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TEGR:A comprehensive Ericaceae genome resource database

Journal of Integrative Agriculture 2025年第3期24卷 1140-1151页

作者： Xiaojing Wang Yunfeng Wei Zhuo Liu Tong Yu Yanhong Fu Xiaoming Song Institute of Agro-Bioengineering/The Key Laboratory of Plant Resources Conservation and Germplasm Innovation in the Mountainous Region(Ministry of Education)/College of Life Sciences Guizhou UniversityGuiyang 550025China School of Life Sciences North China University of Science and TechnologyTangshan 063210China

Ericaceae is a diverse family of flowering plants distributed nearly worldwide,and it includes 126 genera and more than 4,000 *** the present study,we developed The Ericaceae Genome Resource(TEGR,http://***)as a comprehensive,user-friendly,web-based functional genomic database that is based on 16 published genomes from 16 Ericaceae *** TEGR database contains information on many important functional genes,including 763 auxin genes,2,407 flowering genes,20,432 resistance genes,617 anthocyanin-related genes,and 470 N^(6)-methyladenosine(m^(6)A)modification *** identified a total of 599,174 specific guide sequences for CRISPR in the TEGR *** gene duplication events,synteny analysis,and orthologous analysis of the16 Ericaceae species were performed using the TEGR *** TEGR database contains 614,821 functional genes annotated through the GO,Nr,Pfam,TrEMBL,and Swiss-Prot *** TEGR database provides the Primer Design,Hmmsearch,Synteny,BLAST,and JBrowse tools for helping users perform comprehensive comparative genome *** the high-quality reference genome sequences,genomic features,gene annotations,and bioinformatics results can be downloaded from the TEGR *** the future,we will continue to improve the TEGR database with the latest data sets when they become available and to provide a useful resource that facilitates comparative genomic studies.

关键词： TEGR Ericaceae gene functional annotation m^(6)A CRISPR bioinformatic tools

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IsoVISoR: Towards 3D Mesoscale Brain Mapping of Large Mammals at Isotropic Sub-micron Resolution

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Neuroscience Bulletin 2025年第2期41卷 344-348页

作者： Chao-Yu Yang Yan Shen Xiaoyang Qi Lufeng Ding Yanyang Xiao Qingyuan Zhu Hao Wang Cheng Xu Pak-Ming Lau Pengcheng Zhou Fang Xu Guo-Qiang Bi Division of Life Sciences and Medicine CAS Key Laboratory of Brain Function and DiseaseUniversity of Science and Technology of ChinaHefei230026China Interdisciplinary Center for Brain Information Shenzhen-Hong Kong Institute of Brain ScienceShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055China Center for Integrative Imaging Hefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei230027China National Engineering Laboratory for Brain-Inspired Intelligence Technology and Application MoE Key Laboratory of Brain-Inspired Intelligent Perception and CognitionSchool of Information Science and TechnologyUniversity of Science and Technology of ChinaHefei230026China Anhui Province Key Laboratory of Biomedical Imaging and Intelligent Processing Institute of Artificial IntelligenceHefei Comprehensive National Science CenterHefei230088China Faculty of Life and Health Sciences Shenzhen University of Advanced TechnologyShenzhen518107China CAS Key Laboratory of Brain Connectome and Manipulation The Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055China

Dear Editor,The mammalian brain exhibits cross-scale complexity in neuronal morphology and connectivity,the study of which demands high-resolution morphological reconstruction of individual neurons across the entire brain[1-4].Current commonly used approaches for such mesoscale brain mapping include two main types of three-dimensional fluorescence microscopy:the block-face methods,and the lightsheet-based methods[5,6].In general,the high imaging speed and light efficiency of light-sheet microscopy make it a suitable tool for high-throughput volumetric imaging,especially when combined with tissue-clearing ***,large brain samples pose major challenges to this approach.

关键词： brain mapping three dimensional fluorescence microscopy mesoscale brain mapping lightsheet based methods block face methods high throughput volumetric imaging tissue clearing techniques

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Adaptive Closed-Loop Functional Electrical Stimulation System With Visual Feedback for Enhanced Grasping in Neurological Impairments

IEEE Transactions on Medical Robotics and Bionics

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IEEE Transactions on Medical Robotics and Bionics 2025年第2期7卷 678-686页

作者： Lin, Chengyu Cheng, Kong Hoi Pan, Wei Sun, Jinxin Gou, Guotao Fu, Junyun Leng, Yuquan Fu, Chenglong Southern University of Science and Technology Shenzhen Key Laboratory of Biomimetic Robotics and Intelligent Systems Guangdong Provincial Key Laboratory of Human-Augmentation Rehabilitation Robotics in Universities Department of Mechanical and Energy Engineering Shenzhen518055 China Guilin University of Electronic Technology Guangxi Human Physiological Information Non Invasive Detection Engineering Technology Research Center School of Life and Environmental Sciences Guilin541004 China

Grasping is a critical motor skill essential for daily activities, but it is often compromised in individuals with neural impairments. Functional Electrical Stimulation (FES) has emerged as a promising intervention, utilizing electrical pulses to stimulate muscles and thereby restore impaired motor functions. However, existing closed-loop FES systems depend on pre-calibrated angles or forces specific to individual objects, which limits their practicality in dynamic, real-world environments with varying object properties. This paper presents a novel closed-loop FES (CLFES) system with visual feedback, designed to dynamically adjust stimulation parameters based on real-time interaction states without requiring object-specific calibration. The system employs a finite state machine to manage sequential grasp-release tasks and integrates a visual perception module for slip detection and intent recognition. The system was tested with two individuals with disabilities on five common household objects. Experimental results demonstrate significant improvements, including a 42.6% increase in success rate and a 45.9% reduction in task completion time compared to tasks performed without the system. These results underscore the system's potential to improve daily task performance for individuals with neural impairments. © 2018 IEEE.

关键词： Visual servoing

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Dual-template synthesis of microalgae-derived biochar for uranium removal from aqueous solution

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Journal of Industrial and Engineering Chemistry 2025年 148卷 560-568页

作者： Li, Hui Cheng, Yanxia Li, Feize Wang, Hairong Qing, Renwei Lan, Tu Yang, Yuanyou Yang, Jijun Liao, Jiali Liu, Ning Key Laboratory of Radiation Physics and Technology of the Ministry of Education Institute of Nuclear Science and Technology Sichuan University Chengdu610064 China Nuclear Power Institute of China Chengdu610213 China Co. Ltd. Chengdu610213 China Key Laboratory of Bio-Resource and Eco - Environment of the Ministry of Education College of Life Science Sichuan University Chengdu610065 China

Biochar as an adsorbent is paid more attention for treating uranium-containing wastewater. In this work, a novel microalgae-derived biochar(A-HTC) was synthesized by dual-template one-step carbonization for uranium adsorption. This biochar exhibited a maximum adsorption capacity of 472.3 mg·g−1. Especially, A-HTC demonstrated excellent selectivity for uranium over 11 competing cations and remarkable reusability after 10 adsorption-desorption cycles. The adsorption behavior with time and uranium concentration followed the pseudo-second-order kinetic model and the Langmuir isotherm model, respectively. Moreover, the adsorption process was spontaneous and endothermic. Zeta potential, XPS, and FTIR analyses revealed that A-HTC adsorbs U(VI) mainly through electrostatic attraction and complexation. The present study offers an innovative adsorbent and a novel method to produce biochar for uranium recovery from aquatic environments. © 2025 The Korean Society of Industrial and Engineering Chemistry

关键词： Microalgae

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ImSpiRE: image feature-aided spatial resolution enhancement method

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science China(life sciences) 2025年第1期68卷 272-283页

作者： Yuwei Hua Yizhi Zhang Zhenming Guo Shan Bian Yong Zhang State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center Institute for Regenerative MedicineDepartment of NeurosurgeryShanghai East HospitalShanghai Key Laboratory of Signaling and Disease ResearchFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China

The resolution of most spatially resolved transcriptomic technologies usually cannot attain the single-cell level,limiting their applications in biological ***,we introduce ImSpiRE,an image feature-aided spatial resolution enhancement method for in situ capturing spatial *** the information stored in histological images,ImSpiRE solves an optimal transport problem to redistribute the expression profiles of spots to construct new transcriptional profiles with enhanced resolution,together with extending the gene expression profiles into unmeasured *** to multiple datasets confirm that ImSpiRE can enhance spatial resolution to the subspot level while contributing to the discovery of tissue domains,signaling communication patterns,and spatiotemporal characterization.

关键词： spatial transcriptome histological images spatial resolution enhancement

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TaWRKY55-TaPLATZ2 module negatively regulate saline-alkali stress tolerance in wheat

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Journal of Integrative Plant Biology 2025年第1期67卷 19-34页

作者： Lin Wei Xinman Ren Lumin Qin Rong Zhang Minghan Cui Guangmin Xia Shuwei Liu Key Laboratory of Plant Development and Environmental Adaptation Biology Ministry of EducationSchool of Life ScienceShandong UniversityQingdao 266237China Crop Research Institute Anhui Academy of Agricultural SciencesHefei 230031China State Key Laboratory of Microbial Technology Shandong UniversityQingdao 266237China

Saline-alkaline soils are a major environmental problem that limit plant growth and crop *** membrane H^(+)-ATPases and the salt overly sensitive(SOS)signaling pathway play important roles in plant responses to saline-alkali ***,little is known about the functional genes and mechanisms regulating the transcription of H^(+)-ATPases and SOS pathway genes under saline–alkali *** the present study,we identified that the plant AT-rich sequence and zinc-binding(TaPLATZ2)transcription factor are involved in wheat response to saline-alkali stress by directly suppressing the expression of TaHA2/*** knockdown of TaPLATZ2 enhances salt and alkali stress tolerance,while overexpression of TaPLATZ2 leads to salt and alkali stress sensitivity in *** addition,TaWRKY55 directly upregulated the expression of TaPLATZ2 during saline-alkali *** knockdown and overexpression of Ta WRKY55 in wheat,Ta WRKY55 was shown to negatively modulate salt and alkali stress *** analyses confirmed that Ta PLATZ2 functions downstream of Ta WRKY55 in response to salt and alkaline *** findings provide a TaWRKY55–TaPLATZ2–TaHA2/TaSOS3 regulatory module that regulates wheat responses to saline-alkali stress.

关键词： alkali stress PLATZ transcription factor salt stress Triticum aestivum

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Degradation of chloroxylenol by CoS_x activated peroxomonosulfate:Role of cobalt-sulfur ratio

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Chinese Chemical Letters 2025年第4期36卷 379-383页

作者： Jiayi Guo Liangxiong Ling Qinwei Lu Yi Zhou Xubiao Luo Yanbo Zhou State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process East China University of Science and TechnologyShanghai 200237China School of Life Sciences Key Laboratory of Jiangxi Province for Functional Biology and Pollution Control in Red Soil RegionsJinggangshan UniversityJi'an 343009China State Key Laboratory of Coal Liquification Gasification and Utilization with High Efficiency and Low Carbon TechnologyShanghai 200237China

Cobalt sulfide has received widespread attention in the advanced oxidation treatment of wastewater,and its catalytic activity is infiuenced by crystal structure and exposed active *** work successfully constructed three types of cobalt sulfides,namely Co_(9)S_(8),Co_(3)S_(4)and CoS_(2),by changing the molar ratio of cobalt to *** results showed that the degradation efficiency of Co_(9)S_(8),Co_(3)S_(4)and CoS_(2) on chloroxylenol by activated peroxomonosulfate(PMS)were 100%,88.70%and 67.73%,*** with density functional theory(DFT),the structural properties and reaction energy barriers of different cobaltsulfur ratios were *** the ratio of cobalt to sulfur increases,the sulfur vacancies realized a fuller exposure of active sites(Co_(surf.)^(2+))on the surface of the catalysts,with a highly linear relationship with the reaction rate constant(R^(2)=0.945).This work explores the structure-activity relationship between cobalt sulfur ratio and degradation efficiency,which can guide new catalyst synthesis.

关键词： Peroxymonosulfate Fenton-like reaction Cobalt sulfides Chloroxylenol degradation Morphology control

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Crystalline@amorphous core-shell structure of WO3@WO_(3-x)S_(x) established via doping strategy for enhancing magnesium ions storage performance

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Journal of Magnesium and Alloys 2025年第3期13卷 1353-1363页

作者： Shiqi Ding Yuxin Tian Jiankang Chen Guofeng Wang Bing Sun He Lv Lei Wang Guicun Li Alan Meng Zhenjiang Li College of Materials Science and Engineering Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life ScienceMOEShandong Key Laboratory of Biochemical AnalysisCollege of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042ShandongPR China Qingdao Engineering Research Center for New Metallic Functional Materials Characteristic Laboratory of Advanced Metal Functional Materials and Processing in Universities of ShandongQingdao Binhai UniversityQingdao 266555ShandongPR China

Designing cathode possessing crystalline@amorphous core-shell structure with both active core and shell is a meaningful work for resolving the low speciﬁc capacity,unstable cycling performance and sluggish reaction kinetics issues of rechargeable magnesium batteries(RMBs)by providing more active sites as well as releasing inner stress during ***,WO_(3)@WO_(3-x)S_(x) owning crystalline@amorphous core-shell structure containing both active core and active shell is constructed successfully by introducing S into metastable WO3 structure under temperatureﬁeld *** such structure,amorphous shell would provide continuous Mg^(2+)diffusion channels due to its isotropy property for most Mg^(2+)migrating rapidly to interface and then adsorb at ions reservoir formed by interfacial electricﬁeld for increasing speciﬁc *** also makes security for stable structure of WO_(3)@WO_(3-x)S_(x) by alleviating volume expansion of crystalline core WO_(3) during cycling to prolong cycling ***,“softer”ions S^(2-)would weaken interaction between hard acid Mg^(2+) and ionic lattice to enhance Mg^(2+)storage ***,WO_(3)@WO_(3-x)S_(x) delivers the superior cycling performance(1000 cycles with 83.3%),rate capability(88.5 mAh g^(-1) at 1000 mA g^(-1))and speciﬁc capacity(about 150 mAh g^(-1) at 50 mA g^(-1)),which is near 2 times higher than that of *** is believed that the crystalline@amorphous core-shell structure with both active core and shell designing via doping strategy is enlightening for the development of high-performance RMBs,and such design can be extended to other energy storage devices for better electrochemical performance.

关键词： Doping Sulfuration Crystalline@amorphous core-shell structure WO_(3) Rechargeable magnesium batteries

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In situ expansion capacity evaluation of terminal alveoli in chronic obstructive pulmonary disease using an ultrathin optical coherence tomography catheter

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Biomedical Optics Express 2025年第5期16卷 2156-2170页

作者： Fang, Bingyan Cai, Yigen Zhang, Zhuopan Liang, Jiaxi Chen, Jiarui Chen, Xiaowei Huang, Xiangdi Zhang, Jian Wen, Xue Yang, Sihua Xiong, Kedi College of Biophotonics School of Optoelectronic Science and Engineering South China Normal University Guangzhou510631 China MOE Key Laboratory of Laser Life Science Institute of Laser Life Science South China Normal University Guangzhou510631 China The Key Laboratory of Advanced Interdisciplinary Studies The First Affiliated Hospital of Guangzhou Medical University School of Biomedical Engineering Guangzhou Medical University Guangzhou511436 China Shenzhen Photonstream Limited Shenzhen518117 China State Key Laboratory of Precision Electronics Manufacturing Technology and Equipment Guangdong University of Technology Guangzhou510006 China

Morphological structural changes in the peripheral alveoli serve as critical indicators for the early pathological features of chronic obstructive pulmonary disease (COPD). Endoscopic optical coherence tomography (OCT) has emerged as a valuable diagnostic tool for COPD, enabling the assessment of airway mucosa, smooth muscle thickness, lumen diameter, lumen area, and airway wall area. However, conventional transbronchial OCT imaging catheters are limited in size, restricting their access to terminal bronchioles and thereby impeding the morphological and structural analysis of peripheral alveoli. In this study, we present a bronchial ultrathin OCT (Bronchial-uOCT) imaging catheter with an outer diameter of 380 µm, an axial resolution of 8.4 µm, and a lateral resolution of 9.3 µm. Using New Zealand rabbit COPD models, we achieved real-time in situ 3D volumetric imaging of terminal alveoli. Statistical analysis revealed a difference of 5 times in the alveolar area between normal and COPD pathological groups (P = 0.00018). Quantitative analysis of expansion compliance revealed significant differences in the growth rate and trend of the alveolar area between the normal group and the COPD pathology group. Furthermore, the opening direction of the curve obtained through power law fitting may help diagnose COPD. These findings highlight bronchial-uOCT as a clinically significant approach capable of in situ visualization of alveolar structures in the terminal bronchioles, offering a promising approach for the early diagnosis and assessment of COPD. © 2025 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement.

关键词： Catheters

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Lengthening of the CHURC1 3'untranslated region by alternative polyadenylation is associated with the progression of acute myeloid leukemia

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Genes & Diseases 2025年第1期12卷 106-109页

作者： Xi Hu Panxiang Cao Fang Wang Huqin Zhang Tong Wang Hongxing Liu Xiaoming Wu The Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and TechnologyXi'an Jiaotong UniversityXi'anShaanxi 710049China Division of Pathology and Laboratory Medicine Hebei Yanda Lu Daopei HospitalLangfangHebei 065201China

Alternative polyadenylation(APA)is a post-transcriptional process that typically determines the length of mature mRNAs'3'untranslated region(3'UTR).The global shortened 3'UTR alters mRNA stability,localization,and translation and contributes to cancer progression.1 The APA characteristics and its effects on acute myeloid leukemia(AML)remain to be comprehensively ***,we identified churchill domain containing 1(CHURC1)as an upregulated gene with a lengthened 3'UTR in CD34+enriched AML cells compared with healthy hematopoietic stem and progenitor *** for APA regulation of CHURC1,we found that rs6745 and RNA binding protein TIA1 potentially contribute to the distal poly(A)site usage in cis-and transways,***,a lengthened CHURC13'UTR affected the apoptosis of AML cells by disrupting the expression of DICER1 by sponging *** chemotherapeutic sensitivity of 8 drugs was associated with CHURC1 poly(A)site ***,our analysis indicated a previously undetected gene,CHURC1,that affected AML progression through 3'UTR length change resulting from *** collection and detailed analysis methods were described in the supplementary material.

关键词： URC myeloid acute

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