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10th Symposium on Novel Optoelectronic Detection technology and Applications

作者： Chen, Weiwei Chen, Shanyong Xiong, Yupeng Liu, Junfeng College of Intelligence Science and Technology National University of Defense Technology Changsha410073 China National Key Laboratory of Equipment State Sensing and Smart Support National University of Defense Technology Changsha410073 China Hunan Key Laboratory of Ultra-Precision Machining Technology Changsha410073 China

ISBN: (数字)9781510688155

ISBN: (纸本)9781510688148

The current research on coherent scanning interferometry (CSI) shows that many factors have a negative impact on measurement accuracy. The collection and transmission of interferograms are easily influenced by the material properties of the image sensor, working environment, electronic components, and circuit structure, which makes the gray distribution of interferograms uneven. In addition, the intrinsic error of piezoelectric ceramic (PZT), environmental vibration, air and temperature fluctuation, and other external interference factors will also affect the accuracy and stability of PZT scanning. The above factors are complex and interact with each other, which together cause the non-ideal interference signal in the actual measurement process. The influence of the factors mentioned above on the measurement is manifested as the influence on the interference signal in the topography reconstruction, which can be finally defined as the interferogram noise and the PZT scanning error. Based on the analysis of the influence of PZT scanning error and interferogram noise on the measurement accuracy and performance of commonly used three-dimensional topography reconstruction algorithms, this paper explores the algorithms with strong anti-interference ability in practical application. © 2025 SPIE.

关键词： Piezoelectric materials

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Improved Metabolic Functions and Gut Microbiota Rebalance: the Therapeutic Potential of Ficus Carica Polysaccharides for Type 2 Diabetes Mellitus

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Food science and Human Wellness 2024年

作者： Weilan Wang Guirong Song Fujun Liu Chenxin Zhang Wei Jiang Yiwen Gao Xiang Zhang Lixue Wang Xinran Xu Qingxian Zhao Yan Yang Kexin Liu Jie Lü Jinyao Li Xinjiang Key Laboratory of Biological Resources and Genetic Engineering， College of Life Science and Technology， Xinjiang University

The present study investigated the potential therapeutic potential of Ficus carica polysaccharides (FCPS) in type 2 diabetic (T2DM) mice， focusing on elucidating the underlying molecular mechanisms. Network pharmacology analysis identified 37 shared targets between FCPS and T2DM， including PPARα， highlighting the significance of PPAR signaling pathways in FCPS-mediated T2DM treatment. The results demonstrated that FCPS treatment significantly reduced markers of glucose and lipid metabolism (FBGL， NEFA， TG， TC， LDL-C)， inflammatory cytokines (TNF-α， IL-6， IL-1β， MCP-1)， and liver damage (GPT and GOT) in T2DM mice. Additionally， FCPS ameliorated hepatic lipid droplet accumulation， fatty degeneration， and hepatocyte structural abnormalities. Western blot analysis confirmed FCPS-induced upregulation of key proteins in the IRS-1/AKT/PPARα signaling pathway， (IRS-1， PI3K， p-AKT， GLUT2， p-GSK-3β， p-AMPKα， PGC-1α， PPARα， PPAR-γ) and downregulation of GSK-3β， SREBP-1c， FAS， and HMGCR. 16S rDNA sequencing results revealed FCPS's ability to modulate gut microbiota dysbiosis in T2DM mice by promoting beneficial bacteria (e.g.，Lactobacillus＿reuteri，Candidatus＿Saccharimonas) and suppressing opportunistic pathogens (e.g.，Proteobacteria， Gammaproteobacteria， Escherichia-Shigella). These findings collectively suggest that FCPS has a marked effectiveness in improving glucose and lipid metabolism， decreasing inflammatory responses， as well as modulating the gut microbiota in T2DM mice via the gut-hepatic axis， demonstrating its potential as a functional food for diabetes prevention and management.

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Time-restricted feeding is an intervention against excessive dark-phase sleepiness induced by obesogenic diet

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National science Review 2023年第1期10卷 127-142页

作者： Xu Wang Keke Xing Mengge He Ting He Xinkuan Xiang Tao Chen Luoying Zhang Haohong Li Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and Technology MOE Key Laboratory for Biomedical Photonics Collaborative Innovation Center for Biomedical Engineering School of Engineering SciencesHuazhong University of Science and Technology Department of Anatomy Histology &Embryology Fourth Military Medical University Key Laboratory of Molecular Biophysics of Ministry of Education College of Life Science and Technology Huazhong University of Science and Technology Department of Neurobiology Affiliated Mental Health Center &Hangzhou Seventh People's HospitalZhejiang University School of Medicine Liangzhu Laboratory The MOE Frontier Research Center of Brain &Brain-machine Integration State Key Laboratory of Brain-machine Intelligence

High-fat diet(HFD)-induced obesity is a growing epidemic and major health *** excessive daytime sleepiness(EDS) is a common symptom of HFD-induced obesity,preliminary findings suggest that reduced wakefulness could be improved with time-restricted feeding(TRF).At present,however,the underlying neural mechanisms remain largely *** paraventricular thalamic nucleus(PVT) plays a role in maintaining *** found that chronic HFD impaired the activity of PVT ***,inactivation of the PVT was sufficient to reduce and fragment wakefulness during the active phase in lean mice,similar to the sleep-wake alterations observed in obese mice with HFD-induced *** the other hand,enhancing PVT neuronal activity cons olidated wakefulness in mice with HFD-induced *** observed that the fragmented wakefulness could be eliminated and reversed by ***,TRF prevented the HFD-induced disruptions on synaptic transmission in the PVT,in a feeding duration-dependent ***,our findings demonstrate that ad libitum access to a HFD results in inactivation of the PVT,which is critical to impaired nocturnal wakefulness and increased sleep,while TRF can prevent and reverse diet-induced PVT dysfunction and excessive *** establish a link between TRF and neural activity,through which TRF can potentially serve as a lifestyle intervention against diet/obesity-related ED S.

关键词： high-fat diet excessive daytime sleepiness sleep–wake cycle fragmented wakefulness paraventricular thalamic nucleus time-restricted feeding

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Advancing PAM-less genome editing in soybean using CRISPR-SpRY

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园艺研究（英文） 2024年第8期11卷 41-49页

作者： Xiao Chen Zhaohui Zhong Xu Tang Suxin Yang Yaohua Zhang Shoudong Wang Yiqian Liu Ye Zhang Xuelian Zheng Yong Zhang Xianzhong Feng Key Laboratory of Soybean Molecular Design Breeding National Key Laboratory of Black Soils Conservation and UtilizationNortheast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun 130102China Department of Biotechnology School of Life Sciences and TechnologyCenter for Informational BiologyUniversity of Electronic Science and Technology of ChinaChengdu 610054China Department of Biotechnology School of Life Sciences and TechnologyCenter for Informational BiologyUniversity of Electronic Science and Technology of ChinaChengdu 610054China Integrative Science Center of Germplasm Creation in Western China(Chongqing)Science City Chongqing Key Laboratory of Plant Resource Conservation and Germplasm InnovationSchool of Life SciencesSouthwest UniversityChongqing 400715China Key Laboratory of Soybean Molecular Design Breeding National Key Laboratory of Black Soils Conservation and UtilizationNortheast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun 130102China College of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijing 100049China College of Life Sciences Jilin Agricultural UniversityChangchun 130118China

Although CRISPR-Cas9 technology has been rapidly applied in soybean genetic improvement,it is difficult to achieve the targeted editing of the specific loci in the soybean complex genome due to the limitations of the classical protospacer adjacent motif(PAM).Here,we developed a PAM-less genome editing system mediated by SpRY in *** performing targeted editing of representative agronomic trait targets in soybean and evaluating the results,we demonstrate that the SpRY protein can achieve efficient targeted mutagenesis at relaxed PAM sites in ***,the SpRY-based cytosine base editor SpRY-hA3A and the adenine base editor SpRY-ABE8e both can accurately induce C-to-T and A-to-G conversion in soybean,***,our data illustrate that the SpRY toolbox can edit the soybean genomic sequence in a PAM-free manner,breaking restrictive PAM barriers in the soybean genome editing technology *** importantly,our research enriches soybean genome editing tools,which has important practical application value for precise editing and molecular design in soybean breeding.

关键词： genome advancing crispr-spry editing pam-less soybean using

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Atomic cerium-doped CuO_(x) catalysts for efficient electrocatalytic CO_(2) reduction to CH_(4)

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Chinese Chemical Letters 2025年第1期36卷 326-331页

作者： Xiangyu Chen Aihao Xu Dong Wei Fang Huang Junjie Ma Huibing He Jing Xu Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology School of Chemistry and Chemical EngineeringGuangxi UniversityNanning 530004China State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures Guangxi UniversityNanning 530004China State Key Laboratory of Green Chemical Engineering and Industrial Catalysis School of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China

Copper(Cu)is widely used in the electrochemical carbon dioxide reduction reaction(ECO_(2)RR)for efficient methane(CH_(4))***,the morphology and valence of Cu-based catalysts are usually unstable under reaction *** this work,we prepared Ce-doped MOF-199 precursor(Ce/HKUST-1)and further obtained nanoparticle electrocatalyst Ce/CuO_(x)-NPs by cyclic voltammetry(CV)*** Faradic efficiency of methane(FE_(CH_(4)))maintains above 62%within a broad potential window of 350 mV and the maximum FE_(CH_(4))reaches 67.4%with a partial current density of 293 mA/cm^(2)at-1.6 V vs.a reversible hydrogen *** characterization and theoretical calculations revealed that the unique electronic structure and large ionic radius of Cerium(Ce)not only promoted the generation of key intermediate*CO but also lowered energy barrier of the*CO to*CHO *** study provides a novel and efficient catalyst for methane production in ECO_(2)RR and offers profound insights into constructing high performance Cu-based catalysts.

关键词： ECO_(2)RR Cu-based catalyst Structure evolution DFT calculation

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Overexpression of arginase gene CAR1 renders yeast Saccharomyces cerevisiae acetic acid tolerance

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Synthetic and Systems Biotechnology 2024年第4期9卷 723-732页

作者： Liang Xiong Ya-Ting Wang Ming-Hai Zhou Hiroshi Takagi Jiufu Qin Xin-Qing Zhao State Key Laboratory of Microbial Metabolism Joint International Research Laboratory of Metabolic and Developmental Scienceand School of Life Science and BiotechnologyShanghai Jiao Tong UniversityShanghai200240China School of Life Science and Biotechnology Dalian University of TechnologyDalian116024China College of Biomass Science and Engineering Sichuan UniversityChengdu610065China Institute for Research Initiatives Nara Institute of Science and Technology8916-5 TakayamaIkomaNara 630-0192Japan

Acetic acid is a common inhibitor present in lignocellulose hydrolysate,which inhibits the ethanol production by yeast ***,the cellulosic ethanol industry requires yeast strains that can tolerate acetic acid *** we demonstrate that overexpressing a yeast native arginase-encoding gene,CAR1,renders Saccharomyces cerevisiae acetic acid ***,ethanol yield increased by 27.3%in the CAR1-overexpressing strain compared to the control strain under 5.0 g/L acetic acid *** global intracellular amino acid level and compositions were further analyzed,and we found that CAR1 overexpression reduced the total amino acid content in response to acetic acid ***,the CAR1 overexpressing strain showed increased ATP level and improved cell membrane ***,we demonstrated that the effect of CAR1 overexpression was independent of the spermidine and proline metabolism,which indicates novel mechanisms for enhancing yeast stress *** studies also suggest that CAR1 is a novel genetic element to be used in synthetic biology of yeast for efficient production of fuel ethanol.

关键词： Saccharomyces cerevisiae Arginase CAR1 Acetic acid tolerance Amino acid metabolism Ethanol production

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Carbazole-Bearing Conjugated Microporous Polymer Electrodes for Uranium Extraction from Seawater with Good Anti-biofouling Feature

Chem and Bio Engineering

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Chem and Bio Engineering 2025年第1期2卷 53-63页

作者： Zhang, Xinyue Lei, Xinying Sun, Hongfei Ke, Hanming Xu, Jingxuan Yang, Yuhao Zhang, Sai Wen, Tao Ji, Zhuoyu Wang, Xiangke MOE Key Laboratory of Resources and Environmental Systems Optimization College of Environmental Science and Engineering North China Electric Power University Beijing102206 China Beijing Key Laboratory of Environmental and Viral Oncology College of Chemistry and Life Science Beijing University of Technology Beijing100124 China

Emerging electrochemical uranium extraction from seawater offers a promising route for a sustainable fuel supply for nuclear reactor operation. In this work, we intentionally synthesized a conjugated microporous polymer (CMP) with π-conjugated skeletons and permanent porosity, which was induced by in situ electropolymerization on flexible carbon cloths, followed by postdecorating amidoxime groups to create functional materials (CMP-AO). Driven by an extra asymmetrical alternating current electrochemical extraction, the self-supporting and binder-free electrode is exceptionally capable of selectively and rapidly capturing U(VI) from simulated solution, affording an extraction capacity of ∼1806.4 mg/g without saturation. Experimental observation in combination with ex/in situ spectroscopy revealed that CMP-AO enabled surface selective binding sites (amidoxime groups) to U(VI), followed by electrocatalytic reduction (carbazole groups) to yield yellow precipitates (Na2O(UO3·H2O)x) via reversible electron transfer in the presence of sodium electrolyte. Furthermore, the integrating adsorption-electrocatalysis system achieved an extraction capacity of 18.8 mg/g in real seawater for 21 days and good antibiofouling abilities, validating its feasibility for practical application. © 2024 The Authors. Co-published by Zhejiang University and American Chemical Society.

关键词： Electropolymerization

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Aging-induced YTHDF aggregates impair mitochondrial function by trapping mitochondrial RNAs and suppressing their expression in the brain

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Protein & Cell 2024年第2期15卷 149-155页

作者： Juan Zhang Dingfeng Li Keqiang He Qiang Liu Zhongwen Xie School of Life Sciences Anhui Agricultural UniversityHefei 230036China State Key Laboratory of Tea Plant Biology and Utilization School of Tea and Food Sciences and TechnologyAnhui Agricultural UniversityHefei230036China Division of Life Sciences and Medicine Hefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Department of Anesthesiology The First Affliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Anhui Province Key Laboratory of Biomedical Aging Research University of Science and Technology of ChinaHefei 230026China Center for Advanced Interdisciplinary Science and Biomedicine of IHM Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China

DearEditor,Brain aging is associated with a decrease in cognitive function,which is often accompanied by defective changes in mitochondrial morphology and reduction in mitochondrial function(Faitg et al.,2021).The main function of mitochondria is to produce energy in the form of ATP,which is vital to fulfill high energy demand of neurons,mainly for synaptic processes(Lee et al.,2018).Mitochondrial dysfunction acts as a key factor for age-related cognitive decline(Grimm and Eckert,2017).

关键词： function trapping

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GAN-GMHI: a generative adversarial network with high discriminative power for microbiome-based disease prediction

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Journal of Genetics and Genomics 2023年第12期50卷 1026-1028页

作者： Yuxue Li Gang Xie Yuguo Zha Kang Ning MOE Key Laboratory of Molecular Biophysics Hubei Key Laboratory of Bioinformatics and Molecular-imagingCenter of Artificial Intelligence BiologyDepartment of Bioinformatics and Systems BiologyCollege of Life Science and TechnologyHuazhong University of Science and TechnologyWuhanHubei 430074China

With the rapid development of research on the human gut microbiome,associations between the microbiome and various complex chronic diseases have been revealed(Bergot et al.,2019).These advancements provide great oppor... 详细信息

关键词： prediction diseases

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Cocrystal@protein-anchoring nanococktail for combinatorially treating multidrug-resistant cancer

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Acta Pharmaceutica Sinica B 2024年第10期14卷 4509-4525页

作者： Jiahui Zou Xuyang Xing Chao Teng Qingling Zhao Wei He Xuri Wu Yuanzheng Xia School of Pharmacy China Pharmaceutical UniversityNanjing 211198China School of Computer Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China School of Life Science and Technology China Pharmaceutical UniversityNanjing 211198China State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 211198China

Multidrug resistance(MDR),the major mechanism by which various cancers develop specific resistance to therapeutic agents,has set up enormous obstacles to many forms of tumor *** cocktail therapy administration,based on the combination of multiple drugs for anti-MDR chemotherapy,often suffers from inconsistent in vivo pharmacokinetic behaviors that cannot act synchronously on the lesions,leading to limited pharmacodynamic *** the emergence of nanomedicines,which has improved chemotherapeutic drugs’bioavailability and therapeutic effect on clinical application,these monotherapy-based nano-formulations still show poor progression in overcoming ***,a“one stone and three birds”nanococktail integrated by a cocrystal@protein-anchoring strategy was purposed for triple-payload delivery,which paclitaxel-disulfiram cocrystal-like nanorods(NRs)were anchored with the basic protein drug Cytochrome c(Cyt C),followed by hyaluronic-acid *** particular,NRs were utilized as carrier-like particles to synchronously deliver biomacromolecule Cyt C into tumor cells and then promote cell *** note,on A549/Taxol drug-resistant tumor-bearing mice,the system with extraordinarily high encapsulation efficiency demonstrated prolonged in vivo circulation and increased tumor-targeting accumulation,significantly reversing tumor drug resistance and improving therapeutic *** mechanistic study indicated that the system induced the apoptosis of Taxol-resistant tumor cells through the signal axis P-glycoprotein/Cyt C/caspase ***,this nanococktail strategy offers a promising approach to improve the sensitivity of tumor cells to chemotherapeutic drugs and strengthen intractable drug-resistant oncotherapy.

关键词： Cocktail Multidrug-resistant Co-delivery combined therapy Cytochrome C Nanocrystals

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