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29th IEEE International Conference on Emerging Technologies and Factory Automation, ETFA 2024

作者： Mock, Michael Viedt, Isabell Urbas, Leon Tud Dresden University of Technology Process Control Systems Dresden Germany Tud Dresden University of Technology Process to Order Lab Dresden Germany

ISBN: (纸本)9798350361230

The increasing need for simulation-based analysis along the life-cycle of modern process plants introduces new requirements and limitations in the development of simulation models. In the context of modular plants, according to VDI 2776, the distributed knowledge arises as a challenge in enabling system simulations. Co-simulation can enable a provider-independent simulation of chemical processes, but the co-simulation interfaces need further standardization to be efficiently integrated in the modular plant life-cycle. This paper works toward the usability of process models for co-simulation to support standardization efforts and make simulation models more usable and re-usable. To increase the usability of co-simulation in the process industry by working towards a common standard, two co-simulation standards, namely the Functional Mock-Up Interface and the CAPE-OPEN standard, are semantically linked. A use-case for a co-simulation-based operability analysis of a heterogeneous electrolysis plant is presented and necessary model requirements and interfaces are defined. Criteria to assess the compatibility of the model interfaces as a first step of a usability analysis are collected and presented. With the available requirements and interface specifications Functional Mock-Up Units can be created and the shown use-case can be carried out. Challenges regarding the potential integration of varying thermophysical properties have been pointed out and methods to overcome these challenges in the context of usability have been outlined. © 2024 IEEE.

关键词： Mockups

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A procedure ontology for advanced diagnosis of process systems

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12th International Conference on Knowledge-Based Intelligent Information and Engineering Systems

作者： Hangos, Katalin M. Nemeth, Erzsebet Lakner, Rozalia Univ Pannonia Dept Comp Sci Veszprem Hungary Comp & Automat Res Inst Syst & Control Lab Process Control Res Grp Budapest Hungary

ISBN: (纸本)9783540855620

An ontology for representing operation, safety and control procedures is proposed in this paper that supports diagnosis based on following these procedures and combining observed malfunctions with Failure Mode and Effects Analysis (FMEA) information. The procedure ontology is defined within interconnected components of the process plant, diagnostic analysis (where the FMEA is described) and procedures. The proposed method is illustrated on a simple operating procedure.

关键词： knowledge management intelligent systems ontology multi-agent systems

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Research on the virtual prototype of multifunction filter material detection device 5

Research on the virtual prototype of multifunction filter ma...

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5th International Conference on Computing, control and Industrial Engineering, CCIE 2014

作者： Zhang, Jie Zeng, Tao Sichuan University of Science and Engineering Sichuan Provincial Key Lab of Process Equipment and Control Zigong China

ISBN: (纸本)9783038352686

This paper introduces the characteristics and working principle of multifunctional filter material detection device, The design of detection device filter, Can be assembled and disassembled quickly, By the combination of different height of the supporting cylinder, Can adapt to the changes of different thickness of Filter layer, Device can realize the performance of filter material under different conditions, The application of a detection scheme is illustrated by an example. Based on the way of parametric design with SolidWorks, Reasonable modeling ideas are put forward, Combined with the instance, Completed the multifunctional filter material detection device prototype of virtual design, the method can effectively improve design efficiency, For the similar product design provides a new way of thinking. © (2014) Trans Tech Publications, Switzerland.

关键词： Product design

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A study of the temperature dependence of adsorption and silicidation kinetics at the Mg/Si(111) interface

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THIN SOLID FILMS 2007年第22期515卷 8192-8196页

作者： Galkin, K. N. Kumar, Mahesh Govind Shivaprasad, S. M. Korobtsov, Vv. Galkin, N. G. Russian Acad Sci Inst Automat & Control Process Far Eastern Branch Vladivostok 690041 Russia Natl Phys Lab Surface Phys & Nanostructure Grp New Delhi India

The adsorption studies of magnesium on Si(111) substrate have been performed using AES, LEED and EELS at various substrate temperatures. It is observed that the sticking coefficient of magnesium on the silicide surface is close to zero for temperatures greater than 100 degrees C. It has been shown that the magnesium silicide grows as continuous films on Si substrate at temperature 100-140 degrees C, while for temperatures higher than 170 degrees C the magnesium silicide grows in the form of islands. (c) 2007 Elsevier B.V. All rights reserved.

关键词： magnesium silicon magnesium silicide adsorption electron energy loss spectroscopy

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Multivariable control of unstable systems by goal attainment method 9

Multivariable control of unstable systems by goal attainment...

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9th International Conference on Trends in Industrial Measurement and Automation, TIMA 2017

作者： Ravikumar, N. Shekarbesta, Chandra Chidambaram, M. Process Control Lab Department of Chemical Engineering Indian Institute of Technology Madras600 036 India

ISBN: (纸本)9781509030019

Goal attainment method is used to design (i) decentralized PI controllers for a 3×3 stable multivariable transfer function matrix and (ii) decentralized and centralized PI controllers for an unstable 2×2 transfer function matrix. The performance of the closed loop system of 3×3 stable multivariable system is compared with that of the biggest log modulus (BLT) method, sequential tuning method, and the method of inequality. For unstable systems, the performance of the present method is compared with the method proposed by Govindhakannan and Chidambaram. The present method gives the improved performances. © 2017 IEEE.

关键词： Closed loop systems

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Targeted modulation of dual-metal ion homeostasis to induce ER stress and cuproptosis for synergistic breast tumor suppression

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Chemical Engineering Journal 2025年 515卷

作者： Zhang, Xiaoxian Zhang, Xuequan Zhu, Jiahui Li, Tinghua Yang, Lianyi Lei, Lei Wu, Fang He, Bin Cao, Jun National Engineering Research Center for Biomaterials College of Biomedical Engineering Sichuan University Chengdu 610065 China Key Lab of Process Analysis and Control of Sichuan Universities Faculty of Materials and Chemical Engineering Yibin University Yibin 644000 China

Targeted modulation of metal ion homeostasis in tumor cells has emerged as a promising method for cancer therapy. However, the coordination efficiency and stability of different metal ions posed significant challenges for current multi-metal ions delivery systems. In this study, we presented an innovative strategy that utilized a single-metal ion nanoregulator capable of precisely modulating intracellular dual-metal ion homeostasis. This nanoregulator induced endoplasmic reticulum (ER) stress and cuproptosis, which worked synergistically to inhibit tumor growth. Specifically, a calcium-selective chelator, BAPTA (BA), formed a metal coordination complex with copper ions (Cu²⁺), which remained stable in the physiological environment but disassembled upon internalized by tumor cells. Once inside, the released BA selectively chelated intracellular calcium ions (Ca²⁺), depleting ER Ca²⁺ stores and triggering ER stress. This stress activated the PERK/p-eIF2α/ATF4/CHOP apoptotic pathway, leading to tumor cell apoptosis. Meanwhile, Cu²⁺ induced cuproptosis and was reduced to Cu⁺ in the cytosol, where it consumed hydrogen peroxide and generated cytotoxic hydroxyl radicals. These radicals induced oxidative stress, which, combined with glutathione depletion, further amplified ER stress and promoted tumor cell apoptosis. Both in vitro and in vivo experiments exhibited that the nanoregulator effectively suppressed tumor growth through apoptosis and cuproptosis pathways, with favorable biocompatibility. This study highlighted the synergistic roles of copper and calcium ions in tumor therapy and introduced a novel strategy for modulating intracellular dual-metal ion homeostasis, offering more efficient and low toxicity anti-cancer treatments. © 2025 Elsevier B.V.

关键词： Calcium Chelation Cuproptosis Dual-metal ion homeostasis ER stress Nanoregulator Tumor therapy

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Distributed Online Convex Optimization with Time-Varying Constraints: Tighter Cumulative Constraint Violation Bounds under Slater's Condition

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IEEE Transactions on Automatic control 2025年

作者： Yi, Xinlei Li, Xiuxian Yang, Tao Xie, Lihua Hong, Yiguang Chai, Tianyou Johansson, Karl H. National Key Laboratory of Autonomous Intelligent Unmanned Systems Shanghai Institute of Intelligent Science and Technology China Ministry of Education Frontiers Science Center for Intelligent Autonomous Systems China Massachusetts Institute of Technology Lab for Information & Decision Systems CambridgeMA02139 United States Northeastern University State Key Laboratory of Synthetical Automation for Process Industries Shenyang110819 China Nanyang Technological University School of Electrical and Electronic Engineering 50 Nanyang Avenue 639798 Singapore Kth Royal Institute of Technology Division of Decision and Control Systems School of Electrical Engineering and Computer Science Sweden Digital Futures Stockholm10044 Sweden

This paper considers distributed online convex optimization with time-varying constraints. In this setting, a network of agents makes decisions at each round, and then only a portion of the loss function and a coordinate block of the constraint function are privately revealed to each agent. The loss and constraint functions are convex and can vary arbitrarily across rounds. The agents collaborate to minimize static network regret and network cumulative constraint violation. A novel distributed online algorithm with a vanishing stepsize is proposed and it achieves an O(Tmax {c,1-c}) static network regret bound and an O(T1-c/2) network cumulative constraint violation bound, where T is the number of rounds and c∈ (0,1) is a user-defined trade-off parameter. When Slater's condition holds (i.e, there is a point that strictly satisfies the inequality constraints), the network cumulative constraint violation bound is reduced to O(T1-c). Moreover, if the loss functions are strongly convex, then static network regret bound is reduced to O(log (T)), and the network cumulative constraint violation bound is reduced to O(√log (T)T) and O(log (T)) without and with Slater's condition, respectively. To the best of our knowledge, this paper is the first to achieve tighter (network) cumulative constraint violation bounds for (distributed) online convex optimization with time-varying constraints under Slater's condition. Finally, the theoretical results are verified through numerical simulations. © 1963-2012 IEEE.

关键词： Convex optimization

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Finite element stress, vibration and buckling analysis of laminated beams with the use of refined elements

Finite element stress, vibration and buckling analysis of la...

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International Workshop on Nondestructive Testing and Computer Simulations in Science and Engineering

作者： Borovkov, A Avdeev, I Artemyev, A St Petersburg State Tech Univ Dept Mech & Control Process Lab Computat Mech St Petersburg 195251 Russia

ISBN: (纸本)0819431613

In present work, the stress, vibration and buckling finite element analysis of laminated beams is performed. Review of the equivalent single-layer (ESL) laminate theories is done. Finite element algorithms and procedures integrated into the original FEA program system and based on the classical laminated plate theory (CLPT), first-order shear deformation theory (FSDT), third-order theory of Reddy (TSDT-R) and third-order theory of Kant (TSDT-K) with the use of the Lanczos method for solving of the eigenproblem are da eloped. Several numerical tests and examples of bending, free vibration and buckling of multilayered and sandwich beams with various material, geometry properties and boundary conditions are solved. New effective higher-order hierarchical element for the accurate calculation of transverse shear stress is proposed. The comparative analysis of results obtained by the considered models and solutions of 2D problems of the heterogeneous anisotropic elasticity is fulfilled.

关键词： laminated beams equivalent single layer theories finite element analysis new refined beam element stress computation

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Research on anti-interference measures for the control system of flow calibration facility

Research on anti-interference measures for the control syste...

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2012 International Conference on Advances in Mechanics Engineering, ICAME 2012

作者： Yanchao, Han Lijun, Sun Yanxing, Wei Shengjie, Li Haishan, Niu Tianjin Key Lab of Process Parameters Measurement Control School of Electrical Engineering and Automation Tianjin University China

ISBN: (纸本)9783037855287

Eliminating or reducing the influence of electromagnetic interference to control system is the key problem to improve the performance of flow calibration facility. In the paper, the sources, the action principles and the propagation paths of electromagnetic interference were analyzed. Anti-interference measures to control system of flow calibration facility were investigated based on the New 2# water flow calibration facility at Tianjin University Flow lab. © (2012) Trans Tech Publications, Switzerland.

关键词： control systems

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Balancing DC Link Using the Redundant States Method in Selective Harmonics Elimination PWM

Balancing DC Link Using the Redundant States Method in Selec...

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8th International Symposium on Advanced Electromechanical Motion Systems (ELECTROMOTION 2009)/EPE Chapter Electric Drives Joint Symposium

作者： Imarazene, Khoukha Chekireb, H. Berkouk, E. M. Univ Sci & Technol Houari Boumediene Lab Elect & Ind Syst Algiers Algeria Natl Polytech Univ Algiers Lab Process Control Algiers Algeria

ISBN: (纸本)9781424451500

A method is presented to balance the two DC-link capacitor voltages for a three-level inverter. Previous work has shown that using the redundant states in space-vector PWM algorithm solves this problem, leaving lower order harmonics or using high switching frequency. Here, it is shown that, the redundant states can be used in selective harmonics elimination PWM in the case of multilevel inverters, so as to produce the required fundamental voltage and to balance the two DC-link voltage sources without an additional circuitry.

关键词： Pulse width modulation

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