检索结果-内蒙古大学图书馆

Aggregate 2024年第4期5卷 182-198页

作者： Chen Chao Shiqing Huang Cuiping Wang Rong Sun Jinglin Yu Les Copeland Shujun Wang State Key Laboratory of Food Nutrition and Safety School of Food Science and EngineeringTianjin University of Science&TechnologyTianjinChina School of Life and Environmental Sciences The University of SydneySydneyNew South WalesAustralia

New concept for the development of supramolecular assemblies from intricate inter-actions between different classes of biomacromolecules(polysaccharides,proteins and lipids)is yet to come,due to their intrinsic chemical and structural complex-ity and ***,we report an interaction mechanism among multiple biomacromolecules,and the structural and digestive properties of their assemblies using amylose(AM),lauric acid(LA),andβ-lactoglobulin(βLG)as ***,LA,andβLG interact to form a water-soluble ternary complex through van der Waals forces between AM and LA and high affinity binding between AM andβLG,which can further assemble into uniform-sized,semi-crystalline nanospheres under certain thermodynamic *** nanospheres are substantially resis-tant to amylolysis,thus can be well utilized by gut microbiota,including increasing short-chain fatty acid levels and shaping bacterial *** the com-plexation of AM,LA,andβLG and their assemblies from disorder to order,this work offers potential rationale of assemblies for multiple biomacromolecules driven by non-covalent interactions and substantial potentials for supramolecular biomaterials development.

关键词： amylose–lipid–protein complex biomacromolecules gut microbiota multicomponent interaction polymeric nanospheres supramolecular self-assembly

来源：评论

学校读者我要写书评

暂无评论

Aloin ameliorates cecal ligation and puncture-induced sepsis in mice by attenuating inflammation and modulating gut microbiota

引用

Food science and Human Wellness 2025年第2期14卷 550-568页

作者： Jingqian Su Jianbin Xiao Siyuan Chen Heng Zhao Xiaoni Zhang Zhihua Feng Kunsen Chen Biyun Guan Wenzhi Chen Youqiang Chen Duo Chen Qi Chen Fujian Key Laboratory of Innate Immune Biology Biomedical Research Center of South ChinaCollege of Life ScienceFujian Normal UniversityFuzhou 350117China The Public Service Platform for Industrialization Development Technology of Marine Biological Medicine and Products of the State Oceanic Administration Fujian Key Laboratory of Special Marine Bioresource Sustainable UtilizationSouthern Institute of OceanographyCollege of Life ScienceFujian Normal UniversityFuzhou 350117China

Most Aloe species are used as new food or functional food *** though widely known for its health benefits,the anti-inflammatory effects and underlying mechanisms of Aloin(Alo),an anthraquinone compound isolated from plant species of the genus Aloe,remain ***,we investigated the protective effects of Alo against cecal ligation and puncture(CLP)-induced sepsis and microflora in *** significantly improved CLP-induced sepsis and the survival rate of septic mice,downregulated the expression of proinflammatory factors,and decreased the infiltration of inflammatory cells in *** upregulated the proportion of peritoneal macrophages,reduced the number of peritoneal bacteria,decreased the content of short-chain fatty acids and bile acids in the abdominal cavity,and suppressed Toll-like receptor(TLR)-2/4/nuclear factor kappa-B(NF-κB)/NOD-like receptor thermal protein domain associated protein 3(NLRP3)/Caspase-1/3/8 ***,Alo altered the composition of the microbiome and promoted the growth of Lactobacillus,which showed a stronger anti-inflammatory ***-genome analysis identified the genes Saa3,Il10,Fpr1,and Eif4a1 associated with the protective effects of Alo in mice with CLP-induced ***,our results provide novel insights into the therapeutic potential and mechanism of action of Alo in the treatment of sepsis.

关键词： Aloin Gut microbiome Sepsis Inflammation Cecal ligation and puncture

来源：评论

学校读者我要写书评

暂无评论

Enhancement of astaxanthin accumulation via energy reassignment by removing the flagella of Haematococcus pluvialis

引用

Bioresources and Bioprocessing 2024年第1期11卷 1041-1046页

作者： Yuyong Hou Zhile Guo Zhiyong Liu Suihao Yan Meijie Cui Fangjian Chen Weijie Wang Longjiang Yu Lei Zhao College of Life Science North China University of Science and TechnologyTangshanChina Photosynthesis Research Center Key Laboratory of PhotobiologyInstitute of BotanyChinese Academy of SciencesBeijingChina Key Laboratory of Engineering Biology for Low-carbon Manufacturing Tianjin Institute of Industrial BiotechnologyChinese Academy of SciencesTianjinChina National Center of Technology Innovation for Synthetic Biology TianjinChina University of Chinese Academy of Sciences BeijingChina

Astaxanthin biosynthesis in Haematococcus pluvialis is driven by ***,the effect of the flagella-mediated energy-consuming movement process on astaxanthin accumulation has not been well *** this study,the profiles of astaxanthin and NADPH contents in combination with the photosynthetic parameters with or without flagella enabled by pH shock were *** results demonstrated that there was no significant alteration in cell morphology,with the exception of the loss of flagella observed in the pH shock treatment *** contrast,the astaxanthin content in the flagella removal groups was 62.9%,62.8%and 91.1%higher than that of the control at 4,8 and 12 h,***,the increased Y(II)and decreased Y(NO)suggest that cells lacking the flagellar movement process may allocate more energy towards astaxanthin *** finding was verified by NADPH analysis,which revealed higher levels in flagella removal *** results provide preliminary insights into the underlying mechanism of astaxanthin accumulation enabled by energy reassignment in movement-lacking cells.

关键词： Haematococcus pluvialis Astaxanthin Flagella Energy flow pH-shock

来源：评论

学校读者我要写书评

暂无评论

A CRISPR/RfxCas13d-mediated strategy for efficient RNA knockdown in mouse embryonic development

引用

science China(life sciences) 2024年第11期67卷 2297-2306页

作者： Lin Zhang Shi-Meng Cao Hao Wu Meng Yan Jinsong Li Ling-Ling Chen Key Laboratory of RNA Innovation Science and EngineeringCAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China State Key Laboratory of Cell Biology Shanghai Key Laboratory of Molecular AndrologyShanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China New Cornerstone Science Laboratory Shenzhen 518054China

The growing variety of RNA classes,such as mRNAs,lncRNAs,and circRNAs,plays pivotal roles in both developmental processes and various pathophysiological ***,our comprehension of RNA functions in live organisms remains limited due to the absence of durable and effective strategies for directly influencing RNA *** this study,we combined the CRISPR-RfxCas13d system with spermlike stem cell-mediated semi-cloning techniques,which enabled the suppressed expression of different RNA *** approach was employed to interfere with the expression of three types of RNA molecules:Sfmbt2 mRNA,Fendrr lncRNA,and circMan1a2(2,3,4,5,6).The results confirmed the critical roles of these RNAs in embryonic development,as their loss led to observable phenotypes,including embryonic lethality,delayed embryonic development,and embryo *** summary,our methodology offers a potent toolkit for silencing specific RNA targets in living organisms without introducing genetic alterations.

关键词： sperm-like stem cell semi-cloned technology CRISPR-RfxCas13d RNA knockdown embryonic development

来源：评论

学校读者我要写书评

暂无评论

NUMERICAL SIMULATION AND EXPERIMENTAL RESEARCH ON TAYLOR COUETTE FLOW CHARACTERISTICS IN AIR GAP OF AVIATION MOTOR

NUMERICAL SIMULATION AND EXPERIMENTAL RESEARCH ON TAYLOR COU...

引用

2024 CSAA/IET International Conference on Aircraft Utility Systems, AUS 2024

作者： Ma, Hui Liang, Shuyue Zhan, Hongbo Qi, Lin Chen, Weijian Aviation Key Laboratory of Science and Technology on Aero Electromechanical System Integration No.33 Shuige Road Nanjing China Key Laboratory of Aircraft Environment Control and Life Support MIIT Nanjing University of Areonautics and Astronautics No.29 Yudao Street Nanjing China

A test bench with PIV technology was built and visualization research on Taylor vortex between concentric rotating cylinders was carried out to explore the flow morphology within the annular gap by changing the rotational speed of the inner cylinder. The numerical method and accuracy were verified by experiments. The selected turbulence model was then applied for numerical simulation of the Taylor Couette flow in a simplified air gap model of an aviation motor with smooth inner and outer walls. The Taylor Couette flow characteristics in the air gap under varying rotational speed were studied, and simulation results were given for flow with axial flow and without axial flow. © The Institution of Engineering & technology 2024.

关键词： Axial flow

来源：评论

学校读者我要写书评

暂无评论

Investigating the Genetic Bases of Growth Regulation by E2F3 in Dwarf Surf Clams Mulinia lateralis

引用

Journal of Ocean University of China 2024年第5期23卷 1347-1358页

作者： YAO Ruixing WANG Chen KONG Lingling WANG Yujue BAO Zhenmin HU Xiaoli MOE Key Laboratory of Marine Genetics and Breeding College of Marine Life SciencesOcean University of ChinaQingdao 266003China Laboratory for Marine Fisheries Science and Food Production Processes Qingdao Marine Science and TechnologyCenterQingdao 266237China Key Laboratory of Tropical Aquatic Germplasm of Hainan Province Sanya Oceanographic InstitutionOcean University of ChinaSanya 572000China

Bivalve aquaculture plays a crucial role in the aquaculture industry due to the economic value of many bivalve *** the underlying genetic basis of bivalve growth regulation is essential for enhancing germplasm innovation and ensuring sustainable development of the *** numerous candidate genes have been identified,their functional validation remains ***,the dwarf surf clam(Mulinia lateralis)serves as a promising model organism for investigating genetic mechanisms underlying growth regulation in *** GWAS study in the Yesso scallop(Patinopecten yessoensis)has pinpointed the E2F3 gene as a key regulator of growth-related ***,the specific role of E2F3 in bivalve growth remains *** study aimed to further confirm the regulatory function of the E2F3 gene in the dwarf surf clam through RNA interference *** results revealed several genes are associated with individual growth and development,including CTS7,HSP70B2,and PGLYRP3,as well as genes involved in lipid metabolism such as FABP2 and *** enrichment analysis indicated that E2F3 primarily modulates critical processes like amino acid and lipid *** findings suggest that E2F3 likely regulates growth in the dwarf surf clam by influencing amino acid and lipid ***,this study advances our understanding on the function of E2F3 gene in growth regulation in bivalves,providing valuable insights for future research in this field.

关键词： growth regulation E2F3 RNA interference experiment transcriptomic analysis dwarf surf clam Mulinia lateralis bivalve

来源：评论

学校读者我要写书评

暂无评论

Interaction Between Memory Load and Experimental Design on Brain Connectivity and Network Topology

引用

Neuroscience Bulletin 2023年第4期39卷 631-644页

作者： Heming Zhang Xin Di Bart Rypma Hang Yang Chun Meng Bharat Biswal The Clinical Hospital of Chengdu Brain Science Institute MOE Key Laboratory for NeuroinformationCenter for Information in MedicineSchool of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu611731China Department of Biomedical Engineering New Jersey Institute of TechnologyNewark07102USA Department of Psychology University of Texas at DallasDallas75390USA

The conventional approach to investigating functional connectivity in the block-designed study usually concatenates task blocks or employs residuals of task *** providing many insights into brain functions,the block design adds more manipulation in functional network analysis that may reduce the purity of the blood oxygenation level-dependent *** studies utilized one single long run for task trials of the same condition,the so-called continuous design,to investigate functional connectivity based on task functional magnetic resonance *** brain activities associated with the single-task condition can be directly utilized for task-related functional connectivity assessment,which has been examined for working memory,sensory,motor,and semantic task experiments in previous *** it remains unclear how the block and continuous design influence the assessment of task-related functional connectivity *** study aimed to disentangle the separable effects of block/continuous design and working memory load on task-related functional connectivity networks,by using repeated-measures analysis of *** 50 young healthy adults,behavioral results of accuracy and reaction time showed a significant main effect of design as well as interaction between design and *** results revealed that the cingulo-opercular,fronto-parietal,and default model networks were associated with not only task activation,but significant main effects of design and load as well as their interaction on intra-and inter-network functional connectivity and global network ***,a significant behavior-brain association was identified for the continuous *** work has extended the evidence that continuous design can be used to study task-related functional connectivity and subtle brain-behavioral relationships.

关键词： Working memory Functional connectivity Network topology Block design Continuous design Memory load

来源：评论

学校读者我要写书评

暂无评论

Mobilization of heavy metals from floodplain sediments of the Yellow River during redox fluctuations

引用

Journal of Environmental sciences 2025年第4期150卷 432-439页

作者： Fuyu Xie Xiaoqing Li Qingxiang Yang Ying Meng Fubo Luan Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China College of Life Sciences Henan Normal UniversityXinxiang 453007China

The floodplain of the Yellow River is a typical area characterized by redox fluctuations and heavy metal ***,the mobilization behavior of heavy metals in floodplain sediments during redox fluctuations remains poorly *** this study,reductive mobilization of Fe and Mn was observed under reducing environments through reduction and dissolution,leading to the subsequent release of adsorbed *** contrast,the mobilization of U occurred under oxic conditions,as the oxidative state of U(VI)has higher ***,insignificant effects on the mobilization of Cd,Cu,Pb,and Hg were noticed during redox fluctuations,indicating higher stability of these ***,we demonstrated that carbon sources can play a key role in the mobilization of heavy metals in floodplain sediments,amplifying the reductive mobilization of Fe,Mn,As and the oxidative mobilization of *** findings contribute to the understanding of the biogeochemical cycling of heavy metal in floodplain sediments of the Yellow River and the factors that control this cycling.

关键词： Biogeochemical cycling Redox fluctuation Heavy metal Carbon supplementation The Yellow River

来源：评论

学校读者我要写书评

暂无评论

Simulation Study on Cutting Titanium Alloy with Micro-Textured tool

Simulation Study on Cutting Titanium Alloy with Micro-Textur...

引用

2024 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, 3M-NANO 2024

作者： Zhang, Chuang Xu, Jinkai Geng, Xuan Wang, Zhe College of Mechanical and Electrical Engineering Changchun University of Science and Technology Ministry of Education Key Laboratory for Cross-Scale Micro and Nano Manufacturing Changchun China Changchun University of Science and Technology School of Life Science and Technology Changchun China

ISBN: (纸本)9798350362107

Titanium alloy (TC4), as a typical difficult-to- machining material, greatly affects the cutting force in the process of cutting titanium alloy. This paper studied the influence of the surface texture of the turning tool on the cutting performance. The simulation model of turning titanium alloy material is established by using ABAQUS finite element simulation software, and orthogonal cutting experiments are carried out. Three kinds of micro-textured tool with different distances from the edge are designed. The study examines how the distance of texture from the edge influences the cutting capability of a micro-textured tool. The results show that when he texture distance from edge is 35um, the cutting capability of the tool is improved most obviously, relatived to the untextured tool, the cutting force decreases by 10.4%, and the shear angle increases by 5.39%. Micro-textures can induce secondary cutting, making the inner surface of the chip more smooth and smooth. © 2024 IEEE.

关键词： Titanium alloys

来源：评论

学校读者我要写书评

暂无评论

Chromothripsis:an emerging crossroad from aberrant mitosis to therapeutic opportunities

引用

Journal of Molecular Cell Biology 2024年第4期16卷 1-16页

作者： Umer Ejaz Zhen Dou Phil YYao Zhikai Wang Xing Liu Xuebiao Yao MOE Key Laboratory for Membraneless Organelles and Cellular Dynamics University of Science and Technology of China School of Life SciencesHefei 230027China Anhui Key Laboratory for Chemical Biology Hefei National Science Center for Inter-disciplinary SciencesHefei 230027China University of California San Diego School of Medicine San DiegoCA 92103USA

Shen Chromothripsis,a type of complex chromosomal rearrangement originally known as chromoanagenesis,has been a subject of extensive investigation due to its potential role in various diseases,particularly *** involves the rapid acquisition of tens to hundreds of structural rearrangements within a short period,leading to complex alterations in one or a few *** phenomenon is triggered by chromosome mis-segregation during *** in accurate chromosome segregation lead to formation of aberrant structural entities such as micronuclei or chromatin *** association between chromothripsis and cancer has attracted significant interest,with potential implications for tumorigenesis and disease *** review aims to explore the intricate mechanisms and consequences of chromothripsis,with a specific focus on its association with mitotic ***,we discuss a comprehensive analysis of crucial molecular entities and pathways,exploring the intricate roles of the CIP2A–TOPBP1 complex,micronuclei formation,chromatin bridge processing,DNA damage repair,and mitotic ***,the review will highlight recent advancements in identifying potential therapeutic targets and the underlying molecular mechanisms associated with chromothripsis,paving the way for future therapeutic interventions in various diseases.

关键词： genomic stability DNA damage repair chromothripsis synthetic lethality cell division

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：