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Multi-walled carbon nanotubes reversing the bone formation of bone marrow stromal cells by activating M2 macrophage polarization

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Regenerative Biomaterials 2023年第1期10卷 980-989页

作者： Runlian Lin Kun Ge Dehui Fan Jing Li Guoqiang Zhou Kaihan Zhang Yuanyu Huang Lili Ma Jinchao Zhang Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Key Laboratory of Chemical Biology of Hebei ProvinceCollege of Chemistry and Material ScienceHebei UniversityBaoding 071002China College of Basic Medical Science Hebei UniversityBaoding 071000China Department of Chemistry The University of ManchesterManchester M139PLUK School of Life Science School of Medical TechnologyAdvanced Research Institute of Multidisciplinary ScienceKey Laboratory of Molecular Medicine and BiotherapyKey Laboratory of Medical Molecule Science and Pharmaceutics EngineeringBeijing Institute of TechnologyBeijing 100081China

Multi-walled carbon nanotubes(MWCNTs)are an excellent bone tissue repair material both in vitro and in *** interactions between MWCNTs and single type of cells of bone tissue,including osteoblasts,bone marrow stromal cells(BMSCs)or osteoclasts,have been extensively ***,the interactions between MWCNTs with different types of cells in the bone microenvironment remain *** microenvironment is a complex system composed of different types of cells,which have interactions between each *** this work,the effects of MWCNTs on bone microenvironment were firstly studied by culture of MWCNTs with BMSCs,osteoblasts,osteoclasts,macrophages and vascular endothelial cells,***,co-culture systems of macrophages-BMSCs,macrophages-calvaria and macrophages-BMSCs-vascular endothelial cells were treated with MWCNTs,*** osteogenic differentiation of BMSCs and osteoblasts was inhibited when these two types of cells were cultured with MWCNTs,***,when co-culture MWCNTs with BMSCs and macrophages,the osteogenesis of BMSCs was promoted by inducing the M2 polymerization of ***,MWCNTs promoted the bone formation in the osteolysis model of calvaria ex *** addition,the formation of osteoclasts was inhibited,and angiogenesis was increased when treated with *** study revealed the inconsistent effects of MWCNTs on single type of bone cells and on the bone *** results provided basic research data for the application of MWCNTs in bone tissue repair.

关键词： multi-walled carbon nanotubes bone microenvironments osteogenesis bone marrow stromal cells M2 macrophages cellular interactions

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High-strong-ductile magnesium alloys by interactions of nanoscale quasi-long period stacking order unit with twin

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Journal of Magnesium and Alloys 2024年第12期12卷 4953-4965页

作者： Lutong Zhou Tingting Niu Guodong Zou Huhu Su Suyun He Shijian Zheng Yulong Zhu Peng Chen Carlos Fernandez Qiuming Peng State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao066004PR China School of Materials Science and Engineering Hebei University of TechnologyTianjin300401PR China Key Laboratory of Automobile Materials of Ministry of Education&School of Materials Science and Engineering Nanling CampusJilin UniversityChangchun 130025PR China School of Pharmacy and life sciences Robert Gordon UniversityAberdeenAB107GJUK

Magnesium alloys with high strength in combination of good ductility are especially desirable for applications in transportation,aerospace and bio-implants owing to their high stiffness,abundant raw materials,and environmental ***,the majority of traditional strengthening approaches including grain refining and precipitate strengthening can usually prohibit dislocation movement at the expense of ductility ***,we report an effective strategy for simultaneously enhancing yield strength(205 MPa,2.41 times)and elongation(23%,1.54 times)in a Mg-0.2Zn-0.6Y(at.%)alloy at room temperature,based on the formation of a nanosized quasi-long period stacking order unit(QLPSO)-twin structure by ultrahigh-pressure treatment followed by *** formation reason and strong-ductile mechanism of the unique QLPSO-twin structure have been clarified by transmission electron microscopy observations and molecule dynamics *** improved strength is mainly associated with the presence of nanosized QLPSO and the modified∠86.3oQLPSO-twin boundary(TB)interface,effectively pinning dislocation ***,the enhanced ductility is related to the∠3.7oQLPSO-TB interface and micro-kinks of nanoscale QLPSO,providing some paths for plastic *** strategy on the QLPSO-twin structure might provide an alternative perspective for designing innovative hexagonal close-packed structural materials with superior mechanical properties.

关键词： QLPSO Twin boundary Molecule dynamics High resolution TEM

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Allotetraploidization event of Coptis chinensis shared by all Ranunculales

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Horticultural Plant Journal 2024年第1期10卷 288-303页

作者： Yan Zhang Weina Ge Jia Teng Yanmei Yang Jianyu Wang Zijian Yu Jiaqi Wang Qimeng Xiao Junxin Zhao Shaoqi Shen Yishan Feng Shoutong Bao Yu Li Yuxian Li Tianyu Lei Yuxin Pan Lan Zhang Jinpeng Wang Department of Bioinformatics School of Life SciencesNorth China University of Science and TechnologyTangshanHebei 063000China School of Life Sciences North China University of Science and TechnologyTangshanHebei 063000China State Key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of ScienceBeijing 100093China University of Chinese Academy of Sciences Beijing 100049China

Coptis chinensis Franch.,also named Chinese goldthread is a member of Ranunculaceae in the order Ranunculales and represents an important lineage of early eudicots with traditional medicinal *** our study,by using syntenic analysis combined with phylogenomic analysis of *** and four other representative genomes from basal and core eudicots,we confirmed that the WGD event in *** was shared by Aquilegia coerulea and Papaver somniferum *** quickly occurred after Ranunculales diverged from other eudicots,likely a Ranunculales common tetraploidization(RCT).The synonymous nucleotide substitutions at synonymous sites distribution of syntenic blocks across these genomes showed that the evolutionary rate of the *** genome is faster than that of the *** genome by approximately 13.7%,possibly due to Papaveraceaes having an additional special tetraploidization event(PST).After Ks correction,the RCT dated to 115—130 million years ago(MYA),which was close to the divergence of Ranunculaceaes and Papaveraceaes approximately115.45—130.51 ***,we identified homologous genes related to polyploidization and speciation and constructed multiple sequence alignments with different reference ***,the event-related subgenomes in the basal genomes all showed genomic fractionation bias,suggesting a likely allopolyploid nature of the RCT,PST and T-Alpha and T-Beta events in Tetracentron *** addition,we detected that the sixteen P450 subfamilies were markedly expanded in the genomes of Ranunculales,and most of them were related to the RCT and PST *** constructed a new platform for Early Eudicot Comparative Genomic Research(http://***/***)to store more *** summary,our findings support the WGD of *** shared by Ranunculales,which is likely an allotetraploidization *** present effort offered new insights into the evolution of key polyploidization events and the genes related to second

关键词： Coptis chinensis Ranunculales Polyploidization Genomic fractionation P450 genes

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Improving high-field strain and temperature stability on KNN-based ceramics sintered in reducing atmosphere via defect engineering

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Journal of Materiomics 2024年第6期10卷 1165-1175页

作者： Zhenyong Cen Meiyi Feng Fuzhi Cao Yuqi Jiang Ze Xu Changrong Zhou Ke Wang Nengneng Luo State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures MOE Key Laboratory of New Proce sing Technology for Nonferrous Metals and MaterialsSchool of ResourcesEnvironment and MaterialsGuangxi Univers ityNanning530004China Guangexi Key Laboratory of Information Materials Guilin University of Electronic TechnologyGuilin541004China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

High-field strain and its temperature stability of(1-x)K_(0.48)Na_(0.52)Nb_(0.96)Ta_(0.04)O_(3)-xBaZrO_(3)+8%MnO+3%ZrO_(2)(in mole,KNNT-xBZ+8Mn)ceramics sintered in reducing atmosphere are improved simultaneously via defect design in A and B *** is a conducting type transition from n-type to p-type at x=*** BaZrO_(3) dopant not only induces the increase of defects(Zr′_(Nb),Ba_(Na),Ba_(K))concentration,but also results in the increase of defect(Mn″_(Nb))concentration,because more Mn ions as+2 oxidation state in ceramics is triggered by BaZrO3 doping *** dipoles(Mn″_(Nb)-V_(o),Zr′_(Nb)-V_(o),Ba_(Na)-V′_(Na),Ba_(Na)-V′_(Na))in poled and aged ceramics enhance the reversibility of the non-180°domains switching,which increases the high-field strain of KNNT-xBZ+8Mn *** reversibility of non-180°domain switching can be preserved to high temperature due to stable defect dipoles(Ba_(Na)-V′_(Na),Ba_(K)-V′_(K))in *** KNNT-xBZ+8Mn ceramics at x=0.07 show the largest high-field strain coefficient(543 pm/V@20 kV/cm)and the highest temperature stability(125℃).The KNNT-xBZ+8Mn ceramic is a lead-free material with great potential to be applied in the fabrication of multilayer ceramic actuators with Ni inner electrodes in the future.

关键词： Lead-free ceramics Piezoelectric materials Reducing atmosphere Defects

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Intranasal iron administration induces iron deposition,immunoactivation,and cell-specific vulnerability in the olfactory bulb of C57BL/6 mice

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Zoological Research 2025年第1期46卷 209-224页

作者： Xiao-Qing Mi Bao-Chen Liu Le Qu Yu Yuan Hui Li Ao-Yang Xu Yu-Lin Zhang Jun-Xia Xie Ning Song School of Basic Medicine Institute of Brain Science and DiseaseShandong Provincial Key Laboratory of Pathogenesis and Prevention of Brain DiseasesQingdao UniversityQingdaoShandong266071China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China

Iron is the most abundant transition metal in the brain and is essential for brain development and neuronal function;however,its abnormal accumulation is also implicated in various neurological *** olfactory bulb(OB),an early target in neurodegenerative diseases,acts as a gateway for environmental toxins and contains diverse neuronal populations with distinct *** study explored the cell-specific vulnerability to iron in the OB using a mouse model of intranasal administration of ferric ammonium citrate(FAC).Olfactory function was assessed through olfactory discrimination tests,while iron levels in OB tissues,cerebrospinal fluid(CSF),and serum were quantified using inductively coupled plasma mass spectrometry(ICP-MS),immunohistochemical staining,and iron *** changes and immune responses were assessed using RNA sequencing and immune cell infiltration *** showed that intranasal FAC administration impaired olfactory function,accompanied by iron deposition in the olfactory mucosa and OB,as well as damage to olfactory sensory ***,these effects occurred without elevations in CSF or serum iron *** iron accumulation activated multiple immune cells,including microglia and astrocytes,but did not trigger *** transcriptomic sequencing of healthy adult mouse OBs revealed significant cellular heterogeneity,with an abundance of neuroglia and *** neurons,GABAergic neurons were the most prevalent,followed by glutamatergic and dopaminergic neurons,while cholinergic and serotonergic neurons were sparsely *** iron-stressed conditions,oligodendrocytes,dopaminergic neurons,and glutamatergic neurons exhibited significant damage,while GABAergic neurons remained *** findings highlight the selective vulnerability of neuronal and glial populations to iron-induced stress,offering novel insights into the loss of specific cell types in the OB during iron dysregulation.

关键词： Intranasal administration Olfactory bulb Iron Ferroptosis Immune response

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Advancing neuroscience through real-time processing of big data:Transition from open-loop to closed-loop paradigms

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Zoological Research 2024年第3期45卷 518-519页

作者： Yu-Fan Wang Jiu-Lin Du Institute of Neuroscience State Key Laboratory of NeuroscienceCenter for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China School of Life Science and Technology ShanghaiTech UniversityShanghai 200031China

The brain functions as a closed-loop system that continuously generates behavior in response to the external environment and adjusts actions based on the *** research methodologies in neuroscience,especially those employed in brain imaging experiments,have mainly adopted an open-loop paradigm(Grosenick et al.,2015).Functional neural circuits are analyzed offline and subsequently tested through manipulation of neuronal activities within specific regions or with genetic *** establishing a closed-loop research paradigm,functional ensembles can be detected and tested in real time with temporal *** functional ensembles,rather than brain regions or genetically labeled neural populations,serve as fundamental units of neural networks,offering valuable insights into the dissection of neural *** closed-loop research paradigm also enables the capture of high-dimensional activities of internal brain dynamics and precise elucidation of physiological processes such as learning,decision-making,and sleep.

关键词： neural loop Transition

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Mechanistic study of SCOOPs recognition by MIK2-BAK1 complex reveals the role of N-glycans in plant ligand-receptor-coreceptor complex formation (nov,10.1038/s41477-024-01836-3,2024)

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NATURE PLANTS 2024年第12期10卷 2079-2079页

作者： Wu, Huimin Wan, Lihao Liu, Zunyong Jian, Yunqing Zhang, Chenchen Mao, Xiakun Wang, Zhiyun Wang, Qiang Hu, Yaxin Xiong, Lizhong Xia, Zhujun Xue, Juan Li, Shan He, Ping Shan, Libo Xu, Shutong National Key Lab of Agricultural Microbiology Hubei Hongshan Laboratory College of Life Science and Technology Huazhong Agricultural University Wuhan China Department of Molecular Cellular and Developmental Biology University of Michigan Ann Arbor MI USA National Key Laboratory of Crop Genetic Improvement Hubei Hongshan Laboratory College of Life Science and Technology Huazhong Agricultural University Wuhan China Taihe Hospital Hubei University of Medicine Shiyan China

Ligand-induced receptor and co-receptor heterodimerization is a common mechanism in receptor kinase (RK) signalling activation. SERINE-RICH ENDOGENOUS PEPTIDEs (SCOOPs) mediate the complex formation of Arabidopsis RK MIK2 and co-receptor BAK1, triggering immune responses. Through structural, biochemical and genetic analyses, we demonstrate that SCOOPs use their SxS motif and adjacent residues to bind MIK2 and the carboxy-terminal GGR residues to link MIK2 to BAK1. While N-glycosylation of plant RKs is typically associated with protein maturation, plasma membrane targeting and conformation maintenance, a surprising revelation emerges from our crystal structural analysis of MIK2–SCOOP–BAK1 complexes. Specific N-glycans on MIK2 directly interact with BAK1 upon SCOOP sensing. The absence of N-glycosylation at the specific site in MIK2 neither affects its subcellular localization and protein accumulation in plant cells nor alters its structural conformation, but markedly reduces its affinity for BAK1, abolishing SCOOP-triggered immune responses. This N-glycan-mediated receptor and co-receptor heterodimerization occurs in both Arabidopsis and Brassica napus. Our findings elucidate the molecular basis of SCOOP perception by the MIK2–BAK1 immune complex and underscore the crucial role of N-glycans in plant receptor–coreceptor interactions and signalling activation, shaping immune *** et al. elucidate the molecular basis for SCOOPs perception by the MIK2–BAK1 immune complex and demonstrate an unexpectedly pivotal role of N-glycans in plant receptor–coreceptor interactions and signalling activation, shaping immune responses.

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Catalytic performance of Nb2O5 modified Ru/CeO2 for dichloromethane oxidation

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Progress in Natural science:Materials International 2023年第4期33卷 486-494页

作者： Wencheng Hao Zhiwei Wang Shaohua Xie Lu Wei Zhiquan Hou Yuxi Liu Hongxing Dai Jiguang Deng Beijing Key Laboratory for Green Catalysis and Separation Key Laboratory of Beijing on Regional Air Pollution Control Faculty of Environment and Life Beijing University of Technology Department of Civil Environmental and Construction Engineering Catalysis Cluster for Renewable Energy and Chemical Transformations(REACT) Nano Science Technology Center(NSTC) University of Central Florida

1 wt% Ru/5 wt% Nb2O5/CeO2（RuNbCe） catalyst was synthesized via the incipient wetness impregnation method, and measured for the catalytic oxidation of dichloromethane（DCM）. The physicochemical properties of catalysts were determined used various characterization techniques. Compared with 1 wt% Ru/CeO2, 5 wt%Nb2O5/CeO2, CeO2, 1 wt% Ru/xNb2O5/CeO2（x = 1 wt%, 2 wt%, and 3 wt%） and 1 wt% Ru/yMO_n/CeO2（M =Co, Cr, Fe, Mg, Cu; y = 5 wt%）, the addition of 5 wt% Nb2O5obviously improved the catalytic performance of 1 wt% Ru/CeO2, with the T90%and apparent activation energy（Ea） being 287℃ and 43.5 kJ/mol, respectively, and less formation of polychlorinated byproducts at space velocity（SV） = 15,000 mL g-1h-1. The RuNbCe catalyst showed good thermal and hydrothermal stability, as well as HCl-resistance performance. We deduced that the higher oxidation performance of the RuNbCe catalyst may be attributed to the suitable acidic sites, good redox capacity, high surface adsorbed oxygen species concentration, and the strong interaction among Ru, Nb2O5and CeO2. The RuNbCe catalyst has the potential to be applied for the elimination of chlorinated volatile organic compounds（CVOCs）.

关键词： Ru/Nb2O5/CeO2 dichloromethane oxidation Catalytic stability Acidic sites CVOCs removal

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Revealing the origin of single-atom W activity in H_(2)O_(2) electrocatalytic production:Charge symmetry-breaking

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Carbon Energy 2024年第10期6卷 289-300页

作者： Changfei Jing Junyang Ding Peipei Jia Mengmeng Jin Lihui Zhou Xijun Liu Jun Luo Sheng Dai Institute for New Energy Materials&Low-Carbon Technologies School of Materials Science and EngineeringTianjin University of TechnologyXiqingTianjinChina ShenSi Lab Shenzhen Institute for Advanced StudyUniversity of Electronic Science and Technology of ChinaLonghuaShenzhenChina Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular EngineeringFrontiers Science Center for Materiobiology and Dynamic ChemistryInstitute of Fine ChemicalsSchool of Chemistry and Molecular EngineeringEast China University of Science&TechnologyXuhuiShanghaiChina State Key Laboratory of Featured Metal Materials and Life−cycle Safety for Composite Structures Guangxi Key Laboratory of Processing for Non-ferrous Metals and Featured MaterialsMOE Key Laboratory of New Processing Technology for Nonferrous Metals and MaterialsSchool of ResourcesEnvironment and MaterialsGuangxi UniversityNanningGuangxiChina

The low-energy electrochemical production of hydrogen peroxide(H_(2)O_(2))has garnered significant attention as a viable alternative to traditional industrial routes,with the goal of achieving carbon *** their H_(2)O_(2) selectivity in the two-electron oxygen reduction reaction(ORR),the coordination environment of tungsten(W)-based materials is *** this study,atomically dispersed W single atoms were immobilized on N-doped carbon substrates by a facile pyrolysis method to obtain a W single-atom catalyst(W-SAC).The coordination environment of an isolated W single atom with a tetra-coordinated porphyrin-like structure in W-SAC was determined by X-ray photoelectron spectroscopy and X-ray absorption spectroscopy ***,the as-prepared W-SAC showed superior two-electron ORR activity in 0.1 M KOH solution,including high onset potential(0.89 V),high H_(2)O_(2) selectivity(82.5%),and excellent *** using differential phase contrast-scanning transmission electron microscopy and density functional theory calculations,it is revealed that the charge symmetry-breaking of W atoms changes the adsorption behavior of the intermediates,leading to enhanced reactivity and selectivity for two-electron *** work broadens the avenue for understanding the charge transfer of W-based electrocatalytic materials and the in-depth reaction mechanism of SACs in two-electron ORR.

关键词： charge symmetry-breaking density functional theory scanning transmission electron microscopy tungsten single-atom catalyst two-electron oxygen reduction reaction

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Promotional effect of cobalt doping on catalytic performance of cryptomelane-type manganese oxide in toluene oxidation

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Journal of Environmental sciences 2023年第4期126卷 263-274页

作者： Ning Dong Mengyue Chen Qing Ye Dan Zhang Hongxing Dai Key Laboratory of Beijing on Regional Air Pollution Control Department of Environmental ScienceSchool of Environmental and Chemical EngineeringFaculty of Environment and LifeBeijing University of TechnologyBeijing 100124China R&D Department of Atmospheric Prevention and Control Technology Guangdong Suncere Technology Co.Ltd.Guangzhou 510220China Beijing Key Laboratory for Green Catalysis and Separation Key Laboratory of Beijing on Regional Air Pollution ControlKey Laboratory of Advanced Functional MaterialsEducation Ministry of Chinaand Laboratory of Catalysis Chemistry and NanoscienceDepartment of Environmental Chemical EngineeringSchool of Environmental and Chemical EngineeringFaculty of Environment and LifeBeijing University of TechnologyBeijing 100124China

The cryptomelane-type manganese oxide (OMS-2)-supported Co (x Co/OMS-2;x=5,10,and15 wt.%) catalysts were prepared via a pre-incorporation *** as-prepared materials were used as catalysts for catalytic oxidation of toluene (2000 ppmV).Physical and chemical properties of the catalysts were measured using the X-ray diffraction (XRD),Fourier transform infrared spectroscopic (FT-IR),scanning electron microscopic (SEM),X-ray photoelectron spectroscopy (XPS),and hydrogen temperature-programmed reduction (H_(2)-TPR)*** all of the catalysts,10Co/OMS-2 performed the best,with the T90%,specific reaction rate at 245℃,and turnover frequency at 245℃ (TOFCo) being 245℃,1.23×10^(-3)moltoluene/(gcat·sec),and 11.58×10^(-3)sec-1for toluene oxidation at a space velocity of 60,000mL/(g·hr),*** excellent catalytic performance of 10Co/OMS-2 were due to more oxygen vacancies,enhanced redox ability and oxygen mobility,and strong synergistic effect between Co species and OMS-2 ***,in the presence of poisoning gases CO_(2),SO_(2)or NH_(3),the activity of 10Co/OMS-2 decreased for the carbonate,sulfate and ammonia species covered the active sites and oxygen vacancies,*** the activation treatment,the catalytic activity was partly *** good low-temperature reducibility of 10Co/OMS-2 could also facilitate the redox process accompanied by the consecutive electron transfer between the adsorbed O_(2)and the cobalt or manganese *** the oxidation process of toluene,the benzoic and aldehydic intermediates werefirst generated,which were further oxidized to the benzoate intermediate that were eventually converted into H_(2)O and CO_(2).

关键词： Cryptomelane-type manganese oxide Cobalt doping Volatile organic compound Toluene oxidation

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