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Repressor elements provide insights into tissue development and phenotypes in pigs

Zoological Research 2024年第6期45卷 1313-1326页

作者： Yue-Dong Zhang Chao Guo Hang Liu Yun Gao Yongjun Tan Longjian Niu Ligang Wang Lixian Wang David MIrwin Chunhui Hou Zhong-Yin Zhou Ya-Ping Zhang Key Laboratory of Genetic Evolution&Animal Models and Yunnan Key Laboratory of Molecular Biology of Domestic Animals Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China State Key Laboratory for Conservation and Utilization of Bio-resources in Yunnan Yunnan UniversityKunmingYunnan 650091China School of Life Science Yunnan UniversityKunmingYunnan 650091China School of Life Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230026China State Key Laboratory of Hybrid Rice Hunan Hybrid Rice Research CenterHunan Academy of Agricultural SciencesChangshaHunan 410125China School of Public Health and Emergency Management Southern University of Science and TechnologyShenzhenGuangdong 518055China Shenzhen Key Laboratory of Cardiovascular Health and Precision Medicine Southern University of Science and TechnologyShenzhenGuangdong 518055China Key Laboratory of Farm Animal Genetic Resources and Germplasm Innovation of Ministry of Agriculture Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100081China Department of Laboratory Medicine and Pathobiology University of TorontoToronto M5S 1A8Canada Yunnan Key Laboratory of Biodiversity Information KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnan 650223China

Repressor elements significantly influence economically relevant phenotypes in pigs;however,their precise roles and characteristics are inadequately *** the present study,we employed H3K27me3 profiling,assay for transposase-accessible chromatin with highthroughput sequencing(ATAC-seq),and RNA sequencing(RNA-seq)data across six tissues derived from three embryonic layers to identify and map 2034 super repressor elements(SREs) and 22223 typical repressor elements(TREs) in the pig ***,many repressor elements were conserved across mesodermal and ectodermal *** exhibited tight regulation of their target genes,affecting a limited number of genes within a specific genomic region with pronounced effects,while TREs exerted broader but weaker regulation over a wider range of target ***,in neuronal tissues,genes regulated by repressor elements started to be repressed during the differentiation of stem cells into progenitor ***,analysis showed that many repressor elements exhibited cooperative and additive effects on the modulation of KLF4 *** research provides the first comprehensive map of pig repressor elements,serving as an essential reference for future studies on repressor elements.

关键词： Repressor elements Super repressor elements Silencer Regulatory model Tissue development KLF4 Pig

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Spatial and temporal dynamics of microbial community composition and factors influencing the surface water and sediments of urban rivers

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Journal of Environmental sciences 2023年第2期124卷 187-197页

作者： Hongjie Wang Xingchun Liu Yali Wang Shengqi Zhang Guangming Zhang Yangyang Han Mengxiang Li Ling Liu College of Ecology and Environment Hebei UniversityBaoding 071002China Institute of Life Science and Green Development Hebei UniversityBaoding 071002China Hebei Key Laboratory of Close-to-Nature Restoration Technology of Wetlands Baoding 071002China School of Energy and Environmental Engineering Hebei University of TechnologyTianjin 300130China

The temporal and spatial characteristics of urban river bacterial communities help us understand the feedback mechanism of bacteria to changes in the aquatic *** Fuhe River plays an important role in determining the water ecological environment of Baiyangdian Lake.16S rRNA gene sequencing was used to study the microbial distribution characteristics in the Fuhe River in different *** results showed that some environmental factors of the surface water(ammonia nitrogen(NH_(3)^(-)N),total nitrogen(TN),and total phosphorus(TP))were different on the spatial and temporal ***,there were no seasonal differences in the contents of TN,TP,total organic carbon(TOC),or heavy metals in the *** distributions of Cyanobacteria,Actinomycetes and Firmicutes in the water and Actinomycetes and Planctomycetes in the sediments differed significantly among seasons(P<0.05).There were significant spatial differences in bacteria in the surface water,with the highest abundance of Proteobacteria recorded in the river along with the highest nutrient concentration,while the abundance of Bacteroidetes was higher in the upstream than the *** communities in the water weremost sensitive to temperature(T)and the TP concentration(P<0.01).Moreover,differences in the bacterial community were better explained by the content of heavy metals in the sediments than by the chemical characteristics.A PICRUStmetabolic inference analysis showed that the effect of high summer temperatures on the enzyme action led to an increase in the abundances of the metabolic-related genes of the river microorganisms.

关键词： Fuhe river Surface water Sediment Bacterial community Spatial and temporal distribution Functional prediction

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The commercial antibiotics with inherent AIE feature: In situ visualization of antibiotic metabolism and specifically differentiation of bacterial species and broad-spectrum therapy

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Bioactive Materials 2023年第5期23卷 223-233页

作者： Bingnan Wang Lirong Wang Haozhong Wu Xiaolin Liu Jiamiao Zhu Rong Hu Dan Ding Anjun Qin Ben Zhong Tang State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Luminescence from Molecular AggregatesSouth China University of TechnologyGuangzhou510640China Center for Aggregation-Induced Emission AIE InstituteSouth China University of TechnologyGuangzhou510640China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhenGuangdong518172China Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration and Reconstruction The Hong Kong University of Science&TechnologyClear Water BayKowloonHong KongChina State Key Laboratory of Medicinal Chemical Biology Frontiers Science Center for Cell ResponsesKey Laboratory of Bioactive MaterialsMinistry of EducationCollege of Life SciencesNankai UniversityTianjin300071China

The research on pharmacology usually focuses on the structure-activity relationships of drugs,such as antibiotics,to enhance their activity,but often ignores their optical ***,investigating the photophysical properties of drugs is of great significance because they could be used to in situ visualize their positions and help us to understand their working *** this work,we identified a class of commercialized antibiotics,such as levofloxacin,norfloxacin,and moxifloxacin(MXF)hydrochloride,featuring the unique aggregation-induced emission(AIE)*** taking advantage of their AIE feature,antibiotic metabolism in cells could be in situ visualized,which clearly shows that the luminescent aggregates accumulate in the ***,after a structure-activity relationship study,we found an ideal site of MXF to be modified with a triphenylphosphonium and an antibiotic derivative MXF-P was prepared,which is able to specifically differentiate bacterial species after only 10 min of ***,MXF-P shows highly effective broad-spectrum antibacterial activity,excellent therapeutic effects and biosafety for ***-infected wound ***,this work not only discovers the multifunctionalities of the antibiotics but also provides a feasible strategy to make the commercialized drugs more powerful.

关键词： Aggregation-induced emission Antibiotics Antibacterial activity In situ visualization

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The alleviation of ammonium toxicity in plants

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Journal of Integrative Plant Biology 2023年第6期65卷 1362-1368页

作者： Chengbin Xiao Yuan Fang Suomin Wang Kai He Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations School of Life SciencesLanzhou UniversityLanzhou 730000China State Key Laboratory of Grassland Agro‐Ecosystems College of Pastoral Agriculture Science and TechnologyLanzhou UniversityLanzhou 730000China

Nitrogen(N)is an essential macronutrient for plants and profoundly affects crop yields and ***(NH4+)and nitrate(NO3-)are major inorganic N forms absorbed by plants from the surrounding ***,NH4+is usually toxic to plants when it serves as the sole or dominant N *** is thus important for plants to coordinate the utilization of NH4+and the alleviation of NH4+*** fully decipher the molecular mechanisms underlying how plants minimize NH4+toxicity may broadly benefit agricultural *** the current minireview,we attempt to discuss recent discoveries in the strategies for mitigating NH4+toxicity in plants,which may provide potential solutions for improving the nitrogen use efficiency(NUE)and stress adaptions in crops.

关键词： alleviation ammonium toxicity channel nitrogen NUE transporter

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Enhanced population of excited single state strategy:Irradiation and ultrasound dual-response and host tumor-driven nanosensitizers construction in triple synergistic therapy

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Nano Research 2024年第6期17卷 5501-5511页

作者： Yaning Li Mengyan Tian Tianyue Yang Jiayu Cao Hongli Chen Jun Guo Pai Liu Yi Liu State Key Laboratory of Separation Membranes and Membrane Processes School of Materials Science and EngineeringTiangong UniversityTianjin 300387China State Key Laboratory of Separation Membranes and Membrane Processes School of ChemistryTiangong UniversityTianjin 300387China State Key Laboratory of Separation Membranes and Membrane Processes School of Life ScienceTiangong UniversityTianjin 300387China State Key Laboratory of Separation Membrane and Membrane Process&Tianjin Key Laboratory of Green Chemical Technology and Process Engineering School of ChemistryTiangong UniversityTianjin 300387China School of Chemical and Environmental Engineering Wuhan Polytechnic UniversityWuhan 430023China Cangzhou Institute of Tiangong University Cangzhou 061000China

Phototheranostics is an emerging field in synergistic antitumor therapy in which irradiation and sensitizers are combined to produce reactive oxygen species(ROS),bio-images,and high *** of these are arrived from the energy of sensitizers,which located in excited single state(S_(1)).Undeniably,the decentralization of the S_(1)population indirectly decreases the effect of each individual *** this study,a strategy was proposed for enhancing the S_(1)population,and a sensitizer with mitochondrial targeting property,1,4-indolyl iodinated pyrrolo[3,2-b]pyrrole derivative(2I-TPIS),was assembled into adenosine triphosphate(ATP)-responsive nanoparticles(DPA-2I NPs)to achieve dual responses to irradiation and ultrasonication(US)for application to photo-sonodynamic therapy(PSDT).Compared with monotherapies,2I-TPIS generated more ROS in PSDT,inducing mitochondrial autophagy and apoptosis,which in turn triggered immunogenic cell death(ICD).Subsequently,DPA-2I NPs were constructed and self-assembled with the chemotherapeutic agents DPA-Cd and 2I-TPIS to achieve a triple synergistic strategy involving chemotherapy(CT)and ***-2I NPs exhibited absolute sensitization,intra-tumoral overexpression of ATP,and ***,the biosafety and potent antitumor efficiency of the DPA-2I NP-based“PSDT+CT”therapy were revealed using a 4T1 tumor *** study results provide insights into the design of sensitizers possessing a sufficient S_(1)population and a highly efficient tumor ablation capacity derived from molecular structural modulation,further enabling triple synergistic antitumor therapies,and expanding the clinical application of sensitizers.

关键词： triphosphate(ATP)-activated nano-sensitizers photo-sonodynamic therapy aggregation-induced emission enhanced excited state population

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Prediction of TrkB Complex and Antidepressant Targets Leveraging Big Data 12th

Prediction of TrkB Complex and Antidepressant Targets Levera...

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12th International Congress on Big Data, BigData 2023

作者： Xiang, Xufu Qian, Chungen Liu, Xin Xia, Fuzhen The Key Laboratory for Biomedical Photonics of MOE at Wuhan National Laboratory for Optoelectronics - Hubei Bioinformatics and Molecular Imaging Key Laboratory Systems Biology Theme Department of Biomedical Engineering College of Life Science and Technology Huazhong University of Science and Technology Wuhan430074 China

ISBN: (纸本)9783031447242

Since Major Depressive Disorder (MDD) represents a neurological pathology caused by inter-synaptic messaging errors, membrane receptors, the source of signal cascades, constitute appealing drugs targets. G protein coupled receptors (GPCRs) and ion channel receptors chelated antidepressants (ADs) high-resolution architectures were reported to realize receptors physical mechanism and design prototype compounds with minimal side effects. Tyrosine kinase receptor 2 (TrkB), a receptor that directly modulates synaptic plasticity, has a finite three-dimensional chart due to its high molecular mass and intrinsically disordered regions (IDRs). Leveraging breakthroughs in deep learning, the meticulous architecture of TrkB was projected employing Alphafold 2 (AF2). Furthermore, the Alphafold Multimer algorithm (AF-M) models the coupling of intra- and extra-membrane topologies to chaperones: mBDNF, SHP2, Etc. Conjugating firmly dimeric transmembrane helix with novel compounds like 2R,6R-hydroxynorketamine (2R,6R-HNK) expands scopes of drug screening to encompass all coding sequences throughout genomes. The operational implementation of TrkB kinase-SHP2, PLCγ1, and SHC1 ensembles has paved the path for machine learning in which it can forecast structural transitions in the self-assembly and self-dissociation of molecules during trillions of cellular mechanisms. In silicon, the cornerstone of the alteration will be big data and artificial intelligence (AI), empowering signal networks to operate at the atomic level and picosecond timescales. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Big data

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PERFORMANCE AND COMPENSATION LOSS ANALYSIS OF EVTOL HEAT PUMP AIR CONDITIONING SYSTEM

PERFORMANCE AND COMPENSATION LOSS ANALYSIS OF EVTOL HEAT PUM...

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2024 CSAA/IET International Conference on Aircraft Utility Systems, AUS 2024

作者： Liu, Yumeng Feng, Shiyu Key Laboratory of Aircraft Environment and Life Support Ministry of Industry and Information Technology College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics Nanjing China Nanjing University of Aeronautics and Astronautics Nanjing China

An AC system was designed to meet the temperature regulation requirements of a specific type of EVTOL cabin. A system model was constructed using the AMESim dynamic simulation platform. The study examined the variations in the operation of the AC system consumes energy when only the size of the heat exchanger was modified, while the internal and external structures remained constant. Furthermore, a compensation loss index was introduced to assess the impact on hovering power due to changes in the weight of the heat exchanger. The simulation results provide a foundation for the design and optimization of EVTOL AC systems. © The Institution of Engineering & technology 2024.

关键词： Air conditioning

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Drug discovery targeting thyroid hormone receptor b (THRb) for the treatment of liver diseases and other medical indications

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Acta Pharmaceutica Sinica B 2025年第1期15卷 35-51页

作者： Kean Wang Feiyang Chen Jiang Wang Hong Liu School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Lingang Laboratory Shanghai 200031China School of Life Science and Technology Shanghai Tech UniversityShanghai 200031China

Thyroid hormone receptors(THRs),a crucial nuclear receptor protein family,primarily consist of two categories:a receptors and b *** them,THRb is the primary subtype of thyroid hormone that confers benefits to the *** the last two decades,there have been efforts to develop THRb agonists that selectively yield beneficial effects on the liver,such as lowering triglycerides and cholesterol,while reducing adverse effects on the heart,muscle,and *** paper systematically reviews strategies to enhance the safety of THRb agonists for the treatment of MASH,with a focus on improving the selectivity of THRa and increasing the distribution of the drug in the ***,we explore the potential application of this target in addressing other medical indications.

关键词： Thyroid hormone Thyroid hormoneβreceptor MASLD MASH THRβagonist

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An EMG-Based Biomimetic Variable Stiffness Modulation Strategy for Bilateral Motor Skills Relearning of Upper Limb Elbow Joint Rehabilitation

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Journal of Bionic Engineering 2023年第4期20卷 1597-1612页

作者： Ziyi Yang Shuxiang Guo Keisuke Suzuki Yi Liu Masahiko Kawanishi Graduate School of Engineering Kagawa UniversityTakamatsuKagawa761-0396Japan Key Laboratory of Convergence Medical Engineering System and Healthcare Technology School of Life Science and TechnologyBeijing Institute of TechnologyBeijing100081China National Rehabilitation Center for Persons with Disabilities Tokorozawa359-8555Japan Faculty of Medicine Kagawa UniversityTakamatsuKagawa761-0793Japan

Bilateral rehabilitation systems with bilateral or unilateral assistive robots have been developed for hemiplegia patients to recover their one-side ***,the compliant robotic assistance to promote bilateral inter-limb coordination remains a challenge that should be *** this paper,a biomimetic variable stiffness modulation strategy for the Variable Stiffness Actuator(VSA)integrated robotic is proposed to improve bilateral limb coordination and promote bilateral motor skills *** Electromyography(EMG)-driven synergy reference stiffness estimation model of the upper limb elbow joint is developed to reproduce the muscle synergy effect on the affected side limb by independent real-time stiffness ***,the bilateral impedance control is incorporated for realizing compliant patient-robot *** experiments were carried out to evaluate the tracking performance and investigate the multiple task intensities’influence on bilateral motor skills *** results evidence the proposed method could enable bilateral motor task skills relearning with wide-range task intensities and further promote bilateral inter-limb coordination.

关键词： Biomimetic stiffness modulation Compliant physical human-robot interaction(pHRI) Electromyography(EMG) Variable stiffness actuator(VSA) Rehabilitation robotics Synergy-based control Skill relearning

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Enhanced Beta2-band Oscillations Denote Auditory Hallucination in Schizophrenia Patients and a Monkey Model of Psychosis

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Neuroscience Bulletin 2024年第3期40卷 325-338页

作者： Shuo Ma Tianzhen Chen Wenjun Jia Jie Liu Shihan Ding Puzhe Li Hong Gan Dapeng Zhang Shuxin Shao Mu-Ming Poo Min Zhao Bomin Sun Jian Jiang Department of Neurosurgery Ruijin HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200020China Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai200030China Shanghai Center for Brain Science and Brain-inspired Technology Lingang LaboratoryShanghai201602China University of California at Berkeley BerkeleyCA94720USA School of Life Science and Technology ShanghaiTech UniversityShanghai201210China Institute of Neuroscience CAS Center for Excellence in Brain Science and Intelligence TechnologyCAS Key Laboratory of Primate NeurobiologyState Key Laboratory of NeuroscienceChinese Academy of SciencesShanghai200031China Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Lingang LaboratoryShanghai201210China Fuyang Third People’s Hospital Fuyang Mental Health CenterFuyang236052China Shanghai Key Laboratory of Psychotic Disorders Shanghai200030China Institute of Psychological and Behavioral Science Shanghai Jiao Tong UniversityShanghai200030China Shanghai Quanlan Technology Co. LtdShanghai201602China

An electroencephalographic(EEG)signature of auditory hallucinations(AHs)is important for facilitating the diagnosis and treatment of AHs in *** recorded EEG from 25 schizophrenia patients with recurrent *** the period of AHs,EEG recordings exhibited significantly elevated beta2-band power in the temporal region,as compared to those recorded in the absence of AHs or during stimulation with verbal *** further generated methamphetamine-treated rhesus monkeys exhibiting psychosis-like behaviors,including repetitive sudden searching actions in the absence of external intrusion,suggesting the occurrence of *** EEG beta2-band power in the temporal region of these monkeys was enhanced immediately after methamphetamine treatment and positively correlated with the frequency of sudden searching ***,the enhancement of temporal beta2-band oscillations represents a signature for AHs in both patients and a monkey model of psychosis,and this monkey model can be used for developing closed-loop neuromodulation approaches for the treatment of refractory AHs in schizophrenia.

关键词： Schizophrenia Auditory hallucinations Non-human primate Methamphetamine Electroencephalography

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