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Communications Biology 2025年第1期8卷 1-12页

作者： Jin, Zhaohui Meng, Zhe Liu, Yanchao Li, Chongyang Zhang, Xuedi Yin, Yue Gao, Guanjun Dou, Kun Huang, Ying Department of General Surgery Shanghai Key Laboratory of Biliary Tract Disease Research State Key Laboratory of Oncogenes and Related Genes Xinhua Hospital Shanghai Jiao Tong University Shanghai China School of Life Science and Technology ShanghaiTech University Shanghai China CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Shanghai Institute for Biological Sciences Chinese Academy of Sciences University of Chinese Academy of Sciences Shanghai China National Facility for Protein Science in Shanghai Shanghai Advanced Research Institute Chinese Academy of Science Shanghai China

Drosophila P75 (dP75), a homolog of the human LEDGF/p75, is crucial for oogenesis by recruiting the histone kinase Jil-1 to euchromatin and impeding H3K9me2 spreading. Like LEDGF, dP75 binds transcriptionally active chromatin, but its precise mechanism remains unclear. Here we show that its PWWP domain prefers binding to thymidine-rich DNA over GC-rich sequences. Crystal structures both in apo and ssDNA-bound states, reveal a domain-swapped homodimer. The aromatic cage, known to recognize histone methyllysine, also engages thymine. Mutations in this cage mimic dP75 knockout phenotypes, including impaired chromatin binding, transposon upregulation, and female sterility. Although dP75 maintains chromatin-bound in H3K36A mutant flies, alterations in the aromatic cage disrupt this localization, underscoring its role in DNA binding. These findings reveal how dP75 targets euchromatin through a PWWP domain that integrates histone reading and nucleotide recognition, advancing our understanding of PWWP domains. © The Author(s) 2025.

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Smartphone Integrated Handheld (Speed) Digital Polymerase Chain Reaction Device

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SSRN 2023年

作者： Liu, Xiaocheng Wang, Xinlu Zhang, Haoqing Yan, Zhiqiang Gaňová, Martina Lednický, Tomáš Xu, Ying Zeng, Wen Korabečná, Marie Neužil, Pavel Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace School of Mechanical Engineering Northwestern Polytechnical University 127 West Youyi Road Shaanxi Xi’an710072 China Ministry of Education Key Laboratory of Biomedical Information Engineering School of Life Science and Technology Xi’an Jiaotong University Shaanxi Xi’an710049 China School of Marine Science and Technology Northwestern Polytechnical University Shaanxi Xi’an710072 China Central European Institute of Technology Brno University of Technology Purkyňova 123 Brno61300 Czech Republic Faculty of Electrical Engineering Brno University of Technology Technická 3058/10 Brno61600 Czech Republic Institute of Biology and Medical Genetics First Faculty of Medicine Charles University General University Hospital of Prague Albertov 4 Prague12800 Czech Republic

We demonstrate a smartphone integrated handheld (SPEED) digital polymerase chain reaction (dPCR) device for point-of-care application. The device has dimensions of 100×200×35 mm3 and a weight of ≈ 400 gm and can perform 45 cycles in ≈ 25 min. The device has integrated, miniaturized modules for thermal cycling, image taking, and wireless data communication that are controlled by self-developed android-based applications. The only consumable is the developed silicon-based dPCR chip, which has the potential to be recycled. The device’s precision and accuracy are comparable with commercial dPCR machines. We have verified the SPEED dPCR prototype’s utility in the testing of severe acute respiratory syndrome coronavirus 2, the detection of cancer-associated gene sequences, and the confirmation of Down syndrome diagnoses. Due to its low upfront capital investment as well as running cost, we envision that the SPEED dPCR device will help perform cancer screenings and non-invasive prenatal tests for the general population and assist in the timely identification and monitoring of infectious diseases testing resulting in fast warning about potential emerging pandemic. © 2023, The Authors. All rights reserved.

关键词： Polymerase chain reaction

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Molecular Basis for the Functional Roles of the Multimorphic T95R Mutation of IRF4 Causing Human Autosomal Dominant Combined Immunodeficiency

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SSRN 2023年

作者： Wang, Guanchao Feng, Xueqian Ding, Jianping State Key Laboratory of Molecular Biology Shanghai Institute of Biochemistry and Cell Biology Center for Excellence in Molecular Cell Science University of Chinese Academy of Sciences Chinese Academy of Sciences 320 Yue-Yang Road Shanghai200031 China School of Life Science and Technology ShanghaiTech University 393 Middle Huaxia Road Shanghai201210 China

Interferon regulatory factor 4 (IRF4) is a transcription factor that regulates the development and function of immune cells. Previously, several mutations were identified in the IRF4 DNA-binding domain (DBD) in lymphatic malignancies, which lead to either gain- or loss-of-function of IRF4. Recently, a new multimorphic mutation T95R was identified in patients with autosomal dominant combined immune deficiency, which results in a combination of gain, loss, and new functions for IRF4. In this work, we characterized the interactions of the wild-type IRF4-DBD (IRF4-DBDWT) and T95R mutant IRF4-DBD (IRF4-DBDT95R) with a canonical ISRE DNA and several noncanonical ISRE DNAs and found that the T95R mutation increased the binding affinities of IRF4-DBDT95R to both canonical and noncanonical DNAs. In addition, IRF4-DBDT95R exhibited the highest preference for GATA and comparable binding affinities for GACA and GAGA as the canonical ISRE GAAA sequence. We determined the crystal structures of IRF4-DBDWT in complex with a noncanonical ISRE DNA and IRF4-DBDT95R in complexes with the canonical and noncanonical ISRE DNAs. Structural analysis showed that the T95R mutation enhanced the interactions between IRF4-DBDT95R and both the canonical and noncanonical DNAs. Collectively, our biochemical and structural data provide the molecular basis for the gain-of-function and new function of IRF4T95R © 2023, The Authors. All rights reserved.

关键词： DNA

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Gold nanoparticle-directed autophagy intervention for antitumor immunotherapy via inhibiting tumor-associated macrophage M2 polarization

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Acta Pharmaceutica Sinica B 2022年第7期12卷 3124-3138页

作者： Siyue Zhang Fangyuan Xie Kaichun Li He Zhang You Yin Yuan Yu Guangzhao Lu Shihao Zhang Yan Wei Ke Xu Yan Wu Hong Jin Lan Xiao Leilei Bao Can Xu Yulin Li Ying Lu Jie Gao Department of Pharmacy Naval Medical UniversityShanghai 200433China Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghai 200433China Institute of Translational Medicine Shanghai UniversityShanghai 200444China Department of Pharmacy Shanghai Eastern Hepatobiliary Surgery HospitalNaval Medical UniversityShanghai 200433China Department of Oncology Shanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghai 200434China Unit for Drug and Instrument Supervision and Inspection of Wuxi Joint Logistic Support Center Nanjing 210000China Key Laboratory for Ultrafine Materials of Ministry of Education Engineering Research Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China Department of Gastroenterology Shanghai Changhai HospitalNaval Medical UniversityShanghai 200433China Department of Neurology Changzheng HospitalNaval Medical UniversityShanghai 200003China Department of Biomaterial College of Life SciencesMudanjiang Medical UniversityMudanjiang 157011China Department of Laboratory Medicine Hongqi HospitalMudanjiang Medical CollegeMudanjiang 157011China Centre for Biomedical Technologies Queensland University of TechnologyBrisbane QLD 4000Australia mWenzhou Institute of Shanghai UniversityWenzhou 325000China

Tumor-associated macrophages(TAMs),one of the dominating constituents of tumor microenvironment,are important contributors to cancer progression and treatment ***,regulation of TAMs polarization from M2 phenotype towards M1 phenotype has emerged as a new strategy for tumor ***,we successfully initiated antitumor immunotherapy by inhibiting TAMs M2 polarization via autophagy intervention with polyethylene glycol-conjugated gold nanoparticles(PEG-Au NPs).PEG-Au NPs suppressed TAMs M2 polarization in both in vitro and in vivo models,elicited antitumor immunotherapy and inhibited subcutaneous tumor growth in *** demonstrated by the m RFP-GFP-LC3 assay and analyzing the autophagy-related proteins(LC3,beclin1 and P62),PEGAu NPs induced autophagic flux inhibition in TAMs,which is attributed to the PEG-Au NPs induced lysosome alkalization and membrane ***,TAMs were prone to polarize towards M2phenotype following autophagy activation,whereas inhibition of autophagic flux could reduce the M2polarization of *** results revealed a mechanism underlying PEG-Au NPs induced antitumor immunotherapy,where PEG-Au NPs reduce TAMs M2 polarization via induction of lysosome dysfunction and autophagic flux *** study elucidated the biological effects of nanomaterials on TAMs polarization and provided insight into harnessing the intrinsic immunomodulation capacity of nanomaterials for effective cancer treatment.

关键词： Macrophage polarization Tumor-associated macrophages Nanomaterials Autophagy flux Lysosomal damage Gold nanoparticles M2 macrophage Cancer therapy

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Uptake of graphene enhanced the photophosphorylation performed by chloroplasts in rice plants

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Nano Research 2020年第12期13卷 3198-3205页

作者： Kun Lu Danlei Shen Shipeng Dong Chunying Chen Sijie Lin Shan Lu Baoshan Xing Liang Mao State Key Laboratory of Pollution Control and Resource Reuse School of the EnvironmentNanjing UniversityNanjing210093China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing100190China College Environmental Science&Engineering State Key Laboratory of Pollution Control and Resource ReuseTongji UniversityShanghai200092China State Key Laboratory of Pharmaceutical Biotechnology School of Life SciencesNanjing UniversityNanjing210023China Stockbridge School of Agriculture University of MassachusettsAmherstMA01003USA

New and enhanced functions were potentially imparted to the plant organelles after interaction with *** this study,we found that∼44%and∼29%of the accumulated graphene in the rice leaves passively transported to the chloroplasts and thylakoid,respectively,significantly enhanced the fluorescence intensity of chloroplasts,and promoted about 2.4 times higher adenosine triphosphate production than that of *** enhancement of graphene on the photophosphorylation was ascribed to two reasons:One is that graphene facilitates the electron transfer process of photosystem II in thylakoid,and the other is that graphene protects the photosystem II against photo-bleaching by acting as a scavenger of reactive oxygen ***,our work here confirmed that graphene translocating in the thylakoid promoted the photosynthetic activity of chloroplast in vivo and in vitro,providing new opportunities for designing biomimetic materials to enhance the solar energy conversion systems,especially for repairing or increasing the photosynthesis activity of the plants grown under stress environment.

关键词： graphene photophosphorylation enhancement photosystem II ROS scavenging protection

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High-resolution mapping of brain vasculature and its impairment in the hippocampus of Alzheimer's disease mice

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National science Review 2019年第6期6卷 1223-1238页

作者： Xiaochuan Zhang Xianzhen Yin Jingjing Zhang Anan Li Hui Gong Qingming Luo Haiyan Zhang Zhaobing Gao Hualiang Jiang School of Pharmacy East China University of Science and Technology CAS Key Laboratory of Receptor Research Shanghai Institute of Materia MedicaChinese Academy of Sciences Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and Technology MoE Key Laboratory for Biomedical Photonics School of Engineering Sciences Huazhong University of Science and Technology Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and TechnologyShanghai Tech University

Accumulating evidence indicates the critical importance of cerebrovascular dysfunction in the pathogenesis of Alzheimer's disease(AD). However, systematic comparative studies on the precise brain vasculature of wild-type and AD model mice are still rare. Using an image-optimization method for analysing Micro-Optical Sectioning Tomography(MOST) data, we generated cross-scale whole-brain 3 D atlases that cover the entire vascular system from large vessels down to smallest capillaries at submicron resolution,for both wild-type mice and a transgenic(APP/PS1) mouse model of AD. In addition to distinct vascular patterns in different brain regions, we found that the main vessels of the molecular layer of the hippocampal dentate gyrus(DG-ml) undergo abrupt changes in both diameter and branch angle, spreading a unique comb-like pattern of capillaries. By using a quantitative analysis workflow, we identified in the hippocampus of AD mice an overall reduction of the mean vascular diameter, volume fraction and branch angle, with most significant impairment in the DG-ml. In addition, virtual endoscopy revealed irregular morphological features in the vessel lumen of the AD mice, potentially contributing to the impairment of blood flow. Our results demonstrate the capability of high-resolution cross-scale evaluation of brain vasculature and underscore the importance of studying hippocampal microcirculation for understanding AD pathogenesis.

关键词： Micro-Optical Sectioning Tomography image optimization Alzheimer’s disease impaired hippocampal vasculature virtual vascular endoscopy

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Exceptionally Well-Preserved Crocodilian Coprolites from the Late Eocene of Northern Vietnam (Na Duong Formation): Ichnology and Paleoecological Significance

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SSRN 2023年

作者： Halaçlar, Kazım Rummy, Paul Liu, Jia Hunt, Adrian P. Van Do, Truong Trung Minh, Nguyen Deng, Tao Key Laboratory of Vertebrate Evolution and Human Origins Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of Sciences Beijing100044 China CAS Center for Excellence in Life and Paleoenvironment Beijing100044 China College of Earth and Planetary Sciences University of Chinese Academy of Sciences Beijing100049 China CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical Garden Chinese Academy of Sciences Mengla666303 China Flying Heritage and Combat Armor Museum EverettWA98204 United States Vietnam National Museum of Nature Vietnam Academy of Science and Technology Hanoi113000 Viet Nam Graduate Academy of Science and Technology Vietnam Academy of Science and Technology Hanoi113000 Viet Nam

This study aims to reconstruct the paleoenvironment of the Na Duong Basin by examining 55 coprolites and coprolite fragments from the fossil site. The use of coproecology is essential for understanding the intensive prey-predator relationships, the tropic relationship, and the ecosystem evolution within the paleo-locality. Through quantitative and multi-disciplinary analyses, a crocodilian producer was identified for the putative coprolites, and a new ichnogenera and species, Crococopros naduongensis ichnogen. et ichnosp. nov., were erected based on derived characters and comparisons. The study provides evidence of an ancient river or lake-like environment dominated by crocodilian fauna, suggesting that the Na Duong food chain was ideal and healthy for the survival of crocodilian species during that period of time. The findings also demonstrate the richness of ichnofauna, fauna, flora, and the suitable climate, indicating that Na Duong Basin was a fossil Lagerstätte of Southeast Asia. Overall, the study offers a unique snapshot of the past and sheds light on the ecosystem of the region, contributing to our understanding of paleoenvironmental conditions and biotic interactions in the area. © 2023, The Authors. All rights reserved.

关键词： Ecosystems

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Stability and Deformation of Vesicles in a Cylindrical Flow

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Langmuir : the ACS journal of surfaces and colloids 2022年第2期38卷 629-637页

作者： Dan Liu Zhihao Zhang Rong Wang Jinglei Hu Department of Polymer Science and Engineering State Key Laboratory of Coordination Chemistry and Collaborative Innovation Center of Chemistry for Life Sciences Key Laboratory of High Performance Polymer Material and Technology of Ministry of Education School of Chemistry and Chemical Engineering Nanjing University Nanjing 210023 China. Kuang Yaming Honors School and Institute for Brain Sciences Nanjing University Nanjing 210023 China.

In this work, we used dissipative particle dynamics to study the stability, deformation, and rupture of polymer vesicles confined in cylindrical channels under the flow field. The morphological evolution, elongation, and rupture of vesicles and the corresponding mechanisms were intensively investigated. Bullet-like vesicles, leaking vesicles, spherical micelles, hamburger-like micelles, and bilayers were observed by changing the degree of confinement and dimensionless shear rate. We found that increasing the dimensionless shear rate and the degree of confinement can cause the deformation or rupture of polymeric vesicles. The asphericity parameter was utilized to describe the degree of elongation of vesicles deviating from the sphere in the direction of the flow. The results show that the aggregates are more likely to be spherical when the confinement is weak, while they become elongated bullet-like shapes when the confinement is strong. The investigation of dynamics reveals that the degree of confinement and the dimensionless shear rate can affect the chain stretching and reorganization during the process of vesicle elongation. Furthermore, the rupture time of the vesicle shows a nonlinear decrease with an increase in the dimensionless shear rate, and the confinement also contributes to the rupture. The results are very useful for guiding the application of vesicles in a flow environment.

关键词： Morphology Vesicles Deformation Solvents Quantum confinement

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Pre-implantation embryo metabolism identified by PEMA reveals endogenous lactate insufficiency contributes to pre-implantation development arrest

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Fundamental Research 2024年

作者： Li, Jingyu Hou, Weibo Zhao, Qi Xi, Haitao Liu, Weiwei Xiao, Songling Song, Entong Zhu, Ling Cai, Yizhen Zong, Ming Zhang, Jiaming Wang, Xinyu Wang, Baicui Cheng, Liang Zhao, Junzhao Huang, Guoning Kong, Qingran Chongqing Key Laboratory of Human Embryo Engineering and Precision Medicine Center for Reproductive Medicine Chongqing Health Center for Women and Children Women and Children's Hospital of Chongqing Medical University Chongqing 400010 China Oujiang Laboratory Zhejiang Provincial Key Laboratory of Medical Genetics Key Laboratory of Laboratory Medicine Ministry of Education School of Laboratory Medicine and Life Sciences Wenzhou Medical University Wenzhou 325000 China Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital Shanghai Key Laboratory of Signaling and Disease Research Frontier Science Center for Stem Cell Research School of Life Sciences and Technology Tongji University Shanghai 200092 China NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy College of Bioinformatics Science and Technology Harbin Medical University Harbin 150081 China Department of Obstetrics and Gynecology The Second Affiliated Hospital of Wenzhou Medical University Wenzhou 325027 China The Second School of Medicine Wenzhou Medical University The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou 325000 China

Metabolism is a major regulator of pre-implantation embryonic development, but pre-implantation development arrest (PIDA) due to abnormal metabolisms remains ambiguous. By estimating a weight for each metabolic reaction using the translatome data, we developed a computational tool to perform pre-implantation embryos metabolic analysis (PEMA), and uncovered that the embryos exist in high activities of lactate dehydrogenase and lactate synthesis when major zygotic genome activation (ZGA) occurs in humans and mice. The insufficiency of endogenous lactate was predicted by PEMA in human 8-cell PIDA and corrected human tripronuclear (ch3PN) embryos, which was coordinated with failed H3K18lac and major ZGA. In transcriptomes, the human PIDA embryos resembled endogenous lactate-deprived mouse embryos. Lac-CoA addition could promote H3K18lac, major ZGA, and ch3PN pre-implantation development. Collectively, our study decodes the metabolic abnormalities in human PIDA embryos. The experimental validation suggests that PEMA offers an opportunity to study metabolic heterogeneity in early embryos. © 2024

关键词： Cell metabolism Endogenous lactate H3k18lac Pre-implantation development arrest Zygotic genome activation

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Observation of gamma rays from the northern celestial sky up to the sub-PeV range with the Tibet air shower array and its underground muon detector array 38

Observation of gamma rays from the northern celestial sky up...

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38th International Cosmic Ray Conference, ICRC 2023

作者： Kato, S. Amenomori, M. Bao, Y.W. Bi, X.J. Chen, D. Chen, T.L. Chen, W.Y. Chen, Xu Chen, Y. Cirennima Cui, S.W. Danzengluobu Ding, L.K. Fang, J.H. Fang, K. Feng, C.F. Feng, Zhaoyang Feng, Z.Y. Gao, Qi Gou, Q.B. Guo, Y.Q. Guo, Y.Y. Hayashi, Y. He, H.H. He, Z.T. Hibino, K. Hotta, N. Hu, Haibing Hu, H.B. Hu, K.Y. Huang, J. Jia, H.Y. Jiang, L. Jiang, P. Jin, H.B. Kasahara, K. Katayose, Y. Kato, C. Kato, S. Kawahara, I. Kawashima, T. Kawata, K. Kozai, M. Labaciren Le, G.M. Li, A.F. Li, H.J. Li, W.J. Li, Y. Lin, Y.H. Liu, B. Liu, C. Liu, J.S. Liu, L.Y. Liu, M.Y. Liu, W. Lu, H. Makishima, T. Masuda, Y. Matsuhashi, S. Matsumoto, M. Meng, X.R. Meng, Y. Mizuno, A. Munakata, K. Nakamura, Y. Nanjo, H. Ning, C.C. Nishizawa, M. Noguchi, R. Ohnishi, M. Okukawa, S. Ozawa, S. Qian, X. Qian, X.L. Qu, X.B. Saito, T. Sakata, M. Sako, T. Sako, T.K. Sasaki, T. Shao, J. Shibasaki, T. Shibata, M. Shiomi, A. Sugimoto, H. Takano, W. Takita, M. Tan, Y.H. Tateyama, N. Torii, S. Tsuchiya, H. Udo, S. Usui, R. Wang, H. Wang, S.F. Wang, Y.P. Wangdui Wu, H.R. Wu, Q. Xu, J.L. Xue, L. Yang, Z. Yao, Y.Q. Yin, J. Yokoe, Y. Yu, Y.L. Yuan, A.F. Zhai, L.M. Zhang, H.M. Zhang, J.L. Zhang, X. Zhang, X.Y. Zhang, Y. Zhang, Yi Zhang, Ying Zhao, S.P. Zhaxisangzhu Zhou, X.X. Zou, Y.H. Institute for Cosmic Ray Research University of Tokyo Chiba Kashiwa277-8582 Japan Department of Physics Hirosaki University Hirosaki036-8561 Japan School of Astronomy and Space Science Nanjing University Nanjing210093 China Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Beijing100049 China National Astronomical Observatories Chinese Academy of Sciences Beijing100101 China Department of Mathematics and Physics Tibet University Lhasa850000 China Department of Physics Hebei Normal University Shijiazhuang050016 China University of Chinese Academy of Sciences Beijing100049 China Shandong University Qingdao266237 China Institute of Modern Physics SouthWest Jiaotong University Chengdu610031 China Department of Physics Shinshu University Matsumoto390-8621 Japan Faculty of Engineering Kanagawa University Yokohama221-8686 Japan Faculty of Education Utsunomiya University Utsunomiya321-8505 Japan Faculty of Systems Engineering Shibaura Institute of Technology Omiya330-8570 Japan Faculty of Engineering Yokohama National University Yokohama240-8501 Japan Institute for Cosmic Ray Research University of Tokyo Kashiwa277-8582 Japan Polar Environment Data Science Center Joint Support-Center for Data Science Research Research Organization of Information and Systems Tachikawa190-0014 Japan National Center for Space Weather China Meteorological Administration Beijing100081 China School of Information Science and Engineering Shandong Agriculture University Taian271018 China Department of Astronomy School of Physical Sciences University of Science and Technology of China Hefei230026 China National Institute of Informatics Tokyo101-8430 Japan National Institute of Information and Communications Technology Tokyo184-8795 Japan Department of Mechanical and Electrical Engineering Shangdong Management University Jinan250357 China College of Science China University of Petroleum Qingdao266555

Gamma-ray observation in the sub-PeV range helps us search for Galactic PeV cosmic-ray accelerators, PeVatrons. Measurement of the energy spectrum of gamma rays from astrophysical sources is especially crucial to discuss their hadronic or leptonic origin. In this study, gamma rays from the sky region of HESS J1843−033 are observed by the Tibet air shower array equipped with the underground muon detector array. A new gamma-ray source TASG J1844−038 is detected above 25 TeV with a 6.2 σ level in the region of interest, the position of which is consistent with HESS J1843−033, eHWC J1842−035, and LHAASO J1843−0338. The gamma-ray energy spectrum of TASG J1844−038 is successfully measured in 25−130 TeV for the first time;it smoothly connects to that of HESS J1843−033 and gives consistent flux levels with those of eHWC J1842−035 and LHAASO J1843−0338 at 56 and 100 TeV, respectively. The analysis of the combined gamma-ray spectra between the H.E.S.S., LHAASO, and TASG sources indicates the cutoff at about 50 TeV. The distribution of the molecular clouds around TASG J1844−038 is investigated by analyzing public CO line-emission data;our study finds the clouds in the velocity range of 75−95 km s−1 lying flat over the region with a 50 K km s−1 level. The association of the observed gamma rays with a nearby supernova remnant SNR G28.6−0.1 is discussed, and it is proposed that cosmic rays accelerated by SNR G28.6−0.1 up to about 500 TeV generate the observed gamma rays from the collisions with the ambient gas found in the analysis. © Copyright owned by the author(s) under the terms of the Creative Commons.

关键词： Cosmic ray detectors

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