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Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations

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Human molecular genetics 2017年第2期26卷 454-465页

作者： Wei Jie Seow Keitaro Matsuo Chao Agnes Hsiung Kouya Shiraishi Minsun Song Hee Nam Kim Maria Pik Wong Yun-Chul Hong H Dean Hosgood Zhaoming Wang I-Shou Chang Jiu-Cun Wang Nilanjan Chatterjee Margaret Tucker Hu Wei Tetsuya Mitsudomi Wei Zheng Jin Hee Kim Baosen Zhou Neil E Caporaso Demetrius Albanes Min-Ho Shin Lap Ping Chung She-Juan An Ping Wang Hong Zheng Yasushi Yatabe Xu-Chao Zhang Young Tae Kim Xiao-Ou Shu Young-Chul Kim Bryan A Bassig Jiang Chang James Chung Man Ho Bu-Tian Ji Michiaki Kubo Yataro Daigo Hidemi Ito Yukihide Momozawa Kyota Ashikawa Yoichiro Kamatani Takayuki Honda Hiromi Sakamoto Hideo Kunitoh Koji Tsuta Shun-Ichi Watanabe Hiroshi Nokihara Yohei Miyagi Haruhiko Nakayama Shingo Matsumoto Masahiro Tsuboi Koichi Goto Zhihua Yin Jianxin Shi Atsushi Takahashi Akiteru Goto Yoshihiro Minamiya Kimihiro Shimizu Kazumi Tanaka Tangchun Wu Fusheng Wei Jason Y Y Wong Fumihiko Matsuda Jian Su Yeul Hong Kim In-Jae Oh Fengju Song Victor Ho Fun Lee Wu-Chou Su Yuh-Min Chen Gee-Chen Chang Kuan-Yu Chen Ming-Shyan Huang Pan-Chyr Yang Hsien-Chih Lin Yong-Bing Xiang Adeline Seow Jae Yong Park Sun-Seog Kweon Chien-Jen Chen Haixin Li Yu-Tang Gao Chen Wu Biyun Qian Daru Lu Jianjun Liu Hyo-Sung Jeon Chin-Fu Hsiao Jae Sook Sung Ying-Huang Tsai Yoo Jin Jung Huan Guo Zhibin Hu Wen-Chang Wang Charles C Chung Charles Lawrence Laurie Burdett Meredith Yeager Kevin B Jacobs Amy Hutchinson Sonja I Berndt Xingzhou He Wei Wu Junwen Wang Yuqing Li Jin Eun Choi Kyong Hwa Park Sook Whan Sung Li Liu Chang Hyun Kang Lingmin Hu Chung-Hsing Chen Tsung-Ying Yang Jun Xu Peng Guan Wen Tan Chih-Liang Wang Alan Dart Loon Sihoe Ying Chen Yi Young Choi Jen-Yu Hung Jun Suk Kim Ho-Il Yoon Qiuyin Cai Chien-Chung Lin In Kyu Park Ping Xu Jing Dong Christopher Kim Qincheng He Reury-Perng Perng Chih-Yi Chen Roel Vermeulen Junjie Wu Wei-Yen Lim Kun-Chieh Chen John K C Chan Minjie Chu Yao-Jen Li Jihua Li Hongyan Chen Chong-Jen Yu Li Jin Yen-Li Lo Ying-Hsiang Chen Joseph F Fraumeni Jie Liu Taiki Yamaji Yang Yang Belynda Hicks Kathleen Wyatt Shengchao A Li Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA. Saw Swee Hock School of Public Health National University of Singapore and National University Health System Singapore. Division of Molecular Medicine Aichi Cancer Center Research Institute Nagoya Japan. Institute of Population Health Sciences National Health Research Institutes Zhunan Taiwan. Division of Genome Biology National Cancer Center Research Institute Tokyo Japan. Department of Statistics Sookmyung Women's University Seoul Republic of Korea. Department of Preventive Medicine Chonnam National University Medical School Gwangju Republic of Korea. Department of Pathology The University of Hong Kong Queen Mary Hospital Hong Kong. Department of Preventive Medicine Seoul National University College of Medicine Seoul Republic of Korea. Department of Epidemiology and Population Health Albert Einstein College of Medicine Bronx NY USA. Department of Computational Biology St. Jude Children's Research Hospital Memphis TN 38105 USA. National Institute of Cancer Research National Health Research Institutes Zhunan Taiwan. Ministry of Education Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai People's Republic of China. State Key Laboratory of Genetic Engineering School of Life Sciences Fudan University Shanghai People's Republic of China. Division of Thoracic Surgery Kinki University School of Medicine Sayama Japan. Division of Epidemiology Department of Medicine Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center Nashville TN USA. Department of Integrative Bioscience & Biotechnology Sejong University Seoul Republic of Korea. Department of Epidemiology School of Public Health China Medical University Shenyang People's Republic of China. Guangdong Lung Cancer Institute Medical Research Center and Cancer Center of Guangdong General Hospital Guangdong Academy of Medical Sciences Guangzhou People's Republic

To evaluate associations by EGFR mutation status for lung adenocarcinoma risk among never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified in genome-wide association studies (GWAS). Genotyping in an additional 10,780 never-smoking cases and 10,938 never-smoking controls from Asia confirmed associations with eight known single nucleotide polymorphisms (SNPs). Two new signals were observed at genome-wide significance (P < 5 × 10-8), namely, rs7216064 (17q24.3, BPTF), for overall lung adenocarcinoma risk, and rs3817963 (6p21.3, BTNL2) which is specific to cases with EGFR mutations. In further sub-analyses by EGFR status, rs9387478 (ROS1/DCBLD1) and rs2179920 (HLA-DPB1) showed stronger estimated associations in EGFR-positive compared to EGFR-negative cases. Comparison of the overall associations with published results in Western populations revealed that the majority of these findings were distinct, underscoring the importance of distinct contributing factors for smoking and non-smoking lung cancer. Our results extend the catalogue of regions associated with lung adenocarcinoma in non-smoking Asian women and highlight the importance of how the germline could inform risk for specific tumour mutation patterns, which could have important translational implications.

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To enhance power distribution network management of local power service enterprise by using cloud platform

To enhance power distribution network management of local po...

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International Conference on Information Science and technology (ICIST)

作者： Gang Xiong Timo R. Nyberg Pekka Hämäläinen Xisong Dong Yuan Liu Jiachen Hou Cloud Computing Center Chinese Academy of Sciences Dongguan CHINA Department of Industrial Engineering and Management Aalto University Aalto FINLAND Tekla Corporations Metsänpojankuja Espoo FINLAND Key Laboratory of Complex System Intelligent Science Chinese Academy of Sciences Beijing CHINA Nanjing Smart Energy Information Technology Co. LTD Nanjing CHINA Beijing Engineering Research Center of Intelligent Systems and Technology Chinese Academy of Sciences Beijing CHINA

The availability of new technologies in the areas of digital electronics, communications, internet, and computer technologies opens a door to build a smart grid, which can increase significantly the capacity, services and intelligence of power systems. This paper proposes a power distribution network management cloud platform based on Tekla Xpower. Proposed system can support the implementation of current power grid and/or the coming smart grid. Utilizing the existing computing and storage installations, cloud platform can integrate the existing resources to improve the computation and storage capacities, the data security of the entire system, and can increase application intelligence, service quality and decision-making capability as well. The four layer architecture of cloud platform is designed, and a pilot case study for DMS is provided.

关键词： Computer network reliability Reliability Databases Business Electronic mail Handheld computers

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Soil legacy data rescue via GlobalSoilMap and other international and national initiatives

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GeoResJ 2017年第9期14卷 1-19页

作者： Arrouays, Dominique Leenaars, Johan G.B. Richer-de-Forges, Anne C. Adhikari, Kabindra Ballabio, Cristiano Greve, Mogens Grundy, Mike Guerrero, Eliseo Hempel, Jon Hengl, Tomislav Heuvelink, Gerard Batjes, Niels Carvalho, Eloi Hartemink, Alfred Hewitt, Alan Hong, Suk-Young Krasilnikov, Pavel Lagacherie, Philippe Lelyk, Glen Libohova, Zamir Lilly, Allan McBratney, Alex McKenzie, Neil Vasquez, Gustavo M. Mulder, Vera Leatitia Minasny, Budiman Montanarella, Luca Odeh, Inakwu Padarian, Jose Poggio, Laura Roudier, Pierre Saby, Nicolas Savin, Igor Searle, Ross Solbovoy, Vladimir Thompson, James Smith, Scott Sulaeman, Yiyi Vintila, Ruxandra Rossel, Raphael Viscarra Wilson, Peter Zhang, Gan-Lin Swerts, Martine Oorts, Katrien Karklins, Aldis Feng, Liu Ibelles Navarro, Alexandro R. Levin, Arkadiy Laktionova, Tetiana Suvannang, Nopmanee Ruam, Waew Prasad, Jagdish Patil, Nitin Husnjak, Stjepan Pásztor, László Okx, Joop Hallet, Stephen Keay, Caroline Farewell, Timothy Lilja, Harri Juilleret, Jérôme Marx, Simone Takata, Yusuke Kazuyuki, Yagi Mansuy, Nicolas Panagos, Panos Van Liedekerke, Mark Skalsky, Rastislav Sobocka, Jaroslava Kobza, Josef Eftekhari, Kamran Alavipanah, Seyed Kacem Moussadek, Rachid Badraoui, Mohamed Da Silva, Mayesse Paterson, Garry Gonçalves, Maria da Conceição Theocharopoulos, Sid Yemefack, Martin Tedou, Silatsa Vrscaj, Borut Grob, Urs Kozák, Josef Boruvka, Lubos Dobos, Endre Taboada, Miguel Moretti, Lucas Rodriguez, Dario INRA InfoSol Unit Orléans 45075 France ISRIC – World Soil Information PO Box 353 Wageningen 6700 AJ Netherlands Department of Agroecology Faculty of Science and Technology Aarhus University Tjele Denmark European Commission – DG JRC Via E. Fermi 2749 Ispra (VA) 21027 Italy CSIRO Australia National Institute of Statistics and Geography INEGI Aguascalientes Mexico US Department of Agriculture Natural Resources Conservation Services Lincoln Nebraska United States University of Wisconsin Department of Soil Science Madison United States Landcare Research Manaaki Whenua New Zealand Department of Agricultural Environment National Academy of Agricultural Science Suwon 441707 South Korea Eurasian Center for Food Security Lomonosov Moscow State University Moscow Russian Federation INRA-IRD-Supagro UMR Lisah Montpellier France Agriculture and Agri-Food Canada Ottawa Canada The James Hutton Institute Craigiebuckler Aberdeen Scotland United Kingdom University of Sydney Sydney Australia Embrapa Solos Rio de Janeiro Brazil Biogeochemistry and Earth System Modelling Sciences de la Terre et de l'Environnement Université Libre de Bruxelles Bruxelles Belgium Dokutchaev Soil Science Institute Moscow Russian Federation West Virginia University WV United States Indonesian Center for Agricultural Land Resource Research and Development Bogor West Java Indonesia National Research and Development Institute for Soil Science Agro-chemistry and Environment (ICPA) Bucharest Romania State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil Science Chinese Academy of Sciences Nanjing China Land and Soil Protection Service Flemish Government Brussels Belgium Latvia Agricultural University Jelgava Latvia National Scientific Center Institute for Soil Science and Agrochemistry Research Kharkiv Ukraine Sistema de Información Geográfica Dirección General de Recursos Naturales Ministerio de Ganadería Agricultura y Pesca Montevideo Uruguay Land Development

Legacy soil data have been produced over 70 years in nearly all countries of the world. Unfortunately, data, information and knowledge are still currently fragmented and at risk of getting lost if they remain in a paper format. To process this legacy data into consistent, spatially explicit and continuous global soil information, data are being rescued and compiled into databases. Thousands of soil survey reports and maps have been scanned and made available online. The soil profile data reported by these data sources have been captured and compiled into databases. The total number of soil profiles rescued in the selected countries is about 800,000. Currently, data for 117, 000 profiles are compiled and harmonized according to GlobalSoilMap specifications in a world level database (WoSIS). The results presented at the country level are likely to be an underestimate. The majority of soil data is still not rescued and this effort should be pursued. The data have been used to produce soil property maps. We discuss the pro and cons of top-down and bottom-up approaches to produce such maps and we stress their complementarity. We give examples of success stories. The first global soil property maps using rescued data were produced by a top-down approach and were released at a limited resolution of 1 km in 2014, followed by an update at a resolution of 250 m in 2017. By the end of 2020, we aim to deliver the first worldwide product that fully meets the GlobalSoilMap specifications. © 2017 Elsevier Ltd

关键词： GlobalSoilMap Legacy data Soil data rescue

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A framework of video coding for compressing near-duplicate videos

A framework of video coding for compressing near-duplicate v...

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20th Anniversary International Conference on MultiMedia Modeling, MMM 2014

作者： Wang, Hanli Ma, Ming Jiang, Yu-Gang Wei, Zhihua Department of Computer Science and Technology Tongji University Shanghai China Key Laboratory of Embedded System and Service Computing Ministry of Education Tongji University Shanghai China School of Computer Science Fudan University Shanghai China

ISBN: (纸本)9783319041131

With the development of multimedia technique and social network, the amount of videos has grown rapidly, which brings about an increasingly substantial percentage of Near-Duplicate Videos (NDVs). It has been a hot research topic to retrieve NDVs for a number of applications such as copyright detection, Internet video ranking, etc. However, there exist a lot of redundancies in NDVs, and to the best of our knowledge it is an untouched research area on how to efficiently compress NDVs in a joint manner. In this work, a novel video coding framework is proposed to effectively compress NDVs by making full use of the relevance among them. Experimental results demonstrate that a significant storage saving can be achieved by the proposed NDV coding framework. © 2014 Springer International Publishing.

关键词： Video signal processing

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Quasi-synchronization for delayed systems with parameter mismatches via aperiodically intermittent control

Quasi-synchronization for delayed systems with parameter mis...

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International Conference on systems and Informatics (ICSAI)

作者： Xiwei Liu Ping Li Yuan Xu Ying Liu Department of Computer Science and Technology Key Laboratory of Embedded System and Service Computing Shanghai China

ISBN: (纸本)9781479954599

Quasi-synchronization is an important type of synchronization because of the parameter mismatches in the real world, so we will investigate it for a delayed network, which is master-slave coupled. By applying the aperiodically and nonlinearly intermittent control on the network, and assuming the time delay is varying, we will present some useful criteria for exponential quasi-synchronization. The main difference of this paper with previous works is that the intermittent mode is aperiodic while that in previous works is periodic. Finally, simulations are also given to show its validity.

关键词： Synchronization Mathematical model Delay effects Numerical models Observers Equations Educational institutions

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Test and repair flow for shared BISR in asynchronous multi-processors

Test and repair flow for shared BISR in asynchronous multi-p...

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20th IEEE International Symposium on Asynchronous Circuits and systems, ASYNC 2014

作者： Wang, Gang Wang, Xu Chen, Xinke Xue, Shuangbai Key Laboratory of Computer System and Architecture Chinese Academy of Sciences Beijing 100190 China Institute of Computing Technology Chinese Academy of Sciences Beijing 100190 China Loongson Technology Corporation Limited Beijing 100190 China Shandong Eway Information and Technology Co. Ltd China

ISBN: (纸本)9781479937899

We present a hierarchical test and repair flow for shared BISR (Built-In Self-Repair) in asynchronous multi-processors. The flow partitions the memories local to a processor in groups and treats the groups as a whole when doing the repair. The flow runs automatically with few interventions except at the beginning stage. It can be used effectively for practical industrial test and repair. Its test time is as good as equivalent to that of parallel BISR, while its test power is substantially lower, about 40% that of parallel repair. It also has a superior repair rate, about 11-12% better compared to sequential and parallel BISR. © 2014 IEEE.

关键词： Repair

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A Method to Check Liveness of WS3PR 33

A Method to Check Liveness of WS3PR

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第三十三届中国控制会议

作者： WANG ShouGuang LIU Miao ZHOU MengChu WU WenHui IEEE School of Information & Electronic Engineering Zhejiang Gongshang University State Key Laboratory for Manufacturing Systems Engineering Xi’an Jiaotong University School of Electro-Mechanical Engineering Xidian University The Key Laboratory of Embedded System and Service Computing Ministry of EducationTongji University Department of Electrical and Computer Engineering New Jersey Institute of TechnologyNewarkNJ 07102USA

ISBN: (纸本)9781479947249

Petri nets are widely used to model flexible manufacturing systems(FMSs) because they can help analyze the properties and synthesize deadlock-free supervisory controllers of *** system of Simple Sequential Processes with Resources(WS3PR) is an important subclass of Petri nets that can well model many *** work first gives new algorithms to check liveness for a WS3 PR net via its subnet trees and *** the computation complexity for the proposed method is shown in this paper,to be polynomial under certain ***,sufficient conditions for deciding liveness of a WS3 PR are *** example is used to illustrate the results.

关键词： Liveness,flexible manufacturing system,deadlock,Petri net.

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A Method of same name disambiguation towards literature search

A Method of same name disambiguation towards literature sear...

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2014 11th Web Information system and Application Conference(第十一届全国web信息系统及其应用学术会议)

作者： Li Liu Dexin Zhao Pengfei Lei Yukun Li Pengcheng Tian Tianjin University of Technology 300384 Key Laboratory of Intelligence Computing and Novel Software Technology TianjinChina Key Laboratory of Computer Vision and System Ministry of Education Tianjin China

ISBN: (纸本)9781479957286

The issue that many authors share the same name results in many problems for paper search and the study of the Scientists Collaboration *** this paper, we study the problem of name ambiguities towards author-based search,propose a framework on same name disambiguation towards literatures searching, and propose a method to classify author-based searching results based on researchers of the real *** experimental results show the effectiveness of the methods we proposed.

关键词： Same Name Disambiguation author search Classification

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Robust control reconfiguration of resource allocation systems with Petri nets and integer programming

Robust control reconfiguration of resource allocation system...

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作者： Li, Jun Zhou, Mengchu Guo, Tao Gan, Yahui Dai, Xianzhong Key Laboratory of Measurement and Control of Complex Systems of Engineering Ministry of Education China School of Automation Southeast University Nanjing 210096 China Key Laboratory of Embedded System and Service Computing Ministry of Education Tongji University Shanghai 201804 China Department of Electrical and Computer Engineering New Jersey Institute of Technology Newark NJ 07102 United States

Supervisory control reconfiguration can handle the uncertainties including resource failures and task changes in discrete event systems. It was not addressed to exploit the robustness of closed-loop systems to accommodate some uncertainties in the prior studies. Such exploitation can cost-efficiently achieve reconfigurability and flexibility for real systems. This paper presents a robust reconfiguration method based on Petri nets (PNs) and integer programming for supervisory control of resource allocation systems (RASs) subject to varying resource allocation relationships. An allocation relationship is seen as a control specification while the execution processes requiring resources as an uncontrolled plant. First, a robust reconfiguration mechanism is proposed. It includes updating the P-invariant-based supervisor and evolving the state of the closed-loop system. The latter adapts to the control specification changes by the self-regulation of the closed-loop system's state. Next, two novel integer programming models for control reconfiguration are proposed, called a reconfiguration model with acceptability and reconfiguration one with specification correction. Since both models integrate the firability condition of transitions, no additional efforts are required for the state reachability analysis. Finally, a hospital emergency service system is used as an example to illustrate them. © 2014 Elsevier Ltd. All rights reserved.

关键词： Integer programming

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A Secure Synchronized Reading system over Time-Critical Online Contests

A Secure Synchronized Reading System over Time-Critical Onli...

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IEEE International Conference on Communications

作者： Wei Wang Peng Xu Hui Li Laurence Tianruo Yang Key Lab of Cloud Computing Technology Peking University Shenzhen China Services Computing Technology and System Lab Cluster and Grid Computing Lab Huazhong University of Science and Technology Wuhan China Embedded and Pervasive Computing Lab Huazhong University of Science and Technology Wuhan China

The time-critical online contest environment calls for an elegant and precise management system to start a contest online. The management system should simultaneously follow three rules of security that are confidentiality, anonymity and fairness. We present in this paper a novel system named Secure Synchronized Reading (SSR) system as well as its corresponding security model according to the three rules. SSR can evoke a synchronized start for all competitors in a contest at the intended time by employing a Randomness-reused Identity-Based Encryption (RIBE) scheme. It can avoid huge differences among delivery delays of heterogeneous competitors and any false start by an adverse competitor. Consequently when an online contest begins, the SSR system performs quasi real-time with ignorable communication delays in the security model. As a complement, the analysis on the provable security of SSR is given finally, as well as a further analysis on the achievement of synchronization.

关键词： Synchronization Encryption Delays Real-time systems Identity-based encryption

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