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Music, Computing, and Health: A Roadmap for the Current and Future Roles of Music Technology for Health Care and Well-Being

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Music and Science 2021年 4卷

作者： Agres, Kat R. Schaefer, Rebecca S. Volk, Anja van Hooren, Susan Holzapfel, Andre Dalla Bella, Simone Müller, Meinard de Witte, Martina Herremans, Dorien Ramirez Melendez, Rafael Neerincx, Mark Ruiz, Sebastian Meredith, David Dimitriadis, Theo Magee, Wendy L. Yong Siew Toh Conservatory of Music National University of Singapore Singapore Social and Cognitive Computing Department Institute of High Performance Computing A*STAR Singapore Institute for Psychology Health Medical Neuropsychology Unit Leiden University Leiden Netherlands Leiden Institute for Brain and Cognition Leiden University Leiden Netherlands Academy of Creative and Performing Arts Leiden University Leiden Netherlands Department of Information and Computing Sciences Utrecht University Utrecht Netherlands Faculty of Health care Department of Arts Therapies Zuyd University of Applied Sciences Heerlen Netherlands KenVaK Research Centre for the Arts Therapies and Psychomotricity Heerlen Netherlands Faculty of Psychology Open University of The Netherlands Heerlen Netherlands Division of Media Technology and Interaction Design KTH Royal Institute of Technology Stockholm Sweden International Laboratory for Brain Music and Sound Research (BRAMS) Outremont QC Canada Department of Psychology University of Montreal Montreal QC Canada Centre for Research on Brain Language and Music (CRBLM) Montreal QC Canada University of Economics and Human Sciences in Warsaw Warsaw Poland International Audio Laboratories Erlangen Friedrich-Alexander Universität Erlangen-Nürnberg Erlangen Germany HAN University of Applied Sciences Department of Arts Therapies and Psychological Studies Nijmegen Netherlands University of Amsterdam Research Institute of Child Development and Education Amsterdam Netherlands Treatment Centre for People with Mild Intellectual Disabilities and Psychiatric and Behavioral Disorders Gennep Netherlands Information Systems Technology and Design Singapore University of Technology and Design Singapore Music and Machine Learning Lab Music Technology Group Universitat Pompeu Fabra Barcelona Spain Faculty of EEMCS Interactive Intelligence Group Delft University of Technology Delft Netherlands Centre for Digital Music School of Electronic Engineerin

The fields of music, health, and technology have seen significant interactions in recent years in developing music technology for health care and well-being. In an effort to strengthen the collaboration between the involved disciplines, the workshop “Music, Computing, and Health” was held to discuss best practices and state-of-the-art at the intersection of these areas with researchers from music psychology and neuroscience, music therapy, music information retrieval, music technology, medical technology (medtech), and robotics. Following the discussions at the workshop, this article provides an overview of the different methods of the involved disciplines and their potential contributions to developing music technology for health and well-being. Furthermore, the article summarizes the state of the art in music technology that can be applied in various health scenarios and provides a perspective on challenges and opportunities for developing music technology that (1) supports person-centered care and evidence-based treatments, and (2) contributes to developing standardized, large-scale research on music-based interventions in an interdisciplinary manner. The article provides a resource for those seeking to engage in interdisciplinary research using music-based computational methods to develop technology for health care, and aims to inspire future research directions by evaluating the state of the art with respect to the challenges facing each field. © The Author(s) 2021.

关键词： health care interdisciplinarity MedTech music information retrieval (MIR) music neuroscience Music psychology music technology music therapy well-being

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Fostering diversity, equity, and inclusion in interdisciplinary marine science

npj Ocean Sustainability

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npj Ocean Sustainability 2024年第1期3卷 1-8页

作者： Laura Kaikkonen Rebecca J. Shellock Samiya Ahmed Selim Renis Auma Ojwala Beatriz S. Dias Sarah Mahadeo Shenghui Li Charles I. Addey Ignacio Gianelli Katherine M. Maltby Sara Garcia-Morales Juliano Palacios-Abrantes Ayodele Oloko Shan Jiang Marta Albo-Puigserver Virginia A. García Alonso Chelsey A. Baker Colleen B. Bove Stephanie Brodie Lol Iana Dahlet Jewel Das Sebastian C. A. Ferse Aislinn Dunne Ellen Johannesen Julia Jung Eugenia Merayo Garcia Denis B. Karcher Lucia Millan Kasali Oladepo Lawal Kelly Ortega-Cisneros Stephanie Otoabasi-Akpan Durlave Roy Samina Sharmin Rouf Szymon Smoliński Natasa Vaidianu Chris Whidden Mia Strand Finnish Environment Institute Helsinki Finland University of Helsinki Helsinki Finland Centre for Sustainable Development Reform Faculty of Law and Justice University of New South Wales Sydney NSW Australia Center for Sustainable Development University of Liberal Arts Bangladesh Dhaka Bangladesh World Maritime University-Sasakawa Global Ocean Institute Malmö Sweden Cooperative Institute for Climate Ocean and Ecosystem Studies University of Washington Seattle WA USA Guangdong Academy of Coastal Economic Belt Development Guangdong Ocean University Zhanjiang China Department of Oceanography University of Hawai’i at Manoa Honolulu HI USA EqualSea Lab-CRETUS. Department of Applied Economics Universidade de Santiago de Compostela Spain South American Institute for Resilience and Sustainability Studies (SARAS) Maldonado Uruguay Gulf of Maine Research Institute Portland ME USA Marine Environmental and Sciences Centre (MARE-ARNET) University of Lisbon Lisbon Portugal Ecology and Biodiversity Institute (IEB) Santiago Chile Institute for the Oceans and Fisheries The University of British Columbia Vancouver BC Canada State Key Laboratory of Estuarine and Coastal Research East China Normal University Shanghai China Centro Oceanográfico de Baleares Instituto Español de Oceanografía (IEO-CSIC) Ecosystem Oceanography Group Palma Spain Departamento de Biodiversidad y Biología Experimental (DBBE) Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires AR Argentina National Oceanography Centre Marine Systems Modelling Southampton UK Ursinus College Biology Department Collegeville PA USA Environment Commonwealth Scientific and Industrial Research Organisation Brisbane QLD Australia Leibniz Centre for Tropical Marine Research (ZMT) Bremen Germany Instituto de Estudos Costeiros Universidade Federal do Pará (UFPA) Bragança Aldeia Brazil Institute of Marine Sciences University of Chittagong Chattogram Bangladesh Faculty for Fisheries and Marine Scien

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The overlapping burden of the three leading causes of disability and death in sub-Saharan African children

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Nature Communications 2022年第1期13卷 1-14页

作者： Reiner, Robert C. Welgan, Catherine A. Troeger, Christopher E. Baumann, Mathew M. Weiss, Daniel J. Deshpande, Aniruddha Blacker, Brigette F. Miller-Petrie, Molly K. Earl, Lucas Bhatt, Samir Abolhassani, Hassan Abosetugn, Akine Eshete Abu-Gharbieh, Eman Adekanmbi, Victor Adetokunboh, Olatunji O. Aghaali, Mohammad Aji, Budi Alahdab, Fares Al-Aly, Ziyad Alhassan, Robert Kaba Ali, Saqib Alizade, Hesam Aljunid, Syed Mohamed Almasi-Hashiani, Amir Al-Mekhlafi, Hesham M. Altirkawi, Khalid A. Alvis-Guzman, Nelson Amare, Azmeraw T. Amini, Saeed Amugsi, Dickson A. Ancuceanu, Robert Andrei, Catalina Liliana Ansari, Fereshteh Anvari, Davood Appiah, Seth Christopher Yaw Arabloo, Jalal Aremu, Olatunde Atout, Maha Moh’d Wahbi Ausloos, Marcel Ausloos, Floriane Ayanore, Martin Amogre Aynalem, Yared Asmare Azene, Zelalem Nigussie Badawi, Alaa Baig, Atif Amin Banach, Maciej Bedi, Neeraj Bhagavathula, Akshaya Srikanth Bhandari, Dinesh Bhardwaj, Nikha Bhardwaj, Pankaj Bhattacharyya, Krittika Bhutta, Zulfiqar A. Bijani, Ali Birhanu, Tesega Tesega Mengistu Bitew, Zebenay Workneh Boloor, Archith Brady, Oliver J. Butt, Zahid A. Car, Josip Carvalho, Felix Casey, Daniel C. Chattu, Vijay Kumar Chowdhury, Mohiuddin Ahsanul Kabir Chu, Dinh-Toi Coelho, Camila H. Cook, Aubrey J. Damiani, Giovanni Daoud, Farah Gela, Jiregna Darega Darwish, Amira Hamed Daryani, Ahmad Das, Jai K. Davis Weaver, Nicole Deribe, Kebede Desalew, Assefa Dharmaratne, Samath Dhamminda Dianatinasab, Mostafa Diaz, Daniel Djalalinia, Shirin Dorostkar, Fariba Dubljanin, Eleonora Duko, Bereket Dwyer-Lindgren, Laura Effiong, Andem El Sayed Zaki, Maysaa El Tantawi, Maha Enany, Shymaa Fattahi, Nazir Feigin, Valery L. Fernandes, Eduarda Ferrara, Pietro Fischer, Florian Foigt, Nataliya A. Folayan, Morenike Oluwatoyin Foroutan, Masoud Frostad, Joseph Jon Fukumoto, Takeshi Gaidhane, Abhay Motiramji Gebrekrstos, Hailemikael Gebrekidan G. K. Gebremeskel, Leake Gebreslassie, Assefa Ayalew Gething, Peter W. Gezae, Kebede Embaye Ghadiri, Keyghobad Ghashghaee, Ahmad Golechha, Mahaveer Gubar Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Malaria Atlas Project University of Oxford Oxford United Kingdom Imperial College London London United Kingdom Department of Laboratory Medicine Karolinska University Hospital Huddinge Sweden Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Department of Public Health Debre Berhan University Debre Berhan Ethiopia Department of Clinical Sciences University of Sharjah Sharjah United Arab Emirates Population Health Sciences King’s College London London United Kingdom Centre of Excellence for Epidemiological Modelling and Analysis Stellenbosch University Stellenbosch South Africa Department of Global Health Stellenbosch University Cape Town South Africa Department of Epidemiology and Biostatistics Qom University of Medical Sciences Qom Iran Faculty of Medicine and Public Health Jenderal Soedirman University Purwokerto Indonesia Mayo Evidence-based Practice Center Mayo Clinic Foundation for Medical Education and Research Rochester MN United States John T. Milliken Department of Internal Medicine Washington University in St. Louis St. Louis MO United States Clinical Epidemiology Center Department of Veterans Affairs St Louis MO United States Institute of Health Research University of Health and Allied Sciences Ho Ghana Department of Information Systems College of Economics and Political Science Sultan Qaboos University Muscat Oman Infectious and Tropical Disease Research Center Hormozgan University of Medical Sciences Bandar Abbas Iran Department of Health Policy and Management Kuwait University Safat Kuwait International Centre for Casemix and Clinical Coding National University of Malaysia Bandar Tun Razak Malaysia Department of Epidemiology Arak University of Medical Sciences Arak Iran Medical Research Center

Despite substantial declines since 2000, lower respiratory infections (LRIs), diarrhoeal diseases, and malaria remain among the leading causes of nonfatal and fatal disease burden for children under 5 years of age (under 5), primarily in sub-Saharan Africa (SSA). The spatial burden of each of these diseases has been estimated subnationally across SSA, yet no prior analyses have examined the pattern of their combined burden. Here we synthesise subnational estimates of the burden of LRIs, diarrhoea, and malaria in children under-5 from 2000 to 2017 for 43 sub-Saharan countries. Some units faced a relatively equal burden from each of the three diseases, while others had one or two dominant sources of unit-level burden, with no consistent pattern geographically across the entire subcontinent. Using a subnational counterfactual analysis, we show that nearly 300 million DALYs could have been averted since 2000 by raising all units to their national average. Our findings are directly relevant for decision-makers in determining which and targeting where the most appropriate interventions are for increasing child survival. © 2022, The Author(s).

关键词： Biogeography Epidemiology Infectious diseases Malaria

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A chirality-based quantum leap

arXiv

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arXiv 2020年

作者： Aiello, Clarice D. Abbas, Muneer Abendroth, John M. Afanasev, Andrei Agarwal, Shivang Banerjee, Amartya S. Beratan, David N. Belling, Jason N. Berche, Bertrand Botana, Antia Caram, Justin R. Celardo, Giuseppe Luca Cuniberti, Gianaurelio Garcia-Etxarri, Aitzol Dianat, Arezoo Diez-Perez, Ismael Guo, Yuqi Gutierrez, Rafael Herrmann, Carmen Hihath, Joshua Kale, Suneet Kurian, Philip Lai, Ying-Cheng Lopez, Alexander Medina, Ernesto Mujica, Vladimiro Naaman, Ron Noormandipour, Mohammadreza Palma, Julio L. Paltiel, Yossi Petuskey, William T. Ribeiro-Silva, João Carlos Saenz, Juan José Santos, Elton J.G. Solyanik, Maria Sorger, Volker J. Stemer, Dominik M. Ugalde, Jesus M. Valdes-Curiel, Ana Varela, Solmar Waldeck, David H. Weiss, Paul S. Zacharias, Helmut Wang, Qing Hua California NanoSystems Institute University of California Los Angeles Los AngelesCA90095 United States Department of Electrical and Computer Engineering University of California Los Angeles Los AngelesCA90095 United States Department of Microbiology Howard University WashingtonDC20059 United States Laboratory for Solid State Physics ETH Zürich Zürich8093 Switzerland George Washington University WashingtonDC20052 United States Department of Materials Science and Engineering University of California Los Angeles Los AngelesCA90095 United States Department of Chemistry Duke University DurhamNC27708 United States Department of Chemistry & Biochemistry University of California Los Angeles Los AngelesCA90095 United States Laboratoire de Physique et Chimie Théoriques UMR Université de Lorraine-CNRS Vandœuvre les Nancy 7019 54506 France Department of Physics Arizona State University TempeAZ85287 United States Institute of Physics IFUAP-BUAP Puebla72000 Mexico Institute for Materials Science Max Bergmann Center of Biomaterials Dresden University of Technology Dresden01062 Germany Donostia International Physics Center Euskal Herriko Unibertsitatea Euskadi Donostia20018 Spain Department of Chemistry Faculty of Natural and Mathematical Sciences King's College London 7 Trinity Street LondonSE1 1DB United Kingdom School for Engineering of Matter Transport and Energy Arizona State University TempeAZ85287 United States Department of Chemistry University of Hamburg Hamburg20146 Germany Department of Electrical and Computer Engineering University of California Davis DavisCA95616 United States School of Molecular Sciences Arizona State University TempeAZ85287 United States Quantum Biology Laboratory Graduate School Howard University WashingtonDC20059 United States School of Electrical Computer and Energy Engineering Arizona State University TempeAZ85287 United States Department of Chemical and Biological Physics Weizmann Institut

Chiral degrees of freedom occur in matter and in electromagnetic fields and constitute an area of research that is experiencing renewed interest driven by recent observations of the chiral-induced spin selectivity (CISS) effect in chiral molecules and engineered nanomaterials. The CISS effect underpins the fact that charge transport through nanoscopic chiral structures favors a particular electronic spin orientation, resulting in large room-temperature spin polarizations. Observations of the CISS effect suggest opportunities for spin control and for the design and fabrication of room-temperature quantum devices from the bottom up, with atomic-scale precision. Any technology that relies on optimal charge transport, including quantum devices for logic, sensing, and storage, may benefit from chiral quantum properties. These properties can be theoretically and experimentally investigated from a quantum information perspective, which is presently lacking. There are uncharted implications for the quantum sciences once chiral couplings can be engineered to control the storage, transduction, and manipulation of quantum information. This forward-looking perspective provides a survey of the experimental and theoretical fundamentals of chiral-influenced quantum effects, and presents a vision for their future roles in enabling room-temperature quantum technologies. Copyright © 2020, The Authors. All rights reserved.

关键词： Quantum optics

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On time-consistent solution to time-inconsistent linear-quadratic optimal control of discrete-time stochastic systems

arXiv

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arXiv 2017年

作者： Li, Xun Ni, Yuan-Hua Zhang, Ji-Feng Department of Applied Mathematics Hong Kong Polytechnic University Hunghom Kowloon Hong Kong College of Computer and Control Engineering Nankai University Tianjin300350 China Key Laboratory of Systems and Control Institute of Systems Science Academy of Mathematics and Systems Science Chinese Academy of Sciences School of Mathematical Sciences University of Chinese Academy of Sciences China

In this paper, we investigate a class of time-inconsistent discrete-time stochastic linear-quadratic optimal control problems, whose time-consistent solutions consist of an open-loop equilibrium control and a linear feedback equilibrium strategy. The open-loop equilibrium control is defined for a given initial pair, while the linear feedback equilibrium strategy is defined for all the initial pairs. Maximum-principle-type necessary and sufficient conditions containing stationary and convexity are derived for the existence of these two time-consistent solutions, respectively. Furthermore, for the case where the system matrices are independent of the initial time, we show that the existence of the open-loop equilibrium control for a given initial pair is equivalent to the solvability of a set of nonsymmetric generalized difference Riccati equations and a set of linear difference equations. Moreover, the existence of linear feedback equilibrium strategy is equivalent to the solvability of another set of symmetric generalized difference Riccati equations.49N10, 49N35, 93E20 Copyright © 2017, The Authors. All rights reserved.

关键词： Stochastic systems

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The 2021 report of the Lancet Countdown on health and climate change: code red for a healthy future

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The Lancet 2021年第10311期398卷 1619-1662页

作者： Romanello, Marina McGushin, Alice Di Napoli, Claudia Drummond, Paul Hughes, Nick Jamart, Louis Kennard, Harry Lampard, Pete Solano Rodriguez, Baltazar Arnell, Nigel Ayeb-Karlsson, Sonja Belesova, Kristine Cai, Wenjia Campbell-Lendrum, Diarmid Capstick, Stuart Chambers, Jonathan Chu, Lingzhi Ciampi, Luisa Dalin, Carole Dasandi, Niheer Dasgupta, Shouro Davies, Michael Dominguez-Salas, Paula Dubrow, Robert Ebi, Kristie L Eckelman, Matthew Ekins, Paul Escobar, Luis E Georgeson, Lucien Grace, Delia Graham, Hilary Gunther, Samuel H Hartinger, Stella He, Kehan Heaviside, Clare Hess, Jeremy Hsu, Shih-Che Jankin, Slava Jimenez, Marcia P Kelman, Ilan Kiesewetter, Gregor Kinney, Patrick L Kjellstrom, Tord Kniveton, Dominic Lee, Jason K W Lemke, Bruno Liu, Yang Liu, Zhao Lott, Melissa Lowe, Rachel Martinez-Urtaza, Jaime Maslin, Mark McAllister, Lucy McMichael, Celia Mi, Zhifu Milner, James Minor, Kelton Mohajeri, Nahid Moradi-Lakeh, Maziar Morrissey, Karyn Munzert, Simon Murray, Kris A Neville, Tara Nilsson, Maria Obradovich, Nick Sewe, Maquins Odhiambo Oreszczyn, Tadj Otto, Matthias Owfi, Fereidoon Pearman, Olivia Pencheon, David Rabbaniha, Mahnaz Robinson, Elizabeth Rocklöv, Joacim Salas, Renee N Semenza, Jan C Sherman, Jodi Shi, Liuhua Springmann, Marco Tabatabaei, Meisam Taylor, Jonathon Trinanes, Joaquin Shumake-Guillemot, Joy Vu, Bryan Wagner, Fabian Wilkinson, Paul Winning, Matthew Yglesias, Marisol Zhang, Shihui Gong, Peng Montgomery, Hugh Costello, Anthony Hamilton, Ian Institute for Global Health University College London London UK United Kingdom Institute for Sustainable Resources University College London London UK United Kingdom UCL Energy Institute University College London London UK United Kingdom Institute for Environmental Design and Engineering University College London London UK United Kingdom Department of Geography University College London London UK United Kingdom The Bartlett School of Sustainable Construction University College London London UK United Kingdom Centre for Human Health and Performance University College London London UK United Kingdom School of Agriculture Policy and Development University of Reading Reading United Kingdom Department of Meteorology University of Reading Reading United Kingdom The Walker Institute University of Reading Reading United Kingdom Department of Health Sciences University of York York United Kingdom Institute for Environment and Human Security United Nations University Bonn Germany Centre on Climate Change and Planetary Health London School of Hygiene & Tropical Medicine London UK United Kingdom Centre for Mathematical Modelling of Infectious Diseases London School of Hygiene & Tropical Medicine London UK United Kingdom Department of Public Health Environments and Society London School of Hygiene & Tropical Medicine London UK United Kingdom Department of Earth System Science Tsinghua University Beijing China Department of Environment Climate Change and Health World Health Organization Geneva Switzerland Institute for Environmental Sciences World Health Organization Geneva Switzerland Centre for Climate Change and Social Transformations School of Psychology Cardiff University Cardiff United Kingdom Yale Center on Climate Change and Health Yale University New Haven CT United States School of Government University of Birmingham Birmingham United Kingdom Economic analysis of Climate Impacts and Policy Centro Euro-Mediterraneo sui Cambiamenti Climatic

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Search for vector-like leptons coupling to first- and second-generation Standard Model leptons in pp collisions at = 13 TeV with the ATLAS detector

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Journal of High Energy Physics 2025年第5期2025卷 1-61页

作者： Aad, G. Aakvaag, E. Abbott, B. Abdelhameed, S. Abeling, K. Abicht, N. J. Abidi, S. H. Aboelela, M. Aboulhorma, A. Abramowicz, H. Abulaiti, Y. Acharya, B. S. Ackermann, A. Adam Bourdarios, C. Adamczyk, L. Addepalli, S. V. Addison, M. J. Adelman, J. Adiguzel, A. Adye, T. Affolder, A. A. Afik, Y. Agaras, M. N. Aggarwal, A. Agheorghiesei, C. Ahmadov, F. Ahuja, S. Ai, X. Aielli, G. Aikot, A. Ait Tamlihat, M. Aitbenchikh, B. Akbiyik, M. Åkesson, T. P. A. Akimov, A. V. Akiyama, D. Akolkar, N. N. Aktas, S. Alberghi, G. L. Albert, J. Albicocco, P. Albouy, G. L. Alderweireldt, S. Alegria, Z. L. Aleksa, M. Aleksandrov, I. N. Alexa, C. Alexopoulos, T. Alfonsi, F. Algren, M. Alhroob, M. Ali, B. Ali, H. M. J. Ali, S. Alibocus, S. W. Aliev, M. Alimonti, G. Alkakhi, W. Allaire, C. Allbrooke, B. M. M. Allen, J. S. Allen, J. F. Allendes Flores, C. A. Allport, P. P. Aloisio, A. Alonso, F. Alpigiani, C. Alsolami, Z. M. K. Alvarez Fernandez, A. Alves Cardoso, M. Alviggi, M. G. Aly, M. Amaral Coutinho, Y. Ambler, A. Amelung, C. Amerl, M. Ames, C. G. Amidei, D. Amini, B. Amirie, K. Amirkhanov, A. Amor Dos Santos, S. P. Amos, K. R. Amperiadou, D. An, S. Ananiev, V. Anastopoulos, C. Andeen, T. Anders, J. K. Anderson, A. C. Andreazza, A. Angelidakis, S. Angerami, A. Anisenkov, A. V. Annovi, A. Antel, C. Antipov, E. Antonelli, M. Anulli, F. Aoki, M. Aoki, T. Aparo, M. A. Aperio Bella, L. Appelt, C. Apyan, A. Arbiol Val, S. J. Arcangeletti, C. Arce, A. T. H. Arguin, J-F. Argyropoulos, S. Arling, J.-H. Arnaez, O. Arnold, H. Artoni, G. Asada, H. Asai, K. Asai, S. Asbah, N. A. Ashby Pickering, R. A. Aslam, A. M. Assamagan, K. Astalos, R. Astrand, K. S. V. Atashi, S. Atkin, R. J. Atmani, H. Atmasiddha, P. A. Augsten, K. Auriol, A. D. Austrup, V. A. Avolio, G. Axiotis, K. Azuelos, G. Babal, D. Bachacou, H. Bachas, K. Bachiu, A. Bachmann, E. Badea, A. Baer, T. M. Bagnaia, P. Bahmani, M. Bahner, D. Bai, K. Baines, J. T. Baines, L. Baker, O. K. Bakos, E. Bakshi Gupta, D. Balabram Filho, L. E. Balakrishnan, V. Balasubramanian, R. Baldin, E. M. Balek CPPM Aix-Marseille Université CNRS/IN2P3 Marseille France Department for Physics and Technology University of Bergen Bergen Norway Homer L. Dodge Department of Physics and Astronomy University of Oklahoma Norman United States of America New York University Abu Dhabi Abu Dhabi United Arab Emirates II. Physikalisches Institut Georg-August-Universität Göttingen Göttingen Germany Fakultät Physik Technische Universität Dortmund Dortmund Germany Physics Department Brookhaven National Laboratory Upton United States of America Physics Department Southern Methodist University Dallas United States of America Faculté des sciences Université Mohammed V Rabat Morocco Raymond and Beverly Sackler School of Physics and Astronomy Tel Aviv University Tel Aviv Israel Department of Physics New York University New York United States of America INFN Gruppo Collegato di Udine Sezione di Trieste Udine Italy ICTP Trieste Italy Department of Physics King’s College London London United Kingdom Kirchhoff-Institut für Physik Ruprecht-Karls-Universität Heidelberg Heidelberg Germany LAPP Université Savoie Mont Blanc CNRS/IN2P3 Annecy France AGH University of Krakow Faculty of Physics and Applied Computer Science Krakow Poland SLAC National Accelerator Laboratory Stanford United States of America School of Physics and Astronomy University of Manchester Manchester United Kingdom Department of Physics Northern Illinois University DeKalb United States of America Department of Physics Istanbul University Istanbul Türkiye Particle Physics Department Rutherford Appleton Laboratory Didcot United Kingdom Santa Cruz Institute for Particle Physics University of California Santa Cruz Santa Cruz United States of America Enrico Fermi Institute University of Chicago Chicago United States of America Institut de Física d’Altes Energies (IFAE) Barcelona Institute of Science and Technology Barcelona Spain Institut für Physik Universität Mainz Mainz Germany Department of Physics Alexand

A search for pair production of vector-like leptons coupling to first- and second-generation Standard Model leptons is presented. The search is based on a dataset of proton-proton collisions at $$ \sqrt{s} $$ = 13 TeV recorded with the ATLAS detector during Run 2 of the Large Hadron Collider, corresponding to an integrated luminosity of 140 fb−1. Events are categorised depending on the flavour and multiplicity of leptons (electrons or muons), as well as on the scores of a deep neural network targeting particular signal topologies according to the decay modes of the vector-like leptons. In each of the signal regions, the scalar sum of the transverse momentum of the leptons and the missing transverse momentum is analysed. The main background processes are estimated using dedicated control regions in a simultaneous fit with the signal regions to data. No significant excess above the Standard Model background expectation is observed and limits are set at 95% confidence level on the production cross-sections of vector-like electrons and muons as a function of the vector-like lepton mass, separately for SU(2) doublet and singlet scenarios. The resulting mass lower limits are 1220 GeV (1270 GeV) and 320 GeV (400 GeV) for vector-like electrons (muons) in the doublet and singlet scenarios, respectively.

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A universal language for finding mass spectrometry data patterns

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Nature Methods 2025年 1-8页

作者： Damiani, Tito Jarmusch, Alan K. Aron, Allegra T. Petras, Daniel Phelan, Vanessa V. Zhao, Haoqi Nina Bittremieux, Wout Acharya, Deepa D. Ahmed, Mohammed M. A. Bauermeister, Anelize Bertin, Matthew J. Boudreau, Paul D. Borges, Ricardo M. Bowen, Benjamin P. Brown, Christopher J. Chagas, Fernanda O. Clevenger, Kenneth D. Correia, Mario S. P. Crandall, William J. Crüsemann, Max Fahy, Eoin Fiehn, Oliver Garg, Neha Gerwick, William H. Gilbert, Jeffrey R. Globisch, Daniel Gomes, Paulo Wender P. Heuckeroth, Steffen James, C. Andrew Jarmusch, Scott A. Kakhkhorov, Sarvar A. Kang, Kyo Bin Kessler, Nikolas Kersten, Roland D. Kim, Hyunwoo Kirk, Riley D. Kohlbacher, Oliver Kontou, Eftychia E. Liu, Ken Lizama-Chamu, Itzel Luu, Gordon T. Luzzatto Knaan, Tal Mannochio-Russo, Helena Marty, Michael T. Matsuzawa, Yuki McAvoy, Andrew C. McCall, Laura-Isobel Mohamed, Osama G. Nahor, Omri Neuweger, Heiko Niedermeyer, Timo H. J. Nishida, Kozo Northen, Trent R. Overdahl, Kirsten E. Rainer, Johannes Reher, Raphael Rodriguez, Elys Sachsenberg, Timo T. Sanchez, Laura M. Schmid, Robin Stevens, Cole Subramaniam, Shankar Tian, Zhenyu Tripathi, Ashootosh Tsugawa, Hiroshi van der Hooft, Justin J. J. Vicini, Andrea Walter, Axel Weber, Tilmann Xiong, Quanbo Xu, Tao Pluskal, Tomáš Dorrestein, Pieter C. Wang, Mingxun Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences Prague Czech Republic Metabolomics Core Facility Immunity Inflammation and Disease Laboratory Division of Intramural Research National Institute of Environmental Health Sciences National Institutes of Health Research Triangle Park NC United States Department of Chemistry and Biochemistry University of Denver Denver CO United States Functional Metabolomics Lab CMFI Cluster of Excellence University of Tuebingen Tuebingen Germany Department of Biochemistry University of California Riverside Riverside CA United States Department of Pharmaceutical Sciences Skaggs School of Pharmacy and Pharmaceutical Sciences University of Colorado Anschutz Medical Campus Aurora CO United States Collaborative Mass Spectrometry Innovation Center Skaggs School of Pharmacy and Pharmaceutical Sciences University of California San Diego La Jolla CA United States Biologicals and Natural Products Discovery Crop Protection R & D Corteva Agrisciences Indianapolis IN United States BioMolecular Sciences School of Pharmacy University of Mississippi Oxford MS United States Pharmacognosy Faculty of Pharmacy Al-Azhar University Nasr City Egypt Department of Fundamental Chemistry Institute of Chemistry University of São Paulo São Paulo Brazil Department of Chemistry Case Western Reserve University Cleveland OH United States Walter Mors Institute of Research on Natural Products Federal University of Rio de Janeiro Rio de Janeiro Brazil Environmental Genomics and Systems Biology Division Lawrence Berkeley National Lab Berkeley CA United States The Joint Genome Institute Lawrence Berkeley National Lab Berkeley CA United States Mass Spectrometry Center of Expertise Regulatory and Stewardship Corteva Agrisciences Indianapolis IN United States Biologicals and Natural Products Crop Protection R & D Corteva Agrisciences Indianapolis IN United States Department of Chemistry – BMC Science for Life Laborat

Despite being information rich, the vast majority of untargeted mass spectrometry data are underutilized;most analytes are not used for downstream interpretation or reanalysis after publication. The inability to dive into these rich raw mass spectrometry datasets is due to the limited flexibility and scalability of existing software tools. Here we introduce a new language, the Mass Spectrometry Query Language (MassQL), and an accompanying software ecosystem that addresses these issues by enabling the community to directly query mass spectrometry data with an expressive set of user-defined mass spectrometry patterns. Illustrated by real-world examples, MassQL provides a data-driven definition of chemical diversity by enabling the reanalysis of all public untargeted metabolomics data, empowering scientists across many disciplines to make new discoveries. MassQL has been widely implemented in multiple open-source and commercial mass spectrometry analysis tools, which enhances the ability, interoperability and reproducibility of mining of mass spectrometry data for the research community. © The Author(s), under exclusive licence to Springer Nature America, Inc. 2025.

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Genomic basis for RNA alterations in cancer (vol 578, pg 129, 2020)

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NATURE 2023年第7948期614卷 E37-E37页

作者： Calabrese, Claudia Davidson, Natalie R. Demircioglu, Deniz Fonseca, Nuno A. He, Yao Lehmann, Kjong-Van Liu, Fenglin Shiraishi, Yuichi Soulette, Cameron M. Urban, Lara Greger, Liliana Li, Siliang Liu, Dongbing Perry, Marc D. Xiang, Qian Zhang, Fan Zhang, Junjun Bailey, Peter Erkek, Serap Hoadley, Katherine A. Hou, Yong Huska, Matthew R. Kilpinen, Helena Korbel, Jan O. Marin, Maximillian G. Markowski, Julia Nandi, Tannistha Pan-Hammarstrom, Qiang Pedamallu, Chandra Sekhar Siebert, Reiner Stark, Stefan G. Su, Hong Tan, Patrick Waszak, Sebastian M. Yung, Christina Zhu, Shida Awadalla, Philip Creighton, Chad J. Meyerson, Matthew Ouellette, B. F. Francis Wu, Kui Yang, Huanming Brazma, Alvis Brooks, Angela N. Goke, Jonathan Ratsch, Gunnar Schwarz, Roland F. Stegle, Oliver Zhang, Zemin European Molecular Biology Laboratory European Bioinformatics Institute Hinxton UK European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Cambridge UK Genome Biology Unit European Molecular Biology Laboratory (EMBL) Heidelberg Germany CIBIO/InBIO - Research Center in Biodiversity and Genetic Resources Universidade do Porto Vairão Portugal Berlin Institute for Medical Systems Biology Max Delbruck Center for Molecular Medicine Berlin Germany German Cancer Consortium (DKTK) partner site Berlin Germany German Cancer Research Center (DKFZ) Heidelberg Germany Berlin Institute for Medical Systems Biology Max Delbrück Center for Molecular Medicine Berlin Germany German Cancer Consortium (DKTK) Partner site Berlin Berlin Germany European Molecular Biology Laboratory Genome Biology Unit Heidelberg Germany Division of Computational Genomics and Systems Genetics German Cancer Research Center (DKFZ) Heidelberg Germany ETH Zurich Zurich Switzerland Memorial Sloan Kettering Cancer Center New York NY USA Weill Cornell Medical College New York NY USA SIB Swiss Institute of Bioinformatics Lausanne Switzerland University Hospital Zurich Zurich Switzerland Computational Biology Center Memorial Sloan Kettering Cancer Center New York NY USA Department of Biology ETH Zurich Zürich Switzerland Department of Computer Science ETH Zurich Zurich Switzerland Korea University Seoul South Korea Computational and Systems Biology Program Memorial Sloan Kettering Cancer Center New York NY USA Department of Physiology and Biophysics Weill Cornell Medicine New York NY USA Institute for Computational Biomedicine Weill Cornell Medicine New York NY USA Controlled Department and Institution New York NY USA Englander Institute for Precision Medicine Weill Cornell Medicine New York NY USA National University of Singapore Singapore Singapore Genome Institute of Singapore Singapore Singapore Computational and Systems Biology Genome Institute of Singap

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Self adaptation of chimera states

arXiv

引用

arXiv 2018年

作者： Yao, Nan Huang, Zi-Gang Ren, Hai-Peng Grebogi, Celso Lai, Ying-Cheng Department of Applied Physics Xi’an University of Technology Xi’an710048 China School of Life Science and Technology Xi’an Jiao Tong University Xi’an710049 China Shaanxi Key Laboratory of Complex System Control and Intelligent Information Processing Xi’an University of Technology Xi’an710048 China Institute for Complex Systems and Mathematical Biology King’s College University of Aberdeen AberdeenAB24 3UE United Kingdom School of Electrical Computer and Energy Engineering Arizona State University TempeAZ85287 United States Department of Physics Arizona State University TempeAZ85287 United States

Chimera states in spatiotemporal dynamical systems have been investigated in physical, chemical, and biological systems, and have been shown to be robust against random perturbations. How do chimera states achieve their robustness? We uncover a self-adaptation behavior by which, upon a spatially localized perturbation, the coherent component of the chimera state spontaneously drifts to an optimal location as far away from the perturbation as possible, exposing only its incoherent component to the perturbation to minimize the disturbance. A systematic numerical analysis of the evolution of the spatiotemporal pattern of the chimera state towards the optimal stable state reveals an exponential relaxation process independent of the spatial location of the perturbation, implying that its effects can be modeled as restoring and damping forces in a mechanical system and enabling the articulation of a phenomenological model. Not only is the model able to reproduce the numerical results, it can also predict the trajectory of drifting. Our finding is striking as it reveals that, inherently, chimera states possess a kind of "intelligence" in achieving robustness through self adaptation. The behavior can be exploited for controlled generation of chimera states with their coherent component placed in any desired spatial region of the system. Copyright © 2018, The Authors. All rights reserved.

关键词： Dynamical systems

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