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Active Targeting of Tumors through Conformational Epitope Imprinting†

Angewandte Chemie 2015年第17期127卷

作者： Yan Zhang Chunyue Deng Sha Liu Jin Wu Zhangbao Chen Chong Li Weiyue Lu Key Laboratory of Luminescence and Real‐time Analytical Chemistry (Ministry of Education) College of Pharmaceutical Sciences Southwest University No. 2 Tiansheng Road Beibei Chongqing 400715 (China) Chongqing Engineering Research Center for Pharmaceutical Process and Quality Control (China) Key Laboratory of Smart Drug Delivery (Ministry of Education) School of Pharmacy Fudan University Shanghai 201203 (China)

Inspired by the knowledge that most antibodies recognize a conformational epitope because of the epitope’s specific three‐dimensional shape rather than its linear structure, we combined scaffold‐based peptide design and surface molecular imprinting to fabricate a novel nanocarrier harboring stable binding sites that captures a membrane protein. In this study, a disulfide‐linked α‐helix‐containing peptide, apamin, was used to mimic the extracellular, structured N‐terminal part of the protein p32 and then serve as an imprinting template for generating a sub‐40 nm‐sized polymeric nanoparticle that potently binds to the target protein, recognizes p32‐positive tumor cells, and successfully mediates targeted photodynamic therapy in vivo. This could provide a promising alternative for currently used peptide‐modified nanocarriers and may have a broad impact on the development of polymeric nanoparticle‐based therapies for a wide range of human diseases.

关键词： Gezielte Tumortherapie Konformationsepitope Photodynamische Therapie Prägung Wirkstofftransport

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Arbitrated Network control systems: A Co-Design of control and Platform for Cyber-Physical systems

Arbitrated Network Control Systems: A Co-Design of Control a...

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Workshop on control of Cyber-Physical systems, CPS 2013

作者： Annaswamy, Anuradha M. Soudbakhsh, Damoon Schneider, Reinhard Goswami, Dip Chakraborty, Samarjit Active-adaptive Control Laboratory MIT Cambridge MA United States Institute for Real-time Systems TU Munich Germany

ISBN: (纸本)9783319011585

关键词： Embedded systems

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The arbitrated networked control systems approach to designing cyber-physical systems

The arbitrated networked control systems approach to designi...

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3rd IFAC Workshop on Distributed Estimation and control in Networked systems, NECSYS 2012

作者： Annaswamy, Anuradha Chakraborty, Samarjit Soudbakhsh, Damoon Goswami, Dip Voit, Harald Active-adaptive Control Laboratory MIT Cambridge MA United States Institute for Real-Time Systems TU Munich Germany

ISBN: (纸本)9783902823229

The domain of networked control systems (NCS) has traditionally been concerned with modeling and designing distributed controllers in the presence of control message loss, varying delay and jitter. Here, the characteristics of the network are assumed to be given and the focus has largely been on the controller. While this is meaningful in the context of control over wireless networks, where the network is assumed to be predesigned, in many other domains there is considerable flexibility in designing the network itself. For example, in an automotive architecture, distributed controllers are implemented on multiple electronic control units (ECUs) that communicate over CAN or FlexRay buses. The network design problem in this case consists of mapping control tasks to ECUs, and determining both the scheduling parameters for the ECUs as well as those for the communication buses. Given a choice of these parameters, the controller design problem is similar to that studied in NCS, i.e., that of designing/analyzing the controller. However, the joint design and optimization of the network and the controller gives rise to new research questions, that have neither been studied within the NCS, nor within the embedded systems domain. We refer to such systems as arbitrated networked control systems (ANCS) to emphasize the fact that the arbitration policy in the network also needs to be determined, and discuss recent results that have been obtained in the literature in this context. © 2012 IFAC.

关键词： Networked control systems

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The Arbitrated Networked control systems Approach to Designing Cyber-Physical systems *

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IFAC Proceedings Volumes 2012年第26期45卷 174-179页

作者： Anuradha Annaswamy Samarjit Chakraborty Damoon Soudbakhsh Dip Goswami Harald Voit Active-adaptive Control Laboratory MIT Cambridge MA USA Institute for Real-time Systems TU Munich Germany

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MISO damping controller design for a TCSC using particle swarm

MISO damping controller design for a TCSC using particle swa...

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iREP Symposium on Bulk Power System Dynamics and control

作者： Swakshar Ray Ganesh K. Venayagamoorthy Balarko Chaudhuri Rajat Majumder Real-Time Power and Intelligent Systems Laboratory University of Missouri Rolla MO USA Power System and Control Group Imperial College London London UK University of Queensland Brisbane Australia

This paper presents a new approach for designing multi-input-single-output (MISO) damping controller for a TCSC in a multi-machine power system. The damping controller design uses particle swarm optimization (PSO) to determine the coefficients of single or multi-stage lead-lag compensators. The classical technique works well in the design of lead-lag compensators for SISO controllers. But, there is no proper step-by-step procedure to achieve the desired performance characteristics for a MISO controller. Hence, in this paper, a computational optimization tool has been used to determine the optimal gains and time constants of a linear MISO damping controller. The damping controller is implemented for a TCSC on a multi-machine multi-modal power system and has shown considerable improvement in minimizing system oscillations.

关键词： Damping Power capacitors Thyristors Particle swarm optimization control systems Power system control Power system dynamics Power system reliability Power systems Power system interconnection

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A neural network based Wide Area Monitor for a power system

A neural network based Wide Area Monitor for a power system

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2005 IEEE Power Engineering Society General Meeting

作者： Li, Xiaomeng Venayagamoorthy, Ganesh K. IEEE Real-Time Power and Intelligent Systems Laboratory University of Missouri Rolla MO 65409 United States Department of Electrical and Computer Engineering University of Missouri Rolla United States South African Institute of Electrical Engineers IEEE St. Louis Computational Intelligence Department of Task Force on Intelligent Control Systems Secretary of the Intelligent Systems Subcommittee IEEE Power Engineering Society

ISBN: (纸本)078039156X

With the deregulation of power industry, many tie lines between control areas are driven to operate near their maximum capacity, especially those serving heavy load centers. Wide area controllers (WACs) using wide-area or global signals can provide remote auxiliary control signals to local controllers such as automatic voltage regulators, power system stabilizers, etc to damp out inter-area oscillations. The power system is highly nonlinear system with fast changing dynamics. In order to have an efficient WAC, an online system monitor/predictor is required to provide inter-area information to the WAC from time to time. This paper presents the design of an online Wide Area Monitor (WAM) using a neural network called the Wide Area Neuroidentifier (WANI). The WANI is used to predict ahead the speed deviations of generators in the different areas using phasor measurement unit (PMU). Results are presented to show the effectiveness of the wide area monitor for different disturbances. © 2005 IEEE.

关键词： Wide area networks

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Reducing OS overhead for real-time industrial controllers with adjustable timer resolution

Reducing OS overhead for real-time industrial controllers wi...

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IEEE International Symposium on Industrial Electronics (ISIE)

作者： Tae Rim Park Jae Hyun Park Wook Hyun Kwon Control Information Systems Laboratory School of Electrical Engineering and Computer Science Seoul National University Seoul South Korea Real-time Embedded Systems Laboratory School of Information and Communication Engineering Inha University Incheon South Korea

ISBN: (纸本)0780370902

In this paper, a new method, named adjustable timer resolution (ATR) is proposed to control tasks in a timely manner, with enhanced performance on real-time operating systems. It prevents useless execution of the timer interrupt service routine (ISR). Features of the proposed method are compared with the conventional method, and the schedulability is analyzed to estimate the performance. As an implementation model, uC/OS-II is modified and ported to a power PC processor system. The metrics and results of the model are presented and discussed.

关键词： Industrial control real time systems control systems Operating systems Communication system control Performance analysis Embedded system processor scheduling Power system modeling time factors

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On the Schedulability Analysis for Distributed real-time systems

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IFAC Proceedings Volumes 1999年第1期32卷 227-232页

作者： Shuhua Wang Georg Färber Laboratory for Process Control and Real-Time Systems Technische Universität München Germany

In distributed hard real-time systems, tasks not only have timing constraints but also often have precedence constraints caused by communication among them. In this paper a new schedulability analysis algorithm for distributed hard real-time systems is proposed in which both precedence constraints and communication costs are considered and represented by offsets and modified deadlines. To obtain a tight upper bound for the worst case response time, the concepts of local critical instant and local worst case response time are introduced. They are used to calculate global worst case response time in the system. The proposed schedulability analysis is compared with other schedulability analyses using test cases. The comparison shows that the proposed analysis is more accurate than the compared analyses.

关键词： Schedulability analysis distributed systems hard real-time precedence constraints

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The REAR framework for emulation and analysis of embedded hard real-time systems

The REAR framework for emulation and analysis of embedded ha...

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International Workshop on Rapid System Prototyping (RSP)

作者： S. Petters A. Muth T. Kolloch T. Hopfner F. Fischer G. Farber Laboratory for Process Control and Real-Time Systems Technische Universität Munich Germany

The aim of rapid prototyping real-time applications is to substantially reduce development times by confirming the functional and timely requirements of the application at a very early stage of development with the help of an executable prototype. Hence, the real-time rapid prototyping system presented in this paper integrates two complementary tasks. On the one hand it provides an automated design environment for a rapid and facile generation of a working prototype. On the other hand, the design process is extended with real-time requirement specification and analysis in order to prove that the embedded system will meet all timing requirements, and to verify that the timing requirements have been modeled correctly. The REAR framework uses annotated SDL for the system specification, from which both the compilable source codes and the real-time analysis model are generated. After instrumentation for timing measurements, the C and VHDL source code is compiled and synthesized, linked with communication libraries and executed on the configurable, heterogeneous multiprocessor target system. Several case studies demonstrate the feasibility of this approach.

关键词： Emulation real time systems Prototypes Timing Embedded system Virtual prototyping Laboratories process control Read only memory Instruments

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Visual determination of 3D grasping points on unknown objects with a binocular camera system

Visual determination of 3D grasping points on unknown object...

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IEEE International Workshop on Intelligent Robots and systems (IROS)

作者： A. Hauck J. Ruttinger M. Sorg G. Farber Laboratory for Process Control and Real-Time Systems Technische Universität München Germany

In the field of hand-eye coordination, most state-of-the-art systems still require the user to select the grasping points manually. We present a system which autonomously determines 3D grasping points on unknown objects from a pair of greyscale images. The object to be grasped is segmented automatically when put into the scene. Grasping points are searched on the object silhouette; their stability is evaluated by a heuristic algorithm, primarily based on the skeleton of the region. The 3D grasping pose is estimated by triangulation using a simplified geometrical model of the camera system; the corresponding points in the second image are determined via dynamic programming. The whole system has been implemented and validated on the experimental hand-eye system MINERVA.

关键词： Cameras Solid modeling Image processing Dynamic programming Grippers Object detection process control real time systems Image segmentation Layout

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