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GardnerNet: An Interpretable Deep Learning Model for Quantitative Human Blastocyst Evaluation - A Retrospective Model Development and Validation Study

SSRN

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SSRN 2024年

作者： Liu, Hang Chen, Longbin Shan, Guanqiao Sun, Chen Liao, Hongqing Lu, Changfu Zhang, Shuoping Dong, Shaonan Xu, Xinxin Yan, Qiuyun Gong, Fei Zhang, Zhuoran Dai, Changsheng Chen, Wenyuan Song, Haocong Chen, Lei Sun, Haixiang Wang, Shanshan Lin, Ge Sun, Yu Gu, Yifan Department of Mechanical and Industrial Engineering University of Toronto 5 King’s College Road TorontoONM5S 3G8 Canada Institute of Reproductive and Stem Cell Engineering School of Basic Medical Science Central South University 172 Tongzipo Road Hunan Province Changsha China Hengyang Nanhua-Xinghui Reproductive Health Hospital 30 Jiefang Road Hunan Province Hengyang China The second Affiliated Hospital Hengyang Medical School University of South China 30 Jiefang Road Hunan Province Hengyang City China Reproductive & Genetic Hospital of CITIC-Xiangya 567 Tongzipo Road Hunan Province Changsha China NHC Key Laboratory of Human Stem Cell and Reproductive Engineering School of Basic Medical Science Central South University 172 Tongzipo Road Hunan Province Changsha China Clinical Research Center for Reproduction and Genetics in Hunan Province Reproductive & Genetic Hospital of CITIC-Xiangya 567 Tongzipo Road Hunan Province Changsha China School of Science and Engineering The Chinese University of Hong Kong-Shenzhen 2001 Longxiang Boulevard Longgang District Shenzhen China Institute of Robotics and Intelligent Systems Dalian University of Technolgy 2 Linggong Road Liaoning Province Dalian China Department of Computer Science University of Toronto 40 St George Street TorontoONM5S 2E4 Canada Center for Reproductive Medicine and Obstetrics and Gynecology Nanjing Drum Tower Hospital Nanjing University Medical School 321 Zhongshan Road Jiangsu Province Nanjing China National Engineering and Research Center of Human Stem Cell 8 Luyun Road Jiangsu Province Changsha China Department of Electrical and Computer Engineering 10 King’s College Road TorontoONM5S 3G8 Canada Institute of Biomedical Engineering University of Toronto 164 College Street TorontoONM5S 3G9 Canada

Background: Selecting the blastocyst with the highest potential for live birth from a cohort is crucial for the success of in vitro fertilization (IVF). While the Gardner and Schoolcraft morphological grading system, commonly known as the Gardner grading system, is widely used by embryologists worldwide, blastocysts having similar or the same inner cell mass (ICM) and trophectoderm (TE) grades cause challenges for embryologists in decision-making. Furthermore, human assessment is subjective and inconsistent in predicting which blastocysts have higher potential to result in live birth. This study aims to develop an interpretable, quantitative method aligned with the Gardner grading system, providing continuous scores that correlate with live birth outcomes, thereby assisting embryologists in improving blastocyst selection. Methods: In this retrospective study, we developed GardnerNet, an interpretable deep learning model that outputs expansion degree grade and continuous scores quantifying a blastocyst's ICM morphology and TE morphology, based on the Gardner grading system. The continuous ICM and TE scores were calculated by weighting each base grade's predicted probability and summing the predicted probabilities. To represent each blastocyst's overall potential for live birth, we combined the ICM and TE scores using their odds ratios (ORs) for live birth. We further assessed the correlation between the ICM score, TE score, and the OR-combined score (adjusted for expansion degree) with live birth rates by applying GardnerNet to blastocysts with known live birth outcomes. To test its generalizability, we also applied GardnerNet to an external IVF institution, accounting for variations in imaging conditions, live birth rates, and embryologists' experience levels. Findings: GardnerNet was developed using data from 2760 blastocysts with majority-voted grades for expansion degree, ICM, and TE. The model achieved mean area under the receiver operating characteristic curve

关键词： Risk assessment

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Brain-inspired global-local learning incorporated with neuromorphic computing

arXiv

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arXiv 2020年

作者： Wu, Yujie Zhao, Rong Zhu, Jun Chen, Feng Xu, Mingkun Li, Guoqi Song, Sen Deng, Lei Wang, Guanrui Zheng, Hao Ma, Songchen Pei, Jing Zhang, Youhui Zhao, Mingguo Shi, Luping Beijing Innovation Center for Future Chip Optical Memory National Engineering Research Center Department of Precision Instrument Tsinghua University Beijing China Department of Computer Science and Technology Tsinghua University Beijing100084 China Department of Automation Tsinghua University Beijing100084 China Laboratory of Brain and Intelligence Department of Biomedical Engineering IDG/ McGovern Institute for Brain Research CBICR Tsinghua University Beijing China Department of Electrical and Computer Engineering University of California Santa BarbaraCA93106 United States

Two main routes of learning methods exist at present including error-driven global learning and neuroscience-oriented local learning. Integrating them into one network may provide complementary learning capabilities for versatile learning scenarios. At the same time, neuromorphic computing holds great promise, but still needs plenty of useful algorithms and algorithm-hardware co-designs for exploiting the advantages. Here, we report a neuromorphic hybrid learning model by introducing a brain-inspired meta-learning paradigm and a differentiable spiking model incorporating neuronal dynamics and synaptic plasticity. It can meta-learn local plasticity and receive top-down supervision information for multiscale synergic learning. We demonstrate the advantages of this model in multiple different tasks, including few-shot learning, continual learning, and fault-tolerance learning in neuromorphic vision sensors. It achieves significantly higher performance than single-learning methods, and shows promise in empowering neuromorphic applications revolution. We further implemented the hybrid model in the Tianjic neuromorphic platform by exploiting algorithm-hardware co-designs and proved that the model can fully utilize neuromorphic many-core architecture to develop hybrid computation paradigm. Copyright © 2020, The Authors. All rights reserved.

关键词： Learning systems

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Vita-slam: Biologically-inspired visuo-tactile slam

arXiv

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arXiv 2019年

作者： Struckmeier, Oliver Tiwari, Kshitij Pearson, Martin J. Kyrki, Ville Department of Electrical Engineering and Automation Aalto University Espoo02150 Finland Bristol Robotics Laboratory BristolBS16 1QY United Kingdom

In this work, we propose a novel, bio-inspired multisensory SLAM approach called ViTa-SLAM. Compared to other multi-sensory SLAM variants, this approach allows for a seamless multi-sensory information fusion whilst naturally interacting with the environment. The algorithm is empirically evaluated in a simulated setting using a biomimetic robot platform called the WhiskEye. Our results show promising performance enhancements over existing bio-inspired SLAM approaches in terms of loop-closure detection. Copyright © 2019, The Authors. All rights reserved.

关键词： Biomimetics

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Opacity of Nondeterministic Transition Systems: A (Bi)Simulation Relation Approach

Opacity of Nondeterministic Transition Systems: A (Bi)Simula...

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作者： Zhang, Kuize Yin, Xiang Zamani, Majid ACCESS Linnaeus Center School of Electrical Engineering KTH Royal Institute of Technology Stockholm10044 Sweden Department of Automation Key Laboratory of System Control and Information Processing Shanghai Jiao Tong University Shanghai200240 China Computer Science Department University of Colorado Boulder BoulderCO80309 United States

In this paper, we propose several opacity-preserving (bi)simulation relations for nondeterministic transition systems (NTSs) in terms of initial-state opacity, current-state opacity, K-step opacity, and infinite-step opacity. We also show how one can leverage quotient constructions to compute such relations. As a result, although the opacity verification problem for infinite NTSs is generally undecidable, if one can find such an opacity-preserving relation from an infinite NTS to a finite one, the (lack of) opacity of the infinite NTS can be easily verified over the finite one, which is decidable. © 1963-2012 IEEE.

关键词： Opacity

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Optimize Student Learning via Random Forest-Based Adaptive Narrative Game

Optimize Student Learning via Random Forest-Based Adaptive N...

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IEEE International Conference on automation Science and engineering (CASE)

作者： Ryan Hare Ying Tang Wei Cui Joleen Liang Department of Electrical and Computer Engineering Rowan University Glassboro USA State Key Laboratory for Management and Control of Complex Systems Institute of Automation Chinese Academy of Sciences Beijing China Institute of Smart Education Qingdao Academy of Intelligent Industries Qingdao China Squirrel AI Learning Shanghai China

ISBN: (数字)9781728169040

ISBN: (纸本)9781728169057

This paper presents an adaptive narrative game system that focuses on sequential logic design. The system adapts a random forest machine learning model to estimate a student's current level of domain knowledge relative to the problem presented to him through his game-playing behavior data, such as time taken to find solutions, errors in solutions, and emotional indicators. Hints, prompts, and/or individualized lessons are then offered to the player to guide their learning in a positive and productive direction. Our preliminary pilot study demonstrates that the model can make accurate classifications, from which proper assistance can then be provided to individual students as they play.

关键词： Games Databases Forestry Education Problem-solving Presses Artificial intelligence

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Cascade Terminal Sliding Mode Control of a Deployable Cable Driven Robot

Cascade Terminal Sliding Mode Control of a Deployable Cable ...

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International Conference on Control, Instrumentation, and automation

作者： S. A. Khalilpour R. Khorrambakht M. J. Harandi H. D. Taghirad Philippe Cardou Advanced Robotics and Automated Systems Faculty of Electrical and Computer Engineering K.N. Toosi University of Technology Tehran Iran Department of Mechanical Engineering Robotics Laboratory Laval University Quebec City QC Canada

ISBN: (数字)9781728158150

ISBN: (纸本)9781728158167

Most control systems used for cable-driven parallel manipulators employ a simple inner control loop for controlling the driving force of the actuators. By this means the effects of some nonlinear uncertainties of the actuator and power transmission systems are significantly reduced, and in turn, this helps the outer user-specified position control loop to perform more accurately. However, this positive impact on performance relies on non achievable assumptions that the inner control loop is fast and accurate enough, and its dynamics can be totally ignored. The main contribution of this paper is to analyze the stability of the system as a whole, considering both inner and outer loop controllers. The outer loop controller proposed in here is a finite time robust sliding mode whose stability is analyzed through the Lyapunov direct method. A deployable cable-driven parallel robot, as the case study, is also considered in this paper, which is characterized by several intrinsic kinematic and dynamic uncertainties. Finally, the performance and effectiveness of the proposed robust controller is evaluated through some simulations and experiments in order to verify the effectiveness and the characteristics of the cascade controller structure in practice.

关键词： Robots Mathematical model Actuators Jacobian matrices Force Uncertainty Kinematics

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Roadmap on soft robotics: multifunctionality, adaptability and growth without borders

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Multifunctional Materials 2022年第3期5卷 032001-032001页

作者： Mazzolai, Barbara Mondini, Alessio Del Dottore, Emanuela Margheri, Laura Carpi, Federico Suzumori, Koichi Cianchetti, Matteo Speck, Thomas Smoukov, Stoyan K. Burgert, Ingo Keplinger, Tobias Siqueira, Gilberto De Freitas Vanneste, Felix Goury, Olivier Duriez, Christian Nanayakkara, Thrishantha Vanderborght, Bram Brancart, Joost Terryn, Seppe Rich, Steven I. Liu, Ruiyuan Fukuda, Kenjiro Someya, Takao Calisti, Marcello Laschi, Cecilia Sun, Wenguang Wang, Gang Wen, Li Baines, Robert Patiballa, Sree Kalyan Kramer-Bottiglio, Rebecca Rus, Daniela Fischer, Peer Simmel, Friedrich C Lendlein, Andreas Bioinspired Soft Robotics Laboratory Istituto Italiano di Tecnologia Italy Department of Industrial Engineering University of Florence Via di S. Marta 3 Florence50139 Italy Department of Mechanical Engineering Tokyo Institute of Technology Ookayama Meguro Tokyo152-8550 Japan The BioRobotics Institute Scuola Superiore Sant’Anna Pisa56025 Italy Department of Excellence in Robotics & AI Scuola Superiore Sant’Anna Pisa56025 Italy Plant Biomechanics Group & Botanic Garden and Cluster of Excellence livMatS @ FIT University of Freiburg Germany Active and Intelligent Materials Laboratory Queen Mary University of London LondonE1 4NS United Kingdom Wood Materials Science Institute for Building Materials ETH Zurich Zurich8093 Switzerland Cellulose and Wood Materials Laboratory Empa Swiss Federal Laboratories for Materials Science and Technology Dübendorf8600 Switzerland University of Lille Inria CNRS Centrale Lille UMR 9189 CRIStAL LilleF-59000 France Dyson School of Design Engineering Imperial College London United Kingdom Vrije Universiteit Brussel and imec Brussels Belgium Thin-Film Device Laboratory RIKEN 2-1 Hirosawa Saitama Wako351-0198 Japan Center for Emergent Matter Science RIKEN 2-1 Hirosawa Saitama Wako351-0198 Japan Electrical and Electronic Engineering and Information Systems The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo113-8656 Japan The BioRobotics Institute Scuola Superiore Sant’Anna Italy Lincoln Institute for Agri-food Technology University of Lincoln Lincoln United Kingdom Department of Mechanical Engineering National University of Singapore Singapore School of Mechanical Engineering and Automation Beihang University Beijing100191 China Department of Mechanical Engineering and Materials Science Yale University New HavenCT06511 United States CSAIL MIT Schwarzman College of Computing United States Max Planck Institute for Intelligent Systems Heisenbergstr. 3 Stuttgart70569 Germany Institute of Physical Chemistry

Soft robotics aims at creating systems with improved performance of movement and adaptability in unknown, challenging, environments and with higher level of safety during interactions with humans. This Roadmap on Soft robotics covers selected aspects for the design of soft robots significantly linked to the area of multifunctional materials, as these are considered a fundamental component in the design of soft robots for an improvement of their peculiar abilities, such as morphing, adaptivity and growth. The roadmap includes different approaches for components and systems design, bioinspired materials, methodologies for building soft robots, strategies for the implementation and control of their functionalities and behavior, and examples of soft-bodied systems showing abilities across different environments. For each covered topic, the author(s) describe the current status and research directions, current and future challenges, and perspective advances in science and technology to meet the challenges. © 2022 The Author(s). Published by IOP Publishing Ltd.

关键词： Machine design

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Linear precoding for fading cognitive multiple access wiretap channel with finite-alphabet inputs

arXiv

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arXiv 2020年

作者： Jin, Juening Xiao, Chengshan Tao, Meixia Chen, Wen Department of Electronic Engineering Shanghai Jiao Tong University Shanghai200240 China Department of Electrical and Computer Engineering Missouri University of Science and Technology RollaMO65409 United States Shanghai Key Laboratory of Navigation and Location Based Services Shanghai Jiao Tong University Shanghai200240 China School of Electronics Engineering and Automation Guilin University of Electronics Technology Guilin541004 China

We investigate the fading cognitive multiple access wiretap channel (CMAC-WT), in which two secondary-user transmitters (STs) send secure messages to a secondary-user receiver (SR) in the presence of an eavesdropper (ED) and subject to interference threshold constraints at multiple primaryuser receivers (PRs). We design linear precoders to maximize the average secrecy sum rate for multiple-input multiple-output (MIMO) fading CMAC-WT under finite-alphabet inputs and statistical channel state information (CSI) at STs. For this nondeterministic polynomial time (NP)-hard problem, we utilize an accurate approximation of the average secrecy sum rate to reduce the computational complexity, and then present a two-layer algorithm by embedding the convex-concave procedure into an outer approximation framework. The idea behind this algorithm is to reformulate the approximated average secrecy sum rate as a difference of convex functions, and then generate a sequence of simpler relaxed sets to approach the non-convex feasible set. Subsequently, we maximize the approximated average secrecy sum rate over the sequence of relaxed sets by using the convexconcave procedure. Numerical results indicate that our proposed precoding algorithm is superior to the conventional Gaussian precoding method in the medium and high signal-to-noise ratio (SNR) regimes. Copyright © 2020, The Authors. All rights reserved.

关键词： Signal to noise ratio

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Auxiliary Demographic Information Assisted Age Estimation With Cascaded Structure

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IEEE TRANSACTIONS ON CYBERNETICS 2018年第9期48卷 2531-2541页

作者： Wan, Jun Tan, Zichang Lei, Zhen Guo, Guodong Li, Stan Z. Center for Biometrics and Security Research and the National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences Beijing China Lane Department of Computer Science and Electrical Engineering West Virginia University Morgantown WV USA

Owing to the variations including both intrinsic and extrinsic factors, age estimation remains a challenging problem. In this paper, five cascaded structure frameworks are proposed for age estimation based on convolutional neural networks. All frameworks are learned and guided by auxiliary demographic information, since other demographic information (i.e., gender and race) is beneficial for age prediction. Each cascaded structure framework is embodied in a parent network and several subnetworks. For example, one of the applied framework is a gender classifier trained by gender information, and then two subnetworks are trained by the male and female samples, respectively. Furthermore, we use the features extracted from the cascaded structure frameworks with Gaussian process regression that can boost the performance further for age estimation. Experimental results on the MORPH II and CACD datasets have gained superior performances compared to the state-of-the-art methods. The mean absolute error is significantly reduced from 3.63 to 2.93 years under the same test protocol on the MORPH II dataset.

关键词： Age estimation convolutional neural networks (CNNs) demographic Gaussian process regression (GPR)

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Generalized Quadratic Matrix Programming: A Unified Framework for Linear Precoding With Arbitrary Input Distributions

arXiv

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arXiv 2020年

作者： Jin, Juening Zheng, Yahong Rosa Chen, Wen Xiao, Chengshan Department of Electronic Engineering Shanghai Jiao Tong University Shanghai200240 China Department of Electrical and Computer Engineering Missouri University of Science and Technology RollaMO65409 United States Shanghai Key Laboratory of Navigation and Location Based Services Shanghai Jiao Tong University Shanghai200240 China School of Electronics Engineering and Automation Guilin University of Electronics Technology Guilin541004 China

This paper investigates a new class of non-convex optimization, which provides a unified framework for linear precoding in single/multi-user multiple-input multiple-output (MIMO) channels with arbitrary input distributions. The new optimization is called generalized quadratic matrix programming (GQMP). Due to the nondeterministic polynomial time (NP)hardness of GQMP problems, instead of seeking globally optimal solutions, we propose an efficient algorithm which is guaranteed to converge to a Karush-Kuhn-Tucker (KKT) point. The idea behind this algorithm is to construct explicit concave lower bounds for non-convex objective and constraint functions, and then solve a sequence of concave maximization problems until convergence. In terms of application, we consider a downlink underlay secure cognitive radio (CR) network, where each node has multiple antennas. We design linear precoders to maximize the average secrecy (sum) rate with finite-alphabet inputs and statistical channel state information (CSI) at the transmitter. The precoding problems under secure multicast/broadcast scenarios are GQMP problems, and thus they can be solved efficiently by our proposed algorithm. Several numerical examples are provided to show the efficacy of our algorithm. Copyright © 2020, The Authors. All rights reserved.

关键词： Cognitive radio

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