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作者： Xianglu Zhou Haiyang Jia College of Computer Science and Technology Jilin University College of Software Jilin University Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of EducationJilin University

Gene regulatory network(GRN) describes dynamic and complex gene interactions that determine the functions of ***,understanding of GRNs has played a great role in cancer treatment,drug design,and gene ***,the GRN study suffers from a lack of experiment measurement data and the complexity of the *** approaches have evolved in recent years to promote the study of *** this review,we summarized popular Computational approaches for GRN *** started with traditional bioinformatic methods,such as Bayesian networks and mutual information ***,we introduced how today's hot technology in the computer field-machine learning benefited GRN ***-based approaches and other machine-learning methods are elaborated on in this *** discussed not only the advantages and progression brought by various methods but also the drawbacks and limitations,such as the accuracy and robustness of GRN *** expect to inspire readers for improved GRN study approaches via our introduction to this field.

关键词： Gene Regulatory Network Bioinformatics Machine Learning

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Deep Convolutional Neural Network Based Sperm Detection in Microscopic Videos

Deep Convolutional Neural Network Based Sperm Detection in M...

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International Conference on Image, Vision and Intelligent Systems, ICIVIS 2023

作者： Ma, Shiyi Li, Jindong Zhang, Wenbo Yang, Jinzhu Grzegorzek, Marcin Li, Chen Microscopic Image and Medical Image Analysis Group College of Medicine and Biological Information Engineering Northeastern University Shenyang China Key Laboratory of Intelligent Computing in Medical Image Ministry of Education Northeastern University Shenyang China Institute of Medical Informatics University of Luebeck Luebeck Germany Department of Knowledge Engineering University of Economics in Katowice Katowice Poland

ISBN: (纸本)9789819708543

In recent years, with the increasingly serious quality problems of human sperm, the performance of traditional sperm analysis methods has been unable to meet the growing demand for diagnosis and treatment. The purpose of this study was to explore the application of deep convolutional neural network microvideo in computer assisted sperm analysis (CASA). For the sperm detection task, the model structure, loss function and non-maximum suppression algorithm were optimized to improve the performance of the model, reflecting the advantages of deep learning. To avoid the impact of data differences, cross-validation test was adopted in this study, and multiple indexes such as F1-score and AP were compared with the original model after training. These improvements significantly improved the average accuracy and F1 scores of the models. The performance of the model not only has an important impact on the indicators of the target detection model, but also has an important impact on the visualization results of the model. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2024.

关键词： Computer aided diagnosis

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High Order Conditional Random Field Based Cervical Cancer Histopathological Image Classification

High Order Conditional Random Field Based Cervical Cancer Hi...

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International Conference on Image, Vision and Intelligent Systems, ICIVIS 2023

作者： Zhou, Shangqi Li, Xintong Fu, Yanyu Ouyang, Xinyu Yang, Jinzhu Grzegorzek, Marcin Li, Chen Microscopic Image and Medical Image Analysis Group College of Medicine and Biological Information Engineering Northeastern University Shenyang China Key Laboratory of Intelligent Computing in Medical Image Ministry of Education Northeastern University Shenyang China Institute of Medical Informatics University of Luebeck Luebeck Germany Department of Knowledge Engineering University of Economics in Katowice Katowice Poland

ISBN: (纸本)9789819708543

Cervical cancer ranks as the fourth most frequently diagnosed cancer. This disease has an extended precancerous stage and can be completely cured and prevented through early detection. Currently, the analysis of histopathological images of cervical cancer relies on manual assessment by pathologists, a subjective and time-consuming process. Moreover, there is limited research on differentiating the severity of cervical cancer in histopathological images. To address these challenges, this study proposes a classification algorithm based on high-order conditional random field for cervical cancer histopathologic images. The algorithm effectively categorizes images into high differentiation, medium differentiation, and low differentiation stages. Three deep learning models, namely VGG-16, Inception-V3, and ResNet-50, are utilized for pre-classification at the image block level. For image-level classification, the Visual Transformer model is employed. Finally, the block-level and image-level classification components are integrated using the conditional random field model, resulting in the high-order conditional random field model. Following training and testing using the dataset, the model achieves an overall accuracy of 75.4%. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2024.

关键词： Computer aided diagnosis

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Visual Analysis of the National Characteristics of the COVID-19 Vaccine Based on knowledge Graph

Visual Analysis of the National Characteristics of the COVID...

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作者： Yong Feng Ning Zhang Hongyan Xu Rongbing Wang Yonggang Zhang College of Information Liaoning University Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin University

The aim is to construct a country-dimension knowledge graph of COVID-19 vaccines from the information of COVID-19 vaccines and to analyze the leading countries of vaccine R&D by combining the advantages of easy operation and intuitive feeling of knowledge graph visualization,to provide a reference for Chinese vaccine R&D departments and international *** this paper,through data collection,based on entity extraction and relationship construction,a knowledge graph of country dimensions was established by specifying the central vaccine R&D countries and vaccine distribution,and multidimensional microdata such as word frequency and betweenness centrality were combined to analyze the national characteristics of the COVID-19 *** analysis of the knowledge graph of the country dimension of the COVID-19 vaccine shows that countries with robust technology and economies,such as the US and China,choose to develop vaccine distribution independently,countries with advanced economies,such as Saudi Arabia,decide to purchase vaccine distribution,and less developed countries,such as South Africa and Latin America,need international aid for vaccines or purchase low-cost *** paper constructs the correlation between nodes and nodes of the COVID-19 vaccine with the help of a knowledge graph,systematically and comprehensively reveals the research mainstay and distribution model of the COVID-19 vaccine from the national level,and provides rationalized suggestions for international cooperation in vaccine R&D in China.

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Skeleton-based Action Recognition with Non-linear Dependency Modeling and Hilbert-Schmidt Independence Criterion

arXiv

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arXiv 2024年

作者： Chen, Haipeng Yang, Yuheng Lyu, Yingda College of Computer Science and Technology Jilin University China Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin University China Public Computer Education and Research Center Jilin University China

Human skeleton-based action recognition has long been an indispensable aspect of artificial intelligence. Current state-of-the-art methods tend to consider only the dependencies between connected skeletal joints, limiting their ability to capture non-linear dependencies between physically distant joints. Moreover, most existing approaches distinguish action classes by estimating the probability density of motion representations, yet the high-dimensional nature of human motions invokes inherent difficulties in accomplishing such measurements. In this paper, we seek to tackle these challenges from two directions: (1) We propose a novel dependency refinement approach that explicitly models dependencies between any pair of joints, effectively transcending the limitations imposed by joint distance. (2) We further propose a framework that utilizes the Hilbert-Schmidt Independence Criterion to differentiate action classes without being affected by data dimensionality, and mathematically derive learning objectives guaranteeing precise recognition. Empirically, our approach sets the state-of-the-art performance on NTU RGB+D, NTU RGB+D 120, and Northwestern-UCLA datasets. © 2024, CC BY-SA.

关键词： Probability density function

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Multiscale Bilateral Attention Fusion Network for Pansharpening

IEEE Transactions on Artificial Intelligence

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IEEE Transactions on Artificial Intelligence 2024年第11期5卷 5828-5843页

作者： Guo, Zhongyuan Li, Jiawei Lei, Jia Liu, Jinyuan Zhou, Shihua Wang, Bin Kasabov, Nikola K. Dalian University Key Laboratory of Advanced Design and Intelligent Computing Ministry of Education School of Software Engineering Dalian116622 China University of the Science and Technology Beijing School of Computer and Communication Engineering Beijing100083 China Dalian University of Technology School of Mechanical Engineering Dalian116024 China Auckland University of Technology Knowledge Engineering and Discovery Research Institute Auckland1061 New Zealand University of Ulster Intelligent Systems Research Center LondonderryBT48 7JL United Kingdom Bulgarian Academy of Sciences IICT Sofia1000 Bulgaria

High-resolution multispectral (HRMS) images combine spatial and spectral information originating from panchromatic (PAN) and reduced-resolution multispectral (LRMS) images. Pansharpening performs well and is widely used to obtain HRMS images. However, most pansharpening approaches determine the ratio of PAN and LRMS images through direct interpolation, which may introduce artifacts and distort the color of the fused results. To address this issue, an unsupervised progressive pansharpening framework, MSBANet, is proposed, which adopts a multistage fusion strategy. Each stage contains an attention interactive extraction module (AIEM) and a multiscale bilateral fusion module (MBFM). The AIEM extracts spatial and spectral features from input images and captures the correlations between features. The MBFM can efficiently integrate information from the AIEM and improve MSBANet context awareness. We design a hybrid loss function that enhances the ability of the fusion network to store spectral and texture details. In qualitative and quantitative experimental studies on four datasets, MSBANet outperformed state-of-the-art pansharpening techniques. The code will be released. © 2024 IEEE.

关键词： Data mining

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ON A COUPLED-PHYSICS TRANSMISSION EIGENVALUE PROBLEM AND ITS SPECTRAL PROPERTIES WITH APPLICATIONS

arXiv

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arXiv 2024年

作者： Diao, Huaian Liu, Hongyu Meng, Qingle Wang, Li School of Mathematics Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin University Jilin Changchun130012 China Department of Mathematics City University of Hong Kong Kowloon Hong Kong

In this paper, we investigate a transmission eigenvalue problem that couples the principles of acoustics and elasticity. This problem naturally arises when studying fluid-solid interactions and constructing bubbly-elastic structures to create metamaterials. We uncover intriguing local geometric structures of the transmission eigenfunctions near the corners of the domains, under typical regularity conditions. As applications, we present novel unique identifiability and visibility results for an inverse problem associated with an acoustoelastic system, which hold practical significance. © 2024, CC BY.

关键词： Inverse problems

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Multiple Machine Learning Fusion Based Analysis of Fat Composition in CT Images

Multiple Machine Learning Fusion Based Analysis of Fat Compo...

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International Conference on Image, Vision and Intelligent Systems, ICIVIS 2023

作者： Fu, Yanyu Quanyu, E. Zhou, Shangqi Ouyang, Xinyu Yang, Jinzhu Grzegorzek, Marcin Li, Chen Microscopic Image and Medical Image Analysis Group College of Medicine and Biological Information Engineering Northeastern University Shenyang China Key Laboratory of Intelligent Computing in Medical Image Ministry of Education Northeastern University Shenyang China Institute of Medical Informatics University of Luebeck Luebeck Germany Department of Knowledge Engineering University of Economics in Katowice Katowice Poland

ISBN: (纸本)9789819708543

Intra-abdominal fat is a crucial factor in determining metabolic syndrome and insulin resistance. Therefore, high levels of intra-abdominal fat are always accompanied by a series of diseases such as diabetes, ischemia, hypertension, and dyslipidemia. Although methods such as the ultrasonic method and electrical impedance method have been widely used to calculate body fat tissue in recent years, these methods only provide qualitative analysis of the overall degree of obesity. However, for quantitative analysis of abdominal fat and adipose tissue distribution in the human body, the computed tomography (CT) fat segmentation method is necessary. This paper focuses on machine learning, image segmentation, and multi-feature fusion of mean clustering as its main technical directions. In terms of application, it aims to perform a quantitative analysis of the distribution and proportion of intra-abdominal fat in the abdominal cavity of the human body. The study concluded that the quantitative analysis of fat after the fusion method is more accurate, with a subcutaneous fat accuracy rate of 84.26% and a visceral fat accuracy rate of 70.20%. It can effectively, conveniently, and objectively analyze the degree of obesity in the human body. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2024.

关键词： Machine learning

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DeciLS-PBO: an Effective Local Search Method for Pseudo-Boolean Optimization

arXiv

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arXiv 2023年

作者： Jiang, Luyu Ouyang, Dantong Zhang, Qi Zhang, Liming College of Computer Science and Technology Jilin University Changchun130012 China Key Laboratory of Symbolic Computation and Knowledge Engineering Ministry of Education Jilin University Changchun130012 China

Local search is an effective method for solving large-scale combinatorial optimization problems, and it has made remarkable progress in recent years through several subtle mechanisms. In this paper, we found two ways to improve the local search algorithms in solving Pseudo-Boolean Optimization(PBO): Firstly, some of those mechanisms such as unit propagation are merely used in solving MaxSAT before, which can be generalized to solve PBO as well;Secondly, the existing local search algorithms utilize the heuristic on variables, so-called score, to mainly guide the search. We attempt to gain more insights into the clause, as it plays the role of a middleman who builds a bridge between variables and the given formula. Hence, we first extended the combination of unit propagation-based decimation algorithm to PBO problem, giving a further generalized definition of unit clause for PBO problem, and apply it to the existing solver LS-PBO for constructing an initial assignment;then, we introduced a new heuristic on clauses, dubbed care, to set a higher priority for the clauses that are less satisfied in current iterations. Experiments on benchmarks from the most recent PB Competition, as well as three real-world application benchmarks including minimum-width confidence band, wireless sensor network optimization, and seating arrangement problems show that our algorithm DeciLS-PBO has a promising performance compared to the state-of-the-art algorithms. Copyright © 2023, The Authors. All rights reserved.

关键词： Wireless sensor networks

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MS²-GNN: Exploring GNN-Based Multimodal Fusion Network for Depression Detection

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IEEE transactions on cybernetics 2023年第12期53卷 7749-7759页

作者： Tao Chen Richang Hong Yanrong Guo Shijie Hao Bin Hu Key Laboratory of Knowledge Engineering with Big Data Ministry of Education and the School of Computer Science and Information Engineering Hefei University of Technology Hefei China Gansu Provincial Key Laboratory of Wearable Computing School of Information Science and Engineering Lanzhou University Lanzhou China

Major depressive disorder (MDD) is one of the most common and severe mental illnesses, posing a huge burden on society and families. Recently, some multimodal methods have been proposed to learn a multimodal embedding for MDD detection and achieved promising performance. However, these methods ignore the heterogeneity/homogeneity among various modalities. Besides, earlier attempts ignore interclass separability and intraclass compactness. Inspired by the above observations, we propose a graph neural network (GNN)-based multimodal fusion strategy named modal-shared modal-specific GNN, which investigates the heterogeneity/homogeneity among various psychophysiological modalities as well as explores the potential relationship between subjects. Specifically, we develop a modal-shared and modal-specific GNN architecture to extract the inter/intramodal characteristics. Furthermore, a reconstruction network is employed to ensure fidelity within the individual modality. Moreover, we impose an attention mechanism on various embeddings to obtain a multimodal compact representation for the subsequent MDD detection task. We conduct extensive experiments on two public depression datasets and the favorable results demonstrate the effectiveness of the proposed algorithm.

关键词： Task analysis Feature extraction Semantics Depression Graph neural networks Electroencephalography Data mining Mental disorders Multisensory integration

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