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Multidimensional regulation of Ti-Zr-Cr-Mn hydrogen storage alloys via Y partial substitution

Nano Research 2024年第5期17卷 4211-4220页

作者： Haixiang Xiu Wanqiang Liu Dongming Yin Nan Ding Wenfeng Qiao Shaolei Zhao Long Liang Cong Liu Shaohua Wang Qingshuang Wang Bingbing Chen Limin Wang Yong Cheng School of Materials Science and Engineering Changchun University of Science and TechnologyChangchun 130022China State Key Laboratory of Rare Earth Resources Utilization Changchun Institute of Applied ChemistryChinese Academy of Sciences(CAS)Changchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China Department of Energy Science and Engineering Nanjing Tech UniversityNanjing 211816China National Engineering Research Center of Nonferrous Metals Materials and Products for New Energy GRINM Group Co.Ltd.Beijing 100088China GRIMAT Engineering Institute Co. Ltd.Beijing 101407China College of Life Science and Technology Changchun University of Science and TechnologyChangchun 130022China

High density and safe storage of hydrogen are the preconditions for the large-scale application of hydrogen ***,the hydrogen storage properties of Ti_(0.6)Zr_(0.4)Cr_(0.6)Mn_(1.4) alloys are systematically studied by introducing Y element instead of Ti element through vacuum arc *** the partial substitution of Y,a second phase of rare earth oxide is added in addition to the main suction hydrogen phase,C14 Laves *** to the unique properties of rare earth elements,the partial substitution of Y can not only improve the activation properties and plateau pressure of the alloys,but also increase the effective hydrogen storage capacity of the *** comprehensive properties of hydrogen storage alloys are improved by multidimensional regulation of rare earth *** them,Ti_(0.552)Y_(0.048)Zr_(0.4)Cr_(0.6)Mn_(1.4) has the best comprehensive *** alloy can absorb hydrogen without activation at room temperature and 5 MPa,with a maximum hydrogen storage capacity of 1.98 wt.%.At the same time,it reduces the stability of the hydride and the enthalpy change value,making it easier to release *** theoretical analysis and first-principle simulation,the results show that the substitution of Y element reduces the migration energy barrier of hydrogen and the structural stability of the system,which is conducive to hydrogen *** alloy has superior durability compared to the original alloy,and the capacity retention rate was 96.79%after 100 hydrogen absorption/desorption cycles.

关键词： AB_(2)-type hydrogen storage alloy rare earth element first-principles simulation multidimensional regulation

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利用双金属纳米颗粒协同提高抗生素对耐碳青霉烯类细菌的疗效

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science China Materials 2023年第7期66卷 2885-2892页

作者：赵晓慧刘绍琴蒋兴宇 School of Life Science and Technology Harbin Institute of TechnologyHarbin 150001China Shenzhen Key Laboratory of Smart Healthcare Engineering Guangdong Provincial Key Laboratory of Advanced BiomaterialsDepartment of Biomedical EngineeringSouthern University of Science and TechnologyShenzhen 518055China

细菌对碳青霉烯类抗生素耐药性的日益增加,已成为一个备受关注的问题.联合治疗是应对耐药细菌感染的有效策略.在本研究中,双金属纳米颗粒(AuRh NPs)与小分子抗生素(亚胺培南)具有协同抗菌作用,它们通过增加细菌胞内的活性氧水平和增强... 详细信息

细菌对碳青霉烯类抗生素耐药性的日益增加,已成为一个备受关注的问题.联合治疗是应对耐药细菌感染的有效策略.在本研究中,双金属纳米颗粒(AuRh NPs)与小分子抗生素(亚胺培南)具有协同抗菌作用,它们通过增加细菌胞内的活性氧水平和增强细菌膜的渗透性表现出优异的抗菌效果.特别地,联合治疗恢复了亚胺培南对耐碳青霉烯类肺炎克雷伯菌(CRKP)的疗效,最低抑菌浓度降低了128倍.在治疗肺部感染时,AuRh NPs与亚胺培南联合使用能更有效地抑制CRKP感染,与单独使用亚胺培南或AuRh NPs实验组相比,小鼠的存活率提升了50%.体外和体内安全性研究表明,AuRh NPs与亚胺培南联合使用没有明显的毒性.这种联合疗法为耐药细菌感染提供了有效的治疗策略.

关键词： antibiotic resistance combination therapy bimetallic nanoparticles antibiotics lung infection

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Graphitic carbon nitride-based photocatalysts in the applications of environmental catalysis

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Journal of Environmental sciences 2023年第2期124卷 570-590页

作者： Hongxia Lin JinmoWu Fan Zhou Xiaolong Zhao Pengfei Lu Guanghui Sun Yuhan Song Yayun Li Xiaoyong Liu Hongxing Dai Hefei Institute for Public Safety Research Tsinghua UniversityHefei 230601China Anhui Province Key Laboratory of Human Safety Hefei 230601China Beijing Key Laboratory for Green Catalysis and Separation Key Laboratory of Beijing on Regional Air Pollution ControlKey Laboratory of Advanced Functional MaterialsEducation Ministry of ChinaLaboratory of Catalysis Chemistry and NanoscienceDepartment of Environmental Chemical EngineeringSchool of Environmental and Chemical EngineeringFaculty of Environment and Life ScienceBeijing University of TechnologyBeijing 100124China

Semiconductor photocatalytic technology has shown great prospects in converting solar energy into chemical energy to mitigate energy crisis and solve environmental pollution *** key issue is the development of high-efficiency *** strategies in the state-of-the-art advancements,such as heterostructure construction,heteroatom doping,metal/single atom loading,and defect engineering,have been presented for the graphitic carbon nitride(g-C3N4)-based nanocomposite catalysts to design their surface chemical environments and internal electronic structures to make them more suitable for different photocatalytic *** this review,nanoarchitecture design,synthesis methods,photochemical properties,potential photocatalytic applications,and related reaction mechanisms of the modified high-efficiency carbon nitride-based photocatalysts were briefly *** superior photocatalytic performance was identified to be associated with the enhanced visible-light response,fast photoinduced electron-hole separation,efficient charge migration,and increased unsaturated active ***,the further advance of the visible-light harvesting and solar-to-energy conversions are proposed.

关键词： Graphitic carbon nitride-based photocatalyst Photocatalytic reduction Photocatalytic degradation Chemical modification Heterostructure construction Metal doping

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New horizons for therapeutic applications of nanozymes in oral infection

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Particuology 2023年第9期80卷 61-73页

作者： Yanting Cai Yue Li Jin Zhang Nan Tang Xingfu Bao Zhen Liu Department of Orthodontics Jilin Provincial Key Laboratory of Tooth Development and Bone RemodelingSchool and Hospital of StomatologyJilinUniversityChangchun130021China Beijing Advanced Innovation Center for Soft Matter Science and Engineering College of Life Science and TechnologyBeijing University of ChemicalTechnologyBeijing100029China

As a category of nanomaterials with excellent catalytic efficiency,great substrate specificity,and highrecovery efficiency,nanozymes have attracted increasing attention in various biomedical ***,numbers of nanozyme-assisted strategies have been well developed for the theranostics ofvarious diseases by taking advantages of their multienzyme-like characteristics,low cost,and *** the most prevalent oral diseases,oral infection poses a global hazard to human health,andcurrent therapeutic options are insufficient to resolve all the clinical *** on their admirableactivity,nanozymes can be frequently employed in the identification and treatment of various oral infectious ***,we provide a brief review focused on the classification of nanozymes,analysesof nanozyme-based antibacterial mechanism,research progress in oral bacterial control,and representative studies of nanozyme-assisted oral inflammatory ***,major challenges andpotential opportunities regarding the use of nanozymes in oral infectious diseases are also highlightedand *** review not only summarizes the recent studies of nanozymes in oral infection butalso promotes the further development of enzyme-mimetic strategies towards various oral diseases.

关键词： Nanozymes Oral infection Antibacterial therapy Anti-inflammatory therapy

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Single-cell profiling reveals Müller glia coordinate retinal intercellular communication during light/dark adaptation via thyroid hormone signaling

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Protein & Cell 2023年第8期14卷 603-617页

作者： Min Wei Yanping Sun Shouzhen Li Yunuo Chen Longfei Li Minghao Fang Ronghua Shi Dali Tong Jutao Chen Yuqian Ma Kun Qu Mei Zhang Tian Xue Division of Life Sciences and Medicine Department of OphthalmologyThe First Affiliated Hospital of USTCUniversity of Science and Technology of ChinaHefei 230026China Hefei National Research Center for Physical Sciences at the Microscale Neurodegenerative Disorder Research CenterCAS Key Laboratory of Brain Function and DiseaseUniversity of Science and Technology of ChinaHefei 230026China Division of Life Sciences and Medicine School of Life SciencesUniversity of Science and Technology of ChinaHefei 230026China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100864China

Light adaptation enables the vertebrate visual system to operate over a wide range of ambient *** of phototransduction in photoreceptors is considered a major mechanism underlying light ***,various types of neurons and glial cells exist in the retina,and whether and how all retinal cells interact to adapt to light/dark conditions at the cellular and molecular levels requires systematic ***,we utilized single-cell RNA sequencing to dissect retinal cell-type-specific transcriptomes during light/dark adaptation in *** results demonstrated that,in addition to photoreceptors,other retinal cell types also showed dynamic molecular changes and specifically enriched signaling pathways under light/dark ***,Müller glial cells(MGs)were identified as hub cells for intercellular interactions,displaying complex cell‒cell communication with other retinal ***,light increased the transcription of the deiodinase Dio2 in MGs,which converted thyroxine(T4)to active triiodothyronine(T3).Subsequently,light increased T3 levels and regulated mitochondrial respiration in retinal cells in response to light *** cones specifically express the thyroid hormone receptor Thrb,they responded to the increase in T3 by adjusting light *** of the expression of Dio2 specifically in MGs decreased the light responsive ability of *** results suggest that retinal cells display global transcriptional changes under light/dark adaptation and that MGs coordinate intercellular communication during light/dark adaptation via thyroid hormone signaling.

关键词： single cell Müller glial cells intercellular communication light/dark adaptation thyroid hormone signaling

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Surface-rare-earth-rich upconversion nanoparticles induced by heterovalent cation exchange with superior loading capacity

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Journal of Materials science & technology 2022年第2期97卷 223-228页

作者： Meifeng Wang Yiru Qin Wei Shao ZhiWang Cai Xiaoyu Zhao Yongjun Hu Tao Zhang Sheng Li Mark T.Swihart Yang Liu Wei Wei MOE&Guangdong Provincial Key Laboratory of Laser Life Science Guangzhou Key Laboratory of Spectral Analysis and Functional ProbesCollege of BiophotonicsSouth China Normal UniversityGuangzhou 510631China Department of Chemical and Biological Engineering University at Buffalothe State University of New YorkBuffaloNY 14260United States Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology Institute of Insect Science and Technology&School of Life SciencesSouth China Normal UniversityGuangzhou 510631China State Key Laboratory Breeding Base of Green Chemistry Synthesis Technology and College of Chemical Engineering Zhejiang University of TechnologyHangzhou 310014China

Surface modification of different functional molecules onto NaREF_(4)(RE=rare earth)upconversion nanoparticles(UCNPs)impart their multiple *** molecules can be loaded onto NaREF_(4) UCNPs through the formation of coordination bonds between the surface-exposed RE^(3+) ions and the appropriate chemical groups of functional *** density of surface RE^(3+) ions directly determines the loading efficiency of Na REF4 ***,NaREF_(4) is a binary cation system,rendering the surface-distributed Na;and RE^(3+) ions remains a ***,we develop an effective strategy to significantly enhance the density of surface RE^(3+) ions,thus maximizing the loading capacity of NaREF_(4) *** strategy is based on a heterovalent cation exchange(HCE)reaction in the surface region in which Na^(+)ions are replaced by RE^(3+) *** density of surface ligands enhances from 3.6 to 8.8 molecules/nm^(2) after reaction,suggesting that the loading efficiency increases by approximately 150%.Benefiting from the improved loading capacity,we demonstrate such surface-RE-rich nanoparticles have the ability to offer higher colloidal stability and more desirable photodynamic therapy(PDT)*** work not only advances our understanding of cation exchange reactions in RE-based nanoparticles,but also provides significant value for considerable applications such as sensing,bioimaging,and therapy.

关键词： Heterovalent cation exchange Surface-rare-earth-rich Upconversion nanoparticles Superior loading capacity

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Cloud computing-enabled IIOT system for neurosurgical simulation using augmented reality data acces

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Digital Communications and Networks 2023年第2期9卷 347-357页

作者： Jun Liu Kai Qian Zhibao Qin Mohammad Dahman Alshehri Qiong Li Yonghang Tai Yunnan Key Laboratory of Opto-electronic Information Technology Yunnan Normal UniversityKunming650500China Department of Thoracic Surgery Institute of The First People's Hospital of Yunnan ProvinceKunmingChina Faculty of Life and Biotechnology Kunming University of Science and TechnologyKunmingChina Department of Computer Science College of Computers and Information TechnologyTaif UniversityP.O.Box 11099Taif21944Saudi Arabia

In recent years,statistics have indicated that the number of patients with malignant brain tumors has increased ***,most surgeons still perform surgical training using the traditional autopsy and prosthesis model,which encounters many problems,such as insufficient corpse resources,low efficiency,and high *** the advent of the 5G era,a wide range of Industrial Internet of Things(IIOT)applications have been *** Reality(VR)and Augmented Reality(AR)technologies that emerged with 5G are developing rapidly for intelligent medical *** address the challenges encountered during neurosurgery training,and combining with cloud computing,in this paper,a highly immersive AR-based brain tumor neurosurgery remote collaborative virtual surgery training system is developed,in which a VR simulator is *** system enables real-time remote surgery training interaction through 5G *** experts and 18 novices were invited to participate in the experiment to verify the ***,the two simulators were evaluated using face and construction validation *** results obtained by training the novices 50 times were further analyzed using the Learning Curve-Cumulative Sum(LC-CUSUM)evaluation method to validate the effectiveness of the two *** results of the face and content validation demonstrated that the AR simulator in the system was superior to the VR simulator in terms of vision and scene authenticity,and had a better effect on the improvement of surgical ***,the surgical training scheme proposed in this paper is effective,and the remote collaborative training effect of the system is ideal.

关键词： Neurosurgery IIOT Cloud computing Intelligent medical 5G AR

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TRIM21-dependent ultrasmall chiral gold nanoparticles for preventing microglia senescence against Alzheimer's disease

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science China Chemistry 2024年第4期67卷 1360-1372页

作者： Meiru Lu Changlong Hao Liguang Xu Feng Yu Jiwei Jiang Yanli Wang Jun Xu Hua Kuang Chuanlai Xu Maozhong Sun International Joint Research Laboratory for Biointerface and Biodetection State Key Laboratory of Food Science and ResourcesSchool of Food Science and TechnologyJiangnan UniversityWuxi 214122China Institute of Life Sciences Jiangsu UniversityZhenjiang 212013China Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100050China National Clinical Research Center for Neurological Diseases Beijing 100070China

Tripartite motif 21(TRIM21)is an E3 ubiquitin ligase that shows great promise for protein degradation through ***,ultrasmall chiral gold nanoparticles(D-or L-NPs)modified by D-or L-glutathione ligands were *** conjugated with an NLR family pyrin domain-containing protein 3(NLRP3)antibody(D-NP-a NLRP3 or L-NP-a NLRP3),DNP-a NLRP3 showed effective delivery efficiency of the antibody into microglia and prevented Aβ-mediated microglia senescence,and p16^(ink4a),a marker of senescence,in the microglia was reduced by 90.3%±7.8% while L-NP-a NLRP3 decreased by 48.01%±3.1%.Mechanistic investigations revealed that the D-NP-a NLRP3((1.5±0.3)×10^(7)M^(-1))exhibited sixteen-fold larger binding affinity to transmembrane glycoprotein SLC3A2 than L-type((9.5±2.7)×10^(5)M^(-1)),which led to a high efficiency of antibody delivery and TRIM21-dependent NLRP3 ***,the blood-brain barrier(BBB)-crossing ability of chiral NP-a NLRP3 as well as NLRP3 degradation was demonstrated in *** APP/PS1 Alzheimer's disease(AD)model mice experiments exhibited a reduction of 89.7%±6.8% for the NLRP3 protein and 84.2±7.5% for p16^(ink4a)following the intravenous administration of D-NP-a NLRP3 once a week for 60 ***,the levels of the AD markers Aβ and phosphorylatedTau in the brains were reduced by 86.2%±8.2% and 81.6%±9.1%;these were 2.1-fold and 1.9-fold higher than those treated with L-NP-a NLRP3,*** studies provide a method to rescue AD-like pathologies and prevent senescence.

关键词： chiral gold nanoparticles amyloid-β NLRP3 TRIM21 senescence Alzheimer's disease

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Targeting PI3K/Akt signal transduction for cancer therapy

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Signal Transduction and Targeted Therapy 2022年第1期7卷 95-111页

作者： Yan He Miao Miao Sun Guo Geng Zhang Jing Yang Kui Sheng Chen Wen Wen Xu Bin Li MOE Key Laboratory of Tumor Molecular Biology and Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes Institute of Life and Health EngineeringCollege of Life Science and TechnologyJinan UniversityGuangzhouChina Department of Pathology The First Affiliated Hospital of Zhengzhou UniversityHenan Key Laboratory of Tumor PathologyZhengzhouChina MOE Key Laboratory of Tumor Molecular Biology and Guangdong Provincial Key Laboratory of Bioengineering Medicine National Engineering Research Center of Genetic MedicineInstitute of BiomedicineCollege of Life Science and TechnologyJinan UniversityGuangzhouChina

The phosphatidylinositol 3-kinase(PI3K)/Akt pathway plays a crucial role in various cellular processes and is aberrantly activated in cancers,contributing to the occurrenee and progression of *** the upstream and downstream nodes of this pathway could allow full elucidation of its *** on accumulating evidenee,strategies targeting major components of the pathway might provide new in sights for can cer drug *** have explored the use of some in hibitors targeti ng this pathway to block survival ***,because oncogenic PI3K pathway activation occurs through various mechanisms,the clinical efficacies of these inhibitors are ***,pathway activation is accompanied by the development of therapeutic resista ***,strategies involvi ng pathway in hibitors and other can cer treatments in combinati on might solve the therapeutic *** this review,we discuss the roles of the PI3K/Akt pathway in various cancer phenotypes,review the current statuses of different PI3K/Akt in hibitors,and in troduce combi nation therapies con sisti ng of signaling in hibitors and conven tional cancer *** information presented herein suggests that cascading inhibitors of the PI3K/Akt signaling pathway,either alone or in combi nation with other therapies,are the most effective treatment strategy for can cer.

关键词： PI3K/Akt treatment alone

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Advances in NK cell production

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Cellular & Molecular Immunology 2022年第4期19卷 460-481页

作者： Fang Fang Siqi Xie Minhua Chen Yutong Li Jingjing Yue Jie Ma Xun Shu Yongge He Weihua Xiao Zhigang Tian The First Affiliated Hospital of USTC Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui230001China Hefei National Laboratory for Physical Sciences at Microscale CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Life SciencesUniversity of Science and Technology of ChinaHefei230027China Institute of Immunology University of Science and Technology of ChinaHefei230027China Engineering Technology Research Center of Biotechnology Drugs Anhui University of Science and Technology of ChinaHefei230027China Biomedical Sciences and Health Laboratory of Anhui Province University of Science and Technology of ChinaHefei230027China

Immunotherapy based on natural killer(NK)cells is a promising approach for treating a variety of *** T cells,NK cells recognize target cells via a major histocompatibility complex(MHC)-independent mechanism and,without being sensitized,kill the cells *** strategies for obtaining large quantities of NK cells with high purity and high cytotoxicity have been *** strategies include the use of cytokine−antibody fusions,feeder cells or membrane particles to stimulate the proliferation of NK cells and enhance their *** materials,including peripheral blood mononuclear cells(PBMCs),umbilical cord blood(UCB),induced pluripotent stem cells(iPSCs)and NK cell lines,have been used as sources to generate NK cells for ***,genetic modification technologies to improve the proliferation of NK cells have also been developed to enhance the functions of NK ***,we summarize the recent advances in expansion strategies with or without genetic manipulation of NK cells derived from various cellular *** also discuss the closed,automated and GMP-controlled large-scale expansion systems used for NK cells and possible future NK cell-based immunotherapy products.

关键词： NK cells PBMCs UCB iPSCs NK cell lines Genetic manipulation

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