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Lipase-activated glycopeptide nano-assemblies as an antibiotic nano-adjuvant to inhibit Pseudomonas aeruginosa biofilm and enhance antibacterial activity

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science China Chemistry 2022年第12期65卷 2538-2547页

作者： Yifei Song Jingkai Zhang Yue Fei Zhangjian Huang Xiaoxuan Liu Li-Li Li CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology(NCNST)Beijing100190China College of Life Science and Technology Beijing University of Chemical TechnologyBeijing100029China State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases Center of Drug DiscoveryCenter of Advanced Pharmaceutics and BiomaterialsChina Pharmaceutical UniversityNanjing210009China

Bacterial infections,especially those caused by biofilms,pose a serious threat to public *** this work,we propose a glycopeptide-based antibiotic nano-adjuvant(GalAc-2) that can synergistically enhance the antibacterial activity of antibiotics through its biofilm inhibition *** glycopeptide nanoparticles can be specifically activated by bacterial infection overexpressed lipase and sequentially enlarged by glycosyl exposure on the *** stability and bonding affinity of the nanoparticles were enhanced through the increase in β-sheet *** bacterial growth inhibition rate of the mixture of levofloxacin(LEV) and GalAc-2 at 0.54 μg/m L was over sevenfold higher than that of LEV alone because of the electrostatic and multivalence Lec A interactions that inhibited biofilm formation on the bacterial ***,the mixture of the antibiotic with GalAc-2 significantly inhibited the abscess exposed to skin infection and significantly reduced the infiltration of immune *** believe that GalAc-2 can be further used to enhance broad-spectrum antibiotic sensitization and prolong the lifetime of antibiotics.

关键词： glycopeptide self-assembly antibiotic nano-adjuvant bacteria biofilm

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Critical review on anti-fatigue effects of natural dietary products: Present insights and future trends

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Food science and Human Wellness 2025年

作者： Syam P.K.Jeepipalli Nidesha Randeni Bin Du Baojun Xu Food Science and Technology Program， Department of Life Sciences， Beijing Normal-Hong Kong Baptist University Department of Agricultural and Plantation Engineering， Faculty of Engineering Technology， The Open University of Sri Lanka Hebei Key Laboratory of Natural Products Activity Components and Function， Hebei Normal University of Science and Technology

Fatigue impacts both mental and physical health， significantly reducing quality of life and daily productivity. Natural bioactive compounds have emerged as promising agents to combat fatigue due to their multifaceted biological activities and minimal side effects. key mechanisms through which these compounds exert anti-fatigue effects include enhancing energy metabolism， reducing oxidative stress， supporting mitochondrial integrity， modulating the immune response， and regulating neurotransmitter balance. Plant-derived metabolites such as flavonoids， ginsenosides， saponins， and polysaccharides， as well as animal-based peptides and microbial-derived substances， have demonstrated significant potential in alleviating fatigue symptoms in both clinical and preclinical studies. Additionally， fermented products like kefir， fermented rice bran， and yogurt enhance endurance performance， reduce lactate buildup， and improve glycogen storage， further contributing to fatigue mitigation. As consumer interest in natural alternatives grows， future research should prioritize improving the bioavailability， stability， and targeted delivery of these compounds. This review consolidates recent advances in the understanding of anti-fatigue mechanisms of natural products and highlights emerging directions for their development as functional foods and therapeutic agents.

关键词： Anti-fatigue activity plant metabolites animal products microbial products fermented products amino acid

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siRNA-functionalized lanthanide nanoparticle enables efficient endosomal escape and cancer treatment

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Nano Research 2022年第10期15卷 9160-9168页

作者： Chanchan Yu Kun Li Lin Xu Bo Li Chunhui Li Shuai Guo Ziyue Li Yuquan Zhang Abid Hussain Hong Tan Mengyu Zhang Yongxiang Zhao Yuanyu Huang Xing-Jie Liang School of Life Science Advanced Research Institute of Multidisciplinary ScienceSchool of Medical Technology(Institute of Engineering Medicine)Key Laboratory of Molecular Medicine and BiotherapyKey Laboratory of Medical Molecule Science and Pharmaceutics EngineeringBeijing Institute of TechnologyBeijing 100081China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of ChinaBeijing 100190China National Center for International Research of Biological Targeting Diagnosis and Therapy Guangxi Key Laboratory of Biological Targeting Diagnosis and Therapy ResearchGuangxi Medical UniversityNanning 530021China

Attaching DNA/RNA to nanomaterials is the basis for nucleic acid-based assembly and drug ***,we report that small interfering RNA(siRNA)effectively coordinates with ligand-free lanthanide nanoparticles(NaGdF4 NPs),and forms siRNA/NaGdF4 spherical nucleic acids(SNA).The coordination is primarily attributed to the interaction between Gd and phosphate backbone of the ***,an efficient encapsulation and rapid endosomal escape of siRNA from the endosome/lysosome were achieved,due to its flexible ability to bound to phospholipid head of endosomal membrane,thereby disrupting the membrane *** to the dual properties of NaGdF4 NPs,siRNA loading,and endosomal escape,siRNA targeting programmed cell death-ligand 1(siPD-L1)/NaGdF4 SNA triggers significant gene silencing in vitro and in vivo,and effectively represses the tumor growth in both CT26 tumor model and 4T1 orthotopic murine model.

关键词： coordination chemistry nuclei acid lanthanide nanomaterials small interfering RNA(siRNA)delivery endosome escape

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A nitrogen-rich halogen-bonded organic framework (XOF) for efficient iodine capture and security printing

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science China Chemistry 2025年第2期68卷 631-640页

作者： Qi Zhao Penghao Sun Guanfei Gong Yi Chen Lingzhi Luo Yongfei Yin Chunsheng Li Jike Wang Lu Wang Shigui Chen The Institute for Advanced Studies Wuhan UniversityWuhan 430072China Ningxia Vocational Technical College of Industry and Commerce Yinchuan 750100China Key Laboratory of Advanced Electrode Materials for Novel Solar Cells for Petroleum and Chemical Industry of China School of Chemistry and Life SciencesSuzhou University of Science and TechnologySuzhou 215009China

The escalating utilization of nuclear energy and nuclear medicine raises concerns about the environmental impact of radioactive iodine,necessitating the development of effective iodine adsorbents,especially under a real-world scenario with extremely low iodine concentration and elevated ***,we have presented the construction of a nitrogen-abundant two-dimensional(2D)halogen-bonded organic framework,XOF-TNP,characterized by exceptional crystallinity,thermal stability,and nitrogen-rich ***-TNP exhibits strong binding to iodine,thanks to the fact that iodine can be pre-enriched into the framework through N…I *** nitrogen-rich framework and I^(+) synergistically have extremely high binding force to iodine,enabling the rapid and efficient capture of iodine in both vapor and solution phases,with significant *** flow-through adsorption experiments using an XOF-TNP-packed column achieve 99%iodine removal from hexane and aqueous solutions,surpassing traditional activated *** highlights its potential for environmental *** enables the development of a novel rewritable security paper,utilizing its iodine adsorption properties to encrypt and decrypt QR *** research expands the application scope of halogen-bonded organic frameworks,providing insights into the design of materials for environmental remediation and security applications.

关键词： [N…I+…N]halogen bond halogen-bonded organic framework iodine capture security printing supramolecular assembly

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On-chip ultrasensitive and rapid hydrogen sensing based on plasmon-induced hot electron-molecule interaction

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Light(science & Applications) 2023年第4期12卷 625-635页

作者： Long Wen Zhiwei Sun Qilin Zheng Xianghong Nan Zaizhu Lou Zhong Liu David R.S.Cumming Baojun Li Qin Chen Guangdong Provincial Key Laboratory of Nanophotonic Manipulation Institute of NanophotonicsJinan University511443 GuangzhouChina College of Life Science and Technology Jinan University510632 GuangzhouChina School of Engineering University of GlasgowGlasgow G128QQUK

Hydrogen energy is a zero-carbon replacement for fossil ***,hydrogen is highly flammable and explosive hence timely sensitive leak detection is *** optical sensing techniques rely on complex instruments,while electrical sensing techniques usually operate at high temperatures and biasing *** this paper an on-chip plasmonic-catalytic hydrogen sensing concept with a concentration detection limit down to 1 ppm is presented that is based on a metal-insulator-semiconductor(MIS)nanojunction operating at room temperature and zero *** sensing signal of the device was enhanced by three orders of magnitude at a one-order of magnitude higher response speed compared to alternative non-plasmonic *** excellent performance is attributed to the hydrogen induced interfacial dipole charge layer and the associated plasmonic hot electron modulated photoelectric *** agreements were achieved between experiment and theoretical calculations based on a quantum tunneling *** an on-chip combination of plasmonic optics,photoelectric detection and photocatalysis offers promising strategies for next-generation optical gas sensors that require high sensitivity,low time delay,low cost,high portability and flexibility.

关键词： hydrogen interaction hence

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The chordata olfactory receptor database

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Protein & Cell 2025年第4期16卷 283-292页

作者： Wei Han Siyu Bao Jintao Liu Yiran Wu Liting Zeng Tao Zhang Ningmeng Chen Kai Yao Shunguo Fan Aiping Huang Yuanyuan Feng Guiquan Zhang Ruiyi Zhang Hongjin Zhu Tian Hua Zhijie Liu Lina Cao Xingxu Huang Suwen Zhao Human Institute ShanghaiTech UniversityShanghai 201210China Research Center for Life Sciences Computing Zhejiang LabHangzhou 311121China Department of Intelligent Edge Cloud China Telecom Cloud Technology Co.Ltd.Shanghai 200120China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China School of Information Science and Technology Shanghai Tech UniversityShanghai 201210China Shanghai Key Laboratory of High-Resolution Electron Microscopy Shanghai Tech UniversityShanghai 201210China Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated Hospitaland Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Shanghai Clinical Research and Trial Center Shanghai 201210China

Introduction of database Olfaction is one of the oldest chemosensory systems in chordates,playing crucial roles in their foraging,predator evasion,social communication,mating and parental care(Guo et al.,2023;Li and Liberles,2015;Liberles,2014).The initial step of olfaction is the binding and activation of olfactory receptors(ORs)by odorants in a combinatorial way(Malnic et al.,1999).

关键词： chordates chemosensory systems introduction database olfaction foraging olfaction binding activation olfactory olfactory receptors odorants

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Ionizable liposomal siRNA therapeutics enables potent and persistent treatment of Hepatitis B

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Signal Transduction and Targeted Therapy 2022年第3期7卷 802-815页

作者： Yuanyu Huang Shuquan Zheng Zhaoxu Guo Xavier de Mollerat du Jeu Xing-Jie Liang Zhiwei Yang Hong-Yan Zhang Shan Gao Zicai Liang Suzhou Ribo Life Science Co.Ltd. Jiangsu 215300China Advanced Research Institute of Multidisciplinary Science School of Life ScienceSchool of Medical Technology(Institute of Engineering Medicine)Key Laboratory of Molecular Medicine and BiotherapyKey Laboratory of Medical Molecule Science and Pharmaceutics EngineeringBeijing Institute of TechnologyBeijing 100081China Thermo Fisher Scientific CarlsbadCAUSA Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Chinese Academy of Sciences(CAS)National Center for Nanoscience and TechnologyBeijing 100190China

Small interfering RNA(siRNA)constitutes a promising therapeutic modality supporting the potential functional cure of hepatitis B.A novel ionizable lipidoid nanoparticle(RBP131)and a state-of-the-art lyophilization technology were developed in this study,enabling to deliver siRNA targeting apolipoprotein B(APOB)into the hepatocytes with an ED_(50)of 0.05 mg/kg after intravenous *** addition,according to the requirements of Investigational New Drug(IND)application,a potent siRNA targeting hepatitis B virus(HBV)was selected and encapsulated with RBP131 to fabricate a therapeutic formulation termed RB-HBV008.

关键词： injection APOB intravenous

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Trustworthy deep learning for encrypted traffic classification

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Soft Computing 2025年第2期29卷 645-662页

作者： Li, Zheng Liu, Yanbei Zhang, Changqing Shan, Wanjin Zhang, Haifeng Zhu, Xiaoming School of Electronic and Information Engineering Tiangong University Tianjin300387 China School of Life Sciences Tiangong University Tianjin300387 China Tianjin Key Laboratory of Optoelectronic Detection Technology and Systems Tianjin300387 China College of Intelligence and Computing Tianjin University Tianjin300072 China Science and Technology on Communication Networks Laboratory Shijiazhuang050081 China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang050081 China

Network traffic classification refers to the identification of collected network traffic data of various applications, which is widely used in research fields such as network resource allocation, traffic scheduling and intrusion detection systems. With the widespread application of encryption technology in the network, encrypted traffic classification has become a hot research topic. At present, most existing methods only focus on the accuracy of network traffic classification. Yet, few work studies the reliability of the classification model, which plays an important role in network regulation and network security. In this paper, we propose a novel traffic classification method based on trustworthy deep learning model, which can effectively improve the reliability of encrypted traffic classification models by correcting the confidence of model output. Specifically, we firstly perform data preprocessing on the original network traffic, and then adopt a ConvNet for feature learning and a ClassifyNet for traffic classification in the initial stage. At the same time, we utilize a trustworthy confidence criterion to design a ConfidNet trained according to the probability of the true class. The ConfidNet can provide a reliable confidence measure for the prediction of the classification model. Finally, we demonstrate the effectiveness of our framework through comprehensive experiments on two benchmark datasets ISCX VPN-nonVPN and USTC-TFC2016, and show that our method can improve the reliability of the classification model and has a good ability to identify misclassified samples compared with state-of-the-art methods. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2025.

关键词： Network intrusion

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Naringenin inhibits lipid accumulation by activating the AMPK pathway in vivo and in vitro

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Food science and Human Wellness 2023年第4期12卷 1174-1183页

作者： Xiaoyu Cai Songxue Wang Huali Wang Suwen Liu Guishan Liu Huibin Chen Ji Kang Hao Wang State Key Laboratory of Food Nutrition and Safety College of Food Science and EngineeringTianjin University of Science and TechnologyTianjin 300457China China National Center for Food Safety Risk Assessment Beijing 100022China College of Food Science and Technology Hebei Normal University of Science and TechnologyQinhuangdao 066004China School of Food and Wine Ningxia UniversityYinchuan 750021China College of Life Sciences Fujian Normal UniversityFuzhou 350117China

The aim of this study was to explore the lipid-lowering effect of naringenin and the underlying mechanism in high-fat-diet-fed SD rats and 3T3-L1 *** this study,SD rats were divided into the normal chow diet group(NCD),high fat diet group(HFD),three treatment groups feeding high-fat diet with naringenin(100,200,400 mg/kg)for 12 *** indicated that naringenin treatment decreased total cholesterol(TC),triglyceride(TG)and the non-high-density lipoprotein cholesterol(non-HDL-C)levels in *** also alleviated hepatic steatosis and reduced the adipocyte size in the epididymis in high-fat-diet-induced SD *** addition,naringenin(25−75μg/mL)decrease TG and TC levels in 3T3 mature *** molecular mechanism of naringenin in the treatment of obesity were predicted by using network ***-time PCR analysis results showed that naringenin regulated the expression of lipid metabolism ***,naringenin increased the AMPK(AMP-activated protein kinase)activity and the expression of AMPK phosphorylated protein in 3T3 mature *** the inhibitory effect of naringenin on lipid accumulation in 3T3 adipocytes was abolished by Compound *** docking results indicated that naringenin could bind to AMPK *** results indicated naringenin reduced lipid accumulation through AMPK pathway.

关键词： Naringenin Lipid accumulation Molecular docking

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Transcriptomic and Macroscopic Architectures of Multimodal Covariance Network Reveal Molecular–Structural–Functional Co-alterations

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Research 2024年第1期2023卷 471-487页

作者： Lin Jiang Yueheng Peng Runyang He Qingqing Yang Chanlin Yi Yuqin Li Bin Zhu Yajing Si Tao Zhang Bharat B.Biswal Dezhong Yao Lan Xiong Fali Li Peng Xu The Clinical Hospital of Chengdu Brain Science Institute MOE Key Lab for NeuroinformationUniversity of Electronic Science and Technology of ChinaChengdu 611731China School of Life Science and Technology Center for Information in BioMedicineUniversity of Electronic Science and Technology of ChinaChengdu 611731China School of Psychology Xinxiang Medical UniversityXinxiang 453003China School of Science Xihua UniversityChengdu 610039China Department of Biomedical Engineering New Jersey Institute of TechnologyNewarkNJUSA School of Electrical Engineering Zhengzhou UniversityZhengzhou 450001China Research Unit of NeuroInformation Chinese Academy of Medical Sciences2019RU035ChengduChina Montreal Neurological Institute and Hospital McGill UniversityMontrealQCCanada Department of Electrical and Computer Engineering Faculty of Science and TechnologyUniversity of MacaoMacaoChina Radiation Oncology Key Laboratory of Sichuan Province 610041 ChengduChina Rehabilitation Center Qilu Hospital of Shandong UniversityJinan 250012China

Human cognition is usually underpinned by intrinsic structure and functional neural co-activation in spatially distributed brain *** to lacking an effective approach to quantifying the covarying of structure and functional responses,how the structural–functional circuits interact and how genes encode the relationships,to deepen our knowledge of human cognition and disease,are still ***,we propose a multimodal covariance network(MCN)construction approach to capture interregional covarying of the structural skeleton and transient functional activities for a single *** further explored the potential association between brain-wide gene expression patterns and structural–functional covarying in individuals involved in a gambling task and individuals with major depression disorder(MDD),adopting multimodal data from a publicly available human brain transcriptomic atlas and 2 independent *** analysis showed a replicable cortical structural–functional fine map in healthy individuals,and the expression of cognition-and disease phenotype-related genes was found to be spatially correlated with the corresponding MCN *** analysis of cell type-specific signature genes suggests that the excitatory and inhibitory neuron transcriptomic changes could account for most of the observed correlation with task-evoked MCN differences.

关键词： alterations evoked spatially

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