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Optoelectronic-Coupled-Driven Microrobot for Biological Cargo Transport in Conductive Isosmotic Glucose Solution

ACS Applied Materials and Interfaces 2025年第19期17卷 28425-28435页

作者： Zhuang, Rencheng Chang, Xiaocong Sha, Jinrui Yu, Zehao Shi, Enbo Lu, Minqiao Liu, Junmin Zhang, Guangyu Zhou, Dekai Li, Longqiu State Key Laboratory of Robotics and System Harbin Institute of Technology Heilongjiang Harbin150001 China Chongqing Research Institute Harbin Institute of Technology Chongqing400722 China Zhengzhou Research Institute Harbin Institute of Technology Zhengzhou450000 China School of Life Science and Technology Harbin Institute of Technology Heilongjiang Harbin150001 China

Electric field-driven micro/nanorobots, as micro/nanodevices with autonomous motion capability, have emerged as promising candidates for targeted cargo delivery in biomedical applications due to their advantages of label-free operation, selectivity, and controllability. In biological systems, many biological cargos need to be operated in conductive isosmotic solutions to ensure their viability. However, in the conductive solution, electric field-driven micro/nanorobots exhibit significantly reduced propulsion performance, despite retaining the capability to manipulate cargos by the dielectrophoretic force. This limitation restricts the wider applicability of electric field-driven micro/nanorobots in biomedical fields. This paper presents a novel optoelectronic-coupled-driven α-Fe2O3@aTiO2/Au microrobot, which exhibits significantly improved mobility and enables biological cargo transportation in the conductive isosmotic glucose solution. Benefiting from the flowerlike surface structure and composite photocatalytic material, the proposed microrobot exhibits enhanced photocatalytic capability, enabling efficient propulsion in glucose solution under light irradiation. In addition, the motion behavior of the microrobot under light, electric, and optoelectronic-coupled fields is investigated. It is found that the speed of the microrobot could exceed 300 μm/s under coupled fields, which is more than ten times faster than that of previously reported electric field-driven micro/nanorobots. Due to the magnetic property, the proposed microrobot can be precisely navigated under the guidance of an external uniform magnetic field. Furthermore, the proposed microrobot can achieve the transportation of various biological cargos in a conductive isosmotic glucose solution. The proposed microrobot opens a new avenue for targeted delivery and holds great potential for applications in the biological and pharmaceutical fields. © 2025 American Chemical Society.

关键词： Medical nanotechnology

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Optimized inner ear organoids for efficient hair cell generation and ototoxicity response modeling

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science China life sciences 2025年第5期68卷 1369-1383页

作者： Xuanhe Qin Liping Fu Chunying Li Xilin Tan Xiaolei Yin Institute for Regenerative Medicine State Key Laboratory of Cardiology and Medical Innovation CenterShanghai East HospitalFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji University

Hair cells in the mammalian cochlea are highly vulnerable to damage from drug toxicity, noise exposure, aging, and genetic mutations, with no capacity for regeneration. Progress in hair cell protection research has been limited by the scarcity of cochlear tissue and suitable in vitro models. Here, we present a novel one-step, self-organizing inner ear organoid system optimized with small molecules, which bypasses the need for multi-step expansion and forced differentiation protocols. This approach efficiently generates hair cells and supporting cells that recapitulate the molecular, cellular, and structural characteristics of the inner ear. Single-cell RNA sequencing revealed the diversity and fidelity of cell populations within the organoids. Utilizing this platform, we validated the protective effects of candidate compounds against hair cell damage, highlighting its potential as a powerful tool for drug discovery and mechanistic studies of hair cell protection.

关键词： inner ear organoid hair cell protection ototoxic drugs

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Tuning intramolecular dipole interactions in dinuclear single-molecule magnetic complexes of Er(Ⅲ) with monosubstituted cyclooctatetraenide ligands

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Journal of Rare Earths 2025年第6期43卷 1213-1219页

作者： Chen, Qiwei Ding, Yousong Zhu, Xiaofei Wang, Bingwu Zheng, Zhiping School of Chemistry and Life Science Changchun University of Technology Changchun130012 China Department of Chemistry Southern University of Science and Technology Shenzhen518055 China Beijing National Laboratory for Molecular Sciences College of Chemistry and Molecular Engineering Peking University Beijing100871 China Key University Laboratory of Rare Earth Chemistry of Guangdong Southern University of Science and Technology Shenzhen518055 China

Manipulating magnetic couplings in molecular magnets is of great importance in improving the magnetic properties of such materials. It has been proved that by adjusting the strength of magnetic couplings and the arrangement of the intermolecular magnetic dipoles, magnetic blocking can be significantly enhanced. Herein manipulating the intramolecular dipole interactions by ligand modification was attempted with the use of three closely related dinuclear Er(Ⅲ) complexes of a common chemical formula of [(COTR)Er(μ-Cl) (THF)]2 (COTR is monosubstituted cyclooctatetraenide dianions with R = diphenylmethylsilyl (Ph2MeS) for 1, triethylsilyl (TES) for 2, and triisopropylsilyl (TIPS) for 3). Each of these complexes features a centrosymmetric dinuclear core unit with their component Er(III) ions doubly bridged by two chloro ligands and further coordinated with a capping substituted COTR ligand and a coordinated THF molecule. Magnetic studies reveal that the complexes display similar ferromagnetic couplings with comparable single-molecule magnetic behaviors. The ferromagnetic couplings dominated by the intramolecular dipole interactions are found to be 0.7614, 0.7380, and 0.5635 cm−1 for 1, 2, and 3, respectively. The angles (θ) between the magnetic easy axes and the intramolecular Er–Er lines are 24.88(2)°, 25.23(1)°, and 31.85(5)°, leading to transversal dipole fields of 0.0114, 0.0113, and 0.0125 T for 1, 2, and 3, respectively. Although the different ligand substitution generates a sizable difference of about 7° in the θ angle, the resulting difference in the dipole interactions is not sufficiently strong to cause any significant differences in their magnetic properties. Further change in the θ angles to the "side-by-side" (θ = 90°) or "head-to-tail" (θ = 0°) arrangement of the magnetic easy axes, achievable by rational molecular design, is expected to lead to molecular magnetic materials with much enhanced properties. © 2024 Chinese Society of Rare Earths

关键词： Ligands

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Modulation of cell proliferation and differentiation on implantable biomaterials using femtosecond laser micro/nano-patterning technology

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Journal of Manufacturing Processes 2025年 146卷 225-235页

作者： Xu, Jiayi Jiang, Chengao Wang, Lizhong Chen, Tian Shi, Yan Ye, Fuqiang Guo, Bingxu Rui, Pan Wang, Xiayan Chen, Shujun College of Mechanical and Energy Engineering Beijing University of Technology Beijing100124 China State Key Laboratory of Materials Processing and Die & Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology Wuhan430074 China School of Materials Science and Engineering Tsinghua University Beijing100084 China College of Chemistry and Life Science Beijing University of Technology Beijing100124 China

Achieving efficient bone regeneration and robust osseointegration stands as the fundamental pursuit in the design of orthopedic implants. To address this need, the surface morphological design of biomaterial is proposed to improve cell-material interaction. This study investigated the behavioral responses of MC3T3-E1 cells to nano-textured micropatterns produced by femtosecond laser texturing treatment on TC4 alloy. It was demonstrated that laser micro/nano-patterning treatment not only did not attenuate the cytocompatibility and surface mechanical stability of the substrate, but also effectively improved the cell adhesion and proliferation due to the increased physical anchoring sites. To further investigate the regulatory mechanism, microgrooves, micropillars and labyrinth patterns with identical characteristic sizes and nano-textures were produced. It was found that cell proliferation behavior was closely related to the enhancement of surface energy/wettability dominated by nanoscale roughness and insensitive to the micrometer-scale topography of the substrate. However, cell osteogenic differentiation was influenced by the cell growth morphology on different surface micropatterns. The more severe the cell nucleus deformation, i.e., the smaller the axial ratio of the cellular nucleus, the stronger the osteogenic differentiation properties of the cells on the corresponding surface. This work provides experimental guidance and experience in the design and selection of surface morphology for orthopedic implants, contributing to their widespread application. © 2025 The Society of Manufacturing Engineers

关键词： Cell proliferation

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Monocular meta-imaging camera sees depth

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Light(science & Applications) 2025年第1期14卷 8-9页

作者： Yujin Liu Xueli Chen nnovation Center for Advanced Medical Imaging and Intelligent Medicine Guangzhou Institute of TechnologyXidian UniversityGuangzhou510555GuangdongChina Center for Biomedical-photonics and Molecular Imaging Advanced Diagnostic-Therapy Technology and Equipment Key Laboratory of Higher Education Institutions in Shaanxi ProvinceSchool of Life Science and TechnologyXidian UniversityXi’an710126ShaanxiChina Engineering Research Center of Molecular and Neuro Imaging Ministry of Education&Xi’an Key Laboratory of Intelligent Sensing and Regulation of trans-Scale Life InformationSchool of Life Science and TechnologyXidian UniversityXi’an710126ShaanxiChina

A novel monocular depth-sensing camera based on meta-imaging sensor technology has been developed,offering more precise depth sensing with millimeter-level accuracy and enhanced robustness compared to conventional 2D ... 详细信息

关键词： offering precise millimeter

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WF-A2D: Enhancing Privacy with Asymmetric Adversarial Defense Against Website Fingerprinting

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IEEE Transactions on Information Forensics and Security 2025年 20卷 4739-4754页

作者： Huang, Jianan Liu, Weiwei Liu, Guangjie Gao, Bo Nie, Fengyuan Nanjing University of Science and Technology School of Automation Nanjing210094 China Nanjing University of Information Science and Technology School of Electronics and Information Engineering Nanjing210044 China Key Laboratory of Intelligent Support Technology for Complex Environments Ministry of Education Nanjing210044 China

Despite the end-to-end encryption capabilities provided by network protocols such as QUIC in HTTP/3 and the additional tunneling functions offered by proxy tools like virtual private networks (VPNs) and the onion router (Tor), website fingerprinting (WF) techniques can still identify specific network services by exploiting the spatio-temporal characteristics of network traffic. Therefore, defending against WF attacks is crucial for ensuring comprehensive privacy protection for network services. Existing WF defenses typically rely on proxy-based solutions that require coordinated packet manipulations between the client and the proxy node to counteract WF attacks. These symmetric architectures cannot protect network traffic between proxy nodes and web servers from WF attacks. Furthermore, the ability to counter more powerful traffic analysis tools remains a challenging issue. In this paper, we propose WF-A2D, an asymmetric adversarial defense method against website fingerprinting for HTTP/3. WF-A2D employs a two-stage cascading adversarial learning strategy, leveraging packet direction and length patterns to enhance defense performance. Position-based perturbation vectors representing packet operations are generated for packet-by-packet manipulations to achieve real-time WF defense. Experimental results on a real-world HTTP/3-QUIC website browsing traffic dataset demonstrate that WF-A2D can achieve a defense success rate of 97.10% on average against seven state-of-the-art traffic analysis tools, while incurring less than 2% bandwidth overhead. More importantly, WF-A2D can operate independently on the client side and ensure end-to-end protection to web servers. © 2005-2012 IEEE.

关键词： HTTP

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Rich{100}faceted Pt Ir W nanocubes with high-filling bonding orbitals of NH_(2)dimerization for enhancing electrochemical ammonia oxidation

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Journal of Energy Chemistry 2025年第4期103卷 361-370页

作者： Xiaoting Huang Jiawang Li Huanzheng Yang Tao Zhou Yuanyan Luo Shui Yu Jia Liu Pei Kang Shen Luwei Chen Zhi Qun Tian Collaborative Innovation Center of Sustainable Energy Materials School of Physical Science and TechnologyGuangxi UniversityGuangxi Key Laboratory of Electrochemical Energy MaterialsState Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite StructuresNanning 530004GuangxiChina Institute of Sustainability for Chemicals Energy and Environment(ISCE2)Agency for ScienceTechnology and Research(A*STAR)1 Pesek RoadJurong IslandSingapore 627833Singapore

Efficiently utilizing ammonia(carbon-free fuel)via low-temperature fuel cells is severely hindered by the sluggish kinetics of ammonia oxidation reaction(AOR).Herein,platinum-iridium-tungsten nanocubes(PtIrW-NCBs)with exposed{100}-rich facets were synthesized by a glucose-assisted solvent-thermal method,in which alloying W not only can facilitate the formation of such specific nanostructures to expose more active sites for AOR,but also modulate the electronic structure of PtIr to promote the kinetics of *** PtIrW-NCBs featuring the small nanoparticle size of 5.05±0.07 nm exhibit superior AOR performance,wherein the onset potential is down to 0.319 V and the mass activity is 30.15 A g_((PGM=Pt,Ir))^(-1)at 0.50 V ***,significantly higher than those of reported majority of AOR catalysts and even commercial PtIr/***,in situ Fourier transform infrared spectroscopy measurement further reveals that AOR on PtIrW-NCBs dominantly undergoes the dimerization path of NH_(x)(1≤x≤2).In addition,the theoretical calculations also identify that alloying W into PtIr can contribute additional electrons to 5d orbitals of PtIr,enabling the d-band center approaching the Femi level,which in turn induces the high-filling of bonding orbitals of N-N bond in^(*)N_(2)H_(4),promoting the dimerization of^(*)NH_(2)to^(*)N_(2)H_(4)and thus leading to high AOR activity of *** work provides new insights for designing efficient AOR electrocatalysts.

关键词： Ammonia oxidation reaction Fuel cell PtIrW Nanocubes

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Data driven multi-objective optimization of sustainable aviation emergency network for forest fire rescue

Sustainable Operations and Computers

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Sustainable Operations and Computers 2025年 6卷 116-129页

作者： Huang, Jun Zhao, Qiuhong School of Economics and Management Beihang University Beijing100191 China Beijing Key Laboratory of Emergency Support Simulation Technologies for City Operations Beijing100191 China Beijing International Science and Technology Cooperation Base for City Safety Operation and Emergency Support Beijing100191 China

Forest fires occur abruptly and can be detrimental, posing significant threats to human safety, forest resources, and the overall environment. Timely detection and effective response are important to fight against forest fires. Aviation emergency rescue plays an increasingly important role in forest fire response due to the characteristics of fast response speed, low terrain requirements and less fire site restrictions. At present, forest fire aviation emergency has been paid more attention in the world, however, current researches provide limited support to actual situation due to the lack of systematization and pertinently. In this paper, based on remote sensing information and other multi-party data, a two-stage multi-objective stochastic optimization model of sustainable aviation emergency network for forest fire rescue is presented. The proposed model aims to minimize the maximum of effective operational distance for aerial emergency rescue efforts and the total cost, which includes ecological losses caused by forest fires. To solve the model, an algorithm incorporating the NSGA-II algorithm and SAA method is proposed. Further, a case of Hainan Province in China is studied, guiding the application of the proposed theoretical methods. The findings demonstrate considerable value in addressing forest fires and safeguarding forest resources, thereby contributing to the sustainable development of both the environment and society. © 2025

关键词： Multiobjective optimization

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Continuously adjustable mechanical metamaterial based on planetary gear trains and external meshing gears

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Applied Mathematics and Mechanics(English Edition) 2025年第2期46卷 233-252页

作者： Shuai MO Xu TANG Keren CHEN H.HOUJOH Wei ZHANG State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures School of Mechanical EngineeringGuangxi UniversityNanning 530004China State Key Laboratory of Precision Manufacturing for Extreme Service Performance Central South UniversityChangsha 410083China State Key Laboratory of Digital Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074China Precision and Intelligence Laboratory Tokyo Institute of TechnologyYokohama 226-8503Japan

The metamaterial based on external meshing gears(MEG)is designed based on the principle of external meshing gear *** on the meshing transmission principle of external meshing gears and planetary gear trains,the internal and external gear rings are *** on the internal and external gear rings,the metamaterial based on inner and outer planetary gear trains(MIP)is designed to study the shear modulus,Young's modulus,and amplitude-frequency characteristics of the metamaterial based on gears at different *** effects of the number of planetary gears on the physical characteristics of the MIP are *** results show that the MEG can be continuously adjusted by adjusting the shear modulus and Young's modulus due to its meshing *** the same number of gears,the adjustment range of the MIP is larger than the adjustment range of the *** the number of planetary gears increases,the adjustment range of the MIP ***,when the metamaterial based on gears rotates,the harmonic response changes with the change of the angle.

关键词： metamaterial adjustable external inner and outer planetary gear train

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Research on the impact of scanning error and interferogram noise on algorithm accuracy in coherent scanning interferometry 10

Research on the impact of scanning error and interferogram n...

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10th Symposium on Novel Optoelectronic Detection technology and Applications

作者： Chen, Weiwei Chen, Shanyong Xiong, Yupeng Liu, Junfeng College of Intelligence Science and Technology National University of Defense Technology Changsha410073 China National Key Laboratory of Equipment State Sensing and Smart Support National University of Defense Technology Changsha410073 China Hunan Key Laboratory of Ultra-Precision Machining Technology Changsha410073 China

ISBN: (数字)9781510688155

ISBN: (纸本)9781510688148

The current research on coherent scanning interferometry (CSI) shows that many factors have a negative impact on measurement accuracy. The collection and transmission of interferograms are easily influenced by the material properties of the image sensor, working environment, electronic components, and circuit structure, which makes the gray distribution of interferograms uneven. In addition, the intrinsic error of piezoelectric ceramic (PZT), environmental vibration, air and temperature fluctuation, and other external interference factors will also affect the accuracy and stability of PZT scanning. The above factors are complex and interact with each other, which together cause the non-ideal interference signal in the actual measurement process. The influence of the factors mentioned above on the measurement is manifested as the influence on the interference signal in the topography reconstruction, which can be finally defined as the interferogram noise and the PZT scanning error. Based on the analysis of the influence of PZT scanning error and interferogram noise on the measurement accuracy and performance of commonly used three-dimensional topography reconstruction algorithms, this paper explores the algorithms with strong anti-interference ability in practical application. © 2025 SPIE.

关键词： Piezoelectric materials

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