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5th China Aviation science and technology Conference, 2021

作者： Jin, Lou Wu, Yibin Wu, Liang Cui, Dongyue Yang, Pin Overall Technology R&D Department AVIC Aerospace Life-Support Industries Ltd Xianyang441000 China Aviation Key Laboratory of Science and Technology On Life-Support Technology Xianyang441000 China Institute of Mechanical and Electrical System AVIC The First Aircraft Institute Xi’an710000 China

ISBN: (纸本)9789811674228

This paper proposes a simulation method and technology for the effect of the ejection seat rocket pack tail flame on the heat flow field of the engine room under the multi-seat ejection condition, combines the six-degree-of-freedom motion model of the ejection seat with the CFD numerical simulation method to realize the simulation process of the thermal flow field in the engine room according to the working mechanism of the seat. The motion trajectory and attitude change law of the first ejected seat under different ejection conditions is calculated by a program written in C#, the movement of the human-seat system and the rocket at the boundary in FLUENT is specified with UDF, then the temperature and pressure change law of the second ejected seat, occupant and the surface of the cockpit during a side ejection at different ejection speeds are simulated. The simulation results show that the temperature of different characteristic points in the engine room rises first and then decreases after the rocket package is working, reaching a peak at about 60ms. The temperature at the back of the seat is the highest, and the temperature in the engine room drops faster while the pressure peak is lower when the seat is ejected at a certain speed. The analysis results can provide a theoretical basis for the design and verification of occupant thermal protection equipment. © 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

关键词： Computational fluid dynamics

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DNA methylation-mediated expression of zinc finger protein 615 affects embryonic development in Bombyx mori

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Zoological Research 2022年第4期43卷 552-565页

作者： Guan-Feng Xu Cheng-Cheng Gong Yu-Lin Tian Tong-Yu Fu Yi-Guang Lin Hao Lyu Yu-Ling Peng Chun-Mei Tong Qi-Li Feng Qi-Sheng Song Si-Chun Zheng Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology Guangzhou Key Laboratory of Insect Development Regulation and Applied ResearchInstitute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhouGuangdong 510631China Division of Plant Science and Technology College of AgricultureFood and Natural ResourcesUniversity of MissouriColumbia MO 65211USA

Cell division and differentiation after egg fertilization are critical steps in the development of embryos from single cells to multicellular individuals and are regulated by DNA methylation via its effects on gene ***,the mechanisms by which DNA methylation regulates these processes in insects remain ***,we studied the impacts of DNA methylation on early embryonic development in Bombyx *** methylation and transcriptome analysis of early embryos showed that DNA methylation events mainly occurred in the 5'region of protein metabolism-related *** transcription factor gene zinc finger protein 615(ZnF615)was methylated by DNA methyltransferase 1(Dnmt1)to be up-regulated and bind to protein metabolism-related ***1 RNA interference(RNAi)revealed that DNA methylation mainly regulated the expression of nonmethylated nutrient metabolism-related genes through *** same sites in the ZnF615 gene were methylated in ovaries and *** of ZnF615 using CRISPR/Cas9 gene editing decreased the hatching rate and egg number to levels similar to that of Dnmt1 *** of the ZnF615 methylation rate revealed that the DNA methylation pattern in the parent ovary was maintained and doubled in the offspring ***,Dnmt1-mediated intragenic DNA methylation of the transcription factor ZnF615 enhances its expression to ensure ovarian and embryonic development.

关键词： DNA methylation Embryonic development Transcriptional regulation Epigenetic

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Boosting genome editing in plants with single transcript unit surrogate reporter systems

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Plant Communications 2024年第6期5卷 32-43页

作者： Xu Tang Qiurong Ren Xiaodan Yan Rui Zhang Li Liu Qinqin Han Xuelian Zheng Yiping Qi Hongyuan Song Yong Zhang Chongqing Key Laboratory of Plant Resource Conservation and Germplasm Innovation Integrative Science Center of Germplasm Creation in Western China(Chongqing)Science CitySchool of Life SciencesSouthwest UniversityChongqing 400715China Key Laboratory of Agricultural Biosafety and Green Production of Upper Yangtze River Ministry of EducationChongqing 400715China College of Horticulture and Landscape Architecture Southwest UniversityChongqing 400715China Department of Biotechnology School of Life Sciences and TechnologyCenter for Informational BiologyUniversity of Electronic Science and Technology of ChinaChengdu 610054China School of Synbiology School of Life ScienceShanxi UniversityTaiyuan 030006China Department of Plant Science and Landscape Architecture University of MarylandCollege ParkMD 20742USA Institute for Bioscience and Biotechnology Research University of MarylandRockvilleMD 20850USA

CRISPR-Cas-based genome editing holds immense promise for advancing plant genomics and crop ***,the challenge of low editing activity complicates the identification of editing *** this study,we introduce multiple single transcript unit surrogate reporter(STU-SR)systems to enhance the selection of genome-edited *** systems use the same single guide RNAs designed for endogenous genes to edit reporter genes,establishing a direct link between reporter gene editing activity and that of endogenous *** strategies are used to restore functional reporter genes after genome editing,including efficient single-strand annealing(SSA)for homologous recombination in STUSR-SSA ***-SR-base editor systems leverage base editing to reinstate the start codon,enriching C-to-T and A-to-G base editing *** results showcase the effectiveness of these STU-SR systems in enhancing genome editing events in the monocot rice,encompassing Cas9 nuclease-based targeted mutagenesis,cytosine base editing,and adenine base *** systems exhibit compatibility with Cas9 variants,such as the PAM-less SpRY,and are shown to boost genome editing in Brassica oleracea,a dicot vegetable *** summary,we have developed highly efficient and versatile STU-SR systems for enrichment of genome-edited plants.

关键词： CRISPR-Cas9 single transcript unit STU surrogate reporter SR single strand annealing SSA cyto-sine base editing adenine base editing

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Seasonal shifts in assembly dynamics of phytoplankton communities in a humans-affected river in NE China

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Journal of Oceanology and Limnology 2022年第5期40卷 1985-2000页

作者： Zhenxiang LI Xinxin LU Yawen FAN College of Life Science and Technology Harbin Normal UniversityHarbin 150025China Key Laboratory of Biodiversity of Aquatic Organisms Harbin Normal UniversityHarbin 150025China

Identifying seasonal shift in phytoplankton community is essential for understanding the significance of eutrophication and finding biological indicators of ecological health of a lotic *** communities,as well as the seasonal changes in the Ashi River Basin(ASRB)of Heilongjiang Province were investigated from April 2018 to January 2019.A survey in April(spring),July(summer),October(autumn),and January(winter)at 16 sampling sites was *** composition,abundance,and biodiversity indices of phytoplankton were studied and 127 taxa of phytoplankton were *** them,Bacillariophyta dominated the phytoplankton communities in the whole *** were significant spatio-temporal changes in the structures of the phytoplankton communities during the study *** state index(TSI)show that the nutritional status of the ASRB was at mesotrophic-middle eutrophic *** analysis(RDA)revealed that total nitrogen(TN),water temperature(WT),oxidation reduction potential(ORP),pH,and dissolved oxygen(DO)were the critical factors in the dynamic phytoplankton community *** multivariate regression tree(MRT)analysis showed that Chlamydomonas microsphaerella Pascher et Jahoda,Melosira granulata(Ehrenberg)Ralfs,Merismopedia tenuissima Lemmermann,and Asterionella formosa Hassall were valuable indicators in the determination of water quality in *** findings provide a scientific basis for water quality protection and management at basin scale.

关键词： Ashi River Basin eutrophication community structure succession indicator

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Qualitative analysis of caffeine in beverages based on Raman spectroscopy 17

Qualitative analysis of caffeine in beverages based on Raman...

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17th International Conference on Photonics and Imaging in Biology and Medicine, PIBM 2024

作者： Yang, Yuhang Zhao, Zexian Pu, Wenjun Wu, Huikang Wang, Nan Zeng, Qi Chen, Xueli Center for Biomedical-photonics and Molecular Imaging Advanced Diagnostic-Therapy Technology and Equipment Key Laboratory of Higher Education Institutions in Shaanxi Province School of Life Science and Technology Xidian University Shaanxi Xi'an710126 China Engineering Research Center of Molecular and Neuro Imaging Ministry of Education Xi'an Key Laboratory of Intelligent Sensing and Regulation of Trans-Scale Life Information School of Life Science and Technology Xidian University Shaanxi Xi'an710126 China Inovation Center for Advanced Medical Imaging and Intelligent Medicine Guangzhou Institute of Technology Xidian University Guangdong Guangzhou510555 China

ISBN: (数字)9781510688070

ISBN: (纸本)9781510688063

Caffeine is an alkaloidal stimulant prevalently in food additives. The widespread presence of caffeine in a wide range of beverages has led to increased consumption, commonly exceeding safe levels. In this study, about 30 beverages available in the Chinese market, were analyzed using a 785 nm Raman spectrometer. The raw spectral data were preprocessed by noise reduction and baseline correction. The qualitative model was established using principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA), and the classification discrimination was carried out using K-nearest neighbor algorithm (KNN) and support vector machine algorithms (SVM). Especially, the two models could identify "Spirte" (without caffeine) from other beverages. It was demonstrated that Raman spectroscopy combined with machine learning can provide non-destructive, fast and efficient qualitative detection of caffeine in liquid beverages. © 2025 SPIE.

关键词： Noise abatement

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Blockade of CD300A enhances the ability of human NK cells to lyse hematologic malignancies

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Cancer Biology & Medicine 2024年第4期21卷 331-346页

作者： Shuangcheng Li Tianci Wang Xinghui Xiao Xiaodong Zheng Haoyu Sun Rui Sun Hongdi Ma Zhigang Tian Xiaohu Zheng Hefei National Research Center for Physical Sciences at Microscale The CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesCenter for Advanced Interdisciplinary Science and Biomedicine of IHMDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China Institute of Immunology University of Science and Technology of ChinaHefei 230027China Hefei TG ImmunoPharma Corporation Limited Hefei 230601China Research Unit of NK Cell Study Chinese Academy of Medical SciencesBeijing 100864China Key Laboratory of Quantitative Synthetic Biology Shenzhen Institute of Synthetic BiologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Objective: The human cluster of differentiation(CD)300A, a type-I transmembrane protein with immunoreceptor tyrosine-based inhibitory motifs, was investigated as a potential immune checkpoint for human natural killer(NK) cells targeting hematologic malignancies(HMs).Methods: We implemented a stimulation system involving the CD300A ligand, phosphatidylserine(PS), exposed to the outer surface of malignant cells. Additionally, we utilized CD300A overexpression, a CD300A blocking system, and a xenotransplantation model to evaluate the impact of CD300A on NK cell efficacy against HMs in in vitro and in vivo settings. Furthermore, we explored the association between CD300A and HM progression in ***: Our findings indicated that PS hampers the function of NK cells. Increased CD300A expression inhibited HM lysis by NK cells. CD300A overexpression shortened the survival of HM-xenografted mice by impairing transplanted NK cells. Blocking PS–CD300A signals with antibodies significantly amplified the expression of lysis function-related proteins and effector cytokines in NK cells, thereby augmenting the ability to lyse HMs. Clinically, heightened CD300A expression correlated with shorter survival and an “exhausted” phenotype of intratumoral NK cells in patients with HMs or solid ***: These results propose CD300A as a potential target for invigorating NK cell-based treatments against HMs.

关键词： NK cell CD300A phosphatidylserine immune checkpoint hematologic malignancy

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Rice domestication-associated transcription factor PROSTRATE GROWTH 1 controls plant and panicle architecture by regulating the expression of LAZY 1 and OsGIGANTEA,respectively

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Molecular Plant 2023年第9期16卷 1413-1426页

作者： Jun Wang Jing Huang Jinlin Bao Xizhi Li Liang Zhu Jian Jin State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of Life Science and TechnologyGuangxi UniversityNanning 530004China National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200031China

Plant architecture and panicle architecture are two critical agronomic traits that greatly affect the yield of rice(Oryza sativa).PROSTRATE GROWTH 1(PROG1)encodes a key C2H2-type zinc-finger transcription factor and has pleiotropic effects on the regulation of both plant and panicle architecture,thereby influencing the grain ***,the molecular mechanisms through which PROG1 controls plant and panicle architecture remain *** this study,we showed that PROG1 directly binds the LAZY 1(LA1)promoter and acts as a repressor to inhibit LA1 ***,LA1 acts as a repressor of PROG1 by directly binding to the PROG1 *** two genes play antagonistic roles in shaping plant architecture by regulating both tiller angle and tiller ***,our data showed that PROG1 controls panicle architecture through direct binding to the intragenic regulatory regions of OsGIGANTEA(OsGI)and subsequent activation of its ***,we have identified two crucial targets of PROG1,LA1 and OsGI,shedding light on the molecular mechanisms underlying plant and panicle architecture control by *** study provides valuable insights into the regulation of key domestication-related traits in rice and identifies potential targets for future high-yield rice breeding.

关键词： PROG1 LA1 OsGI plant architecture panicle architecture

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Study on the Effectiveness of Focused Microwave Stimulation in Improving Motor Dysfunction in Stroke Rats 17

Study on the Effectiveness of Focused Microwave Stimulation ...

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17th International Convention on Rehabilitation Engineering and Assistive technology, i-CREATe 2024

作者： Li, Sinan Wu, Linyan Shang, Sen Wen, Bin Chen, Jiawen Yuan, Ye Li, Long Liu, Tian Wang, Jue Institute of Health and Rehabilitation Science School of Life Science and Technology Xi'an Jiaotong University Key Laboratory of Biomedical Information Engineering of Ministry of Education Xi'an710049 China School of Rehabilitation Science and Engineering University of Health and Rehabilitation Sciences Qingdao266071 China School of Life Science and Technology Institute of Biomedical Engineering Xi'an Jiaotong University Key Laboratory of Biomedical Information Engineering of Ministry of Education Xi'an710049 China

ISBN: (纸本)9798350355154

This paper presents a non-invasive microwave brain stimulation system for improving motor function after a stroke. The system uses a small circular antenna to generate 6.0 GHz focused pulsed signals, effectively stimulating rat brains. Unlike traditional methods using DC or AC, this system employs centimeter-wave microwaves for non-invasive, precise stimulation. It uses a frequency synthesizer chip with a voltage-controlled oscillator (VCO) for stable signal generation. The circular design enhances the main lobe energy, reduces side lobe energy, and focuses microwave energy on the central unit. We tested the system with a 5 dBm power, 1 Hz pulse, and 50% duty cycle on rats for 20 minutes. The local field potentials (LFPs) from the primary and secondary motor cortices (M1, M2 regions) showed an increased power spectrum. Brain temperature was monitored during stimulation. A 14-day behavioral study confirmed the method's safety and effectiveness, showing improved motor function in stroke-affected rats. This study demonstrates that non-thermal microwave radiation can positively affect brain neurons. © 2024 IEEE.

关键词： Antenna lobes

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Ubiquitination in the regulation of autophagy

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生物化学与生物物理学报（英文版） 2023年第9期55卷 1348-1357页

作者： Xueyan Cen Ziling Li Xinpeng Chen Hubei Key laboratory of Edible Wild Plants Conservation & Utilization Hubei Engineering Research Center of Special Wild Vegetables Breeding and Comprehensive Utilization TechnologySchool of Life ScienceHubei Normal UniversityHuangshi 435002China Hubei Key laboratory of Edible Wild Plants Conservation & Utilization Hubei Engineering Research Center of Special Wild Vegetables Breeding and Comprehensive Utilization TechnologySchool of Life ScienceHubei Normal UniversityHuangshi 435002China National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China

Autophagy,an efficient and effective approach to clear rapidly damaged organelles,macromolecules,and other harmful cellular components,enables the recycling of nutrient materials and supply of nutrients to maintain cellular *** plays an important regulatory role in *** paper summarizes the most recent progress in ubiquitin modification in various stages of autophagy,including initiation,elongation,and ***,this paper shows that ubiquitination is an important way through which selective autop-hagy achieves substrate ***,we note the distinction between monoubiquitination and pooly-ubiquitination in the regulation of *** with monoubiquitination,polyubiquitination is a more common strategy to regulate the activity of the autophagy molecular *** addition,the role of ubiquiti-nation in the closure and fusion of autophagosomes warrants further *** article not only clarifies the regulatory mechanism of autophagy but also contributes to a deeper understanding of the importance of ubiqui-tination modification.

关键词： monoubiquitination polyubiquitination autophagy molecule machine selective autophagy

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Chemically triggered life control of“smart”hydrogels through click and declick reactions

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Frontiers of Chemical science and Engineering 2022年第9期16卷 1399-1406页

作者： Xing Feng Meiqing Du Hongbei Wei Xiaoxiao Ruan Tao Fu Jie Zhang Xiaolong Sun Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China The Fourth Military Medical University Xi’an 710032China

The degradation of polymeric materials is recognized as one of the goals to be fulfilled for the sustainable *** this study,a novel methodology was presented to synthesize multiple highly cross-linked polymers(i.e.,hydrogels)through amine–thiol scrambling under mild ***-terminated poly(ethylene glycol)(PEGNH_(2))was reacted with the representative conjugate acceptors to synthesize hydrogels in organic and aqueous solutions,*** materials above exhibited high water-swelling properties,distributed porous structures,as well as prominent mechanical *** is noteworthy that the mentioned hydrogels could be degraded efficiently in hours to release the original coupling partner,which were induced by ethylene diamine at ambient temperature through amine-amine *** recovered PEG-NH2 reagent could be employed again to regenerate *** to the multiple architectures and functions in polymeric synthesis,degradation and regeneration,a new generation of“smart”materials is revealed.

关键词： hydrogels degradation synthesis regeneration

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