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Optineurin restrains CCR7 degradation to guide type II collagen-stimulated dendritic cell migration in rheumatoid arthritis

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Acta Pharmaceutica Sinica B 2025年第3期15卷 1626-1642页

作者： Wenxiang Hong Hongbo Ma Zhaoxu Yang Jiaying Wang Bowen Peng Longling Wang Yiwen Du Lijun Yang Lijiang Zhang Zhibin Li Han Huang Difeng Zhu Bo Yang Qiaojun He Jiajia Wang Qinjie Weng Center for Drug Safety Evaluation and Research Zhejiang Province Key Laboratory of Anti-Cancer Drug ResearchCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Nanhu Brain-Computer Interface Institute Hangzhou 311100China The Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310009China Key Laboratory of Drug Safety Evaluation and Research of Zhejiang Province Center of Safety Evaluation and ResearchHangzhou Medical CollegeHangzhou 310059China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310018China School of Medicine Hangzhou City UniversityHangzhou 310015China Taizhou Institute of Zhejiang University Taizhou 318000China

Dendritic cells(DCs)serve as the primary antigen-presenting cells in autoimmune diseases,like rheumatoid arthritis(RA),and exhibit distinct signaling profiles due to antigenic *** II collagen(CII)has been recognized as an RA-specific antigen;however,little is known about CII-stimulated DCs,limiting the development of RA-specific therapeutic *** this study,we show that CII-stimulated DCs display a preferential gene expression profile associated with migration,offering a new perspective for targeting DC migration in RA ***,saikosaponin D(SSD)was identified as a compound capable of blocking CII-induced DC migration and effectively ameliorating ***(OPTN)is further revealed as a potential SSD target,with Optn deletion impairing CII-pulsed DC migration without affecting *** analyses uncover that OPTN prevents the proteasomal transport and ubiquitin-dependent degradation of C-C chemokine receptor 7(CCR7),a pivotal chemokine receptor in DC ***-deficient DCs exhibit reduced CCR7 expression,leading to slower migration in CII-surrounded environment,thus alleviating arthritis *** findings underscore the significance of antigen-specific DC activation in RA and suggest OPTN is a crucial regulator of CII-specific DC *** emerges as a promising drug target for RA,potentially offering significant value for the therapeutic management of RA.

关键词： Rheumatoid arthritis Dendritic cells Migration Optineurin CCR7 Degradation Saikosaponin D Type II collagen

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Exploring Humanoid Robot Face Preference Using brain Functional Connectivity and Graph neural Network 12

Exploring Humanoid Robot Face Preference Using Brain Functio...

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12th International Conference on CYBER Technology in Automation, Control, and Intelligent Systems, CYBER 2022

作者： Wang, Pengchao Mu, Wei Zhan, Gege Wang, Aiping Song, Zuoting Fang, Tao Zhang, Xueze Wang, Junkongshuai Niu, Lan Bin, Jianxiong Zhang, Lihua Jia, Jie Kang, Xiaoyang State Key Laboratory of Medical Neurobiology Institute of Ai and Robotics Academy for Engineering and Technology Fudan University Laboratory for Neural Interface and Brain Computer Interface Engineering Research Center of Ai and Robotics Ministry of Education Shanghai Engineering Research Center of Ai and Robotics Moe Frontiers Center for Brain Science Shanghai200433 China Ji Hua Laboratory Guangdong Province Foshan528200 China Huashan Hospital Fudan University Department of Rehabilitation Medicine Shanghai200040 China Yiwu Research Institute of Fudan University Zhejiang Yiwu City322000 China Research Center for Intelligent Sensing Zhejiang Lab Hangzhou311121 China

ISBN: (数字)9781665472678

ISBN: (纸本)9781665472678

Graph neural networks (GNN) have been applied in EEG signal analysis. However, it is not clear how to describe the connection relationships between electrodes, and a reasonable representation of the adjacency matrix cannot be neglected for the study of GNN based on EEG signals. In this paper, we use brain functional connectivity to analyze the face preferences of a humanoid robot and explore the feasibility of using the matrix obtained based on brain functional connectivity measurements as a GNN connectivity matrix. The results show that it is feasible and an average accuracy of 73.47% is achieved. In addition, the results of the brain functional connectivity analysis also show that there is a difference between preferences and non-preferences. © 2022 IEEE.

关键词： Anthropomorphic robots

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Route Control of Four-rotor UAV based on brain-computer interface in Virtual Reality 12

Route Control of Four-rotor UAV based on Brain-Computer Inte...

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12th International Conference on CYBER Technology in Automation, Control, and Intelligent Systems, CYBER 2022

作者： Niu, Lan Bin, Jianxiong Wang, Junkongshuai Zhan, Gege Jiang, Haifeng Dong, Zhiyan Zhang, Lihua Kang, Xiaoyang Moe Frontiers Center for Brain Science State Key Laboratory of Medical Neurobiology Institute of Ai and Robotics Academy for Engineering and Technology Fudan University Laboratory for Neural Interface and Brain Computer Interface Engineering Research Center of Ai and Robotics Ministry of Education Shanghai Engineering Research Center of Ai and Robotics Shanghai200433 China Ji Hua Laboratory Guangdong Province Foshan China Shanghai Mental Center Shanghai Jiao Tong University School of Medicine Shanghai China Yiwu Research Institute of Fudan University Chengbei Road Zhejiang Province Yiwu City China Research Center for Intelligent Sensing Zhejiang Lab Hangzhou China

ISBN: (数字)9781665472678

ISBN: (纸本)9781665472678

This article presented an experiment to determine the effect of dynamic 3D vision-evoked modules on the performance of the system we designed to steer a four-rotor unmanned aerial vehicle (UAV). Nowadays, UAV system is widely used in various industries, and UAV control has always been a focus of research. The brain-computer interface (BCI) system was based on the well-known steady-state visually evoked potentials (SSVEP). The specificity of the interface was the integration of dynamic 3D paradigms in virtual reality. In order to achieve a more immersive and interactive scene, VR scenes were moving synchronously with the UAV. Users can achieve remote control of four-rotor UAV through virtual scenarios. Ten subjects participated in the experiment and operated the UAV to complete a specific track. The dynamic paradigm based on the experimenter's feedback may indeed affect their attention, we proposed an effective solution to overcome this problem. The detailed results of these experiments were reported in this paper and we discussed the possible causes of performance loss under such conditions. © 2022 IEEE.

关键词： brain computer interface

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Electrochemical impedance behavior of implantable neural interface following the change of equivalent circuit element 12

Electrochemical impedance behavior of implantable neural int...

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12th International Conference on CYBER Technology in Automation, Control, and Intelligent Systems, CYBER 2022

作者： Zhang, Jing Liu, Lusheng Wang, Aiping Wang, Junkongshuai Fang, Tao Niu, Lan Bin, Jianxiong Wang, Pengchao Mu, Wei Jia, Jie Zhang, Lihua Kang, Xiaoyang Laboratory for Neural Interface and Brain Computer Interface Engineering Research Center of Ai and Robotics Ministry of Education Shanghai Engineering Research Center of Ai and Robotics Moe Frontiers Center for Brain Science State Key Laboratory of Medical Neurobiology Institute of Ai and Robotics Academy for Engineering and Technology Fudan University Shanghai200433 China Ji Hua Laboratory Guangdong Province Foshan528200 China Department of Rehabilitation Medicine Huashan Hospital Fudan University Shanghai200040 China Yiwu Research Institute of Fudan University Zhejiang Yiwu City322000 China Research Center for Intelligent Sensing Zhejiang Lab Hangzhou311121 China

ISBN: (数字)9781665472678

ISBN: (纸本)9781665472678

The simulation of two basic equivalent circuit models of the implantable neural interface is described in this paper. The simulated equivalent circuits are created based on the physicochemical mechanism of charge transfer on the surface of the implantable neural interface. Each parameter of the equivalent circuit model was varied to investigate the regular pattern of individual element affecting the performance of the implantable neural interface. In this paper, one circuit model is based on the charge transfer process, and another circuit model is based on the mixed charge transfer and diffusion process. The equivalent circuits are split into two parts. The neural interface of the implantable neural interface device is simulated in one part, and the rest of that is simulated in another part. The electrochemical impedance data is acquired firstly by simulating the equivalent circuit with Z-view software. Then, the simulated data was analyzed to investigate the change tendency of a single parameter, providing a theoretical method for developing customized implantable neural interface with specific electrochemical impedance. © 2022 IEEE.

关键词： Equivalent circuits

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A TB-CSP Motor Imagery EEG Recognition Method for neural-controlled Manipulator System 12

A TB-CSP Motor Imagery EEG Recognition Method for Neural-con...

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12th International Conference on CYBER Technology in Automation, Control, and Intelligent Systems, CYBER 2022

作者： Mu, Wei Wang, Pengchao Wang, Junkongshuai Fang, Tao Wang, Aiping Niu, Lan Bin, Jianxiong Liu, Lusheng Zhang, Jing Jia, Jie Zhang, Lihua Kang, Xiaoyang Laboratory for Neural Interface and Brain Computer Interface Engineering Research Center of Ai and Robotics Ministry of Education Shanghai Engineering Research Center of Ai and Robotics Moe Frontiers Center for Brain Science State Key Laboratory of Medical Neurobiology Institute of Ai and Robotics Academy for Engineering and Technology Fudan University Shanghai200433 China Ji Hua Laboratory Guangdong Province Foshan528200 China Department of Rehabilitation Medicine Huashan Hospital Fudan University Shanghai200040 China Yiwu Research Institute of Fudan University Zhejiang Yiwu City322000 China Research Center for Intelligent Sensing Zhejiang Lab Hangzhou311121 China

ISBN: (数字)9781665472678

ISBN: (纸本)9781665472678

To develop a manipulator system based on spontaneous EEG signal control, this paper proposes a common spatial pattern method combined with the Bhattacharyya distance of time-frequency signal (TB-CSP) for EEG signal feature extraction. Firstly, for different subjects, the original EEG signal is divided by a specific time window and different frequency band;Secondly, the average Bhattacharyya distance of different frequency bands in a specific time window is calculated to select the optimal time-frequency signal and input it to CSP for feature extraction;Finally, the extracted features are input into SVM and LDA to classify and complete the control of the manipulator. The proposed method achieves 82.6% accuracy on the public dataset BCI IVa and 79.48% accuracy on the self-collected dataset. © 2022 IEEE.

关键词： Feature extraction

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Multimodal brain-computer interfaces: AI-powered Decoding Methodologies

arXiv

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arXiv 2025年

作者： Li, Siyang Wang, Hongbin Chen, Xiaoqing Wu, Dongrui The Ministry of Education Key Laboratory of Image Processing and Intelligent Control School of Artificial Intelligence and Automation Huazhong University of Science and Technology Wuhan430074 China The Henan Key Laboratory of Brain Science and Brain Computer Interface Technology School of Electrical and Information Engineering Zhengzhou University China

brain-computer interfaces (BCIs) enable direct communication between the brain and external devices. This review highlights the core decoding algorithms that enable multimodal BCIs, including a dissection of the elements, a unified view of diversified approaches, and a comprehensive analysis of the present state of the field. We emphasize algorithmic advancements in cross-modality mapping, sequential modeling, besides classic multi-modality fusion, illustrating how these novel AI approaches enhance decoding of brain data. The current literature of BCI applications on visual, speech, and affective decoding are comprehensively explored. Looking forward, we draw attention on the impact of emerging architectures like multimodal Transformers, and discuss challenges such as brain data heterogeneity and common errors. This review also serves as a bridge in this interdisciplinary field for experts with neuroscience background and experts that study AI, aiming to provide a comprehensive understanding for AI-powered multimodal BCIs. © 2025, CC BY-NC-ND.

关键词： brain computer interface

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Non-Invasive brain-computer interfaces: a New Perspective on the Assessment and Classification of Individuals with Methamphetamine Addiction

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SN Comprehensive Clinical Medicine 2023年第1期5卷 1-12页

作者： Zhan, Gege Su, Haolong Wang, Pengchao Wang, Junkongshuai Jiang, Haifeng Zhang, Lihua Kang, Xiaoyang Laboratory for Neural Interface and Brain Computer Interface Engineering Research Center of AI & Robotics Ministry of Education Shanghai Engineering Research Center of AI & Robotics MOE Frontiers Center for Brain Science State Key Laboratory of Medical Neurobiology Institute of AI & Robotics Academy for Engineering & Technology Fudan University Shanghai China Shanghai Mental Center Shanghai Jiao Tong University School of Medicine Shanghai China CAS Center for Excellence in Brain Science and Intelligence Technology (CEBSIT) Chinese Academy of Sciences Shanghai China Ji Hua Laboratory Foshan Guangdong Province China Yiwu Research Institute of Fudan University Yiwu City China

Methamphetamine addiction is a brain disease that causes abnormalities in the structure and function of the brain. EEG, a common signal acquired based on the noninvasive brain-computer interface, can reflect the altered brain activity associated with methamphetamine addiction. EEG-based analysis methods provide a perspective to explore the neural mechanisms of methamphetamine addiction and the effects on brain activity. This paper reports the results of a review of EEG-based assessment and classification of methamphetamine addiction. Current methods commonly used in EEG-based methamphetamine addiction research include traditional resting-state EEG analysis, brain network analysis, and analysis of event-related potentials. A small number of studies have classified methamphetamine addiction and healthy individuals based on resting state EEG features or event-related potentials. EEG is one of the common tools used to examine the effects of methamphetamine on brain function. In follow-up studies, new methods for analyzing resting-state EEG and event-related potentials may help to investigate the neural mechanisms of methamphetamine addiction.

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Using Determinant Point Process in Generative Adversarial Networks for SSVEP Signals Synthesis

Using Determinant Point Process in Generative Adversarial Ne...

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Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

作者： Junkongshuai Wang Lu Wang Jiaguan Han Wei Mu Pengchao Wang Xueze Zhang Gege Zhan Lihua Zhang Zhongxue Gan Xiaoyang Kang MOE Frontiers Center for Brain Science State Key Laboratory of Medical Neurobiology Institute of AI and Robotics Academy for Engineering & Technology Laboratory for Neural Interface and Brain Computer Interface Engineering Research Center of AI & Robotics Ministry of Education Shanghai Engineering Research Center of AI & Robotics Fudan University Shanghai China Ji Hua Laboratory Foshan China Yiwu Research Institute of Fudan University Yiwu City China Research Center for Intelligent Sensing Zhejiang Lab Hangzhou China

Steady-state visual evoked potential (SSVEP) is one of the main paradigms of brain-computer interface (BCI). However, the acquisition method of SSVEP can cause subject fatigue and discomfort, leading to the insufficiency of SSVEP databases. Inspired by generative determinantal point process (GDPP), we utilize the determinantal point process in generative adversarial network (GAN) to generate SSVEP signals. We investigate the ability of the method to synthesize signals from the Benchmark dataset. We further use some evaluation metrics to verify its validity. Results prove that the usage of this method significantly improved the authenticity of generated data and the accuracy (97.636%) of classification using deep learning in SSVEP data augmentation.

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Revolutionizing Intrusive neural interfaces: Vascular Stent-Based neural Electrodes

Revolutionizing Intrusive Neural Interfaces: Vascular Stent-...

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International Winter Workshop on brain-computer interface (BCI)

作者： Liang Shen Bo Wen Zihua Chen Minjie Wang Linlin Han Bo Shen Kai Cao Lihua Zhang Jianjun Wu Xiaoyang Kang Shanghai Engineering Research Center of AI & Robotics MOE Frontiers Center for Brain Science State Key Laboratory of Medical Neurobiology Laboratory for Neural Interface and Brain Computer Interface Engineering Research Center of AI & Robotics Ministry of Education Institute of AI & Robotics Institute of Meta-Medical Academy for Engineering & Technology Fudan University Shanghai China Department of Neurology and National Research Center for Aging and Medicine & National Center for Neurological Disorders State Key Laboratory of Medical Neurobiology Huashan Hospital Fudan University Shanghai China Yiwu Research Institute of Fudan University Chengbei Road Yiwu City Zhejiang China

This review delves into the emerging field of endovascular stent electrodes in the realm of brain-computer interfaces, highlighting advancements in their fabrication methods, signal acquisition performance, electrical stimulation effects, and research progress in electrochemical characteristics, mechanical stability, and biocompatibility. In comparison to traditional invasive procedures, endovascular stent electrodes, implanted through minimally invasive means, mitigate the risks associated with extensive trauma and tissue inflammation, demonstrating commendable signal acquisition capabilities. While exhibiting a slight deficiency in visual evoked potentials, they showcase accuracy in the acquisition and decoding of motor perception signals, rivaling or surpassing traditional surgical methods. Additionally, the technology shows potential therapeutic efficacy in electrical stimulation applications. Nevertheless, challenges such as electrical stimulation thresholds and visibility issues warrant further research and refinement. In summary, endovascular stent electrodes, as an emerging avenue in brain-computer interfaces, hold promise for significant breakthroughs in future research, opening up new possibilities in the field of neuroscience.

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Single-Molecule Bioelectronic Sensors with AI-Aided Data Analysis:Convergence and Challenges

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Precision Chemistry 2024年第10期2卷 518-538页

作者： Yuxin Yang Yueqi Li Longhua Tang Jinghong Li State Key Laboratory of Extreme Photonics and Instrumentation College of Optical Science and EngineeringZhejiang UniversityHangzhou 310027China Nanhu Brain-Computer Interface Institute HangzhouZhejiang 311100China Center for BioAnalytical Chemistry Hefei National Laboratory of Physical Science at MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Department of Chemistry Center for BioAnalytical ChemistryKey Laboratory of Bioorganic Phosphorus Chemistry&Chemical BiologyTsinghua UniversityBeijing 100084China Beijing Institute of Life Science and Technology Beijing 102206ChinaNew Cornerstone Science InstituteBeijing 102206China

Single-molecule bioelectronic sensing,a groundbreaking domain in biological research,has revolutionized our understanding of molecules by revealing deep insights into fundamental biological *** advent of emergent technologies,such as nanogapped electrodes and nanopores,has greatly enhanced this field,providing exceptional sensitivity,resolution,and integration ***,challenges persist,such as complex data sets with high noise levels and stochastic molecular *** intelligence(AI)has stepped in to address these issues with its powerful data processing *** algorithms effectively extract meaningful features,detect subtle changes,improve signal-to-noise ratios,and uncover hidden patterns in massive *** review explores the synergy between AI and single-molecule bioelectronic sensing,focusing on how AI enhances signal processing and data analysis to boost accuracy and *** also discuss current limitations and future directions for integrating AI,highlighting its potential to advance biological research and technological innovation.

关键词： single-molecule bioelectronic sensing artificial intelligence machine learning signal processing biosensors

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