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Rice domestication-associated transcription factor PROSTRATE GROWTH 1 controls plant and panicle architecture by regulating the expression of LAZY 1 and OsGIGANTEA,respectively

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Molecular Plant 2023年第9期16卷 1413-1426页

作者： Jun Wang Jing Huang Jinlin Bao Xizhi Li Liang Zhu Jian Jin State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of Life Science and TechnologyGuangxi UniversityNanning 530004China National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200031China

Plant architecture and panicle architecture are two critical agronomic traits that greatly affect the yield of rice(Oryza sativa).PROSTRATE GROWTH 1(PROG1)encodes a key C2H2-type zinc-finger transcription factor and has pleiotropic effects on the regulation of both plant and panicle architecture,thereby influencing the grain ***,the molecular mechanisms through which PROG1 controls plant and panicle architecture remain *** this study,we showed that PROG1 directly binds the LAZY 1(LA1)promoter and acts as a repressor to inhibit LA1 ***,LA1 acts as a repressor of PROG1 by directly binding to the PROG1 *** two genes play antagonistic roles in shaping plant architecture by regulating both tiller angle and tiller ***,our data showed that PROG1 controls panicle architecture through direct binding to the intragenic regulatory regions of OsGIGANTEA(OsGI)and subsequent activation of its ***,we have identified two crucial targets of PROG1,LA1 and OsGI,shedding light on the molecular mechanisms underlying plant and panicle architecture control by *** study provides valuable insights into the regulation of key domestication-related traits in rice and identifies potential targets for future high-yield rice breeding.

关键词： PROG1 LA1 OsGI plant architecture panicle architecture

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Blockade of CD300A enhances the ability of human NK cells to lyse hematologic malignancies

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Cancer Biology & Medicine 2024年第4期21卷 331-346页

作者： Shuangcheng Li Tianci Wang Xinghui Xiao Xiaodong Zheng Haoyu Sun Rui Sun Hongdi Ma Zhigang Tian Xiaohu Zheng Hefei National Research Center for Physical Sciences at Microscale The CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesCenter for Advanced Interdisciplinary Science and Biomedicine of IHMDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China Institute of Immunology University of Science and Technology of ChinaHefei 230027China Hefei TG ImmunoPharma Corporation Limited Hefei 230601China Research Unit of NK Cell Study Chinese Academy of Medical SciencesBeijing 100864China Key Laboratory of Quantitative Synthetic Biology Shenzhen Institute of Synthetic BiologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Objective: The human cluster of differentiation(CD)300A, a type-I transmembrane protein with immunoreceptor tyrosine-based inhibitory motifs, was investigated as a potential immune checkpoint for human natural killer(NK) cells targeting hematologic malignancies(HMs).Methods: We implemented a stimulation system involving the CD300A ligand, phosphatidylserine(PS), exposed to the outer surface of malignant cells. Additionally, we utilized CD300A overexpression, a CD300A blocking system, and a xenotransplantation model to evaluate the impact of CD300A on NK cell efficacy against HMs in in vitro and in vivo settings. Furthermore, we explored the association between CD300A and HM progression in ***: Our findings indicated that PS hampers the function of NK cells. Increased CD300A expression inhibited HM lysis by NK cells. CD300A overexpression shortened the survival of HM-xenografted mice by impairing transplanted NK cells. Blocking PS–CD300A signals with antibodies significantly amplified the expression of lysis function-related proteins and effector cytokines in NK cells, thereby augmenting the ability to lyse HMs. Clinically, heightened CD300A expression correlated with shorter survival and an “exhausted” phenotype of intratumoral NK cells in patients with HMs or solid ***: These results propose CD300A as a potential target for invigorating NK cell-based treatments against HMs.

关键词： NK cell CD300A phosphatidylserine immune checkpoint hematologic malignancy

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Ubiquitination in the regulation of autophagy

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生物化学与生物物理学报（英文版） 2023年第9期55卷 1348-1357页

作者： Xueyan Cen Ziling Li Xinpeng Chen Hubei Key laboratory of Edible Wild Plants Conservation & Utilization Hubei Engineering Research Center of Special Wild Vegetables Breeding and Comprehensive Utilization TechnologySchool of Life ScienceHubei Normal UniversityHuangshi 435002China Hubei Key laboratory of Edible Wild Plants Conservation & Utilization Hubei Engineering Research Center of Special Wild Vegetables Breeding and Comprehensive Utilization TechnologySchool of Life ScienceHubei Normal UniversityHuangshi 435002China National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China

Autophagy,an efficient and effective approach to clear rapidly damaged organelles,macromolecules,and other harmful cellular components,enables the recycling of nutrient materials and supply of nutrients to maintain cellular *** plays an important regulatory role in *** paper summarizes the most recent progress in ubiquitin modification in various stages of autophagy,including initiation,elongation,and ***,this paper shows that ubiquitination is an important way through which selective autop-hagy achieves substrate ***,we note the distinction between monoubiquitination and pooly-ubiquitination in the regulation of *** with monoubiquitination,polyubiquitination is a more common strategy to regulate the activity of the autophagy molecular *** addition,the role of ubiquiti-nation in the closure and fusion of autophagosomes warrants further *** article not only clarifies the regulatory mechanism of autophagy but also contributes to a deeper understanding of the importance of ubiqui-tination modification.

关键词： monoubiquitination polyubiquitination autophagy molecule machine selective autophagy

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Blockade of the deubiquitinating enzyme USP48 degrades oncogenic HMGA2 and inhibits colorectal cancer invasion and metastasis

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1624-1643页

作者： Can Cheng Hanhui Yao Heng Li Jingwen Liu Zhengyi Liu Yang Wu Liang Zhu Hejie Hu Zhengdong Fang Liang Wu Department of General Surgery the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Comprehensive Surgery Anhui Provincial Cancer HospitalWest District of the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Anhui Provincial Hospital Health Management Center the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Breast Surgery Henan Provincial People's HospitalPeople's Hospital of Zhengzhou UniversityPeople's Hospital of Henan UniversityZhengzhou 450003China

HMGA2,a pivotal transcription factor,functions as a versatile regulator implicated in the progression of diverse aggressive *** this study,mass spectrometry was employed to identify ubiquitin-specific proteases that potentially interact with HMGA2,and USP48 was identified as a deubiquitinating enzyme of *** enforced expression of USP48 significantly increased HMGA2 protein levels by inhibiting its degradation,while the deprivation of USP48 promoted HMGA2 degradation,thereby suppressing tumor invasion and *** discovered that USP48 undergoes SUMOylation at lysine 258,which enhances its binding affinity to *** subsequent phenotypic screening of small molecules,we identified DUB-IN-2 as a remarkably potent pharmacological inhibitor of ***,the small-molecule inhibitor targeting USP48 induces destabilization of ***,upregulation of USP48 or HMGA2 in cancerous tissues is indicative of poor prognosis for patients with colorectal cancer(CRC).Collectively,our study not only elucidates the regulatory mechanism of DUBs involved in HMGA2 stability and validates USP48 as a potential therapeutic target for CRC,but also identifies DUB-IN-2 as a potent inhibitor of USP48 and a promising candidate for CRC treatment.

关键词： Colorectal cancer Invasion and metastasis Post-translational modification Ubiquitination SUMOylation USP48 HMGA2 Specific inhibitors

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Study on the Effectiveness of Focused Microwave Stimulation in Improving Motor Dysfunction in Stroke Rats 17

Study on the Effectiveness of Focused Microwave Stimulation ...

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17th International Convention on Rehabilitation Engineering and Assistive technology, i-CREATe 2024

作者： Li, Sinan Wu, Linyan Shang, Sen Wen, Bin Chen, Jiawen Yuan, Ye Li, Long Liu, Tian Wang, Jue Institute of Health and Rehabilitation Science School of Life Science and Technology Xi'an Jiaotong University Key Laboratory of Biomedical Information Engineering of Ministry of Education Xi'an710049 China School of Rehabilitation Science and Engineering University of Health and Rehabilitation Sciences Qingdao266071 China School of Life Science and Technology Institute of Biomedical Engineering Xi'an Jiaotong University Key Laboratory of Biomedical Information Engineering of Ministry of Education Xi'an710049 China

ISBN: (纸本)9798350355154

This paper presents a non-invasive microwave brain stimulation system for improving motor function after a stroke. The system uses a small circular antenna to generate 6.0 GHz focused pulsed signals, effectively stimulating rat brains. Unlike traditional methods using DC or AC, this system employs centimeter-wave microwaves for non-invasive, precise stimulation. It uses a frequency synthesizer chip with a voltage-controlled oscillator (VCO) for stable signal generation. The circular design enhances the main lobe energy, reduces side lobe energy, and focuses microwave energy on the central unit. We tested the system with a 5 dBm power, 1 Hz pulse, and 50% duty cycle on rats for 20 minutes. The local field potentials (LFPs) from the primary and secondary motor cortices (M1, M2 regions) showed an increased power spectrum. Brain temperature was monitored during stimulation. A 14-day behavioral study confirmed the method's safety and effectiveness, showing improved motor function in stroke-affected rats. This study demonstrates that non-thermal microwave radiation can positively affect brain neurons. © 2024 IEEE.

关键词： Antenna lobes

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Chemically triggered life control of“smart”hydrogels through click and declick reactions

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Frontiers of Chemical science and Engineering 2022年第9期16卷 1399-1406页

作者： Xing Feng Meiqing Du Hongbei Wei Xiaoxiao Ruan Tao Fu Jie Zhang Xiaolong Sun Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China The Fourth Military Medical University Xi’an 710032China

The degradation of polymeric materials is recognized as one of the goals to be fulfilled for the sustainable *** this study,a novel methodology was presented to synthesize multiple highly cross-linked polymers(i.e.,hydrogels)through amine–thiol scrambling under mild ***-terminated poly(ethylene glycol)(PEGNH_(2))was reacted with the representative conjugate acceptors to synthesize hydrogels in organic and aqueous solutions,*** materials above exhibited high water-swelling properties,distributed porous structures,as well as prominent mechanical *** is noteworthy that the mentioned hydrogels could be degraded efficiently in hours to release the original coupling partner,which were induced by ethylene diamine at ambient temperature through amine-amine *** recovered PEG-NH2 reagent could be employed again to regenerate *** to the multiple architectures and functions in polymeric synthesis,degradation and regeneration,a new generation of“smart”materials is revealed.

关键词： hydrogels degradation synthesis regeneration

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Improvement in bioconversion efficiency and reduction of ammonia emission by introduction of fruit fermentation broth in a black soldier fly larvae and kitchen waste conversion system

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Insect science 2023年第4期30卷 975-990页

作者： Lusheng Li lifei Chen Rongsheng Shang Guiying Wang Jibin Zhang School of Agricultural Science and Engineering Engineering Research Center of Shandong Province for Black Soldier Fly Breeding and Organic Waste ConversionLiaocheng UniversityLiaochengShandong ProvinceChina State Key Laboratory of Agricultural Microbiology National Engineering Research Centre of Microbial PesticidesCollege of Life Science and TechnologyCollege of Animal Science&TechnologyHuazhong Agricultural UniversityWuhanChina

The black soldier fly(BSF),Hermetia illucens(Diptera:Stratiomyidae),is an insect commonly used for the bioconversion of various organic *** only can the BSF convert organic waste into macromolecular organic substances,such as insect pro-teins,but it can also lessen the pollution associated with these waste products by reducing ammonia emissions,for *** this study,we measured the effects of adding fruit fermentation broth(Fer)and commercial lactic acid bacteria fermentation broth(Em)to kitchen waste(KW),as deodorizing auxiliary substances,on the growth performance of black soldier fly larvae(BSFL),the intestinal flora structure of BSFL,the ammonia emis-sion from the KW substrate,and the microbial community structure of the KW *** found that the addition of Fer or Em increased the body weight of BSFL after 6 d of culture,increasing the growth rate by 9.96%and 7.96%,*** addition of Fer not only reduced the pH of the KW substrate but also increased the relative abundance of probiotics,such as Lactobacillus,Lysinibacillus,and Vagococcus,which inhibited the growth of ammonifiers such as Bacillus,Oligella,Paenalcaligenes,Paenibacillus,Pseu-dogracilibacillus,and Pseudomonas,resulting in the reduction of ammonia emission in the KW ***,the addition of Fer or Em significantly increased the rela-tive abundances of Bacteroides,Campylobacter,Dysgonomonas,Enterococcus,and Ig-natzschineria in the gut of BSFL and increased the species diversity and richness in the K W *** findings provide a novel way to improve the conversion rate of organic waste and reduce the environmental pollution caused by BSF.

关键词： ammonia emissions black soldier fly fruit fermentation broth growth per-formance kitchen waste lactic acid bacteria fermentation broth

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PDLLMs:A group of tailored DNA large language models for analyzing plant genomes

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Molecular Plant 2025年第2期18卷 175-178页

作者： Guanqing Liu Long Chen Yuechao Wu Yangshuo Han Yu Bao Tao Zhang Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding/Zhongshan Biological Breeding Laboratory/Key Laboratory of Plant Functional Genomics of the Ministry of Education Agricultural College of Yangzhou UniversityYangzhou 225009China Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops/Jiangsu Key Laboratory of Crop Genetics and Physiology Yangzhou UniversityYangzhou 225009China Chongqing Key Laboratory of Plant Resource Conservation and Germplasm Innovation Integrative Science Center of Germplasm Creation in Western China(Chongqing)Science CitySchool of Life SciencesSouthwest UniversityChongqing 400715China

Dear Editor,Over the past 2 years,large language models(LLMs)have witnessed a notable achievement in the realms of artificial intelli-gence-generated *** advanced artificial intelligence-generated content systems are powered by state-of-the-art deep learning algorithms,which undergo training on vast amounts of data and possess the ability to comprehend extensive volumes of complex ***,more and more LLMs have been developed and applied to a diverse range of tasks,such as inter-active chat,auto-generated drawings,and even biological research(Kaddour et al.,2023).

关键词： language such artificial

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Qualitative analysis of caffeine in beverages based on Raman spectroscopy 17

Qualitative analysis of caffeine in beverages based on Raman...

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17th International Conference on Photonics and Imaging in Biology and Medicine, PIBM 2024

作者： Yang, Yuhang Zhao, Zexian Pu, Wenjun Wu, Huikang Wang, Nan Zeng, Qi Chen, Xueli Center for Biomedical-photonics and Molecular Imaging Advanced Diagnostic-Therapy Technology and Equipment Key Laboratory of Higher Education Institutions in Shaanxi Province School of Life Science and Technology Xidian University Shaanxi Xi'an710126 China Engineering Research Center of Molecular and Neuro Imaging Ministry of Education Xi'an Key Laboratory of Intelligent Sensing and Regulation of Trans-Scale Life Information School of Life Science and Technology Xidian University Shaanxi Xi'an710126 China Inovation Center for Advanced Medical Imaging and Intelligent Medicine Guangzhou Institute of Technology Xidian University Guangdong Guangzhou510555 China

ISBN: (数字)9781510688070

ISBN: (纸本)9781510688063

Caffeine is an alkaloidal stimulant prevalently in food additives. The widespread presence of caffeine in a wide range of beverages has led to increased consumption, commonly exceeding safe levels. In this study, about 30 beverages available in the Chinese market, were analyzed using a 785 nm Raman spectrometer. The raw spectral data were preprocessed by noise reduction and baseline correction. The qualitative model was established using principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA), and the classification discrimination was carried out using K-nearest neighbor algorithm (KNN) and support vector machine algorithms (SVM). Especially, the two models could identify "Spirte" (without caffeine) from other beverages. It was demonstrated that Raman spectroscopy combined with machine learning can provide non-destructive, fast and efficient qualitative detection of caffeine in liquid beverages. © 2025 SPIE.

关键词： Noise abatement

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L-Ergothioneine ameliorates MPTP-induced Parkinson's disease in C57BL/6J mice by activating DJ-1

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Food science and Human Wellness 2024年

作者： Xianshe Meng# Huawen Meng# Shuzeng Hou Zequn Yin Xuerui Wang Ke Gong Feng Zhang Qingshan Li Shuang Zhang Yuanli Chen Xiaoxiao Yang Zhiwei Zhao Chenzhong Liao Yajun Duan Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes， Hefei University of Technology Department of Cardiology， the First Affiliated Hospital of USTC， Division of Life Sciences and Medicine， University of Science and Technology of China

Parkinson's disease （PD） is one of the most common neurodegenerative diseases. The loss of dopaminergic （DAergic） neurons in the substantia nigra and the decrease of dopamine （DA） levels accelerate the process of PD. L-Ergothioneine （EGT） is a natural antioxidant derived from microorganisms， especially in edible mushrooms. EGT can penetrate blood-brain barrier and its levels are significantly decreased in the plasma of PD patients. Therefore， we speculated that EGT could ameliorate PD， and determined its effect on PD development by using 1-methyl-4-phenyl-1，2，3，6-tetrahydropyridine （MPTP）-induced PD mouse models and neurotoxin 1-methyl-4-phenylpyridinium (MPP+)-induced cell models. Our results show that EGT alleviated MPTP-induced behavioral dysfunction in mice. Mechanistically， we innovatively revealed that EGT is a key regulator of DJ-1. EGT restored DA levels by activating the DJ-1-Nuclear receptor-related factor 1（Nurr1） axis. Furthermore， it reduced reactive oxygen species （ROS） levels by regulating the DJ-1-Nuclear factor erythroid 2-related factor 2 （Nrf2） pathway， which inhibited oxidative stress-induced DAergic neuronal apoptosis. Combined treatment with DJ-1-siRNA transfection revealed that blocking DJ-1 reversed EGT upregulated Nurr1 and Nrf2 expression in the nucleus， which significantly decreased the benefits of EGT. Taken together， our study suggests that EGT can ameliorate PD and be considered as a strategy for PD treatment.

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