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Subcellular redistribution of Rhein from whole cellular to single mitochondria for enhancing anti-hepatoma efficacy

Phytomedicine 2025年

作者： Ling-Ling Wu Weihua Di Litao Shao Jie Zhou Yu-Yu Qiu Mengrui Zhang Zhenye Li Yanqun Zhang Pengcheng Luan Jifan Li Gongchang Yu Guiqian Fang Caicai Meng Bin Shi Xuemei Zhao Qixin Chen Xintian Shao School of Pharmaceutical Sciences National Key Laboratory of Advanced Drug Delivery System Medical Science and Technology Innovation Center Shandong First Medical University & Shandong Academy of Medical Sciences Jinan Shandong 250062 PR China Department of Traditional Chinese Medicine Orthopedics Neck-Shoulder and Lumbocrural Pain Hospital of Shandong First Medical University Shandong First Medical University & Shandong Academy of Medical Sciences Jinan Shandong 250062 PR China School of Life Sciences Medical Science and Technology Innovation Center Shandong First Medical University & Shandong Academy of Medical Sciences Jinan Shandong 250117 PR China Departments of Diagnostic Radiology Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and College of Design and Engineering National University of Singapore Singapore 119074 Singapore

Background RECQL4 is a critical factor in DNA repair and serves as a significant biomarker for liver cancer. Inhibiting RECQL4 induces apoptosis in liver cancer cells. Given the role of mitochondria in regulating apoptosis and the dual localization of RECQL4 in both the mitochondria and nucleus, targeting mitochondrial RECQL4 may induce mitochondrial dysfunction, thereby enhancing the therapeutic efficacy of liver cancer treatments. Purpose Unlike traditional drug structure optimization, which focuses solely on protein target interactions, our approach optimizes drug structure based on both organelle distribution and protein interactions. Methods As a proof of concept, we selected Rhein (4,5-dihydroxyanthraquinone-2-carboxylic acid), an auto-fluorescent, lipophilic anthraquinone found in a variety of different medicinal herbs used in TCM that is known to bind to RECQL4, a protein that is distributed throughout the cytosol, mitochondria, and other subcellular locations, albeit unevenly. Rhein has the tendency to accumulate in different subcellular organelles, which reduces the overall efficacy of the drug. To overcome this limitation, we conjugated a triphenylphosphonium group Rhein to direct the drug to the mitochondria, resulting in Rh-Mito . Results Our results demonstrated that this chemical modification retains the ability to intervene in the expression of RECQL4 protein while also improving the cellular uptake of Rh-Mito . Utilizing advanced imaging techniques, we show that Rh-Mito preferentially accumulated in the mitochondria, where it targeted RECQL4 to inhibit the repair of mtDNA, altered the morphology of mitochondrial cristae, and induced apoptosis. Notably, Rh-Mito displayed superior anti-tumor efficacy compared to unmodified Rhein. Conclusion Rh-Mito was designed to selectively target mitochondria, avoiding interactions with other organelles. This modification strengthens its binding to RECQL4, disrupts mitochondrial cristae, inhibits tumor cell migrati

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The Effect of External Weight Distribution on Muscle Activation Pattern during Obstacle Negotiation for Male Participants

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Proceedings of the Human Factors and Ergonomics Society Annual Meeting 2019年第1期63卷 37 - 41页

作者： Guofu Yi Xinting Wang Junxia Zhang Shuai Hao Boyi Hu School of Mechanical Engineering Tianjin University of Science and Technology Tianjin ChinaTianjin Key Laboratory of Integrated Design and On-line Monitoring for Light Industry & Food Machinery and Equipment Human System Engineering Laboratory Department of Industrial and Systems Engineering University of Florida Gainesville FL USA

Effects of different age groups and different external loading distribution on lower extremity muscle activation during obstacle crossing tasks were tested in this study. Four young participants and five healthy senior participants performed different walking tasks at their own speed carrying multiple different weights while their lower extremity muscle activation patterns were recorded and compared. Older adults showed significantly increased muscle activation patterns in obstacle negotiation. Furthermore, participants showed altered lower extremity muscle activation patterns with different load distribution.

关键词： weight distribution obstacle crossing obstacle contact surface myoelectricity (EMG) falling

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Fast reaction of AlNPs promoted by oxide shell

Fast reaction of AlNPs promoted by oxide shell

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中国力学大会（CCTAM 2019）

作者： Bao Wu FengChao Wu YinBo Zhu AnMin He Pei Wang HengAn Wu CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern Mechanics CAS Center for Excellence in Complex System Mechanics University of Science and Technology of China Laboratory of Computational Physics Institute of Applied Physics and Computational Mathematics

Combustion of Aluminum nanoparticles(AlNPs) has long been investigated experimentally because of its use in various energetic formulations for propellants and explosives. But the limited spatio-temporal resolution in experiments in particular makes it challenging to explore the microstructural evolution of AlNPs oxidation and associated mechanisms. Here we perform large-scale reactive molecular dynamics simulations to study the structural evolution of AlNPs with 2-4 nm thick oxide shell in oxygen environment. We find the temporal hollowing processes of AlNPs for both symmetrical and asymmetrical oxidations, in which the morphological evolution can be understood by discrepant electric field and temperature distributions for different system. In the early time, core Aluminum atoms experience a fast reaction with oxide shell. Environmental oxygen does not react with AlNPs until the surface O/Al ratio decreases to ～1.2. Moreover, based on our simulation results, previous experimental data agree well with the proposed model, which can well describe the relationship between combustion efficiency and oxide shell thickness, reveling that oxide shell promotes other than hinders combustion of AlNPs. The molecular insights obtained here would be significant for understanding the underlying mechanism and further modelling of AlNPs combustion

关键词： Fast reaction of AlNPs promoted by oxide shell

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Connectors Based on 2-Way SMA Actuator for Self-reconfigurable Chain Robots

Connectors Based on 2-Way SMA Actuator for Self-reconfigurab...

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IEEE International Conference on Mechatronics and Automation

作者： Fenglei Ni Yongqiang Li Yunhu Zhou Hong Liu Yuan Tang State Key Laboratory of Robotics and System Harbin Institute of Technology Harbin Heilongjiang Province China Science and Technology on Reactor System Design Technology Laboratory Nuclear Power Institute of China Chengdu China

Self-reconfigurable modular robots have shown great potential in carrying out multiple tasks in different conditions. A connection of both flexibility and reliability is critical for realizing the docking and transformation of the modular robots. We propose a new design of connectors based on SMA which has the advantages of high autonomy, small size and high speed. The couples of connectors consist of active and passive connector. In the active connector, a two-way rotary SMA actuator is used as the actuation mechanism. The double-layer cam and claws are used as an executive mechanism. The passive connector can be securely docked in five different facets for 3D reconfigurations. The multisensory system and hardware architecture provide the foundation for control strategies. The design and the prototype of the connector are described in this paper. Finally, experimental results to evaluate the performance of docking are presented.

关键词： Connectors Robots Contacts Wires Actuators Springs Task analysis

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Locomotion Mode Recognition based on Foot posture and Ground Reaction Force 15

Locomotion Mode Recognition based on Foot posture and Ground...

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15th International Conference on Ubiquitous Robots, UR 2018

作者： Zhu, Aibin Li, Ying Wu, Yuexuan Wu, Mengke Zhang, Xiaodong Key Laboratory of Intelligent Robot of Shaanxi Province Key Laboratory of Education Ministry for Modern Design and Rotor-Bearing System Xi'an Jiaotong University Xi'an710049 China Shaanxi University of Science Technology Xi'an710000 China

ISBN: (纸本)9781538663349

Efficient and accurate locomotion mode recognition is the basis and the key to compliance control of exoskeleton. Considering the fact that single ground reaction force information can not realize continuous gait phase recognition in the whole gait cycle and traditional inertial sensors' installation method tends to cause binding error, this paper established a wearable gait analysis system based on inertial sensor and foot pressure sensor which entirely embedded in a shoe insole. An inertial sensor mounting structure for foot posture information acquisition was designed to reduces the binding errors caused by the uncertain binding position and the random errors caused by the relative position changes with the movement. Two force sensors was set to measure the force load on the shoe insole at the heel and the forefoot during walking. Then, the gait curve of the normal human beings measured by this wearable gait analysis system is segmented by a periodic segmentation method combining power spectrum and feature points, and features is extracted from the time series of sensor signals according to the characteristics of the human gait. Probabilistic neural network is used to identify the locomotion modes and to verify the effectiveness of this wearable gait analysis system, experiments on different terrains are performed. The experiment results show that this method can effectively reduce binding error and random error, and reflect the foot movement during walking. Furthermore, the measurement method can accurately and effectively identify level-ground walking, stair ascent and stair decent, showing great potential for further development and applicability in control of exoskeleton. © 2018 IEEE.

关键词： Random errors

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Small Cluster Underwater Robot design with Variable Pitch Propeller 15

Small Cluster Underwater Robot design with Variable Pitch Pr...

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15th International Conference on Ubiquitous Robots, UR 2018

作者： Zhu, Aibin Song, Jiyuan Li, Ying Wu, Mengke Zhang, Xiaodong Key Laboratory of Intelligent Robot of Shaanxi Province Key Laboratory of Education Ministry for Modern Design and Rotor-Bearing System Xi'an Jiaotong University Xi'an710049 China Shaanxi University of Science Technology Xi'an710021 China

ISBN: (纸本)9781538663349

Most underwater robots use multiple sets of thrusters with motors and propellers to drive them independently that makes them bulky, inflexible and complex. In this paper, the propeller is innovatively designed that it can change the pitch that can be applied to underwater robots. The compact design, propeller response speed and high movement flexibility are the biggest advantage of this robot over current conventional designs. The movement of robot is controlled by three propellers and their rotations are driven by a common motor and each propeller is equipped with a servo to control the pitch. Transmission structure designed is symmetrical and compact that creates dynamic balance of the strong structure in itself. The retractable float completes the data transfer between the robot and the ground control also informs space assisted position of the robot when it is underwater and the float is outside of water. In addition, the robot also includes a matching electronic drive and remote control box. Basic movement requirements can be achieved through the independent and coordinated control of the three actuators of the robot. The actual underwater test of the robot verifies the flexibility and horizontal stability of the robot designed. The characteristics of carrying sensors in underwater robots to move more flexibly and effectiveness of the proposed control method is also verified in the actual water test. © 2018 IEEE.

关键词： Robots

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Passivity and Synchronization of Coupled Complex-Valued Memristive Neural Networks

Passivity and Synchronization of Coupled Complex-Valued Memr...

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IEEE Symposium Series on Computational Intelligence (SSCI)

作者： Yanli Huang Jie Hou Shunyan Ren Erfu Yang Tianjin Key Laboratory of Optoelectronic Detection Technology and System School of Computer Science and Technology Tiangong University Tianjin China School of Mechanical Engineering Tiangong University Tianjin China Department of Design Manufacture and Engineering Management University of Strathclyde Glasgow Scotland UK

ISBN: (数字)9781728124858

ISBN: (纸本)9781728124865

The coupled complex-valued memristive neural networks (CCVMNNs) are investigated in this study. First, we analyze the passivity of the proposed network model by designing an appropriate controller and using certain inequalities as well as Lyapunov functional method, and provide a passivity condition for the considered CCVMNNs. In addition, a criterion for guaranteeing synchronization of this kind of network is established. Finally, the effectiveness and correctness of the acquired theoretical results are verified by a numerical example.

关键词： Synchronization Biological neural networks Memristors Couplings Neurons

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Utilizing Cationic Vacancies and Spontaneous Polarization on Cathode to Enhance Zinc-Ion Storage and Inhibit Dendrite Growth in Zinc-Ion Batteries

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Angewandte Chemie 2023年第26期135卷

作者： Dr. Liqi Bai Zihan Hu Cheng Hu Songge Zhang Dr. Yiran Ying Yingge Zhang Lu Li Hanfang Zhang Dr. Nan Li Dr. Shanshan Shi Shuo Liu Dr. Lin Hao Tongyao Liu Prof. Hongwei Huang Prof. Haitao Huang Prof. Yihe Zhang Engineering Research Center of Ministry of Education for Geological Carbon Storage and Low Carbon Utilization of Resources Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes National Laboratory of Mineral Materials School of Material Sciences and Technology China University of Geosciences Beijing 100083 China Department of Applied Physics and Research Institute for Smart Energy The Hong Kong Polytechnic University Hung Hom Kowloon Hong Kong 999077 China Contribution: Writing - original draft (lead) Writing - review & editing (lead) Faculty of System Design and Intelligent Manufacturing Southern University of Science and Technology Nanshan District Shenzhen Guangdong 518055 China Songshan Lake Materials Laboratory Guangdong 523808 China School of Fashion and Textiles and Research Institute for Intelligent Wearable Systems The Hong Kong Polytechnic University Hung Hom Kowloon Hong Kong 999077 China

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Ionic liquid choline chloride-urea dissolving cattle bone extracted hydroxyapatite

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Journal of Bionanoscience 2018年第3期12卷 437-441页

作者： Song, Wei Yang, Yan Deng, Yu Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control Tianjin University of Technology Tianjin300384 China National Demonstration Center for Experimental Mechanical and Electrical Engineering Education Tianjin University of Technology Tianjin300384 China Department of Osteo-Internal Medicine Tianjin Hospital Tianjin300211 China School of Materials Science and Chemical Engineering Tianjin University of Science and Technology Tianjin300457 China

The dissolving technique of ionic liquid (IL) was applied in extraction process of hydroxyapatite (HAp). Product HAp was extracted by IL choline chloride-urea (ChCl-Urea) dissolving cattle bone. The optimum conditions for regeneration process of cattle bone were determined by single factor, orthogonal and verification experiments. IR spectra of regenerated bone, undissolved bone and raw bone showed that the main groups of regenerated bone did not change. It was indicated that ionic liquid did not damage the bone collagen of raw bone, and the collagen was only dissolved by IL. IR spectrum of the product HAp revealed that its components were similar to those of the natural bone. SEM pattern showed that the crystal shape of the product HAp appeared rod-like shape mostly, and the crystal structure was relatively complete. XRD diffraction explained that there was no difference between product HAp and standard HAp for the crystalline form and compositions. Copyright © 2018 American Scientific Publishers All rights reserved.

关键词： Hydroxyapatite

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Recent Improvements in the Dart Model for Atmosphere, Topography, Large Landscape, Chlorophyll Fluorescence, Satellite Image Inversion

Recent Improvements in the Dart Model for Atmosphere, Topogr...

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IEEE International Symposium on Geoscience and Remote Sensing (IGARSS)

作者： J.P. Gastellu-Etchegorry Y. Wang O. Regaieg T. Yin Z. Malenovsky Z. Zhen X. Yang Z. Tao L. Landier A. Al Bitar Deschamps N. Lauret J. Guilleux E. Chavanon B. Cao J. Qi A. Kallel Z. Mitraka N. Chrysoulakis B. Cook D. Morton Université de Toulouse CESBIO - UPS CNES CNRS IRD Toulouse France Earth System Science Interdisciplinary Center University of Maryland College Park MD USA School of Technology Environments and Design University of Tasmania Hobart Australia College of Geo-Exploration Science and Technology Jilin University Changchun China Institute of Remote Sensing and Digital Earth Chinese Academy of Sciences Beijing China Key Laboratory of Geographical Information Science East China Normal University Shanghai China CNES Toulouse France Beijing Forestry University Beijing China CRNS ATMS Sfax Tunisia Foundation for Research and Technology Hellas (FORTH) Heraklion Greece NASA Goddard Space Flight Center Greenbelt MD USA

ISBN: (数字)9781728163741

ISBN: (纸本)9781728163758

Physical models simulating the radiative budget (RB) and remote sensing (RS) observation of three-dimensional (3D) landscapes are critical to better understand human and natural components of the Earth system and further develop RS technology. DART is one of the most comprehensive 3D models of Earth-atmosphere optical radiative transfer (RT), from ultraviolet (UV) to thermal infrared (TIR). It simulates the optical signal of proximal, aerial and satellite imaging spectrometers and laser scanners, the 3D RB and solar induced chlorophyll fluorescence (SIF) signal, for any urban or natural landscape and any experimental or instrument configuration. It is freely available for research and teaching activities (https://***). Here, five recent advances are presented. 1) Atmosphere RT. 2) RT in non repetitive topography. 3) Monte Carlo modelling for fast RS image simulation of large landscapes. 4) SIF modelling for vegetation simulated as facets and turbid cells. 5) RS image inversion for mapping the optical properties of urban material and the urban radiative budget.

关键词： Atmospheric modeling Three-dimensional displays Terrestrial atmosphere Earth Satellites Computational modeling Surface topography

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