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Zoological Research 2024年第4期45卷 821-830页

作者： Jing Zhang Yafei Chang Peng Zhang Yanqi Zhang Mengke Wei Chenyang Han Shun Wang Hui-Meng Lu Tiantian Cai Can Xie High Magnetic Field Laboratory Hefei Institutes of Physical ScienceChinese Academy of SciencesScience IslandHefeiAnhui 230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefeiAnhui 230036China Institutes of Physical Science and Information Technology Anhui UniversityHefeiAnhui 230039China School of Life Sciences Key Laboratory for Space Bioscience and BiotechnologyNorthwestern Polytechnical UniversityXi’anShaanxi 710072China Institute of Quantum Sensing Zhejiang UniversityHangzhouZhejiang 310027China

Magnetic sense,or termed magnetoreception,has evolved in a broad range of taxa within the animal kingdom to facilitate orientation and ***,highly conserved A-type iron-sulfur proteins,are widely distributed across all phyla and play essential roles in both magnetoreception and iron-sulfur cluster ***,the evolutionary origins and functional diversification of MagRs from their prokaryotic ancestor remain *** this study,MagR sequences from 131 species,ranging from bacteria to humans,were selected for analysis,with 23 representative sequences covering species from prokaryotes to Mollusca,Arthropoda,Osteichthyes,Reptilia,Aves,and mammals chosen for protein expression and *** studies revealed a gradual increase in total iron content in MagRs during *** types of MagRs were identified,each with distinct iron and/or iron-sulfur cluster binding capacity and protein stability,indicating continuous expansion of the functional roles of MagRs during speciation and *** evolutionary biochemical study provides valuable insights into how evolution shapes the physical and chemical properties of biological molecules such as MagRs and how these properties influence the evolutionary trajectories of MagRs.

关键词： Magnetoreception Magnetoreceptor(MagR) Iron-sulfur cluster Stability Evolutionary biochemistry

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Molecular architecture of mammalian pyruvate dehydrogenase complex

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Protein & Cell 2025年第1期16卷 72-78页

作者： Maofei Chen Yutong Song Sensen Zhang Yitang Zhang Xudong Chen Minghui Zhang Meng Han Xin Gao Sai Li Maojun Yang Tsinghua-Peking Center for Life Sciences Beijing Frontier Research Center for Biological StructureSchool of Life SciencesTsinghua UniversityBeijing 100084China Ministry of Education Key Laboratory of Protein Science Tsinghua UniversityBeijing 100084China State Key Laboratory of Membrane Biology Tsinghua UniversityBeijing 100084China Department of Biochemistry and Molecular Biology School of Basic Medical SciencesShenzhen University Health Science CenterShenzhen 518060China Protein Research Technology Center Protein Chemistry and Omics PlatformSchool of Life SciencesTsinghua UniversityBeijing 100084China Computer Science Program ComputerElectrical and Mathematical Sciences and Engineering DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Kingdom of Saudi Arabia Computational Bioscience Research Center King Abdullah University of Science and TechnologyThuwal 23955-6900Kingdom of Saudi Arabia Cryo-EM Facility Center Southern University of Science and TechnologyShenzhen 518055China Beijing Life Science Academy Beijing 102209China

Dear Editor,Pyruvate dehydrogenase complex(PDHc) is a large multienzyme assembly(Mr = 4–10 million Daltons) consisting of three essential components: pyruvate dehydrogenase(E1p), dihydrolipoyl transacetylase(E2p), and dihydrolipoyl dehydrogenase(E3). These three enzymes perform distinct functions sequentially to catalyze the oxidative decarboxylation of pyruvate with formation of nicotinamide adenine dinucleotide(NADH) and acetyl-coenzyme A(Patel and Roche, 1990).

关键词： sequentially oxidative Dalton

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Direct detection of a single[4Fe-4S]cluster in a tungsten-containing enzyme:Electrochemical conversion of CO_(2) into formate by formate dehydrogenase

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Carbon Energy 2023年第5期5卷 152-164页

作者： Wenjin Li Yanxin Gao Xuan Sun Lei Wan Haishuo Ji Hang Luo Yao Tian Hao Song Geng Wu Liyun Zhang State Key Laboratory of Medicinal Chemical Biology College of Life ScienceNankai UniversityTianjinPeople's Republic of China State Key Laboratory of Microbial Metabolism The Joint International Research Laboratory of Metabolic&Developmental SciencesSchool of Life Science and BiotechnologyShanghai Jiao Tong UniversityShanghaiPeople's Republic of China Max Planck Institute for Chemical Energy Conversion Mülheim an der RuhrGermany Frontier Science Center for Synthetic Biology Key Laboratory of Systems BioengineeringSchool of Chemical Engineering and TechnologyTianjin UniversityTianjinPeople's Republic of China

The conversion of CO_(2) into fuels and valuable chemicals is one of the central topics to combat climate change and meet the growing demand for renewable ***,we show that the formate dehydrogenase from Clostridium ljungdahlii(ClFDH)adsorbed on electrodes displays clear characteristic voltammetric signals that can be assigned to the reduction and oxidation potential of the[4Fe-4S]^(2+/+)cluster under nonturnover *** adding substrates,the signals transform into a specific redox center that engages in catalytic electron *** catalyzes rapid and efficient reversible interconversion between CO_(2) and formate in the presence of *** turnover frequency of electrochemical CO_(2) reduction is determined as 1210 s^(-1) at 25℃ and pH 7.0,which can be further enhanced up to 1786 s^(-1) at 50℃.The Faradaic efficiency at−0.6 V(*** hydrogen electrode)is recorded as 99.3%in a 2-h *** experiments and theoretical modeling disclose interesting pathways for CO_(2) entry,formate exit,and OCN−competition,suggesting an oxidation-state-dependent binding mechanism of *** results provide a different perspective for understanding the catalytic mechanism of FDH and original insights into the design of synthetic catalysts.

关键词： bioelectrocatalysis biofuel CO_(2)conversion formate dehydrogenase iron-sulfur cluster

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Safety is increasingly important in cobweb spiders based on life history

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Integrative Zoology 2023年第4期18卷 736-745页

作者： Haixin ZHANG Rui ZHONG Long YU Jian CHEN Ingi AGNARSSON Jie LIU State Key Laboratory of Biocatalysis and Enzyme Engineering&Centre for Behavioural Ecology&Evolution School of Life SciencesHubei UniversityWuhanChina Faculty of Resources and Environmental Science Hubei UniversityWuhanChina School of Nuclear Technology and Chemistry&Biology Hubei University of Science and TechnologyXianningChina Faculty of Life and Environmental Sciences University of IcelandReykjavikIceland

Detritus-based,bell-shaped cobwebs are an ideal model to research the plasticity of web architecture due to clearly separate defense and foraging *** performed a thoroughﬁeld investigation on the web architectures of Campanicola campanulata to research its cobweb architecture variation during the growth process and analyzed the energy trade-offs between foraging and defense at different developmental *** results indicated that as female *** grew,they dedicated more energy to defense and less energy to foraging,while males dedicated less energy to both defense and foraging through the growth *** hypothesize that cobweb spiders dedicate an increasing amount of energy to safety based on evidence obtained from their ***,we present a new model to investigate web architecture variation and provide a new framework to quantify the energy allocation between foraging and predator defense for web-building spiders.

关键词： Campanicola campanulata detritus-based bell-shaped retreat life-history theory trade-off

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Purple acid phosphatase promoted hydrolysis of organophosphate pesticides in microalgae

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Environmental science and Ecotechnology 2024年第2期18卷 137-149页

作者： Xiang Wang Guo-Hui He Zhen-Yao Wang Hui-Ying Xu Jin-Hua Mou Zi-Hao Qin Carol Sze Ki Lin Wei-Dong Yang Yalei Zhang Hong-Ye Li Key Laboratory of Eutrophication and Red Tide Prevention of Guangdong Higher Education Institutes College of Life Science and TechnologyJinan UniversityGuangzhou510632China School of Energy and Environment City University of Hong KongTat Chee AvenueKowloonHong Kong Centre for Technology in Water and Wastewater School of Civil and Environmental EngineeringUniversity of Technology SydneyUltimoNSW2007Australia Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou510000China State Key Laboratory of Pollution Control and Resources Reuse College of Environmental Science and EngineeringTongji UniversityShanghai200092China

When organophosphate pesticides(OPs)are not used and handled in accordance with the current rules and standards,it results in serious threats to the aquatic environment and human *** tricornutum is a prospective microalgae-based system for pollutant removal and carbon *** engineered ***,designated as the OE line(endogenously expressing purple acid phosphatase 1[PAP1]),can utilize organic phosphorus for cellular ***,the competencies and mechanisms of the microalgae-based system(namely the OE line of ***)for metabolizing OPs remain to be *** this study,the OE line exhibited the effective biodegradation competencies of 72.12%and 68.2%for 30 mg L^(-1)of dichlorvos and 50 mg L^(-1)of glyphosate,accompanied by synergistic accumulations of biomass(0.91 and 0.95 g L^(-1))and lipids(32.71%and 32.08%),***,the biodiesel properties of the lipids from the OE line manifested a high potential as an alternative feedstock for microalgae-based biofuel production.A plausible mechanism of OPs biodegraded by overexpressed PAP1 is that sufficient inorganic P for adenosine triphosphate and concurrent carbon flux for the reduced form of nicotinamide adenine dinucleotide phosphate biosynthesis,which improved the OP tolerance and biodegradation competencies by regulating the antioxidant system,delaying programmed cell death and accumulating lipids via the upregulation of related *** sum up,this study demonstrates a potential strategy using a genetically engineered strain of *** to remove high concentrations of OPs with the simultaneous production of biomass and biofuels,which might provide novel insights for microalgae-based pollutant biodegradation.

关键词： Biodegradation Lipid accumulation Organophosphate pesticide Phaeodactylum tricornutum Purple acid phosphatase

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DUSP2 deletion with CRISPR/Cas9 promotes Mauthner cell axonal regeneration at the early stage of zebrafish

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Neural Regeneration Research 2023年第3期18卷 577-581页

作者： Guo-Jian Shao Xin-Liang Wang Mei-Li Wei Da-Long Ren Bing Hu School of Life Sciences Division of Biomedical SciencesUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Local Livestock and Poultry Genetic Resource Conservation and Bio-Breeding College of Animal Science and TechnologyAnhui Agricultural UniversityHefeiAnhui ProvinceChina

Axon regeneration of central neurons is a complex process that is tightly regulated by multiple extrinsic and intrinsic *** expression levels of distinct genes are changed after central neural system(CNS)injury and affect axon regeneration.A previous study identified dusp2 as an upregulated gene in zebrafish with spinal cord ***,we found that dual specificity phosphatase 2(DUSP2)is a negative regulator of axon regeneration of the Mauthner cell(M-cell).DUSP2 is a phosphatase that mediates the dephosphorylation of *** this study,we knocked out dusp2 by CRISPR/Cas9 and found that M-cell axons of dusp2(-/-)zebrafish had a better regeneration at the early stage after birth(within 8 days after birth),while those of dusp2^(+/-)zebrafish did *** of DUSP2 in Tg(Tol 056)zebrafish by single-cell electroporation retarded the regeneration of M-cell *** blotting results showed that DUSP2 knockout slightly increased the levels of phosphorylated *** findings suggest that knocking out DUSP2 promoted the regeneration of zebrafish M-cell axons,possibly through enhancing JNK phosphorylation.

关键词： axon regeneration central nervous system CRISPR/Cas9 DUSP2 JNK Mauthner cell single-cell electroporation spinal cord injury two-photon axotomy zebrafish

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Influence of non-iso-velocity casting on flow-field index of a 41-ton six-strand Tundish by physical and numerical modeling

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Journal of Iron and Steel Research International 2023年第1期30卷 51-63页

作者： Hang-hang Zhu Min Wang Cheng Yao Zhong-liang Wang Xiao-liang Wang Yan-ping Bao State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China Technical Support Center for Prevention and Control of Disastrous Accidents in Metal Smelting Beijing 100083China Fengbao Special Steel Co. Ltd.Linzhou 456552HenanChina

The flow-field index in a 41-ton six-strand tundish is considered through adjusting the ratio of the casting velocity between the strands to eliminate the negative impact of iso-velocity casting in multi-strand tundish on the consistency of each strand due to the large ratio of length to width with narrow shape structure,resulting in poor consistency of each *** particular,the response time of strand-1 and strand-6 is relatively long,which affects the uniformity of the temperature field and flow field of the entire *** the basis of verifying that the error between the numerical simulations and hydraulic experiments is less than 6%,six cases with the casting velocity ratio changing from 0.8 to 1.3(with an interval of 0.1)are considered by calculation of numerical *** is concluded that the consistency of each flow can be obviously improved by increasing the casting velocity ratio between side-strand and *** increasing the casting velocity ratio,the flow field in the tundish became much active,the temperature field presented well uniformity,and the tracer concentration distribution in local dead zones was improved.

关键词： Six-strand tundish Non-iso-velocity casting Casting velocity ratio Residence time distribution curve Tracer concentration

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Aptamers targeting SARS-CoV-2 nucleocapsid protein exhibit potential ant1ip1 an-coronavirus activity

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1186-1198页

作者： Minghui Yang Chunhui Li Guoguo Ye Chenguang Shen Huiping Shi Liping Zhong Yuxin Tian Mengyuan Zhao Pengfei Wu Abid Hussain Tian Zhang Haiyin Yang Jun Yang Yuhua Weng Xinyue Liu Zhimin Wang Lu Gan Qianyu Zhang Yingxia Liu Ge Yang Yuanyu Huang Yongxiang Zhao School of Life Science Advanced Research Institute of Multidisciplinary ScienceKey Laboratory of Molecular Medicine and BiotherapyBeijing Institute of TechnologyBeijing 100081China National Clinical Research Center for infectious disease Shenzhen Third People’s HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518112China Guangdong Provincial Key Laboratory of Tropical Disease Research School of Public HealthSouthern Medical UniversityGuangzhou 510515China State Key Laboratory of Targeting Oncology National Center for International Research of Biotargeting TheranosticsGuangxi Key Laboratory of Biotargeting TheranosticsCollaborative Innovation Center for Targeting Tumor Diagnosis and TherapyGuangxi Medical UniversityNanning 530021China CAMS Key Laboratory of Antiviral Drug Research Beijing Key Laboratory of Antimicrobial AgentsInstitute of Medicinal BiotechnologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Emerging and recurrent infectious diseases caused by human coronaviruses(HCoVs)continue to pose a significant threat to global public health *** light of this ongoing threat,the development of a broad-spectrum drug to combat HCoVs is an urgently ***,we report a series of anti-pan-coronavirus ssDNA aptamers screened using Systematic Evolution of Ligands by Exponential Enrichment(SELEX).These aptamers have nanomolar affinity with the nucleocapsid protein(NP)of Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and also show excellent binding efficiency to the N proteins of both SARS,MERS,HCoV-OC43 and-NL63 with affinity KD values of 1.31 to 135.36 *** aptamer-based therapeutics exhibited potent antiviral activity against both the authentic SARS-CoV-2 prototype strain and the Omicron variant(BA.5)with EC50 values at 2.00 nM and 41.08 nM,*** protein docking analysis also evidenced that these aptamers exhibit strong affinities for N proteins of pan-coronavirus and other HCoVs(−229E and-HKU1).In conclusion,we have identified six aptamers with a high pan-coronavirus antiviral activity,which could potentially serve as an effective strategy for preventing infections by unknown coronaviruses and addressing the ongoing global health threat.

关键词： acute threat conclusion

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Influence Mechanism of Surface Shape Accuracy and Surface Quality in Ultra-precision Grinding 2

Influence Mechanism of Surface Shape Accuracy and Surface Qu...

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Advanced Optical Manufacturing Technologies and Applications 2022, AOMTA 2022 and 2nd International Forum of Young Scientists on Advanced Optical Manufacturing, YSAOM 2022

作者： Bao, Jiahui Peng, Xiaoqiang Hu, Hao College of Intelligence Science and Technology National University of Defense Technology 109 Deya Road Changsha410073 China Hunan Key Laboratory of Ultra-Precision Machining Technology Changsha410073 China Laboratory of Science and Technology on Integrated Logistics Support National University of Defense Technology 109 Deya Road Changsha410073 China

ISBN: (纸本)9781510661264

The improvement of surface shape accuracy and surface quality is an important aspect of ultra-precision grinding. In this paper, experiments were carried out by using a four-axis ultra-precision grinder to analyze the influence mechanism of grating machining and polar axis machining on surface shape accuracy and surface quality, and to clarify the advantages and disadvantages of the two machining processes. In the process of polar axis machining, the influence of polishing on the surface shape accuracy is analyzed, and the influence of different feed modes and x direction offset on the surface shape accuracy is clarified. By establishing the influence model of the error source on the surface shape accuracy, the error factors of the tool alignment were analyzed emphatically. Through numerical calculation and analysis of the specific form of tool alignment error, a reasonable grinding wheel center alignment scheme was put forward. The wear law of grinding wheel was analyzed through process test, and a reasonable dressing method of grinding wheel was put forward. © 2023 SPIE.

关键词： Surface properties

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Ternary layered boride MoAlB:A novel thermo-regulation microwave absorbing ceramic material

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Journal of Advanced Ceramics 2024年第5期13卷 699-710页

作者： Zhangjue Wang Fan Zhang Nannan Wang Wei Li Yongqiang Chen Hailong Wang Rui Zhang Yanqiu Zhu Bingbing Fan School of Material Science and Engineering Zhengzhou UniversityZhengzhou 450001China Henan Academy of Sciences Zhengzhou 450046China State Key Laboratory of Featured Metal Materials and Life Cycle Safety for Composite Structures MOE Key Laboratory of New Processing Technology for Nonferrous Metals MaterialsSchool of ResourcesEnvironment and MaterialsGuangxi UniversityNanning 530004China Department of Materials and Earth Sciences Technical University of DarmstadtDarmstadt 64287Germany School of Material Science and Engineering Luoyang Institute of Science and TechnologyLuoyang 471023China Department of Engineering Faculty of EnvironmentScience and EconomyUniversity of ExeterExeter EX44QFUK

In the context of the fifth-generation(5G)smart era,the demand for electromagnetic wave(EMW)-absorbing materials has become increasingly prominent,so it is necessary to explore promising candidate *** work focuses on the exploration of the material absorbing properties of a MoAlB MAB(MAB represents a promising group of alternatives,where M stands for a transition metal,A typically denotes Al,and B is boron)phase ***,the first-principles calculations were performed to reveal the unique crystal and layered structure of the MoAlB ceramics and to predict their potential for use as an EMW absorption ***,a series of MoAlB ceramics were synthesized at temperatures ranging from 800 to 1300℃,and the influence of temperature on the phase compositions and microstructures of the obtained MoAlB ceramics was characterized and ***,the practical EMW absorption performance of the prepared MoAlB ceramics was evaluated via a combination of experiments and radar cross-sectional *** MoAlB sample synthesized at 900℃ exhibits superior EMW absorption performance,achieving an impressive minimum reflection loss(RL)of−50.33 *** unique layered structure and good electrical conductivity of the MoAlB samples are the main reasons for their enhanced wave absorption performance,which provides interfacial polarization and multiple dielectric loss ***,this study not only contributes to the understanding of the preparation of MoAlB materials but also provides potential guidance for their utilization in the realm of electromagnetic wave absorption.

关键词： MoAlB electronic band structure electromagnetic wave(EMW)absorption layered ternary boride density of states

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