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China Semiconductor Technology International Conference (CSTIC)

作者： Yupeng Lu Peng Sun Gangping Yan Luoyun Zhang Yanyu Yang Shuang Liu Gaobo Xu Huaxiang Yin Integrated Circuit Advanced Process R&D Center Institute of Microelectronics Chinese Academy of Sciences Beijing China State Key Lab of Fabrication Technologies for Integrated Circuits Institute of Microelectronics Chinese Academy of Sciences Beijing China School of Integrated Circuits University of Chinese Academy of Sciences Beijing China

ISBN: (数字)9798350362190

ISBN: (纸本)9798350362206

The High Granularity Time detector (HGTd) project need advanced Low-Gain Avalanche detector (LGAd) for constructing the timing precision layer in the ATLAS detector. It undergoes a strong environmental temperature impact for cooling the absorbed high-energy particles. In this paper, an investigation of the manufacturing process of LGAd detectors and their characteristics in terms of dark current and breakdown voltage at high and low temperatures are systematical explored. The behavior of carrier transport within the device at various temperature conditions was analyzed using TCAd simulation tools.

关键词： Integrated circuits Temperature Manufacturing processes Cooling detectors dark current Electric variables

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Abrogation of USP7 is an alternative strategy to downregulate Pd-L1 and sensitize gastric cancer cells to T cells killing

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Acta Pharmaceutica Sinica B 2021年第3期11卷 694-707页

作者： Zhiru Wang Wenting Kang Ouwen Li Fengyu Qi Junwei Wang Yinghua You Pengxing He Zhenhe Suo Yichao Zheng Hong-Min Liu School of Pharmaceutical Sciences Zhengzhou UniversityCo-Innovation Center of Henan Province for New Drug R&D and Preclinical SafetyState Key Laboratory of Esophageal Cancer Prevention and TreatmentKey Laboratory of Advanced Drug Preparation TechnologiesMinistry of Education of ChinaZhengzhou 450001 China Department of Pathology the Norwegian Radium HospitalOslo University HospitalDepartment of PathologyInstitute for Clinical MedicineFaculty of MedicineUniversity of OsloOslo0379Norway

Targeting immune checkpoints such as programmed cell death protein 1(Pd-1)and programmed death ligand-1(Pd-L1)have been approved for treating melanoma,gastric cancer(GC)and bladder cancer with clinical ***,many patients failed to respond to anti-Pd-1/Pd-L1 treatment,so it is necessary to seek an alternative strategy for traditional Pd-1/Pd-L1 targeting *** with the data from The Cancer Genome Atlas(TCGA)and our in-house tissue library,Pd-L1 expression was found to be positively correlated with the expression of ubiquitin-specific processing protease 7(USP7)in ***,USP7 directly interacted with Pd-L1 in order to stabilize it,Gastric cancer;Immunosuppression;Cancer biologywhile abrogation of USP7 attenuated Pd-L1/Pd-1 interaction and sensitized cancer cells to T cell killing in vitro and in ***,USP7 inhibitor suppressed GC cells proliferation by stabilizing P53 in vitro and in ***,our findings indicate that in addition to inhibiting cancer cells proliferation,USP7 inhibitor can also downregulate Pd-L1 expression to enhance anti-tumor immune response ***,these data posit USP7 inhibitor as an anti-proliferation agent as well as a novel therapeutic agent in Pd-L1/Pd-1 blockade strategy that can promote the immune response of the tumor.

关键词： USP7 Pd-L1 Epigenetics Immunotherapy Ubiquitination Gastric cancer Immunosuppression Cancer biology

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Effect of Combustion Chamber Geometry on Performance and Emissions of direct Injection Hydrogen Engines

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SSrN 2024年

作者： Li, Lezhen Zheng, Zhaolei rao, Shunlu Li, Qian Tang, Xuelin deng, Wei Key Laboratory of Low-grade Energy Utilization Technologies and Systems Ministry of Education Chongqing University Chongqing400044 China New Powertrain R&D Institute Chongqing Changan Automobile Co. Ltd Chongqing401133 China College of Mechanical and Vehicle Engineering Chongqing University Chongqing400030 China

Using hydrogen in internal combustion engines (ICEs) not only reduces CO2 emissions but also leverages the high technological maturity of ICEs for rapid popularization, making it a very promising method. However, hydrogen ICEs face the challenge of high NOX emissions. Optimizing the combustion chamber geometry can significantly improve the mixing quality of the fuel-air mixture, thereby increasing combustion stability and reducing original NOX emissions. This paper discusses in detail the effects of five different chamber geometries on performance and emissions in a direct-injection spark-ignition hydrogen engine under ultra-lean conditions. The research results indicate that the nebula combustion chamber (NECC) achieves reasonable mixture concentration distribution and turbulent kinetic energy (TKE) distribution by enhancing the flow of in-cylinder gases at the end of the compression stroke, thereby exhibiting the optimal combustion performance. The eccentric hemispherical combustion chamber (EHCC), with its offset hemispherical structure, achieves stratified mixing and combustion effects with high concentration at the cylinder center and low concentration around the periphery. However, due to the weaker TKE of the mixture, the combustion performance of the EHCC is slightly inferior to that of the NECC. Compared to the initial combustion chamber (INCC), the NECC expands the excess air coefficient corresponding to the lean-burn limit from 2.52 to 2.91. Furthermore, at λ=2.5, the NECC achieves both high thermal efficiency (46.2%) and nearly zero emissions. © 2024, The Authors. All rights reserved.

关键词： Combustion chambers

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Fast Simulation of Quantum Characteristics for Advanced Si Mosfets Under Extreme Conditions by Incorporating Simplified Master Equation with Tcad

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SSrN 2023年

作者： Zhu, Xiaohui Yin, Huaxiang The Integrated Circuit Advanced Process R&D Center State Key Lab of Fabrication Technologies for Integrated Circuits Institute of Microelectronics of the Chinese Academy of Sciences Beijing100029 China The School of Integrated Circuits University of Chinese Academy of Sciences Beijing100049 China

Silicon (Si)-based quantum-dot (Qd) device by advanced CMOS process is one of important technologies for quantum computing application and currently . In this paper, for the first time, a fast hybrid simulation method is proposed by incorporating simplified quantum master equation model with the traditional TCAd tool. The Qd devices forming on advanced stacked Si nanowire (NW) and stacked Si nanosheet (NS) are constructed, extracted and simulated by the method. The diamond-like charge stability diagram and the different charge energy between structures are accurately simulated at efficient time cost. With the new introduced transient current correction by SPICE model, the simulated results show great matching degree with those actual characteristics of advanced diamond-like device under 4 K. Meanwhile, the influence of quantum characteristics varying with the transistor ’ s structure and process parameters is also analyzed, which in turn provide a guidance for the design and the optimization of the Qd device by advanced Si CMOS process. © 2023, The Authors. All rights reserved.

关键词： Silicon

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Bio-derived and Cost-Effective Membranes with High Selectivity for redox Flow Batteries Based on Host-Guest Chemistry

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SMALL 2022年第43期18卷 e2107055页

作者： Gao, Li ding, Yu He, Gaohong Yu, Guihua Univ Texas Austin Dept Mech Engn Mat Sci & Engn Program & Walker Austin TX 78712 USA Dalian Univ Technol Sch Chem Engn Ctr Membrane Sci & Technol State Key Lab Fine Chem R&D Dalian 116024 Peoples R China

redox flow batteries (rFBs) stand out as a promising energy storage system to solve the grid interconnection problems of renewable energy. Membranes play a critical role in regulating the performance of rFBs, and the selectivity is commonly controlled via either size exclusion or donnan exclusion. Membranes typically account for 40% of the stack cost of rFBs, and it is essential to develop cost-effective membranes with high selectivity to achieve widespread application. Here, a type of membrane composed of highly abundant materials derived in nature, based on a scalable fabrication process, is reported. Moreover, high selectivity is achieved attributed to the host-guest interactions between membranes and redox species, which effectively alleviate the crossover of redox-active molecules. By incorporating starch into a chitosan matrix for zinc-iodine rFBs, the highly selective recognition of starch and chitosan (host) toward triiodide (guest) builds a "wall" to block the triiodide-based active materials, meanwhile, the conducting properties of such a membrane are not compromised. The proof-of-concept battery delivers a Coulombic efficiency of 98.6% and energy efficiency of 77.4% at a current density of 80 mA cm(-2), showing the promise of such a novel and cost-effective membrane design beyond traditional selectivity chemistry.

关键词： chitosan flow batteries host-guest chemistry starch zinc-iodine

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SSL

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Lighting design + Application 2021年第12期51卷 16 - 18页

作者： Jessica Collier Michael Poplawski Lighting Research Engineer on the Lighting Science Research team at PNNL supported by the Department of Energy Lighting R&D program. Department of Energy Lighting R&D Program. He is the principal investigator for research focused on evaluating and characterizing new connected lighting system technologies.

Study and Act data has the power to shape the future of building design and operation

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Strong and Ultra-tough Ionic Hydrogel Based on Hyperbranched Macro-Cross-linker: Influence of Topological Structure on Properties

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ANGEWANdTE CHEMIE-INTErNATIONAL EdITION 2023年第42期62卷 e202310832页

作者： Jiang, Yu Zhan, dezhi Zhang, Meng Zhu, Ying Zhong, Huiqing Wu, Yangfei Tan, Qinwen dong, Xinhua Zhang, daohong Hadjichristidis, Nikos South Cent Minzu Univ Key Lab Catalysis & Energy Mat Chem Minist Educ Wuhan 430074 Peoples R China South Cent Minzu Univ Hubei R&D Ctr Hyperbranched Polymers Synth & Appli Hubei Key Lab Catalysis & Mat Sci Wuhan 430074 Peoples R China King Abdullah Univ Sci & Technol KAUST Phys Sci & Engn Div KAUST Catalysis Ctr Polymer Synth LabChem Sci Program Thuwal 23955 Saudi Arabia

The application of hydrogels often suffers from their inherent limitation of poor mechanical properties. Here, a carboxyl-functionalized and acryloyl-terminated hyperbranched polycaprolactone (PCL) was synthesized and used as a macro-cross-linker to fabricate a super strong and ultra-tough ionic hydrogel. The terminal acryloyl groups of hyperbranched PCL are chemically incorporated into the network to form covalent cross-links, which contribute to robust networks. Meanwhile, the hydrophobic domains formed by the spontaneous aggregation of PCL chains and coordination bonds between Fe3+ and COO- groups serve as dynamic non-covalent cross-links, which enhance the energy dissipation ability. Especially, the influence of the hyperbranched topological structure of PCL on hydrogel properties has been well investigated, exhibiting superior strengthening and toughening effects compared to the linear one. Moreover, the hyperbranched PCL cross-linker also endowed the ionic hydrogel with higher sensitivity than the linear one when used as a strain sensor. As a result, this well-designed ionic hydrogel possesses high mechanical strength, superior toughness, and well ionic conductivity, exhibiting potential applications in the field of flexible strain sensors. A hyperbranched PCL was used as a macro-cross-linker to fabricate a novel family of strong and ultra-tough ionic hydrogels. By tailoring the hyperbranched topological structure, the optimal balance of covalent/non-covalent cross-linking could be obtained. As a result, the well-designed hydrogel possesses high strength, superior toughness, and good ionic conductivity, with potential applications in the field of flexible strain sensors.+image

关键词： Hydrogels Hyperbranched Cross-Linkers Polycaprolactone Strain Sensors Super Toughness

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An Improved Faster r-CNN for Colorectal Cancer Cell detection 3

An Improved Faster R-CNN for Colorectal Cancer Cell Detectio...

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3rd IEEE International Conference on Electronics and Communication Engineering (ICECE)

作者： Yang Yu Qun Yang Liu Shaohan Nanjing Univ Aeronaut & Astronaut Key R&D Program Jiangsu Prov BE20190 Nanjing Peoples R China Nanjing Univ Aeronaut & Astronaut Nanjing Peoples R China

ISBN: (数字)9781728192581

ISBN: (纸本)9781728192581

Image recognition and object detection of colorectal cancer cell are significant in the medical community. It can help the doctors to diagnose the disease, assess the patient's cure status, and choose a suitable treatment plan. At present, object detection methods based on neural networks have been widely used. However, when applying to the colorectal cancer cell' image object detection, it has a shortage due to the complex background and small object cells. Because of this problem, this paper proposes an improved Faster r-CNN algorithm with multi-scale detection and a multi loss function. In our algorithm, during the feature extraction period, multi-scale detection is not only retaining the semantic information but also the details of the edges and textures of the image. during the recognition period, the discriminative features of cells can be learned from the multi loss in the complex background. The experiment result shows that the accuracy of the improved Faster r-CNN is 2.4% higher than that of the Faster r-CNN.

关键词： colorectal cancer cell object detection improved Faster r-CNN small object

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NSd2 is a requisite subunit of the Ar/FOXA1 neo-enhanceosome in promoting prostate tumorigenesis

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NATUrE GENETICS 2024年第10期56卷 2132-2143页

作者： Parolia, Abhijit Eyunni, Sanjana Verma, Brijesh Kumar Young, Eleanor Liu, Yihan Liu, Lianchao George, James Aras, Shweta das, Chandan Kanta Mannan, rahul rasool, reyaz Ur Mitchell-Velasquez, Erick Mahapatra, Somnath Luo, Jie Carson, Sandra E. Xiao, Lanbo Gajjala, Prathibha r. Venkatesh, Sharan Jaber, Mustapha Wang, Xiaoju He, Tongchen Qiao, Yuanyuan Pang, Matthew Zhang, Yuping Tien, Jean Ching-Yi Louw, Micheala Alhusayan, Mohammed Cao, Xuhong Su, Fengyun Tavana, Omid Hou, Caiyun Wang, Zhen ding, Ke Chinnaiyan, Arul M. Asangani, Irfan A. Univ Michigan Michigan Ctr Translat Pathol Ann Arbor MI 48109 USA Univ Michigan Dept Pathol Ann Arbor MI 48109 USA Univ Michigan Rogel Canc Ctr Ann Arbor MI 48109 USA Univ Michigan Dept Urol Ann Arbor MI 48109 USA Univ Michigan Mol & Cellular Pathol Program Ann Arbor MI USA Univ Penn Perelman Sch Med Dept Canc Biol Philadelphia PA 19104 USA Univ Michigan Canc Biol Program Ann Arbor MI USA Chinese Acad Sci Shanghai Inst Organ Chem State Key Lab Chem Biol Shanghai Peoples R China Univ Michigan Howard Hughes Med Inst Ann Arbor MI 48109 USA AstraZeneca Res & Early Dev Oncol R&D Waltham MA USA Univ Penn Abramson Family Canc Res Inst Perelman Sch Med Philadelphia PA 19104 USA Univ Penn Epigenet Inst Perelman Sch Med Philadelphia PA 19104 USA

Androgen receptor (Ar) is a ligand-responsive transcription factor that drives terminal differentiation of the prostatic luminal epithelia. By contrast, in tumors originating from these cells, Ar chromatin occupancy is extensively reprogrammed to activate malignant phenotypes, the molecular mechanisms of which remain unknown. Here, we show that tumor-specific Ar enhancers are critically reliant on H3K36 dimethyltransferase activity of NSd2. NSd2 expression is abnormally induced in prostate cancer, where its inactivation impairs Ar transactivation potential by disrupting over 65% of its cistrome. NSd2-dependent Ar sites distinctively harbor the chimeric FOXA1:Ar half-motif, which exclusively comprise tumor-specific Ar enhancer circuitries defined from patient specimens. NSd2 inactivation also engenders increased dependency on the NSd1 paralog, and a dual NSd1/2 PrOTAC degrader is preferentially cytotoxic in Ar-dependent prostate cancer models. Altogether, we characterize NSd2 as an essential Ar neo-enhanceosome subunit that enables its oncogenic activity, and position NSd1/2 as viable co-targets in advanced prostate cancer. CrISPr screen identifies coactivators of the androgen receptor (Ar) complex, including NSd2. NSd2 contributes to Ar cistrome reprogramming during prostate cancer progression, and its degradation via a novel PrOTAC reduces prostate cancer cell viability in vitro.

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Triple-Cladding Ytterbium doped Fiber for 12 kW Single Module

Triple-Cladding Ytterbium Doped Fiber for 12 kW Single Modul...

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Asia Communications and Photonics Conference and Exhibition (ACP)

作者： Yue Meng Zuying Xu Xudong Shi Yu Li Tianying Liu Can Li Xiao Yan Wei Zheng Heng Wang Jiangang Yu Zhiyong Zhao Ming Tang Optical fiber R&D center Everfoton Technologies Corp oration Limited State Key Laboratory of Optic al Fiber and Cable Manufactu re Technology Yangtze Optical Fibre and Cable Joint Stock Limited Company Wuhan 4 China Optical fiber R&D center Everfoton Technologies Corp oration Limited Wuhan China Wuhan National Lab for Optoelectronics (WNLO) & National Engineering Laboratory for Next Generation Internet Access System School of Optical and Electronic Information Huazhong University of Science and Technology Wuhan China

High power continuous-wave ytterbium-doped fiber lasers have unique advantages such as high electro-optical efficiency, excellent beam quality and good thermal management, and are widely used in industrial materials processing and scientific research. However, multi-kW $(\geqslant$ 10kW) high-power fiber lasers has encountered numerous technology challenges in double-cladding fibers. In this work, we designed and fabricated a triple-cladding ytterbium doped fiber with large core diameter by using Modified Chemical Vapor deposition (MCVd) combined with all-gas-phase doping method. An excellent laser performance could be demonstrated for such a fiber with an output power of more than 10 kW and a slope efficiency of 82%, no Transverse Mode instability (TMI) is observed. Long-term laser stability at 12 kW-level was carried out in a master oscillator power amplifier (MOPA) laser system for 500 hours with power degradation less than 1%, meanwhile a stimulated raman scattering (SrS) suppression ratio that is larger than 45dB was obtained.

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