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A novel computational approach to predict activity of nuclear export signals

Journal of Computational and Theoretical Nanoscience 2015年第12期12卷 6016-6019页

作者： Chen, Zhihua Zhang, Pan Wu, Tingfang Shi, Xiaolong Wang, Xun Key Laboratory of Image Information Processing and Intelligent Control School of Automation Huazhong University of Science and Technology WuhanHubei430074 China College of Computer and Communication Engineering China University of Petroleum QingdaoShandong266580 China

A nuclear export signal (NES) is a sequence of amino acids, which is a protein localization signal, and contributes to regulate localization of cellular proteins. In recent peering works, activity of NESs were introduced in computational methods, which perform significantly well in identifying unknown NESs even from huge datasets, but suffer from a shortage that only a small number of NESs are associated with experimental verified active scores. In this work, we propose a novel computational method to predict active score of NESs. Specifically, we firstly abstract relevant features to NES activity, and then construct a mathematical model based on principal component analysis (PCA) to find each feature's contribution to activity. In this way, a method to calculate active score of unknown NESs is achieved. In data experiments, it is obtained that our method can achieve accuracy rate 80%. The activity of an unknown NES candidate can give us a preliminary understanding of it, and can be used to identify positive NESs from the negative ones. To the best acknowledge of the authors, this is the first time computational method is proposed to predict NESs' activity. Copyright © 2015 American Scientific Publishers All rights reserved.

关键词： Computational methods

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Multistability analysis of a general class of recurrent neural networks with non-monotonic activation functions and time-varying delays

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Neural networks : the official journal of the International Neural Network Society 2016年 79卷 117-27页

作者： Peng Liu Zhigang Zeng Jun Wang School of Automation Huazhong University of Science and Technology Wuhan 430074 China Key Laboratory of Image Processing and Intelligent Control of Education Ministry of China Wuhan 430074 China. Electronic address: liupengjz@***. Key Laboratory of Image Processing and Intelligent Control of Education Ministry of China Wuhan 430074 China. Electronic address: hustzgzeng@***. Department of Computer Science College of Science and Engineering City University of Hong Kong Kowloon Tong Hong Kong. Electronic address: jwang.cs@cityu.edu.hk.

This paper addresses the multistability for a general class of recurrent neural networks with time-varying delays. Without assuming the linearity or monotonicity of the activation functions, several new sufficient conditions are obtained to ensure the existence of (2K+1)(n) equilibrium points and the exponential stability of (K+1)(n) equilibrium points among them for n-neuron neural networks, where K is a positive integer and determined by the type of activation functions and the parameters of neural network jointly. The obtained results generalize and improve the earlier publications. Furthermore, the attraction basins of these exponentially stable equilibrium points are estimated. It is revealed that the attraction basins of these exponentially stable equilibrium points can be larger than their originally partitioned subsets. Finally, three illustrative numerical examples show the effectiveness of theoretical results.

关键词： Cohen–Grossberg neural networks Multistability Non-monotonic activation functions Time-varying delays

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A novel model and behavior analysis for a swarm of multi-agent systems with finite velocity

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Chinese Physics B 2014年第9期23卷 590-593页

作者：王良顺吴治海 Key Laboratory of Image Processing and Intelligent Control of the Ministry of Education School of AutomationHuazhong University of Science and Technology Key Laboratory for Advanced Process Control of Light Industry of the Ministry of Education School of Internet of Things EngineeringJiangnan University

Inspired by the fact that in most existing swarm models of multi-agent systems the velocity of an agent can be infinite, which is not in accordance with the real applications, we propose a novel swarm model of multi-agent systems where the velocity of an agent is finite. The Lyapunov function method and LaSalle＇s invariance principle are employed to show that by using the proposed model all of the agents eventually enter into a bounded region around the swarm center and finally tend to a stationary state. Numerical simulations are provided to demonstrate the effectiveness of the theoretical results.

关键词： multi-agent systems swarm finite velocity attraction and repulsion

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On string languages generated by spiking neural P systems with astrocytes

Communications in Computer and Information Science

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Communications in Computer and Information Science 2014年 472卷 225-229页

作者： Kong, Yuan Zhang, Zheng Liu, Yang Key Laboratory of Image Information Processing and Intelligent Control School of Automation Huazhong University of Science and Technology Wuhan Hubei430074 China

ISBN: (纸本)9783662450482

Spiking neural P systems with astrocytes (SNPA systems, for short) are a class of distributed parallel computing devices inspired from the way spikes pass through the synapses between the neurons. In this work, we investigate the language generation power of SNPA systems. Specifically, we prove that SNPA systems without the forgetting rules can generate recursively enumerable languages and characterize regular languages. Furthermore, we give a finite language that can be generated by SNPA systems, but which cannot be generated by spiking neural P systems without astrocytes. These results show that astrocyte is a powerful ingredient for generating languages by spiking neural P systems. © Springer-Verlag Berlin Heidelberg 2014.

关键词： Distributed computer systems

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A research on human cognitive modeling in rumor spreading based on HTM

Communications in Computer and Information Science

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Communications in Computer and Information Science 2014年 461卷 268-277页

作者： Li, Xiangchen Chen, X. Wang, Wei School of Automation Huazhong University of Science and Technology Wuhan China Image Processing and Intelligent Control Key Laboratory of Education Ministry of China Wuhan China

ISBN: (纸本)9783662452820

As a sociological phenomenon, rumor spreading has been widely researched by sociologists and other fields’ scholars. How do people generate those strange thinking about the rumor? This paper, from artificial intelligence view, focuses on an algorithm based on Hierarchical Temporal Memory (HTM) to simulate human cognitive process of generating rumors from individual heterogeneous living experience. Comparison with classical Bayesian Networks, our algorithm could effectively and really simulate human cognitive process of rumors, and in accordance with some typical psychology effects proved by sociologists and psychologists. © Springer-Verlag Berlin Heidelberg 2014.

关键词： Bayesian networks

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Tissue P Systems with Look-ahead Mode

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Chinese Journal of Electronics 2014年第1期23卷 81-86页

作者： JIANG Yun SONG Tao ZHANG Zheng School of Computer Science and Information Engineering Chongqing Technology and Business University Image Processing and Intelligent Control Key Laboratory of Education Ministry of China Department of Control Science and Engineering Huazhong University of Science and Technology

Tissue P systems are a class of distributed and parallel computing models inspired from inter-cellular communication and cooperation between cells. In this work, a variant of tissue P system, named tissue P system with look-ahead mode, is discussed for decreasing the inherent non-determinism of tissue P systems and helping implementing tissue P systems on computers. Such systems are proved to be universal by simulating register machine, and they are also proved to be able to efficiently solve computationally hard problems by means of a spacetime tradeoff, which is illustrated with a polynomial solution to 3-coloring problem.

关键词： Tissue P system Look-ahead mode Recursively enumerable language Cell separation 3-Coloring

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AN ADAPTIVE MEMBRANE ALGORITHM FOR SOLVING COMBINATORIAL OPTIMIZATION PROBLEMS

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Acta Mathematica Scientia 2014年第5期34卷 1377-1394页

作者：贺娟娟肖建华邵泽辉 Key Laboratory of Image Processing and Intelligent Control School of AutomationHuazhong University of Science and Technology The Research Center of Logistics Nankai University School of Information Science and Technology Chengdu University

Membrane algorithms （MAs）, which inherit from P systems, constitute a new parallel and distribute framework for approximate computation. In the paper, a membrane algorithm is proposed with the improvement that the involved parameters can be adaptively chosen. In the algorithm, some membranes can evolve dynamically during the computing process to specify the values of the requested parameters. The new algorithm is tested on a well-known combinatorial optimization problem, the travelling salesman problem. The em-pirical evidence suggests that the proposed approach is efficient and reliable when dealing with 11 benchmark instances, particularly obtaining the best of the known solutions in eight instances. Compared with the genetic algorithm, simulated annealing algorithm, neural net-work and a fine-tuned non-adaptive membrane algorithm, our algorithm performs better than them. In practice, to design the airline network that minimize the total routing cost on the CAB data with twenty-five US cities, we can quickly obtain high quality solutions using our algorithm.

关键词： membrane algorithm adaptation travelling salesman problem

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Cell resistance slope combined with LVQ neural network for prediction of anode effect

Cell resistance slope combined with LVQ neural network for p...

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International Conference on intelligent control and Information processing (ICICIP)

作者： Kaibo Zhou Zhikai Lin Dengzhi Yu Bin Cao Ziqian Wang Sihai Guo School of Automation Key Laboratory of Ministry of Education for Image Processing and Intelligent Control Wuhan China Guiyang Aluminum Magnesium Design and Research Institute Guiyang China School of Automation Wuhan University of Technology Wuhan China

It is an important part in aluminum electrolysis production to control the anode effect (AE). Since there are some shortcomings in traditional methods of anode effect prediction in aluminum electrolysis, this paper combined two methods, the slope of cell resistance and learning vector quantization (LVQ) neural network, to predict anode effect. First of all, the first prediction of anode effect will be conducted based on the slope of cell resistance. Afterwards, the inaccurate data are supposed to be re-predicted. The second prediction consists of two steps, one is to estimate the power spectrum from the signal of cell resistance by means of periodogram, the other is to re-predict the anode effect with the LVQ neural network, since the energy of frequency bands are served as the input feature variables of neural network, so as to raise the accuracy of prediction. It turned out that the success rate of ten-minute in advance prediction for anode effect can be above 85%, though just cell resistance signal is studied.

关键词： Resistance Decision support systems Neural networks Spectral analysis Data acquisition Vector quantization

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Global coordinated tracking of multi-agent systems with disturbance uncertainties via bounded control inputs

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Nonlinear Dynamics 2015年第4期82卷 2059-2068页

作者： Su, Housheng Chen, Michael Z. Q. Wang, Xiaofan School of Automation Image Processing and Intelligent Control Key Laboratory of Education Ministry of China Huazhong University of Science and Technology Wuhan China Department of Mechanical Engineering The University of Hong Kong Pokfulam Hong Kong Department of Automation Shanghai Jiao Tong University Shanghai China

This paper investigates the problem of global coordinated tracking of a multi-agent system with input additive uncertainties and disturbances via bounded control inputs. Scheduled low-and-high gain feedback-based distributed coordinated tracking protocols are developed. It is shown that, under the assumptions that each agent is asymptotically null controllable with bounded controls and the network is connected, global coordinated tracking of the multi-agent system can be achieved. We finally show some numerical simulations to verify and illustrate the theoretical results.

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controllable deoxyribonucleic acids sub-tile self-assembly by deoxyribonucleic acids strand displacement

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Journal of Computational and Theoretical Nanoscience 2015年第10期12卷 3774-3780页

作者： Wang, Yanfeng Zhao, Taotao Shi, Xiaolong Li, Mengmeng Cui, Guangzhao School of Electrical and Information Engineering Henan Key Lab of Information-Based Electrical Appliances Zhengzhou University of Light Industry Zhengzhou China Key Laboratory of Image Information Processing and Intelligent Control School of Automation Huazhong University of Science and Technology Wuhan China

Here we report a controllable four DNA sub-tiles, self-assembling into 4-arm DNA tiles, under control of a DNA strand displacement based on DNA sequential circuit. The motif is encoded, compiled and simulated successively in Visual DSD software. The simulation results show that the four kinds of sub-tiles in the motif combine to their neighbors one after another with a certain time delay and finally form into 4-arm DNA tiles. The formation of the 4th arm of a 4-arm DNA tile indicates that all the 4-arm DNA tiles have been assembled, which implies high productivity of the 4-arm DNA tiles. We also analyze the time responses of the DNA sequence circuit by adjusting the concentration proportions of reactants and/or ordering bind and unbind rates of toeholds in simulation. These simulation results demonstrate that high concentration proportions of reactants and/or toeholds reacting at ascending order rates can shorten the time response more sharply than that low concentration proportion of reactants and/or in a descending order. The motif furthers the integration for DNA sub-tile self-assembly and DNA strand displacement. Copyright © 2015 American Scientific Publishers.

关键词： DNA

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