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Persistent Wnt signaling affects IVF embryo implantation and offspring metabolism

science Bulletin 2025年

作者： Yanping Jia Yingdong Liu Yanhe Li Xiaohong Guan Junting Xu Zihui Yan Kuisheng Liu Yalin Zhang Dandan Bai Jiani Xiang Yan Zhang Shangyu Hou Xiaochen Kou Yanhong Zhao Jiqing Yin Hong Wang Kunming Li Shaorong Gao Wenqiang Liu Shanghai Key Laboratory of Maternal Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology Shanghai Key Laboratory of Signaling and Disease Research Frontier Science Center for Stem Cell Research School of Life Sciences and Technology Tongji University Shanghai 200092 China Reproductive Center of Shanghai First Maternity and Infant Hospital School of medicine Tongji University Shanghai 200072 China Reproductive Center of Shanghai Tenth People’s Hospital School of medicine Tongji University Shanghai 200092 China

Assisted reproductive technology (ART) is associated with increased implantation failure and subsequent metabolic abnormalities in offspring, but the underlying mechanisms remain largely elusive. Here, we reveal that persistent Wnt signaling during the peri-implantation stage may be a key obstacle to the implantation of in vitro fertilization (IVF) embryos in a mouse model. Wnt activation affects the deposition of H3K27ac and H3K27me3 on pluripotency genes and bivalent genes, respectively, leading to the abnormal naïve-primed transition and suppressing expression of Otx2 in the epiblast. Furthermore, treatment with the Wnt inhibitor IWP2 promotes the redistribution of histone modifications and gene expression of epiblast. Importantly, Wnt inhibiting significantly improves implantation and intrauterine development of IVF embryos and subsequently ameliorates offspring metabolic abnormalities. Moreover, Wnt inhibiting markedly improves human peri-implantation embryo development and facilitates the transition from a naïve pluripotency state. Our study reveals a novel mechanism underlying the prevention of IVF embryo implantation failure and metabolic disorders in offspring.

关键词： Embryo implantation Wnt signal pathway Naïve pluripotency Otx2 H3K27ac H3K27me3 Metabolic abnormalities

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Study on the Influence of Layout of Double Coal Seam Working Face on Overlying Strata

Study on the Influence of Layout of Double Coal Seam Working...

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作者： Xueyang Sun Qi Zhang Cheng Li Lei Zhang Xi'an University of Science and Technology Shaanxi Provincial Key Laboratory of Geological Support for Coal Green Exploitation Key Laboratory of Mine Geological Hazards Mechanism and Control

The design of mining face is very important, it is not only an basis for rational and effective coal mining, but also affects the subsidence area and surface environment of overlying *** a coal mine as an example, study the development law of coal mining subsidence under the condition of double coal seam mining by means of the combination of similar material simulation experiment and numerical simulation. The results obtained by the two methods are basically the same. The larger the width of the coal pillar, the smaller the overlapping area of the upper and lower coal seam, and the smaller the influence range of coal seam mining deformation and failure. It is suggested that the mining time and mining distance of the two coal seams should be extended, the width of coal pillar should be increased, so as to slow down the deformation and damage range of overburden,and protect the surface ecological environment.

关键词： Double seam mining Coal mining subsidence Simulation of similar materials Numerical simulation

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Fabrication and photocatalytic graphene oxide ability of an Au/TiO2/reduced nanocomposite

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Frontiers of Environmental science & Engineering 2018年第1期12卷 65-70页

作者： Fenghe Lv Hua Wang Zhangliang Li Qi Zhang Xuan Liu Yan Su School of Fisheries and Life Science Dalian Ocean University Dalian 116023 China Key Laboratory of Mariculture ＆ Stock Enhancement in North China＇s Sea Ministry of Agriculture Dalian 1 I6023 China Fujian Provincial Key Laboratory of Ecology-Toxicological Effects ＆ Control for Emerging Contaminants Putian 351100 China Faculty of Chemical Environmental and Biological Science and Technology Dalian University of Technology Dalian 116024 China

A new type of Au/TiO2/reduced graphene oxide （RGO） nanocomposite was fabricated by the hydrothermal synthesis of TiO2 on graphene oxide followed by the photodeposition of Au nanoparticles. Transmission electron microscopy images showed that Au nanoparticles were loaded onto the surface of both TiO2 and RGO. Au/TiO2/RGO had a better photocatalytic activity than Au/ TiO2 for the degradation of phenol. Electrochemical measurements indicated that Au/TiO2/RGO had an improved charge transfer capability. Meanwhile, chemiluminescent analysis and electron spin resonance spectroscopy revealed that Au/TiO2/RGO displayed high production of hydrogen peroxide and hydroxyl radicals in the photocatalytic process. This high photocatalytic performance was achieved via the addition of RGO in Au/TiO2/RGO, where RGO served not only as a catalyst support to provide more sites for the deposition of Au nanoparticles but also as a collector to accept electrons from TiO2 to effectively reduce photogenerated charge recombination.

关键词： Reduced graphene oxideAuTiO2NanocompositePhotocatalysis

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Effects of Shuanghuanglian oral liquids on patients with COVID-19:a randomized,open-label,parallel-controlled,multicenter clinical trial

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Frontiers of Medicine 2021年第5期15卷 704-717页

作者： Li Ni Zheng Wen Xiaowen Hu Wei Tang Haisheng Wang Ling Zhou Lujin Wu Hong Wang Chang Xu Xizhen Xu Zhichao Xiao Zongzhe Li Chene Li Yujian Liu Jialin Duan Chen Chen Dan Li Runhua Zhang Jinliang Li Yongxiang Yi Wei Huang Yanyan Chen Jianping Zhao Jianping Zuo Jianping Weng Hualiang Jiang Dao Wen Wang Division of Cardiology Department of Internal Medicine and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological DisordersTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China The First Affiliated Hospital of University of Science and Technology of China Hefei 230026China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Harbin Pharmaceutical Group Co. Ltd.Harbin 150070China The Sixth Hospital of Harbin Harbin 150036China The Second Hospital of Nanjing and the Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing 210003China Department of Cardiology Chinese People’s Liberation Army Central War Command General HospitalWuhan 430010China Department of Information Management Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Division of Respiratory Department of Internal MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China

We conducted a randomized,open-label,parallel-controlled,multicenter trial on the use of Shuanghuanglian(SHL),a traditional Chinese patent medicine,in treating cases of COVID-19.A total of 176 patients received SHL by three doses(56 in low dose,61 in middle dose,and 59 in high dose)in addition to standard *** control group was composed of 59 patients who received standard therapy *** with SHL was not associated with a difference from standard care in the time to disease *** with 14-day SHL treatment had significantly higher rate in negative conversion of SARS-CoV-2 in nucleic acid swab tests than the patients from the control group(93.4%vs.73.9%,P=0.006).Analysis of chest computed tomography images showed that treatment with high-dose SHL significantly promoted absorption of inflammatory focus of pneumonia,which was evaluated by density reduction of inflammatory focus from baseline,at day 7(mean difference(95%CI),−46.39(−86.83 to−5.94)HU;P=0.025)and day 14(mean difference(95%CI),−74.21(−133.35 to−15.08)HU;P=0.014).No serious adverse events occurred in the SHL *** study illustrated that SHL in combination with standard care was safe and partially effective for the treatment of COVID-19.

关键词： COVID-19 SARS-CoV-2 Shuanghuanglian oral liquid clinical trial

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Hepatitis B virus genotypes and genome characteristics in China

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World Journal of Gastroenterology 2015年第21期21卷 6684-6697页

作者： Hong-Mei Li Jian-Qiong Wang Rui Wang Qian Zhao Li Li Jin-Ping Zhang Tao Shen College of Life Science and Technology Kunming University of Science and Technology Basic and Clinical Medicine Institute of Yunnan Province Provincial Key Laboratory for Birth Defects and Genetic Diseasesthe First People’s Hospital of Yunnan ProvinceAffiliated Hospital of Kunming University of Science and Technology Clinical Laboratory the First People’s Hospital of Yunnan Provinceaffiliated Hospital of Kunming University of Science and Technology Kunming Medical College

AIM:To analyze the hepatitis B virus(HBV) characters in China,as well as the correlation between several HBV mutation and hepatitis ***:A total of 1148 HBV genome sequences from patients throughout China were collected via the National Center For Biotechnology Information database(information including:genotype,territory and clinical status).HBV genotypes were classified by a direct reference from the Genbank sequence annotation,phylogenetic tree and online software analysis(http://***/projects/genotyping/***).The phylogenetic tree was constructed based on the neighbor-joining method by MEGA5.0 *** sequences were grouped based on phylogenetic tree and the distance between the groups was calculated by using the computer between group mean distance *** hundred and twelve HBV sequences with clear annotation of clinical symptoms were selected to analyses the correlation of mutation and clinical *** of sequences were analyzed by using DNAStar and BioEdit software *** codon usage bias and RNA secondary structures analysis were performed by RNAdraw *** analysis was performed by using Simplot ***:In China,HBV genotype C was the predominant in Northeastern,genotype B was predominant in Central Southern areas,genotype B and C were both dominant in Southwestern areas,and the recombinant genotype C/D was predominant in Northwestern areas.C2 and B2 were identified as the two major sub-genotypes,FJ386674 might be a putative sub-genotype as *** basal core promoter double mutation and pre-C mutation showed various significant differences between hepatitis *** addition to ATG,many other HBV initiation codons also *** has codon usage bias;the termination codon of X,C and P open reading frames(ORF) were TAA,TAG,and TGA,*** major stop codons of S-ORF were TAA(96.45%) and TGA(83.60%) in B2 and C2 subtype,***:This study

关键词： Hepatitis B virus Genotype Phylogenetictree Clinical symptoms Mutation Codon usage bias

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CAR-Toner:an Al-driven approach for CAR tonic signaling prediction and optimization

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细胞研究（英文版） 2024年第5期34卷 386-388页

作者： Shizhen Qiu Jian Chen Tao Wu Li Li Gang Wang Haitao Wu Xianmin Song Xuesong Liu Haopeng Wang School of Life Science and Technology ShanghaiTech UniversityShanghaiChina Department of Hematology Shanghai General HospitalShanghai Jiaotong University School of MedicineShanghaiChina ENT Institute and Department of Otorhinolaryngology Eye & ENT HospitalFudan UniversityShanghaiChina School of Life Science and Technology ShanghaiTech UniversityShanghaiChina Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy Cancer InstituteXuzhou Medical UniversityXuzhouJiangsuChina Department of Hematology Shanghai General HospitalShanghai Jiaotong University School of MedicineShanghaiChina School of Life Science and Technology ShanghaiTech UniversityShanghaiChina State Key Laboratory of Advanced Medical Materials and Devices ShanghaiTech UniversityShanghaiChina Shanghai Clinical Research and Trial Center ShanghaiChina

Dear Editor, Tonic signaling of chimeric antigen receptors(CARs)plays a pivotal role in governing CAR-T cell fitness:inefficient tonic signaling results in poor CAR-T persistence,while excessive tonic signaling leads to CAR-T exhaustion.1-3 Our previous work has elucidated that positively charged patches(PCPs)on the surface of the CAR antigen-binding domain facilitate CAR clustering,thereby triggering CAR tonic signals.

关键词： optimization prediction al-driven approach car-toner signaling tonic

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A Novel Computational Nanobiosensing Approach to Improve the Exploitation of In Vivo Computation

A Novel Computational Nanobiosensing Approach to Improve the...

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2023 IEEE Congress on Evolutionary Computation, CEC 2023

作者： Shi, Shaolong Chen, Yifan Jiang, Zhaoyang Liu, Qiang Ding, Jurong Zhang, Qingfu School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China City University of Hong Kong Department of Computer Science Hong Kong Hong Kong City University of Hong Kong Shenzhen Research Institute Shenzhen China University of Electronic Science and Technology of China Quzhou China School of Information and Communication Engineering University of Electronic Science and Technology of China Chengdu China Sichuan University of Science and Engineering Artificial Intelligence Key Laboratory of Sichuan Province Zigong China School of Automation and Information Engineering Sichuan University of Science and Engineering Zigong China

ISBN: (纸本)9798350314588

A novel nanobiosensing framework named 'in vivo computation' has been proposed recently, where the challenge of early tumor detection is overcome from an optimization perspective. The biological gradient field (BGF) triggered by the tumor lesion is viewed as the optimizable objective function with the tumor site being the global optimum. The externally manipulable nanorobots playing the role of agents are manipulated in the search space (i.e., the vascular network of high-risk tissue). Several computational strategies have been proposed to realize tumor targeting by overcoming the in vivo constraints which focused on the tumor detection process without any emphasis on the nanorobots aggregation at the tumor. In this paper, we focus on the utilization rate of agents, which means to improve the percentage of nanorobots that detect the tumor site after it has been found by the first arrival agent (i.e., the nanorobot that detects the tumor at the earliest), and the solution set search, which means to find the tumor region as whole as possible. This process is interpreted as the exploitation process of in vivo computation. An exploitation approach named center-aided weak priority evolution strategy (CWP-ES) is developed for the setting of nanorobot moving direction in this paper. In the approach, a direction generated by the center of agents that have found the tumor mixed with the direction generated by the weak priority evolution strategy (WP-ES) proposed in the previous work is used to steer the motion of nanorobots that have not detected the tumor. Several numerical experiments are performed in a 3D search space to show the effectiveness of this novel computational nanobiosensing approach in three BGF landscapes with different degrees of optimization complexity. © 2023 IEEE.

关键词： Tumors

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An integrative profiling of metabolome and transcriptome in the plasma and skeletal muscle following an exercise intervention in diet-induced obese mice

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Journal of Molecular Cell Biology 2023年第3期15卷 18-31页

作者： Shuang Han Qingqian Wu Mengying Wang Miqi Yang Chen Sun Jiaqi Liang Xiaozhen Guo Zheyu Zhang Jingya Xu Xinyuan Qiu Cen Xie Siyu Chen Yue Gao Zhuo-Xian Meng Department of Pathology and Pathophysiology and Department of Cardiology of the Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310058China Department of Geriatrics Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China Key Laboratory of Disease Proteomics of Zhejiang Province Zhejiang University School of MedicineHangzhou 310058China Department of Big Data in Health Science School of Public Health Zhejiang University School of MedicineHangzhou 310003China State Key Laboratory of Natural Medicines and School of Life Science and Technology China Pharmaceutical UniversityNanjing 211198China State Key Laboratory of Drug Research Shanghai Institute of Material MedicalChinese Academy of SciencesShanghai 201203China Department of Biology and Chemistry College of Liberal Arts and SciencesNational University of Defense TechnologyChangsha 410073China

Exercise intervention at the early stage of type 2 diabetes mellitus(T2DM)can aid in the maintenance of blood glucose homeostasis and prevent the development of macrovascular and microvascular ***,the exercise-regulated pathways that prevent the development of T2DM remain largely *** this study,two forms of exercise intervention,treadmill training and voluntary wheel running,were conducted for high-fat diet(HFD)-induced obese *** observed that both forms of exercise intervention alleviated HFD-induced insulin resistance and glucose *** muscle is recognized as the primary site for postprandial glucose uptake and for responsive alteration beyond exercise *** profiling of the plasma and skeletal muscle in Chow,HFD,and HFD-exercise groups revealed robust alterations in metabolic pathways by exercise intervention in both *** analysis identified nine metabolites,including beta-alanine,leucine,valine,and tryptophan,which were reversed by exercise treatment in both the plasma and skeletal *** analysis of gene expression profiles in the skeletal muscle revealed several key pathways involved in the beneficial effects of exercise on metabolic *** addition,integrative transcriptomic and metabolomic analyses uncovered strong correlations between the concentrations of bioactive metabolites and the expression levels of genes involved in energy metabolism,insulin sensitivity,and immune response in the skeletal *** work established two models of exercise intervention in obese mice and provided mechanistic insights into the beneficial effects of exercise intervention on systemic energy homeostasis.

关键词： type 2 diabetes exercise intervention metabolomics transcriptomics

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Biscaesalmins A and B from Caesalpinia minax,highly oxidized dimeric cassane diterpenoids as interleukin-1β inhibitors

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Chinese Chemical Letters 2021年第4期32卷 1475-1479页

作者： Yunshao Xu Tian Zhang Lu Feng Zheling Feng Qingwen Zhang Yang Ye Lishe Gan Ligen Lin State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoAvenida da UniversidadeTaipaMacao 999078China State Key Laboratory of Drug Research &Natural Products Chemistry DepartmentShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Life Science and Technology Shanghai Tech UniversityShanghai 201203China School of Biotechnology and Health Sciences Wuyi UniversityJiangmen 529020China

To search naturally occurring interleukin-1β(IL-1β) inhibitors,biscaesalmins A(1) and B(2),two highly oxidized dimeric cassane diterpenoids with a newly formed alicyclic skeleton,have been isolated from the traditional Chinese medicine Kushilian(Caesalpinia minax).Their full structures were determined by comprehensive spectroscopic analysis and quantum chemical TD-DFT(time-dependent density functional theory) ***,1 and 2 were formed via an intermolecular [4+2]Diels-Alder cycloaddition of two monomers,affording an additional six-membered carbon ring *** 1 and 2 inhibited nitric oxide production on lipopolysaccharide-stimulated THP-1 macrophages,with IC_(50) values being at 1.20±0.23 and 2.30±0.15 μmol/L,***,compound 1 inhibited NLRP3(NOD-,LRR-and pyrin domain-containing protein 3) inflammasomemediated IL-1β production and blocked the migration of macrophages towards adipocyte conditioned *** A and B might be candidates for treating inflammation-related metabolic diseases.

关键词： Caesalpinia minax IL-1β Dimeric cassane diterpenoids NLRP3 TD-DFT

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[email protected] yolk-shell triangular nanoplates with controlled interior gap for the improved surface-enhanced Raman scattering of rhodamine 6G

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Sensors and Actuators B: Chemical 2018年 271卷 174-182页

作者： Fan Zhang Na Wu Jian Zhu Jing Zhao Guo-jun Weng Jian-jun Li Jun-wu Zhao The Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and Technology Xi’an Jiaotong University Xi’an 710049 China

In this work, a combined seed mediated and galvanic replacement strategy has been proposed to design and fabricate two unique nanostructures, including [email protected] yolk-shell nanostructures with tunable interior gap and Au multi-spiky nanostructures with tunable spike length. The interior gap of the [email protected] yolk-shell nanostructures can be controlled by varying either the amount of AgNO 3 in the first step or the amount of HAuCl 4 in the second step. The SERS activity of [email protected] yolk-shell nanostructures was found to increase with increase in the interior gap. Owing to the build-in electromagnetic hot spots induced by plasmonic coupling effect of the Au triangular nanoplate core and AuAg shell especially the intensive coupling between the three sharp tips of the core and the concave of the inner wall of the shell, [email protected] yolk-shell nanostructures exhibit significantly higher SERS enhancement compared to their original Au triangular nanoplates. The best enhancement has been achieved when the interior gap of [email protected] yolk-shell nanostructures is 10 nm with the enhancement factor of 3.2 × 10 6 for rhodamine 6G, making them promising candidates for SERS-based detection.

关键词： [email protected] yolk-shell nanostructures Surface-enhanced Raman scattering (SERS) Interior gap Hot spots

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