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Advanced Agrochem 2025年第1期4卷 70-77页

作者： Qin, Lihong Cao, Jianbo Zheng, Dengyue Tian, Guimin Chen, Chunli National Key Laboratory of Agricultural Microbiology Huazhong Agricultural University Wuhan 430070 China National Key Laboratory for Germplasm Innovation and Utilization for Fruit and Vegetable Horticultural Crops Hubei Hongshan Laboratory/ College of Life Science and Technology Huazhong Agricultural University Hubei Wuhan 430070 China Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education) Institute of Agro-bioengineering/ College of Life Sciences Guizhou University Guiyang 550025 China

Here we report that the presence of MgCO3 stimulates the extracellular polymeric substance (EPS) secretion of Microcystis Aeruginosa (M. Aeruginosa). This stimulation led to a significant reduction in the total concen... 详细信息

Here we report that the presence of MgCO₃ stimulates the extracellular polymeric substance (EPS) secretion of Microcystis Aeruginosa (M. Aeruginosa). This stimulation led to a significant reduction in the total concentration of NH₄⁺‒N by more than 86％, and effective recovery of PO₄^3-‒P within three days from concentrated wastewater (WW), although the secreted EPS inhibited the conversion of MgCO₃ to specific crystal forms (MgNH₄PO₄.6H₂O or MgHPO₄.7H₂O). Moreover, with an increase in PO₄³⁻ concentration in WW, these crystals appeared, thus the removal of NH₄⁺‒N and PO₄^3-‒P nutrients can be attributed to the combined effect of M. Aeruginosa and MgCO₃. We used Surface-Enhanced Raman Spectroscopy (SERS) combined with X-ray Diffraction (XRD), Field Emission Scanning Electron Microscopy with Energy-Dispersive X-ray Spectroscopy (FESEM-EDS), and X-ray Photoelectron Spectroscopy (XPS) to investigate the mechanism for competitive interactions between M. Aeruginosa and MgCO₃ in removing NH₄⁺‒N and PO₄^3-‒P. We identified that the bound EPS accumulated amorphous Mg–P–O dense particles on M. Aeruginosa, while soluble EPS, containing –COOH groups of humic-like substances decreased the pH of the solution and coordinated with Mg²⁺ ions. Therefore, both secreted bound and soluble EPS play a vital role in hindering the transformation of Mg²⁺ ions or MgCO₃ to MgNH₄PO₄.6H₂O or MgHPO₄.7H₂O crystals within WW, and they enhanced M. Aeruginosa 's ability in absorbing nutrients of NH₄⁺‒N and PO₄^3-‒P. This mechanism plays a crucial role in the efficient recovery of NH₄⁺‒N and PO₄

关键词： Concentrated wastewaters Extracellular polymeric substances (EPS) M. Aeruginosa MgCO3 (magnesite) MgNH4PO4.6H2O (struvite) Recovery of nutrient

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Artificial intelligence is transforming the study of proteins:Structures and beyond

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hlife 2025年第4期3卷 162-163页

作者： Haiyan Liu Quan Chen Yufeng Liu MOE Key Laboratory for Membraneless Organelles and Cellular Dynamics School of Life SciencesDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaAnhuiChina Biomedical Sciences and Health Laboratory of Anhui Province Anhui Basic Discipline Research Center of Artificial Intelligence Biotechnology and Synthetic BiologyUniversity of Science and Technology of ChinaAnhuiChina School of Biomedical Engineering Suzhou Institute for Advanced ResearchUniversity of Science and Technology of ChinaJiangsuChina Department of Rheumatology and Immunology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineHefei National Research Center for Physical Sciences at the MicroscaleCenter for Advanced Interdisciplinary Science and Biomedicine of IHMUniversity of Science and Technology of ChinaAnhuiChina

Recently,the Royal Swedish Academy of sciences announced that one-half of the 2024 Nobel Prize in Chemistry was awarded to David Baker for computational protein design,and the other half was awarded jointly to Demis Hassabis and John Jumper for protein structure *** are the molecule tools of *** carry out their functions,many proteins need to fold into particular three-dimensional(3D)structures,which are programmed by the amino acid sequences of the proteins[1].The goal of protein structure prediction is to predict the 3D structures from given amino acid ***,protein design aims to identify amino acid sequences that achieve desired structural or functional goals.

关键词： amino acid sequences proteindesign computationalproteindesign aminoacids computational protein designand artificialintelligence proteinstructureprediction protein structure predictionproteins

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Plant-derived natural products improve disease: Focus on gut-brain axis

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Food science and Human Wellness 2025年

作者： Chen Song Wenjing Lang Li Meng Wenxiang Ping Jingping Ge Engineering Research Center of Agricultural Microbiology Technology， Ministry of Education & Heilongjiang Provincial Key Laboratory of Ecological Restoration and Resource Utilization for Cold Region & School of Life Sciences， Heilongjiang University Heilongjiang Provincial Key Laboratory of Plant Genetic Engineering and Biological Fermentation Engineering for Cold Region & Key Laboratory of Microbiology， College of Heilongjiang Province， Heilongjiang University Key Laboratory of Science and Engineering for the Multi-modal Prevention and Control of Major Chronic Diseases， Ministry of Industry and Information Technology

Dysbiosis of the gut microbiota may lead to a wide range of metabolic， neurological， intestinal and cardiovascular disorders and even to tumorigenesis. Evidence suggests that the gut-brain axis (GBA) plays a crucial role in the treatment of these diseases. Many plant-derived natural actives modulate the gut microbiota and its metabolites， gut hormones and neurotransmitters through a variety of mechanisms， and these actions contribute to the alleviation of irritable bowel syndrome， type 2 diabetes mellitus， cancer， and brain disorders. This review focuses on how natural products act through GBA to protect the central nervous system， regulate metabolism and promote apoptosis in cancer cells. The role of gut microbiota metabolites and neurotransmitter release in modulating inflammation-related factors， promoting or reducing oxidative stress， and activating or inhibiting related signaling pathways is also discussed. This comprehensive overview of the complex GBA mechanisms deepens the understanding of how natural products can target GBA to treat disease， providing valuable insights into the development and utilization of these natural interventions.

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Association between gut microbiota in HIV-infected patients and immune reconstitution following antiretroviral therapy (ART)

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BMC Infectious Diseases 2025年第1期25卷 1-12页

作者： Shi, Yuru Hu, Miaomiao Wu, Jing Liu, Ting Qi, Yingjie Li, Ang Department of Clinical Laboratory The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China (Hefei Infectious Disease Hospital) Anhui Hefei 230000 China Key Laboratory of Digital Technology in Medical Diagnostics of Zhejiang Province Dian Diagnostics Group Co. Ltd Zhejiang Hangzhou 310030 China Department of Clinical Laboratory The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China Anhui Hefei 230001 China Core Unit of National Clinical Research Center for Laboratory Medicine Anhui Hefei 230001 China

Background: This study aims to examine the potential link between incomplete immune reconstitution following ART treatment and gut microbiota dysbiosis. Methods: We collected clinical data and fecal samples from 50 HIV patients undergoing ART and 30 untreated patients. Based on the observed immune function reconstruction, we further categorized the ART(+) group into a responder group (n = 30) and a non-responder group (n = 20). The gut microbiota composition differences were assessed using Alpha diversity and Beta diversity analysis, while differential genera were identified through linear discriminant analysis effect size (LEfSe). Subsequently, functional disparities in the gut microbiota were investigated using PICRUSt2 and metagenomeSeq software. Results: The results of Alpha diversity and Beta diversity revealed significant differences in the composition of gut microbiota among the three groups. Differential genus analysis identified Morganella as an exclusive genus present only in the Non-responder group, exhibiting a significantly higher relative abundance. Correlation analysis demonstrated a positive association between Morganella and LDL levels. The CAZY analysis revealed that glycosyltransferase 25 (GT25) was significantly expressed in the Non-responder group, whereas it was either undetectable or exhibited extremely low expression levels in both the Responder group and the ART(-) group. Importantly, the correlation analysis indicated a positive association between Morganella and GT25 secretion. Conclusions: The ecological imbalance of Morganella might be associated with incomplete immune reconstitution following ART, potentially mediated by GT25 secretions. Consequently, Morganella could serve as a promising biomarker for predicting incomplete immune reconstitution in AIDS patients undergoing ART. © The Author(s) 2025.

关键词： 16S rRNA Antiretroviral therapy Gut microbiota Human immunodeficiency virus Immunological non-responder

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Emerging MOF-based antibiotic detection methods in water environments: Recent advances, challenges, and prospects

Water Cycle

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Water Cycle 2025年 6卷 335-346页

作者： Zhao, Kexin Li, Xinfei Sun, Cuizhu Chen, Lingyun Li, Fengmin Institute of Coastal Environmental Pollution Control Key Laboratory of Marine Environment and Ecology Ministry of Education College of Environmental Science and Engineering Ocean University of China Qingdao266100 China Marine Ecology and Environmental Science Laboratory Qingdao National Laboratory for Marine Science and Technology Qingdao266071 China Faculty of Agricultural Life and Environmental Science University of Alberta EdmontonABT6G 2P5 Canada Sanya Oceanographic Institution Ocean University of China Sanya572000 China

The misuse and improper disposal of antibiotics lead to the emergence and dissemination of antibiotic-resistant bacteria and antibiotic resistance genes, posing serious threats to water environmental safety and human health. Thus, developing efficient detection methods for residual antibiotics in water environments is crucial for pollution control and public health safety. Traditional methods for detecting antibiotics including chromatographic methods, microbiological methods, and immunoassays, suffering from issues such as complex procedures, the requirement for skilled operators, and high costs, greatly limiting their applicability in in-situ monitoring. Recently, rapid detection methods, including colorimetric, fluorescence, biosensors, and paper-based detection, have received widespread attention, overcoming the aforementioned limitations and being widely adopted. Metal-organic frameworks (MOFs) possess distinct advantages, such as enrichment adsorption, catalytic degradation, and self-generated fluorescence, making them highly promising in the field of rapid antibiotic detection. Herein, the detection principles and recent advances in rapid antibiotic detection methods based on MOFs are summarized, and the unique strengths and potential of MOFs in the field of rapid antibiotic detection are highlighted. Notably, recent progress and challenges in high-throughput computing (HTC) and machine learning (ML) for screening MOFs for specific applications is discussed, and strategies for their use in MOF-based rapid antibiotic detection methods are proposed. This comprehensive review may further guide the development and optimization of antibiotic detection methods utilizing MOFs and promote their practical applications for sensing environmental antibiotics. © 2025 The Authors

关键词： Water pollution control

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Advanced bioanalytical techniques for pharmacokinetic studies of nanocarrier drug delivery systems

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Journal of Pharmaceutical Analysis 2025年第1期15卷 19-29页

作者： Xiangjun Meng Jiayi Yao Jingkai Gu School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin300072China Research Center for Drug Metabolism School of Life SciencesJilin UniversityChangchun130012China State Key Laboratory of Supramolecular Structure and Materials Center for Supramolecular Chemical BiologyCollege of ChemistryJilin UniversityChangchun130012China

Significant investment in nanocarrier drug delivery systems(Nano-DDSs)has yielded only a limited number of successfully marketed nanomedicines,highlighting a low rate of clinical translation.A primary contributing factor is the lack of foundational understanding of in vivo *** knowledge of the pharmacokinetics of Nano-DDSs is essential for developing more efficacious nanomedicines and accurately evaluating their safety and associated ***,the complexity of Nano-DDSs has impeded thorough and systematic pharmacokinetic *** components of pharmacokinetic investigations on Nano-DDSs include the analysis of the released drug,the encapsulated drug,and the nanomaterial,which present a higher level of complexity compared to traditional small-molecule *** an appropriate approach for monitoring the pharmacokinetics of Nano-DDSs is crucial for facilitating the clinical translation of *** review provides an overview of advanced bioanalytical methodologies employed in studying the pharmacokinetics of anticancer organic Nano-DDSs over the past five *** hope that this review will enhance the understanding of the pharmacokinetics of Nano-DDSs and support the advancement of nanomedicines.

关键词： Nanocarrier drug delivery systems Bioanalysis Pharmacokinetics Sample fractionation technique

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microRNA-34 mediates a negative feedback loop in the JAK-STAT pathway to attenuate immune overactivation in an invertebrate

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Cell Communication and Signaling 2025年第1期23卷 1-13页

作者： Zuo, Hongliang Liao, Alian Shen, Sihui Wang, Youxi Yang, Xiya Weng, Shaoping He, Jianguo Xu, Xiaopeng State Key Laboratory of Biocontrol School of Life Sciences/ Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)/ China-ASEAN Belt and Road Joint Laboratory on Mariculture Technology Sun Yat-sen University Guangzhou China Institute of Aquatic Economic Animals and Guangdong Province Key Laboratory for Aquatic Economic Animals Sun Yat-sen University Guangzhou China

The JAK-STAT pathway is an essential signaling mechanism that initiates immune responses against pathogen infections. The intrinsic homeostatic regulation of JAK-STAT signaling is critical for maintaining immune homeostasis. Previous studies have shown that aberrant activation of the invertebrate JAK-STAT pathway leads to inflammation-like symptoms. Understanding the homeostatic mechanisms of this pathway in invertebrates is of significant interest. Pacific white shrimp (Penaeus vannamei) is one of the most extensively studied invertebrates in immune system research. In this study, we demonstrate that the shrimp microRNA-34 (miR-34) attenuates JAK-STAT pathway activation by targeting JAK, thereby inhibiting STAT phosphorylation and nuclear translocation. Interestingly, miR-34 expression is directly regulated by STAT, forming a negative feedback regulatory loop in the JAK-STAT pathway. Disrupting this loop results in excessive JAK-STAT pathway activation and immune overactivation, exacerbating inflammation caused by Vibrio parahaemolyticus infection in shrimp. This study provides new insights into the regulatory mechanism of the JAK-STAT pathway and its roles in maintaining immune homeostasis in invertebrates. © The Author(s) 2025.

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In situ insertion of one or two types of hydroxy-rich noncanonical amino acids into one protein

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Process Biochemistry 2025年 154卷 129-142页

作者： Fan, Xuanhe Liu, Yumei Chen, Zhenya Key Laboratory of Molecular Medicine and Biotherapy School of Life Science Beijing Institute of Technology No. 5 South Zhongguancun Street Haidian District Beijing100081 China Tangshan Research Institute BIT No. 57 South Jianshe Road Lubei District Hebei Tangshan063000 China

Noncanonical amino acids (ncAAs) possess unique properties owing to their distinct functional groups. The predominant method for inserting ncAAs into proteins is genetic code expansion, which mimics the natural translation process and requires exogenous ncAAs supplementation. However, microbial cells often lack specific transporters for ncAAs uptake across the cell membrane and do not recognise them as essential nutrients, leading to limited insertion efficiency. To address these challenges, we developed an in situ insertion method to enhance ncAAs insertion efficiency and explored the feasibility of co-inserting two types of ncAAs into a single protein. Initially, orthogonal translation systems specific to the hydroxy-rich ncAAs 5-hydroxytryptophan (5-HTP) and 4-hydroxyisoleucine (4-HiL) were constructed and introduced into microbial cells. Subsequently, the biosynthetic pathways for 5-HTP and 4-HiL were engineered in Escherichia coli, which harboured the corresponding orthogonal translation systems. Furthermore, a co-insertion strategy was developed based on the dual use of UGA and UAG codons. In situ co-insertion of 5-HTP and 4-HiL into one protein was achieved by introducing biosynthetic pathways and orthogonal translation systems for 5-HTP and 4-HiL into the same microbial cell. These findings establish a robust framework for the precise and scalable insertion of ncAAs in advanced protein design. © 2025 Elsevier Ltd

关键词： Biochemical engineering

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Acid-Triggered Charge-Switchable Antibacterial Hydrogel for Accelerated Healing of Gastric Mucosal Wounds

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ACS Nano 2025年第18期19卷 17533-17553页

作者： Zhou, Ziyi Wang, Liangyu Yang, Dongzhi Li, Qin Wang, Xiaoyue Nie, Jun Ma, Guiping Beijing Laboratory of Biomedical Materials State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing100029 China National Energy R&D Center for Biorefinery College of Life Science and Technology Beijing University of Chemical Technology Beijing100029 China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical University Jiangsu Xuzhou221004 China Department of Gastroenterology Beijing Anzhen Hospital Capital Medical University Beijing100029 China

Infection with Helicobacter pylori (H. pylori) is a primary etiological factor for chronic gastritis, peptic ulcers, and gastric cancer. The limited specificity of antibiotics against H. pylori, combined with the risk of severe adverse events from endoscopic submucosal dissection (ESD), presents a major global health challenge in treating gastric mucosal injuries. To address this issue, we developed a targeted antibacterial hydrogel based on a charge-reversal amphiphilic molecule, designed for the harsh gastric acid environment and capable of immediate and strong adhesion. The hydrogel is composed of acryl aspartate (AASP) and cysteine-grafted carboxymethyl chitosan (CMCS-NAC) as the base matrix, integrated with gastric acid-responsive charge-reversal antibacterial molecules (C16N-DCA). Simulated studies show that C16N-DCA undergoes charge reversal under acidic conditions (pH 3), enabling targeted H. pylori eradication mediated by gastric acid, with 98% efficacy and sustained antibacterial activity for up to 36 h. In vitro and in vivo experiments in rodent and porcine models confirmed its safety and efficacy in acidic gastric conditions. This hydrogel offers strong tissue protection and effectively modulates the gastric wound microenvironment, facilitating wound healing and presenting an easily adoptable solution for gastric wound management. © 2025 American Chemical Society.

关键词： Endoscopy

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Maximum Entropy Deep Reinforcement Learning Based Power Allocation for NOMA Maritime Network 14th

Maximum Entropy Deep Reinforcement Learning Based Power Allo...

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14th EAI International Conference on Wireless and Satellite Systems, WiSATS 2024

作者： He, Jiayi Zhang, Yakai Liu, Zhiyong School of Information Science and Engineering of HIT Weihai264209 China Shandong Provincial Key Laboratory of Marine Electronic Information and Intelligent Unmanned Systems Weihai264209 China Key Laboratory of Cross Domain Synergy and Comprehensive Support for Unmanned Marine Systems of Ministry of Industry and Information Technology Weihai264209 China

ISBN: (纸本)9783031862021

In order to address the challenges of high propagation delays and limited service capabilities in maritime satellite communications, unmanned aerial vehicles have been proposed as an airborne backhaul solution to enhance communications between satellites and maritime base stations. The non-orthogonal multiple access (NOMA) framework can solve the user sparsity problem in maritime networks. In this paper, a deep reinforcement learning algorithm is used to solve the nonconvex power allocation problem under NOMA. In order to mitigate the risk of overestimation of Q values and local optimal convergence of Deep Q Network (DQN) algorithm, we propose an algorithm called Soft Agent Critical Ocean Satellite Communication Power Allocation (SAC-OSCPA) based on the idea of maximum entropy and compare it with the traditional DQN algorithm. The main goal of this research is to maximize network throughput in scenarios with randomly distributed users. Simulation results show that the average system throughput is improved by 13.18% with the SAC-OSCPA algorithm, and the average throughput of the worst performing user is significantly improved by 41.59%. These results demonstrate the efficacy of the proposed algorithm in optimizing the communication performance of maritime satellite networks. © ICST Institute for Computer sciences, Social Informatics and Telecommunications Engineering 2025.

关键词： Deep reinforcement learning

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