The rapid developments of chip-based technology have greatly improved human genetics and made routine the access of thousands of single nucleotide polymorphisms (SNPs) contributing to an informatics challenge. The cha...
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ISBN:
(纸本)9781450328104
The rapid developments of chip-based technology have greatly improved human genetics and made routine the access of thousands of single nucleotide polymorphisms (SNPs) contributing to an informatics challenge. The characterization and interpretation of genes and gene-gene interactions that affect the susceptibility of common, complex multifactorial diseases is a computational and statistical challenge in genome-wide association studies (GWAS). Various methods have been proposed, but they have dificulty to be directly applied to GWAS caused by excessive search space and intensive computational burden. In this paper, we propose an ant colony optimization (ACO) based algorithm by combining the pheromone updating rule with the heuristic information. We tested power performance of our algorithm by conducting suficient experiments including a wide range of simulated datasets experiments and a real genome-wide dataset experiment. Experimental results demonstrate that our algorithm is time efficient and gain good performance in the term of the power of prediction accuracy. Copyright 2014 ACM.
Extensive studies have shown that many complex diseases are influenced by interaction of certain genes, while due to the limitations and drawbacks of adopting logistic regression (LR) to detect epistasis in human Geno...
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Due to the limited computing resource on mobile devices, it is more difficult to get semantically relevant results from a large dataset in time in a mobile image retrieving system, compared with normal content based i...
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A new algorithm combined Eagle Strategy with PSO is proposed. The new algorithm performs by two phases: First Eagle Strategy is used to do global search;Second PSO algorithm is used to do fast local search around a pr...
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The paper aims at tackling the problem of image fusion for panchromatic CT and multispectral CBF images. We proposed a fusion algorithm based on Intensity-hue-saturation (IHS) transform and Discrete Wavelet Transform ...
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The paper aims at tackling the problem of image fusion for panchromatic CT and multispectral CBF images. We proposed a fusion algorithm based on Intensity-hue-saturation (IHS) transform and Discrete Wavelet Transform (DWT) in the paper. We use different fusion rules for different parts of the images. The area energy is adopted to fuse the high frequency parts of the original images. While, for the low frequency parts, weighted averaging is applied. Experimental results show that the proposed algorithm is not only competent for retaining the spatial resolution of the panchromatic image, but also solves the problem of spectral distortions.
XML document is dynamic and dynamic XML document collection cluster analysis is a hot research topic. This paper proposed a data model named TDOM to record the dynamic changing process of XML document, then proposed a...
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XML document is dynamic and dynamic XML document collection cluster analysis is a hot research topic. This paper proposed a data model named TDOM to record the dynamic changing process of XML document, then proposed a method to discover all the conspicuous frequent substructures from TDOM dataset, finally, proposed a method to cluster the XML documents by the conspicuous frequent substructures. The experiment runs on the synthetic dataset, the experimental result shows that our method is efficiency and scalable.
Density-based clustering over huge volumes of evolving data streams is critical for many modern applications ranging from network traffic monitoring to moving object management. In this work, we propose an efficient d...
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We propose a new multi-focus image fusion algorithm which is based on Difference Transform (DT). In this paper, we investigate the use of Difference Transform in image focus detection in Laplacian Pyramid and Discrete...
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Mining newsworthy events from a large number of microblogging information is not only the primary problem that several big microblogging websites need to solve, but also a new research field in micro-information age. ...
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Image fusion is a procedure in which two or more images of one scene captured by different sensors are combined into one image. The target of image fusion is to produce images which are more suitable for human visual ...
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