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Neural Mechanism Underlying Task-Specific Enhancement of Motor Learning by Concurrent Transcranial Direct Current Stimulation

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Neuroscience Bulletin 2023年第1期39卷 69-82页

作者： Ying Wang Jixian Wang Qing-Fang Zhang Ke-Wei Xiao Liang Wang Qing-Ping Yu Qing Xie Mu-Ming Poo Yunqing Wen Institute of Neuroscience State Key Laboratory of NeuroscienceKey Laboratory of Primate NeurobiologyCenter for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai200031China University of Chinese Academy of Sciences Beijing100049China School of Life Science and Technology ShanghaiTech UniversityShanghai201210China Department of Rehabilitation Medicine Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Lingang LaboratoryShanghai201210China

The optimal protocol for neuromodulation by transcranial direct current stimulation(tDCS)remains *** the rotarod paradigm,we found that mouse motor learning was enhanced by anodal tDCS(3.2 mA/cm^(2))during but not before or after the performance of a ***-task experiments showed that motor learning enhancement was specific to the task accompanied by anodal *** using a mouse model of stroke induced by middle cerebral artery occlusion showed that concurrent anodal tDCS restored motor learning capability in a task-specific *** in vivo Ca^(2+)imaging further showed that anodal tDCS elevated and cathodal tDCS suppressed neuronal activity in the primary motor cortex(M1).Anodal tDCS specifically promoted the activity of task-related M1 neurons during task performance,suggesting that elevated Hebbian synaptic potentiation in task-activated circuits accounts for the motor learning ***,application of tDCS concurrent with the targeted behavioral dysfunction could be an effective approach to treating brain disorders.

关键词： Motor learning tDCS effect Neural mechanism of tDCS Neuronal excitability Stroke model mouse

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An enzyme-loaded reactor using metal-organic framework-templated polydopamine microcapsule

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Chinese Journal of Chemical Engineering 2021年第1期34卷 317-325页

作者： Jing Wang Yongqin Lv Beijing Key Laboratory of Bioprocess College of Life Science and TechnologyBeijing University of Chemical TechnologyBeijing 100029China

Ultrathin polydopamine microcapsules with hierarchical structure and porosity were prepared for the immobilization of multienzymes using metal-organic framework(MOF) as the *** multienzyme/MOF composite was first prepared using a "one-pot" co-precipitation approach via the coordination and self-assembly of zinc ions and 2-methylimidazole in the presence of *** obtained nanoparticles were then coated with polydopamine thin layer through the self-polymerization of dopamine under alkaline *** polydopamine microcapsules with an ultrathin shell thickness of ~48 nm were finally generated by removing the MOF template at acidic *** enzymes were encapsulated in PDA microcapsules including carbonic anhydrase(CA),formate dehydrogenase(FateDH),and glutamate dehydrogenase(GDH).FateDH that catalyzed the main reaction of CO_(2) reduction to formic acid retained 94.7% activity of equivalent free *** with free multienzymes,the immobilized ones embedded in PDA microcapsules exhibited 4.5-times higher of formate production and high catalytic efficiency with a co-factor-based formate yield of 342%.

关键词： Biocatalysis Enzyme Immobilization Microcapsule Metal-organic framework Template

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High-quality reference genome decoding and population evolution analysis of prickly Sechium edule

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Horticultural Plant Journal 2025年第2期11卷 827-838页

作者： Xiaojing Wang Shaoqin Shen Yanhong Fu Rui Cao Yunfeng Wei Xiaoming Song Institute of Agro-Bioengineering/The Key Laboratory of Plant Resources Conservation and Germplasm Innovation in the Mountainous Region(Ministry of Education)/College of Life Sciences Guizhou UniversityGuiyangGuizhou 550025China School of Life Sciences North China University of Science and TechnologyTangshanHebei 063210China College of Tea Science Guizhou UniversityGuiyangGuizhou 550025China

Sechium edule(chayote)is an important vegetable crop belonging to the Cucurbitaceae *** decipher the chayote genome,a highquality chromosome-level chayote genome was obtained by genome sequencing and bioinformatic *** total length was612.91 Mb,and 25755 genes were detected in the chayote *** contig N50 was more than 20.01 Mb,and the scaffold N50 was over47.11 *** the genome,60.35%were composed of repetitive sequences,and 31.18%of genome sequences belonged to long-terminal repeats.A global alignment of homologous regions in chayote and other Cucurbitaceae plant genomes was constructed using grape as a *** on this genome-wide and global alignment map,researchers can easily identify homologous collinear genes of the studied genomes in most Cucurbitaceae ***-five chayote accessions were divided into two subgroups based on phylogenetic tree,population structure analysis,and principal component analysis using genome re-sequencing *** chayote genome,re-sequencing dataset,and comprehensive genomic analysis will accelerate comparative and functional genomic analysis of chayote and other Cucurbitaceae species in the future.

关键词： Sechium edule Whole-genome duplication Divergence time Genome evolution Population structure Cucurbitaceae

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PLX8394,a RAF inhibitor,inhibits enterovirus 71 replication by blocking RAF/MEK/ERK signaling

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Virologica Sinica 2023年第2期38卷 276-284页

作者： Chengyuan Wu Guangyan Zhu Fang Qiu Fuli Ren Binbin Lin Dingyu Zhang Qingyu Yang Chaolin Huang Wuhan Jinyintan Hospital Tongji Medical College of Huazhong University of Science and TechnologyWuhan430023China State Key Laboratory of Virology Wuhan Institute of VirologyChinese Academy of SciencesWuhan430071China Division of Life Sciences and Medicine University of Science and Technology of ChinaHefei230027China

Enterovirus 71(EV71)poses a serious threat to human health,with scattered outbreaks *** are several vaccines against a few EV71 strains but no efficient drug for the treatment of EV71 ***,it is urgent and of significance to develop anti-EV71 ***,we found that PLX8394,a RAF inhibitor,possesses high antiviral activity against EV71 in vitro,being superior to the traditional clinical drug ***,PLX8394 exhibits broad-spectrum antiviral activity against ***,in a suckling mouse model,PLX8394 provided a 70%protection rate for EV71-infected mice,reduced the viral load in liver and heart tissues,and relieved the inflammatory response.A mechanistic study showed that PLX8394 inhibited EV71 by suppressing the RAF/MEK/ERK signaling ***,PLX8394 lays a foundation for the development of new drugs against EV71.

关键词： Enterovirus 71(EV71) RAF inhibitor Hand,foot,and mouth disease(HFMD) RAF/MEK/ERK signaling Pathway Antiviral agents

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A microfluidic surface-enhanced Raman scattering(SERS) sensor for microRNA in extracellular vesicles with nucleic acid-tyramine cascade amplification

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Chinese Chemical Letters 2022年第4期33卷 2101-2104页

作者： Yue Zhao Xiaoxing Fang Min Bai Jin Zhang Huahang Yu Feng Chen Yongxi Zhao Institute of Analytical Chemistry and Instrument for Life Science The Key Laboratory of Biomedical Information Engineering of Ministry of EducationSchool of Life Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China

Exosomal micro RNA(mi RNA) is an ideal candidate of noninvasive biomarker for the early diagnosis of cancer. Sensitive and accurate sensing of abnormal exosomal mi RNA plays essential role for clinical promotion due to its close correlation with tumor proliferation and progression. Herein, a microfluidic surface-enhanced Raman scattering(SERS) sensor was proposed for an on-line detection of exosomal mi RNA based on rolling circle amplification(RCA) and tyramine signal amplification(TSA) strategy. The microfluidic chip consists of a magnetic enrichment chamber, a serpentine fluidic mixer and a plasmonic SERS substrate functionalized with capture probes. The released mi RNA activates the capture probe, triggers RCA reaction, and generates a large number of single-stranded DNA products to drive the catalysis of nanotags deposition via TSA, producing numerous “hot spots” to enhance the SERS signals. In merit of the microfluidics chip and nucleic acid-tyramine cascade amplification, the developed SERS sensor significantly improves the sensitivity for the exosomal mi RNA assay, resulting in a limit of detection(LOD) as low as 1 pmol/L and can be successfully applied in the analysis of exosomes secreted from breast tumor cells, which demonstrates the potential utility in practical applications.

关键词： Microfluidic chips Surface-enhanced Raman scattering(SERS) Exosome Tyramide signal amplification Nucleic acid amplification

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Suppression mechanisms on proliferation of glioma U251 cells by FePt nanoparticles through intracellular oxidative stress

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Rare Metals 2022年第4期41卷 1202-1209页

作者： Yao-Min Li Li-Hui Meng Yan-Ru Hu Tian-Tian Zhang Zheng-Nan Su Zhi-Yuan Ouyang Wen-Chao Li Jiang-Ling Wan Qing-Zhi Wu State Key Laboratory of Advanced Technology for Materials Synthesis and Processing and Biomedical Materials and Engineering CentreWuhan University of TechnologyWuhan 430070China National Engineering Research Centre for Nanomedicine College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China

FePt nanoparticles(NPs)have attracted a great deal of attention in biomedical applications due to their excellent superparamagnetic property and anticancer activity,which display promising potential as the MRI/CT contrast imag-ing agent for cancer detection and *** this study,the suppression mechanism induced by FePt NPs on U251 cells is *** U251 cells are co-cultured with FePt NPs at different concentrations,and the intra-cellular oxidative stress was studied by detecting the activities of various redox enzymes and expression of several apoptosis-related *** cell viability assay shows that the highest suppression on the proliferation of glioma U251 cells is 10.5%±5.6%after treatment with 5μg·ml^(-1)FePt NPs for 24 *** this case,the LDH release remarkably *** cytometry and fluorescence assay show that FePt NPs promote the apoptosis and G0/G1 phase arrest of U251 cells.

关键词： nanoparticles U251 stress

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MaizeNetome:A multi-omics network database for functional genomics in maize

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Molecular Plant 2023年第8期16卷 1229-1231页

作者： Jia-Wu Feng Linqian Han Hao Liu Wen-Zhao Xie Hanmingzi Liu Lin Li Ling-Ling Chen National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070China State Key Laboratory for Conservation and Utilization of Subtropical Agrobioresources College of Life Science and TechnologyGuangxi UniversityNanning 530004China

Dear Editor,Eukaryotic life is a complex system(Trewavas,2006).Networks offer a reasonable means of describing complex life *** constructed for animals and plants have significantly furthered our understanding of complex life systems and functional genomics(Consortium,2011;Walley et al.,2016;Altmann et al.,2020;Luck et al.,2020;McWhite et al.,2020;Zander et al.,2020).However,integrative networks spanning different layers of genetic information are lacking.

关键词： network functional networks

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Structures of PSI–FCPI from Thalassiosira pseudonana grown under high light provide evidence for convergent evolution and light-adaptive strategies in diatom FCPIs

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Journal of Integrative Plant Biology 2025年第4期 949-966页

作者： Yue Feng Zhenhua Li Yang Yang Lili Shen Xiaoyi Li Xueyang Liu Xiaofei Zhang Jinyang Zhang Fei Ren Yuan Wang Cheng Liu Guangye Han Xuchu Wang Tingyun Kuang Jian-Ren Shen Wenda Wang Key Laboratory of Photobiology Photosynthesis Research Center Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Laboratory for Ecology of Tropical Islands Ministry of Education College of Life Sciences Hainan Normal University China National Botanical Garden Department of Chemistry and Center of Artificial Photosynthesis for Solar Fuels School of Science Westlake University Academician Workstation of Agricultural High-Tech Industrial Area of the Yellow River Delta National Center of Technology Innovation for Comprehensive Utilization of Saline-Alkali Land Key Laboratory of Plant Resources Conservation and Germplasm Innovation in Mountainous Region Ministry of Education College of Life Sciences Guizhou University Research Institute for Interdisciplinary Science Graduate School of Environmental Life Natural Science and Technology Okayama University

Diatoms rely on fucoxanthin chlorophyll a/c-binding proteins(FCPs) for light harvesting and energy quenching under marine environments. Here we report two cryo-electron microscopic structures of photosystem I(PSI) with either 13 or five fucoxanthin chlorophyll a/c-binding protein Is(FCPIs) at 2.78 and 3.20 ? resolutions from Thalassiosira pseudonana grown under high light(HL) conditions. Among them,five FCPIs are stably associated with the PSI core,these include Lhcr3, Red CAP, Lhcq8, Lhcf10, and FCP3. The eight additional Lhcr-type FCPIs are loosely associated with the PSI core and detached under the present purification conditions. The pigments of this centric diatom showed a higher proportion of chlorophylls a, diadinoxanthins, and diatoxanthins; some of the chlorophyll as and diadinoxanthins occupy the locations of fucoxanthins found in the huge PSI–FCPI from another centric diatom Chaetoceros gracilis grown under low-light conditions. These additional chlorophyll as may form more energy transfer pathways and additional diadinoxanthins may form more energy dissipation sites relying on the diadinoxanthin–diatoxanthin *** results reveal the assembly mechanism of FCPIs and corresponding light-adaptive strategies of T. pseudonana PSI–FCPI, as well as the convergent evolution of the diatom PSI–FCPI structures.

关键词： cryo-EM diatom FCPI light-adaptive strategies photosynthesis PSI

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Environmental heterogeneity and productivity drive the assemblage of benthic diatom:a case study of the Three Gorges Reservoir

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Journal of Oceanology and Limnology 2023年第3期41卷 991-1006页

作者： Songqi YANG Tian OUYANG Shaojun XU Lu ZHAO Lulu JI Junqiong SHI Zhongxing WU Key Laboratory of Eco-environments in Three Gorges Reservoir Region(Ministry of Education) Chongqing Key Laboratory of Plant Ecology and Resources Research in Three Gorges Reservoir RegionSchool of Life ScienceSouthwest UniversityChongqing 400715China Gansu Microalgae Technology Innovation Center Zhangye 734000China College of Horticulture and Plant Protection Henan University of science and TechnologyLuoyang 471000China

Dam construction has a critical effect on river ecosystems in the world,resulting in a rapid decline in biodiversity and ecosystem ***,the effect of dam construction on the assemblage pattern of benthic diatoms remains *** benthic diatoms assemblages in the tributary backwater area of the Three Gorges Reservoir(TGR)were investigated under low water level(LWL)and high water level(HWL)*** show that Discostella stelligera,Nitzschia palea,and Craticula subminuscula were dominant species in LWL,while Achnanthidium minutissimum and Nitzschia dissipata were dominant in ***,environmental variables,productivity parameters,diversity indices,and community similarity were found significantly different between LWL and HWL *** Mantel test indicated that both environmental and spatial factors had significant effects on diatom communities in backwater area,while productivity was also a key driving force in *** variation partitioning analysis(VPA)further demonstrated that environment factors could explain the largest variance of diatom assemblages in HWL(9%)and LWL(11%),followed by spatial *** relative importance of productivity to diatom community was significantly enhanced in LWL,but only a slight effect was found in *** results indicate that the diatom assemblages were shaped by both environmental filtering and spatial *** relative importance of spatial factors depended on the degree of ***,the homogenization of diatom communities due to environmental disturbance,*** and dam building,is the underlying mechanism in assembling the benthic diatoms.

关键词： Three Gorges Reservoir benthic diatom assemblage environmental heterogeneity productivity

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Butyrate metabolism in rumen epithelium affected by host and diet regime through regulating microbiota in a goat model

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Animal Nutrition 2024年第4期19卷 41-55页

作者： Yimin Zhuang Mahmoud M.Abdelsattar Yuze Fu Naifeng Zhang Jianmin Chai Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding College of Life Science and EngineeringFoshan UniversityFoshan 528225China Key Laboratory of Feed Biotechnology of the Ministry of Agriculture and Rural Affairs Institute of Feed Research of Chinese Academy of Agricultural SciencesBeijing 100081China State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China Division of Agriculture Department of Animal ScienceUniversity of ArkansasFayettevilleAR 72701USA

The rumen is an important organ that enables ruminants to digest nutrients. However, the biological mechanism by which the microbiota and its derived fatty acids regulate rumen development is still unclear. In this study, 18 female Haimen goats were selected and slaughtered at d 30, 60, and 90 of ***-omics analyses(rumen microbial sequencing, host transcriptome sequencing, and rumen epithelial metabolomics) were performed to investigate host-microbe interactions from preweaning to postweaning in a goat model. With increasing age, and after the introduction of solid feed, the increased abundances of Prevotella and Roseburia showed positive correlations with volatile fatty acid(VFA) levels and morphological parameters(P < 0.05). Epithelial transcriptomic analysis showed that the expression levels of hub genes, including 3-hydroxy-3-methylglutaryl-CoA synthase isoform 2(HMGCS2), enoyl-CoA hydratase, short chain 1(ECHS1), and peroxisome proliferator activated receptor gamma(PPARG), were positively associated with animal phenotype(P < 0.05). These hub genes were mainly correlated to VFA metabolism, oxidative phosphorylation, and the mammalian target of rapamycin(mTOR) and peroxisome proliferator activated receptor(PPAR) signaling pathways(P < 0.05). Moreover, the primary metabolites in the epithelium changed from glucose preweaning to(R)-3-hydroxybutyric acid(BHBA) and acetoacetic acid(ACAC) postweaning(P < 0.05). Diet and butyrate were the major factors shaping epithelial metabolomics in young ruminants(P < 0.05). Multi-omics analysis showed that the rumen microbiota and VFA were mainly associated with the epithelial transcriptome, and that alterations in gene expression influenced host metabolism. The “butanoate metabolism” pathway, which transcriptomic and metabolomic analyses identified as being upregulated with age, produces ketones that regulate the “oxidative phosphorylation” pathway, which could provide energy for the development of rumen papillae. Our find

关键词： Rumen microbiota Rumen epithelial development Multi-omics Host-microbe interaction

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