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A Novel Drug-Drug Interaction Prediction Model Based on Line Subgraph Generation Strategy

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A Novel Drug-Drug Interaction Prediction Model Based on Line...

IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

作者： Tian Bai Chu Li Xinyue Peng Haotian Guan Zefan Zhang Guishen Wang College of Computer Science and Technology Jilin University Changchun China Key Laboratory of Symbolic Computation and Knowledge Engineering Ministry of Education Jilin University Changchun China College of Software Jilin University Changchun China School of Nursing Jilin University Changchun China School of Life Sciences Jilin University Changchun China College of Computer Science and Engineering Changchun University of Technology Changchun China

Drug-Drug Interaction (DDI) prediction task is helpful for better-understanding drugs. In this paper, we propose a novel drug-drug interaction prediction model based on line subgraph generation strategy, named DDI-LSG model. Our DDI-LSG model consists of three main parts which include drug relation graph construction, line subgraph generation strategy, and graph-level classification. To consider more relationships among drugs, we propose a node feature-enhancing method to encode drug features in drug relation graph construction process. To consider drugs and DDI as equivalent factors of our DDI-LSG model, we introduce line graph transformation to integrate DDI with drug feature enhancing vector. Combining Jaccard similarity with cosine similarity, we propose a line subgraph generation strategy to evaluate node relation and extract key structures around target DDI in the line graph. Then, we reformulate the DDI prediction task into a graph-level classification task for the line subgraph of the target DDI. Therefore, in the final part of our DDI-LSG model, we use a graph-level classifier to classify the line subgraphs. Our DDI-LSG model outperforms better experiment results than baselines. Ablation results have validated the node feature enhancing method and line subgraph generation strategy.

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Improved fluid search optimization-based real-time weed mapping

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Information Processing in Agriculture 2020年第3期7卷 403-417页

作者： Chengcheng Chen Shengsheng Wang Xianchang Wang Helong Yu Ruyi Dong College of Computer Science and Technology Jilin UniversityChangchun 130012China Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Changchun 130012China College of Information Technology Jilin Agricultural UniversityChangchun 130118China Chengdu Kestrel Artificial Intelligence Institute Chengdu 611730China

In the field of agriculture,variable-rate herbicide spraying(VRHS)technology has been used to solve the low efficiency of pesticides and crop chemical *** key of VRHS is the quick and precise identification of weeds from field images,which forms a weed *** search optimization(FSO)was able to simplify the threshold optimization process to create a weed map,which simulated the fluid flowing from high pressure to low pressure,but it is time consuming and often converges ***,an explosion mechanism and a twophase optimization were introduced to improve the FSO-based segmentation *** of segmentation weeds from a corn field at seedling growth stage showed that the IFSO algorithm obtained the best accuracy of 93.3%and the least running time of 0.019 s,compared with the standard PSO,GA,and FSO algorithms.

关键词： Variable-rate herbicide spraying Weed map Fluid search optimization algorithm Otsu

Wide aspect ratio matching for robust face detection

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arXiv 2021年

作者： Luo, Shi Li, Xiongfei Zhang, Xiaoli Key Laboratory of Symbolic Computation Knowledge Engineering of Ministry of Education Jilin University Changchun130012 China College of Computer Science and Technology Jilin University Changchun130012 China

Recently, anchor-based methods have achieved great progress in face detection. Once anchor design and anchor matching strategy determined, plenty of positive anchors will be sampled. However, faces with extreme aspect ratio always fail to be sampled according to standard anchor matching strategy. In fact, the max IoUs between anchors and extreme aspect ratio faces are still lower than fixed sampling threshold. In this paper, we firstly explore the factors that affect the max IoU of each face in theory. Then, anchor matching simulation is performed to evaluate the sampling range of face aspect ratio. Besides, we propose a Wide Aspect Ratio Matching (WARM) strategy to collect more representative positive anchors from ground-truth faces across a wide range of aspect ratio. Finally, we present a novel feature enhancement module, named Receptive Field Diversity (RFD) module, to provide diverse receptive field corresponding to different aspect ratios. Extensive experiments show that our method can help detectors better capture extreme aspect ratio faces and achieve promising detection performance on challenging face detection benchmarks, including WIDER FACE and FDDB datasets. © 2021, CC BY.

关键词： Aspect ratio

Generative AI for Deep Reinforcement Learning: Framework, Analysis, and Use Cases

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arXiv 2024年

作者： Sun, Geng Xie, Wenwen Niyato, Dusit Mei, Fang Kang, Jiawen Du, Hongyang Mao, Shiwen College of Computer Science and Technology Jilin University Changchun130012 China Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin University Changchun130012 China College of Computing and Data Science Nanyang Technological University Singapore639798 Singapore School of Automation Guangdong University of Technology Guangzhou510006 China Department of Electrical and Electronic Engineering The University of Hong Kong 999077 Hong Kong Department of Electrical and Computer Engineering Auburn University Auburn36830 United States

As a form of artificial intelligence (AI) technology based on interactive learning, deep reinforcement learning (DRL) has been widely applied across various fields and has achieved remarkable accomplishments. However, DRL faces certain limitations, including low sample efficiency and poor generalization. Therefore, we present how to leverage generative AI (GAI) to address these issues above and enhance the performance of DRL algorithms in this paper. We first introduce several classic GAI and DRL algorithms and demonstrate the applications of GAI-enhanced DRL algorithms. Then, we discuss how to use GAI to improve DRL algorithms from the data and policy perspectives. Subsequently, we introduce a framework that demonstrates an actual and novel integration of GAI with DRL, i.e., GAI-enhanced DRL. Additionally, we provide a case study of the framework on UAV-assisted integrated near-field/far-field communication to validate the performance of the proposed framework. Moreover, we present several future directions. Finally, the related code is available at: https://***/GAI-enhanced-DRL. Copyright © 2024, The Authors. All rights reserved.

关键词： Deep reinforcement learning

UAV Swarm-enabled Collaborative Post-disaster Communications in Low Altitude Economy via a Two-stage Optimization Approach

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arXiv 2025年

作者： Zheng, Xiaoya Sun, Geng Li, Jiahui Wang, Jiacheng Wu, Qingqing Niyato, Dusit Jamalipour, Abbas College of Computer Science d Technology Jilin University Changchun130012 China Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin University Changchun130012 China College of Computing and Data Science Nanyang Technological University 639798 Singapore College of Computing and ta Science Nanyang Technological University 639798 Singapore Department of Electronic Engineering Shanghai Jiao Tong University Shanghai200240 China School of Electrical and Computer Engiering The University of Sydney SydneyNSW2006 Australia

The low-altitude economy (LAE), as a new economic paradigm, plays an indispensable role in cargo transportation, healthcare, infrastructure inspection, and especially post-disaster communication. Specifically, unmanned aerial vehicles (UAVs), as one of the core technologies of the LAE, can be deployed to provide communication coverage, facilitate data collection, and relay data for trapped users, thereby significantly enhancing the efficiency of post-disaster response efforts. However, conventional UAV self-organizing networks exhibit low reliability in long-range cases due to their limited onboard energy and transmit ability. Therefore, in this paper, we design an efficient and robust UAV-swarm enabled collaborative self-organizing network to facilitate post-disaster communications. Specifically, a ground device transmits data to UAV swarms, which then use collaborative beamforming (CB) technique to form virtual antenna arrays and relay the data to a remote access point (AP) efficiently. Then, we formulate a rescue-oriented post-disaster transmission rate maximization optimization problem (RPTRMOP), aimed at maximizing the transmission rate of the whole network. Given the challenges of solving the formulated RPTRMOP by using traditional algorithms, we propose a two-stage optimization approach to address it. In the first stage, the optimal traffic routing and the theoretical upper bound on the transmission rate of the network are derived. In the second stage, we transform the formulated RPTRMOP into a variant named V-RPTRMOP based on the obtained optimal traffic routing, aimed at rendering the actual transmission rate closely approaches its theoretical upper bound by optimizing the excitation current weight and the placement of each participating UAV via a diffusion model-enabled particle swarm optimization (DM-PSO) algorithm. Simulation results show the effectiveness of the proposed two-stage optimization approach in improving the transmission rate of the construct

关键词： Unmanned aerial vehicles (UAV)

Dataset-Level Color Augmentation and Multi-Scale Exploration Methods for Polyp Segmentation

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SSRN

SSRN 2024年

作者： Chen, Haipeng Ju, Honghong Qin, Jun Song, Jincai Lyu, Yingda Liu, Xianzhu College of Computer Science and Technology Jilin University Changchun130012 China Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin University Changchun130012 China College of Computer Science and Technology Changchun University of Science and Technology Changchun130022 China Public Computer Education and Research Center Jilin University Changchun130012 China National and Local Joint Engineering Research Center of Space Optoelectronics Technology Changchun University of Science and Technology Changchun130022 China College of Opto-Electronic Engineering Changchun University of Science and Technology Changchun130022 China

Automatic segmentation of polyps from colonoscopy images plays a critical role in early screening and treatment of colorectal cancer. Although deep learning methods have made significant progress, precise polyp segmentation faces two challenges: (1) the imbalance of color appearances in the limited training dataset hinders the generalization of the model, and (2) polyps have the diverse scales, locations and shapes with blurred boundary. To address the issues, Dataset-Level Color Augmentation (DLCA) and Convolutional Multi-scale Attention Module (CMAM) are proposed. DLCA employs the dataset-level color knowledge and generate new color appearances, to avoid the model learning false associations with colors. Meanwhile, CMAM simultaneously explores the region and boundary clues and model multi-scale context, which improves the accuracy of polyp localization and fine-grained segmentation. We conduct comprehensive experiments and compare our network with state-of-the-art methods. The proposed model is superior on multiple polyp datasets, especially on ETIS, where mDice and mIoU reach 0.839 and 0.766. Furthermore, it's validated that DLCA can be widely applied to most polyp segmentation methods, and CMAM is practical and plug-and-play. Finally, the model demonstrates promising generalization to breast ultrasound and skin lesion segmentation. © 2024, The Authors. All rights reserved.

关键词： Color

Multi-site MRI classification using Weighted federated learning based on Mixture of Experts domain adaptation

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Multi-site MRI classification using Weighted federated learn...

IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

作者： Tian Bai Yingfang Zhang Yuzhao Wang Yanguo Qin Fa Zhang College of Computer Science and Technology Jilin University Changchun China Key Laboratory of Symbolic Computation and Knowledge Engineering Ministry of Education Jilin University Changchun China The Department of Orthopaedics The Second Hospital of Jilin University Changchun China School of Medical Technology Beijing Institute of Technology Beijing China

ISBN: (数字)9781665468190

ISBN: (纸本)9781665468206

Deep learning often requires large amounts of data from different institutions. Federated learning, as a distributed training framework, enables multiple participants to collaboratively train models without collecting data together and hence protecting data privacy, but the datasets from different institutions usually bring the problem of domain shift, which affects the performance of the model. When addressing domain shift, previous works often use a single global model to share parameters. Therefore, we propose a novel method to train multiple public models with different structures under the federated framework to improve the reliability and robustness of the public models. And each participant keeps its own domain-tuned private model, the private model does not share parameters with other participants. We use Mixture of Experts (MoE) domain adaptation to dynamically combine different public models and private model, which utilizes the similarity between different datasets to update the parameters of the public models. We apply the proposed method to the multi-site Magnetic resonance imaging (MRI) end-to-end classification, and the experiments demonstrate its effectiveness.

关键词： Weight measurement Training Adaptation models Three-dimensional displays Federated learning Magnetic resonance imaging Biological system modeling

Resource Scheduling for UAVs-aided D2D Networks: A Multi-objective Optimization Approach

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arXiv 2023年

作者： Pan, Hongyang Liu, Yanheng Sun, Geng Wang, Pengfei Yuen, Chau College of Computer Science and Technology Jilin University Changchun130012 China Pillar Singapore University of Technology and Design Singapore487372 Singapore Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin University Changchun130012 China School of Computer Science and Technology Dalian University of Technology Dalian116024 China School of Electrical and Electronics Engineering Nanyang Technological University Singapore639798 Singapore

Unmanned aerial vehicles (UAVs)-aided device-to-device (D2D) networks have attracted great interests with the development of 5G/6G communications, while there are several challenges about resource scheduling in UAVs-aided D2D networks. In this work, we formulate a UAVs-aided D2D network resource scheduling optimization problem (NetResSOP) to comprehensively consider the number of deployed UAVs, UAV positions, UAV transmission powers, UAV flight velocities, communication channels, and UAV-device pair assignment so as to maximize the D2D network capacity, minimize the number of deployed UAVs, and minimize the average energy consumption over all UAVs simultaneously. The formulated NetResSOP is a mixed-integer programming problem (MIPP) and an NP-hard problem, which means that it is difficult to be solved in polynomial time. Moreover, there are trade-offs between the optimization objectives, and hence it is also difficult to find an optimal solution that can simultaneously make all objectives be optimal. Thus, we propose a non-dominated sorting genetic algorithm-III with a Flexible solution dimension mechanism, a Discrete part generation mechanism, and a UAV number adjustment mechanism (NSGA-III-FDU) for solving the problem comprehensively. Simulation results demonstrate the effectiveness and the stability of the proposed NSGA-III-FDU under different scales and settings of the D2D networks. Copyright © 2023, The Authors. All rights reserved.

关键词： Energy utilization

On a coupled-physics transmission eigenvalue problem and its spectral properties with applications

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Journal of Differential Equations 2025年 441卷

作者： Diao, Huaian Liu, Hongyu Meng, Qingle Wang, Li School of Mathematics Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin University Jilin Changchun 130012 China Department of Mathematics City University of Hong Kong Kowloon Hong Kong

In this paper, we investigate a transmission eigenvalue problem that couples the principles of acoustics and elasticity. This problem naturally arises when studying fluid-solid interactions and constructing bubbly-elastic structures to create metamaterials. We uncover intriguing local geometric structures of the transmission eigenfunctions near the corners of the domains, under typical regularity conditions. As applications, we present novel unique identifiability and visibility results for an inverse problem associated with an acoustoelastic system, which hold practical significance. © 2025 Elsevier Inc.

关键词： Acoustoelastic Corner singularity Inverse inclusion problem Spectral geometry Transmission eigenvalue problem Unique identifiability