We report the coordination assembly of the ferrocene-diphenylalanine(Fc-FF)with divalent copper ions(Cu^(2+))into metalpeptide assemblies(MPAs)with hierarchical spiral *** MPA particles are composed of helically organ...
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We report the coordination assembly of the ferrocene-diphenylalanine(Fc-FF)with divalent copper ions(Cu^(2+))into metalpeptide assemblies(MPAs)with hierarchical spiral *** MPA particles are composed of helically organized nanofibers which can be correlated to the logarithmic *** MPAs are hierarchically porous with abundant Fc and Cu2+active sites and show much higher catalytic activity than natural laccase toward the decolorization ***,a series of hierarchical structures of the MPAs can be synthesized by controlling the temperature and enantiomeric excess(ee).The peptide enantiomers with higher ee values will self-assemble into highly complex and ordered structures,which show higher surface area and porosity and thus enhanced catalytic activity compared with those assembled by peptides with lower ee *** results provide new insights into the vital role of chirality in directing the self-assembly of biomolecules into highly ordered complex functional structures.
Flexible electronics/spintronics attracts researchers’attention for their application potential abroad in wearable devices,healthcare,and other *** devices’performance(speed,energy consumption)is highly dependent on...
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Flexible electronics/spintronics attracts researchers’attention for their application potential abroad in wearable devices,healthcare,and other *** devices’performance(speed,energy consumption)is highly dependent on manipulating information bits(spin-orientation in flexible spintronics).In this work,we established an organic photovoltaic(OPV)/ZnO/Pt/Co/Pt heterostructure on flexible PET substrates with perpendicular magnetic anisotropy(PMA).Under sunlight illumination,the photoelectrons generated from the OPV layer transfer into the PMA heterostructure,then they reduce the PMA strength by enhancing the interfacial Rashba field *** coercive field(Hc)reduces from 800 Oe to 500 Oe at its maximum,and the magnetization can be switched up and down *** stability of sunlight control of magnetization reversal under various bending conditions is also tested for flexible spintronic ***,the voltage output of sunlight-driven PMA is achieved in our prototype device,exhibiting an excellent angular dependence and opening a door towards solar-driven flexible spintronics with much lower energy consumption.
Herein,we report the dynamic kinetic resolution asymmetric acylation ofγ-hydroxy-γ-perfluoroalkyl butenolides/phthalides catalyzed by amino acid-derived bifunctional organocatalysts,and a series of ketals were obtai...
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Herein,we report the dynamic kinetic resolution asymmetric acylation ofγ-hydroxy-γ-perfluoroalkyl butenolides/phthalides catalyzed by amino acid-derived bifunctional organocatalysts,and a series of ketals were obtained in high yields(up to 95%)and excellent enantioselectivities(up to 99%).In terms of synthetic utility,the reaction can be performed on a gram scale,and the product can be converted into potential biological nucleoside analog.
A series of optically active copolymers with various feed ratios have been synthesized through helix-sense-selective copolymerization catalyzed by[Rh(norbornadiene)Cl]*** process involves two proline-derived acetylene...
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A series of optically active copolymers with various feed ratios have been synthesized through helix-sense-selective copolymerization catalyzed by[Rh(norbornadiene)Cl]*** process involves two proline-derived acetylene monomers,(S)-N-(4-chlorophenyl)carbamoyl-2-ethynyl pyrrolidine(MCl)and(S)-N-(tert-butoxycarbonyl)-2-ethynyl pyrrolidine,followed by acidic deprotection and *** copolymers adopt helical conformations with a preferred handedness,as demonstrated by nuclear magnetic resonance spectroscopy and a series of spectroscopic *** chiroptical activity intensity of copolymer has been found to increase with MCl ***,the enantioseparation capabilities of copolymers containing 95 mol%,90 mol%,and 85 mol%MCl units have been assessed as chiral stationary phases in high-performance liquid chromatography because of their good chiroptical *** chiral stationary phases effectively enantioseparate racemic alcohols,sulfoxides,amides,and metal ***,the copolymer with 90 mol%MCl shows superior chiral recognition ability,especially for 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol(α=1.19)and 4-methylbenzenesulfinamide(α=1.47).Insights from molecular dynamic simulation and autodock analysis indicate that hydrogen bonding andπ-πstacking interactions between the chiral stationary phases and enantiomers play a key role for successful chiral *** contribution not only demonstrates the importance of hydrogen bonding donor and copolymer chiroptical activity of chiral stationary phases for chiral resolution,but will also provide valuable insights for the future development of novel stationary phases.
Reactive oxygen species(ROS),involving in many biological reactions,play an important role in disease *** the various ROS-based therapeutic modalities,sonodynamic therapy(SDT)stands out with its unique *** turn,the SD...
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Reactive oxygen species(ROS),involving in many biological reactions,play an important role in disease *** the various ROS-based therapeutic modalities,sonodynamic therapy(SDT)stands out with its unique *** turn,the SDT efficacy is mainly dependent on the ROS levels in the disease ***,in recent years,researchers have extensively investigated SDT with high ROS generation *** this review,we focus on effective strategies to improve the therapeutic ef-ficiency of SDT by modulating ROS,overview the basic mechanisms of ROS generation by sonosensitizers,highlight the rational design of sonosensitizers,and summarize strategies to improve the SDT efficacy by modulating disease *** addition,multiple ROS synergistic treatment modalities and the prospect of SDT are *** believe that the understanding and exploration of SDT enhancement strategies will facilitate the clinical translation of SDT.
Mg-Al alloys have excellent strength and ductility but relatively low thermal conductivity due to Al *** accurate prediction of thermal conductivity is a prerequisite for designing Mg-Al alloys with high thermal ***,d...
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Mg-Al alloys have excellent strength and ductility but relatively low thermal conductivity due to Al *** accurate prediction of thermal conductivity is a prerequisite for designing Mg-Al alloys with high thermal ***,databases for predicting temperature-and composition-dependent thermal conductivities must be *** this study,Mg-Al-La alloys with different contents of Al2La,Al3La,and Al11La3phases and solid solubility of Al in the α-Mg phase were *** influence of the second phase(s) and Al solid solubility on thermal conductivity was *** results revealed a second phase transformation from Al_(2)La to Al_(3)La and further to Al_(11)La_(3)with the increasing Al content at a constant La *** degree of the negative effect of the second phase(s) on thermal diffusivity followed the sequence of Al2La>Al3La>Al_(11)La_(3).Compared with the second phase,an increase in the solid solubility of Al in α-Mg remarkably reduced the thermal *** the basis of the experimental data,a database of the reciprocal thermal diffusivity of the Mg-Al-La system was established by calculation of the phase diagram (CALPHAD)*** a standard error of±1.2 W/(m·K),the predicted results were in good agreement with the experimental *** established database can be used to design Mg-Al alloys with high thermal conductivity and provide valuable guidance for expanding their application prospects.
Messenger RNA(mRNA)has emerged as an innovative therapeutic modality,offering promising avenues for the prevention and treatment of a variety of *** tremendous success of mRNA vaccines in effectively combatting corona...
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Messenger RNA(mRNA)has emerged as an innovative therapeutic modality,offering promising avenues for the prevention and treatment of a variety of *** tremendous success of mRNA vaccines in effectively combatting coronavirus disease 2019(COVID-19)evidences the unlimited medical and therapeutic potential of mRNA *** challenges related to mRNA stability,immunogenicity,and precision targeting has been made possible by recent advancements in lipid nanoparticles(LNPs).This review summarizes state-of-the-art LNP-mRNA-based therapeutics,including their structure,material compositions,design guidelines,and screening ***,we highlight current preclinical and clinical trends in LNP-mRNA therapeutics in a broad range of treatments in ophthalmological conditions,cancer immunotherapy,gene editing,and rare-disease *** attention is given to the translation and evolution of LNP-mRNA vaccines into a broader spectrum of *** explore concerns in the aspects of inadequate extrahepatic targeting efficacy,elevated doses,safety concerns,and challenges of large-scale production *** discussion may offer insights and perspectives on near-and long-term clinical development prospects for LNP-mRNA therapeutics.
Developing non-noble catalyst synthesis under green conditions with efficient electrochemical reactions is a challenging task in green energy *** meet this challenge,the synthesis of hybridized non-noble cobalt and ir...
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Developing non-noble catalyst synthesis under green conditions with efficient electrochemical reactions is a challenging task in green energy *** meet this challenge,the synthesis of hybridized non-noble cobalt and iron in the zeolitic-imidazole framework(Co/Fe-ZIF)through a solid-state thermal(SST)method is *** the obtained Co/Fe-ZIF structure,iron atoms are uniformly dispersed and randomly hybridized with primary cobalt atoms and imidazole linker,similar to the structure of *** hybridized Co/Fe-ZIF shows potential as an electrocatalyst for oxidation evolution reaction(OER).The optimal iron-incorporating catalyst,Co/Fe_(0.2)-ZIF,demonstrates remarkable performance with a minimized overpotential of 285 mV at the current density(j)of 10 mA·cm^(-2)in 1 M *** synergistic effect of iron and cobalt ions on the catalyst provides active sites that bind to intermediate(OOH^(*))more strongly and facilitate high electron charge transfer,enhancing efficient ***,the synergistic Co/Fe_(0.2-)ZIF catalyst demonstrates excellent durable reaction time compared to non-iron catalyst(ZIF-67)and conventional catalyst(RuO_(2)).
The detection algorithms of small objects in remote sensing images is often challenging due to the complex background and limited pixels. This can lead to reduced accuracy in detection and an increased number of misse...
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Although photothermal therapy(PTT)has been developed for fighting cancers,the degradative,toxic,and metabolic nature of photothermal conversion materials(PCMs)has prevented them from being clinically *** advantage of ...
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Although photothermal therapy(PTT)has been developed for fighting cancers,the degradative,toxic,and metabolic nature of photothermal conversion materials(PCMs)has prevented them from being clinically *** advantage of the surface modification strategy of mussel-inspired dopamine chemistry and its excellent photothermal conversion effect,polydopamine(Pdop)represents a versatile PTT platform,providing strategies and methods for the construction of novel Pdop-functionalized *** to its adhesion and secondary reactivity,Pdop can be deposited on virtually all substrates to improve their bioavailability and ***-based PCMs could not be only functionalized with small biomolecules via chemical bonds and/or noncovalent force but also modified with functional polymers via either the“grafting to”or“grafting from”*** review highlights the synthetic methods,therapeutic strategies,and designs of PCMs based on Pdop in recent years to explore its scope and limitations.
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