The rapid developments of chip-based technology have greatly improved human genetics and made routine the access of thousands of single nucleotide polymorphisms (SNPs) contributing to an informatics challenge. The cha...
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ISBN:
(纸本)9781450328104
The rapid developments of chip-based technology have greatly improved human genetics and made routine the access of thousands of single nucleotide polymorphisms (SNPs) contributing to an informatics challenge. The characterization and interpretation of genes and gene-gene interactions that affect the susceptibility of common, complex multifactorial diseases is a computational and statistical challenge in genome-wide association studies (GWAS). Various methods have been proposed, but they have dificulty to be directly applied to GWAS caused by excessive search space and intensive computational burden. In this paper, we propose an ant colony optimization (ACO) based algorithm by combining the pheromone updating rule with the heuristic information. We tested power performance of our algorithm by conducting suficient experiments including a wide range of simulated datasets experiments and a real genome-wide dataset experiment. Experimental results demonstrate that our algorithm is time efficient and gain good performance in the term of the power of prediction accuracy. Copyright 2014 ACM.
The past decade has witnessed the rapid development of search engines, which has become an indispensable part of everyday life. However, people are no longer satisfied with accessing to ordinary information, and they ...
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Adaptive Cross-Generation Differential Evolution(ACGDE)is a recently-introduced algorithm for solving multiobjective problems with remarkable performance compared to other evolutionary algorithms(EAs).However,its conv...
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Adaptive Cross-Generation Differential Evolution(ACGDE)is a recently-introduced algorithm for solving multiobjective problems with remarkable performance compared to other evolutionary algorithms(EAs).However,its convergence and diversity are not satisfactory compared with the latest *** order to adapt to the current environment,ACGDE requires improvements in many aspects,such as its initialization and mutant *** this paper,an enhanced version is proposed,namely *** incorporates a strengthened initialization strategy and optimized parameters in contrast to its *** improvements make the direction of crossgeneration mutation more clearly and the ability of searching more *** experiments show that the new algorithm has better diversity and improves convergence to a certain *** the same time,SIACGDE outperforms other state-of-the-art algorithms on four metrics of 24 test problems.
In this paper,for a zero-dimensional polynomial ideal I,the authors prove that k[x_(1),x_(2),…,x_(n)]/I is cyclic if and only if the breadth of I is 0 or ***,the authors present a new algorithm to compute polynomial ...
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In this paper,for a zero-dimensional polynomial ideal I,the authors prove that k[x_(1),x_(2),…,x_(n)]/I is cyclic if and only if the breadth of I is 0 or ***,the authors present a new algorithm to compute polynomial univariate representation(PUR)of such an ideal.
Dynamic Bayesian Network (DBN) is a graphical model for representing temporal stochastic processes. Learning the structure of DBN is a fundamental step for parameter learning, inference and application. For large scal...
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In recent years, with the development of the wireless sensor networks, the localization method receives the attention of many researchers. However, due to the network cost and characteristics of sensor nodes, most of ...
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The workflow model is the abstract expression of the workflow or the business process. Following the WfMC reference model, a PKI-based lightweight workflow model named as PBLW is put forward in this paper. The framewo...
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Untraceability is an important aspect of RFID security. A BRS-based approach for modeling RFID untraceability is provided in this paper. Elements in a RFID protocol can be represented as bigraphs, communications betwe...
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Untraceability is an important aspect of RFID security. A BRS-based approach for modeling RFID untraceability is provided in this paper. Elements in a RFID protocol can be represented as bigraphs, communications between elements can be represented as reaction rules. RFID untraceability can be represented as behavioral congruences. We take a RFID air interface protocol as a case study and show the usability of this approach.
Extensive studies have shown that many complex diseases are influenced by interaction of certain genes, while due to the limitations and drawbacks of adopting logistic regression (LR) to detect epistasis in human Geno...
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Essential graph is a graphical representation for Markov equivalence classes of Bayesian networks. Learning essential graph can avoid some problems in traditional Bayesian networks learning algorithms: (1) the number ...
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