data to obtain the training label with validation for further wear state classification. A five-layer DBN feature extraction model is constructed and trained using the labeled input data. The model is used to extract features from combined online oil and vibration monitoring data and to classify the wear status of other tested bearings. Finally, the experimental results indicate that the DBN model can effectively classify the wear state of bearings. Compared with the support vector machine (SVM) method previously used, the accuracy of classification has slightly improved. © 2024 IEEE.

关键词： Labeled data

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Biomimetic“Gemini nanoimmunoregulators”orchestrated for boosted photoimmunotherapy by spatiotemporally modulating PD-L1 and tumor-associated macrophages

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1345-1361页

作者： Honglin Huang Ningxi Li Xiaodan Wei Qingzhi Li Junhan Guo Geng Yang Hong Yang Lulu Cai Yiyao Liu Chunhui Wu Department of Pharmacy Personalized Drug Therapy Key Laboratory of Sichuan ProvinceSichuan Provincial People’s Hospitaland School of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu 610054China TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072China

A novel strategy of not only stimulating the immune cycle but also modulating the immunosuppressive tumor microenvironment is of vital importance to efficient cancer ***,a new type of spatiotemporal biomimetic“Gemini nanoimmunoregulators”was engineered to activate robust systemic photoimmunotherapy by integrating the triple-punch of amplified immunogenic cell death(ICD),tumor-associated macrophages(TAMs)phenotype reprogramming and programmed cell death ligand 1(PD-L1)***“Gemini nanoimmunoregulators”PM@RM-T7 and PR@RM-M2 were constructed by taking the biocompatible mesoporous polydopamine(mPDA)as nanovectors to deliver metformin(Met)and toll-like receptor 7/8 agonist resiquimod(R848)to cancer cells and TAMs by specific biorecognition via wrapping of red blood cell membrane(RM)inlaid with T7or M2 ***/Met@RM-T7(abbreviated as PM@RM-T7)was constructed to elicit an amplified in situ ICD effect through the targeted PTT and effectively stimulated the anticancer ***,PD-L1 on the remaining cancer cells was degraded by the burst metformin to prevent immune ***,mPDA/R848@RM-M2(abbreviated as PR@RM-M2)specifically recognized TAMs and reset the phenotype from M2 to M1 state,thus disrupting the immunosuppressive microenvironment and further boosting the function of cytotoxic T *** pair of sister nanoimmunoregulators cooperatively orchestrated the comprehensive anticancer activity,which remarkably inhibited the growth of primary and distant 4T1 tumors and prevented malignant *** study highlights the spatiotemporal cooperative modalities using multiple nanomedicines and provides a new paradigm for efficient cancer immunotherapy against metastatic-prone tumors.

关键词： Biomimetic immunoregulator Spatiotemporal delivery Targeted photothermal therapy Amplified immunogenic cell death Immunosuppressive tumor microenvironment PD-L1 degradation TAMs phenotype reversion Metastasis inhibition

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The plant retromer components SNXs bind to ATG8 and CLASP to mediate autophagosome movement along microtubules

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Molecular Plant 2025年第3期18卷 416-436页

作者： Yanglan Liao Xibao Li Wenlong Ma Xinyi Lin Jiayi Kuang Xuanang Zheng Zien Li Fanfan Qiao Chuanliang Liu Jun Zhou Faqiang Li Ruixi Li Byung-Ho Kang Hongbo Li Caiji Gao Guangdong Provincial Key Laboratory of Biotechnology for Plant Development School of Life SciencesMOE Key Laboratory&Guangdong Provincial Key Laboratory of Laser Life ScienceCollege of BiophotonicsSouth China Normal UniversityGuangzhou 510631China Centre for Cell&Developmental Biology and State Key Laboratory of Agrobiotechnology School of Life SciencesChinese University of Hong KongHong KongChina College of Life Sciences South China Agricultural UniversityGuangzhou 510642China Key Laboratory of Molecular Design for Plant Cell Factory of Guangdong Higher Education Institutes School of Life SciencesInstitute of Plant and Food ScienceSouthern University of Science and TechnologyShenzhen 518055China

In eukaryotic cells,autophagosomes are double-membrane vesicles that are highly mobile and traffic along cytoskeletal *** core autophagy-related proteins(ATGs)and other regulators involved in autophagosome biogenesis in plants have been extensively studied,the specific components regulating plant autophagosome motility remain *** this study,using TurboID-based proximity labeling,we identify the retromer subcomplex comprising sorting nexin 1(SNX1),SNX2a,and SNX2b as interacting partners of ***,SNX proteins decorate ATG8-labeled autophagosomes and facilitate their coordinated movement along *** of SNX proteins restricts the motility of autophagosomes in the cytoplasm,resulting in decreased autophagic ***,we show that the microtubule-associated protein CLASP is a bridge,connecting the SNX-ATG8-decorated autophagosomes to the ***,the clasp-1 mutant phenotype resembles that of plants with disrupted SNXs or microtubule networks,displaying diminished autophagosome motility and reduced autophagic ***,our study unveils a hitherto unanticipated role of the SNXs subcomplex in connecting autophagosomes with microtubules to promote autophagosome mobility in Arabidopsis.

关键词： autophagy SNX CLASP microtubule autophagosome trafficking Arabidopsis thaliana

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Methylthio side-chain modified quinoidal benzo-[1,2-b:4,5-b']dithiophene derivatives for high-performance ambipolar organic field-effect transistors

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science China Chemistry 2024年第10期67卷 3357-3365页

作者： Li Chen Xiaoqi Luo Nuoya Li Shaoqian Peng Qing Jiang Di Wu Jianlong Xia State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Center of Smart Materials and DevicesWuhan University of TechnologyWuhan 430070China School of Chemistry Chemical Engineering and Life ScienceWuhan University of TechnologyWuhan 430070China Department of Chemistry National University of SingaporeSingapore 117543Singapore

Quinoidal small molecule semiconductors hold huge potential in ambipolar organic field-effect transistors(OFETs)and organic spintronic ***,two quinoidal molecules with methylthio side chains were synthesized to develop molecular semiconductors with high ambipolar mobility,designated QBDTS and *** theoretical calculation results reveal that QBDTS has a closed-shell structure while QTBDTS showed an open-shell structure with a biradical character(y0)of 0.46 and its magnetic properties were further investigated using electron paramagnetic resonance(EPR)and superconducting quantum interference device(SQUID)*** methyl side chains showed a large impact on the molecular orbital *** HOMO/LUMO levels of QBDTS and QTBDTS were measured to be-5.66/-4.56 and-5.27/-4.48 eV,respectively,which are favorable for ambipolar charge transport in ***,the spin-coated QBDTS displayed hole and electron mobilities of 0.01 and 0.5 cm^(2)V^(-1)s^(-1)while QTBDTS showed a record high hole mobility of 1.8 cm^(2)V^(-1)s^(-1)and electron mobility of 0.3 cm^(2)V^(-1)s^(-1).Moreover,comparative studies of the thin film morphologies also manifested the beneficial influence of methyl side chains on film crystallinity and molecule *** results strongly proved that methyl side chain engineering can be a simple but efficient strategy for modulating electronic properties and molecular stacking *** work also represents a big advancement for quinoidal molecular semiconductors in ambipolar OFET applications.

关键词： side-chain modification quinoidal molecules ambipolar diradicals organic field-effect transistors

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Enhancing electromagnetic wave absorption in carbon fiber using FeS_(2)nanoparticles

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Nano Research 2023年第7期16卷 9591-9601页

作者： Yuying Guo Meng Zhang Tingting Cheng Yuxin Xie Laibin Zhao Liang Jiang Wenxin Zhao Liying Yuan Alan Meng Jian Zhang Ting Wang Zhenjiang Li College of Electromechanical Engineering Key Laboratory of Polymer Material Advanced Manufacturing’s Technology of Shandong provinceCollege of Materials Science and EngineeringQingdao University of Science and TechnologyQingdao 266061China College of Chemical Engineering Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life ScienceMOEShandong Key Laboratory of Biochemical AnalysisCollege of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042China College of Textiles and Clothing Qingdao UniversityQingdao 266071China

Carbon-based electromagnetic wave absorbing materials(absorbers)adhered with metallic sulfide nanoparticles of good electrical conductivity attract increasing researchers’*** this study,on the basis of carbon fiber(C_(f))@Fe_(3)O_(4) nanocomposites obtained by the electrostatic spinning and reflow method,C_(f)@FeS_(2)nanocomposite was successfully prepared during a further hydrothermal *** products exhibit excellent electromagnetic wave absorption performances with a minimum reflection loss(RLmin)of-54.11 dB at 2.13 mm matching *** the same time,the optimal effective absorption bandwidth(EAB)value of 6.04 GHz at a thickness of 1.98 mm covers the whole Ku band,suggesting its excellent electromagnetic wave absorption *** addition,the interlaced network structure constructed by carbon fiber,outstanding conductivity of FeS_(2)nanoparticles,and interfacial polarization from hetero-structure play significant parts in enhancing the electromagnetic parameters and absorption *** these results suggest that the C_(f)@FeS_(2)nanocomposites can be taken as a new electromagnetic wave-absorbing material under their low density,simple craft,and strong absorption characteristics.

关键词： constructed network structure carbon fiber(C_(f))@FeS_(2)nanocomposite enhanced dielectric loss microwave attenuation mechanism

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Chlorinated Perylene Monoimide Monoanhydrate Synthesized via Hydrolysis and Its Application in Organic Solar Cells

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Chinese Journal of Polymer science 2023年第11期41卷 1686-1694,I0005页

作者： Jian-Hong Gao Lin-Hua Zhang Hao Shen Feng-Bo Sun Xiang Gao Yan-Jie Sun Xin-Zhu Tong Jing Wen Peng-Cheng Li Di Wu Jian-Long Xia Zhi-Tian Liu Hubei Engineering Technology Research Center of Optoelectronic and New Energy Materials Hubei Key Laboratory of Plasma Chemistry and Advanced MaterialsSchool of Materials Science and EngineeringWuhan Institute of TechnologyWuhan 430205China School of Chemistry Chemical Engineering and Life ScienceWuhan University of TechnologyWuhan 430070China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China

Perylene-3,4-(dicarboxylic monoimide)-9,10-(dicarboxylic monoanhydrate)(PIA)is one key intermediate to construct functionalized perylene diimides(PDIs)for various ***,the difficulty in synthesizing chlorinated PIA hinders the study of chlorinated PDIbased *** chlorination has been widely used to modify the properties of organic *** successfully synthesize chlorinated PIA via a simple hydrolysis reaction using LiOH as the base,then a PDI dimer connected at the imide position,N-di-PDI-4Cl,is synthesized as an application example of chlorinated *** heavily chlorinated PDI dimer exhibits deeper energy levels,slightly blue-shifted UV-Vis absorption compared to the non-chlorinated *** addition,the photovoltaic performance of N-di-PDI-4Cl is *** study paves one easy way to synthesize chlorinated PIA and its more delicate derivatives.

关键词： Chlorinated perylene-3 4-(dicarboxylic monoimide)-9 10-(dicarboxylic monoanhydrate) Chlorination Hydrolysis Nonfullerene acceptors Organic solar cells

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Merging non-covalent and covalent crosslinking:En route to single chain nanoparticles

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Chinese Chemical Letters 2024年第6期35卷 307-311页

作者： Yifei Zhang Yuncong Xue Laiwei Gao Rui Liao Feng Wang Fei Wang CAS Key Laboratory of Soft Matter Chemistry Department of Polymer Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026China Department of Neurosurgical The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineHefei 230026China

Single-chain nanoparticles represent an emerging class of nanomaterials designed to mimic protein's folding *** covalent crosslinking toward the formation of single-chain nanoparticles encounters complex energy landscapes,leading to the potential occurrence of misfolding *** noncovalent crosslinking can circumvent this issue,the resulting single-chain nanoparticles exhibit lower structural stability compared to their covalently crosslinked *** this study,we present a novel approach for the synthesis of single-chain nanoparticles,achieved through the combination of non-covalent and covalent intramolecular *** grafted onto the linear polymer form intrachain non-covalent stacks aided by hydrogen bonds,leading to the formation of non-covalently crosslinked single-chain *** nanoparticles undergo conversion to covalently crosslinked nanostructures through subsequent photo-irradiation using[2+2]photocycloaddition,a process facilitated by the supramolecular confinement ***,the resulting single-chain nanoparticles demonstrate both intrachain folding efficiency and substantial stability,offering significant potential for advancing applications across diverse fields.

关键词： Single chain nanoparticles Intrachain folding Supramolecular confinement Cyanostilbenes [2+2]photocycloaddition

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Inference and prioritization of tissue-specific regulons in Arabidopsis and Oryza

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aBIOTECH 2024年第3期5卷 309-324页

作者： Honggang Dai Yaxin Fan Yichao Mei Ling-Ling Chen Junxiang Gao Hubei Key Laboratory of Agricultural Bioinformatics College of InformaticsHuazhong Agricultural UniversityWuhan430070China State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of Life Science and TechnologyGuangxi UniversityNanning530004China

A regulon refers to a group of genes regulated by a transcription factor binding to regulatory motifs to achieve specific biological *** infer tissue-specific gene regulons in Arabidopsis,we developed a novel pipeline named *** utilizes a gene expression matrix that includes 3400 Arabidopsis transcriptomes to make initial predictions about the regulatory relationships between transcription factors(TFs)and target genes(TGs)using co-expression *** further improves these anticipated interactions by integrating TF binding site enrichment analysis to eliminate false positives that are only supported by expression *** further trained a graph convolutional network with 133 transcription factors,supported by ChIP-seq,as positive samples,to learn the regulatory logic between TFs and TGs to improve the accuracy of the regulatory *** evaluate the functionality of InferReg,we utilized it to discover tissue-specific regulons in 5 Arabidopsis tissues:flower,leaf,root,seed,and *** ranked the activities of regulons for each tissue based on reliability using Borda ranking and compared them with existing *** results demonstrated that InferReg not only identified known tissue-specific regulons but also discovered new *** applying InferReg to rice expression data,we were able to identify rice tissue-specific regulons,showing that our approach can be applied more *** used InferReg to successfully identify important regulons in various tissues of Arabidopsis and Oryza,which has improved our understanding of tissue-specific regulations and the roles of regulons in tissue differentiation and development.

关键词： Transcriptional regulation Graph convolutional network Tissue-specific Regulon Transcription factor

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Non-Hermitian Physics in Mesoscopic Electron Transport Through Coupled Quantum Dots

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Chinese Physics Letters 2025年第4期42卷 114-124页

作者： Yiyang Li Jincheng Lu Chen Wang Jian-Hua Jiang School of Physical Science and Technology&Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow UniversitySuzhou215006China Key Laboratory of Intelligent Optoelectronic Devices and Chips of Jiangsu Higher Education Institutions School of Physical Science and TechnologySuzhou University of Science and TechnologySuzhou215009China Advanced Technology Research Institute of Taihu Photon Center School of Physical Science and TechnologySuzhou University of Science and TechnologySuzhou 215009China Department of Physics Zhejiang Normal UniversityJinhua321004China School of Biomedical Engineering Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei230026China Suzhou Institute for Advanced Research University of Science and Technology of ChinaSuzhou215123China School of Physical Sciences University of Science and Technology of ChinaHefei 230026China

We investigate electron mesoscopic transport in a three-terminal setup with coupled quantum dots and a magnetic *** mapping the original transport problem into a non-Hermitian Hamiltonian form,we study the interplay between the coherent couplings between quantum dots,the magnetic flux,and the dissipation due to the tunnel coupling with the reservoirs.

关键词： quantum dots magnetic fluxby electron mesoscopic transport non hermitian physics magnetic fluxand coherent couplings transport problem tunnel coupling

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P2Y_(14)R activation facilitates liver regeneration via CREB/DNMT3b/Dact-2/β-Catenin signals in acute liver failure

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Acta Pharmaceutica Sinica B 2025年第2期15卷 919-933页

作者： Mengze Zhou Yehong Li Jialong Qian Xinli Dong Yanshuo Guo Li Yin Chunxiao Liu Kun Hao Qinghua Hu State Key Laboratory of Natural Medicines School of PharmacyChina Pharmaceutical UniversityNanjing211198China School of Life Science and Technology China Pharmaceutical UniversityNanjing 211198China

Acute liver failure(ALF)is lack of broadly approved therapeutic strategy except liver *** a glycogen metabolic intermediate,UDP-glucose(UDP-G)has been considered to accelerate liver ***,the role of UDP-G and its receptor P2Y purinoceptor 14(P2Y_(14)R)in ALF remains *** present study aims to investigate the role and underlying mechanisms of UDP-G/P2Y_(14)R axis in *** this study,hepatic P2Y_(14)R is significantly increased in TAA-induced and partial hepatectomy-induced ALF,while knockout of whole-body P2Y_(14)R aggravates liver failure,manifested by inhibitingβ-Catenin-mediated liver ***,P2Y_(14)R deficiency exhibits impaired liver regeneration in mice suffer partial ***,only hepatocellular specific deletion of P2Y_(14)R(P2Y_(14)R^(flox/flox)Alb^(cre/+))mice shows a similar phenomenon,rather than stellate cell specific deletion of P2Y_(14)R(P2Y_(14)R^(flox/flox)Lrat^(cre/+))***,P2Y_(14)R induction regulates methylation of Dact-2 through CREB/DNMT3b signals in hepatocytes,subsequently inhibiting the expression of Dact-2 which is a stabilizer ofβ-Catenin degradation complex,leading to the activation ofβ-Catenin-mediated liver ***,the administration of exogenous UDP-G can accelerate liver regeneration and liver function recovery after partial hepatectomy in hepatocellular carcinoma ***,the findings propose an unrecognized role of P2Y_(14)R in ALF and provide an effective adjuvant strategy for treatment of ALF.

关键词： Acute liver failure UDP-Glucose P2Y_(14)R Liver regeneration Hepatocyte Partial hepatectomy b-Catenin Dact-2

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