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Microengineered platforms for characterizing the contractile function of in vitro cardiac models

Microsystems & Nanoengineering 2022年第1期8卷 29-50页

作者： Wenkun Dou Manpreet Malhi Qili Zhao Li Wang Zongjie Huang Junhui Law Na Liu Craig A.Simmons Jason T.Maynes Yu Sun Department of Mechanical and Industrial Engineering University of TorontoTorontoON M5S 3G8Canada Program in Molecular Medicine The Hospital for Sick ChildrenTorontoON M5G 1X8Canada Department of Biochemistry University of TorontoTorontoON M5S 1A8Canada Institute of Robotics and Automatic Information System and the Tianjin Key Laboratory of Intelligent Robotics Nankai UniversityTianjin 300350China School of Mechanical&Automotive Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China School of Mechatronics Engineering and Automation Shanghai UniversityShanghai 200444China Institute of Biomedical Engineering University of TorontoTorontoON M5S 3G9Canada Translational Biology&Engineering Program Ted Rogers Centre for Heart ResearchTorontoON M5G 1M1Canada Department of Anesthesiology and Pain Medicine University of TorontoTorontoON M5S 1A8Canada Department of Anesthesia and Pain Medicine The Hospital for Sick ChildrenTorontoON M5G 1X8Canada Department of Electrical and Computer Engineering University of TorontoTorontoON M5S 3G4Canada Department of Computer Science University of TorontoTorontoON M5T 3A1Canada

Emerging heart-on-a-chip platforms are promising approaches to establish cardiac cell/tissue models in vitro for research on cardiac physiology,disease modeling and drug cardiotoxicity as well as for therapeutic *** still exist in obtaining the complete capability of in situ sensing to fully evaluate the complex functional properties of cardiac cell/tissue *** to contractile strength(contractility)and beating regularity(rhythm)are particularly important to generate accurate,predictive *** new platforms and technologies to assess the contractile functions of in vitro cardiac models is essential to provide information on cell/tissue physiologies,drug-induced inotropic responses,and the mechanisms of cardiac *** this review,we discuss recent advances in biosensing platforms for the measurement of contractile functions of in vitro cardiac models,including single cardiomyocytes,2D monolayers of cardiomyocytes,and 3D cardiac *** characteristics and performance of current platforms are reviewed in terms of sensing principles,measured parameters,performance,cell sources,cell/tissue model configurations,advantages,and *** addition,we highlight applications of these platforms and relevant discoveries in fundamental investigations,drug testing,and disease ***,challenges and future outlooks of heart-on-a-chip platforms for in vitro measurement of cardiac functional properties are discussed.

关键词： cardiac contractile regularity

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Platoon-Based Distributed Control for Automated Material Handling Systems

Platoon-Based Distributed Control for Automated Material Han...

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International Conference on Control, Decision and Information Technologies (CoDIT)

作者： Alessandro Bozzi Jose-Fernando Jimenez Camilo Hernandez-Rodriguez Eliana-Maria Gonzalez-Neira Damien Trentesaux Department of Informatics Bioengineering Robotics and Systems Engineering (DIBRIS) University of Genova Italy Laboratory System and Materials for Mechatronics (SYMME) Université Savoie Mont Blanc Annecy France Industrial Engineering Department Pontificia Universidad Javeriana Bogota Columbia Laboratory of Industrial and Human Automation Control Mechanical Engineering and Computer Science (LAMIH) Université Polytechnique Hauts-de-France Valenciennes France

Smart manufacturing systems combine collaborative and autonomous control systems to provide optimal performance and respond to volatile demands. A key component of smart manufacturing is material management, as raw materials, work-in-progress, and finished products must be transported to the right location at the right time. However, during the production phase, it is imperative to establish an optimal traffic control scheme in order to avoid congestion and optimize material flow. This paper proposes a platooning-based control procedure implemented in a virtual agent-based manufacturing environment to increase the material flow efficiency on a manufacturing shop floor. An analysis of the production makespan and an indicator of the level of congestion in the material handling system was conducted in order to determine productivity improvements. An agent-based simulation is used to test the effectiveness of the novel platooning approach versus a traditional basic approach. A multivariate analysis of variance (MANOVA) reveals that the inclusion of a platoon-based procedure improves production performance and reduces congestion risks.

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IA-LSTM: Interaction-Aware LSTM for Pedestrian Trajectory Prediction

arXiv

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arXiv 2023年

作者： Yang, Jing Chen, Yuehai Du, Shaoyi Chen, Badong Principe, Jose C. School of Automation Science and Engineering Faculty of Electronic and Information Engineering Xi'an Jiaotong Xi'An710049 China Institute of Articial Intelligence and Robotics College of Articial Intelligence Xi'an Jiaotong University Shanxi Xi'An710049 China The Computational NeuroEngineering Laboratory Department of Electrical and Computer Engineering University of Florida GainesvilleFL32611 United States

Predicting the trajectory of pedestrians in crowd scenarios is indispensable in self-driving or autonomous mobile robot field because estimating the future locations of pedestrians around is beneficial for policy decision to avoid collision. It is a challenging issue because humans have different walking motions, and the interactions between humans and objects in the current environment, especially between humans themselves, are complex. Previous researchers focused on how to model human-human interactions but neglected the relative importance of interactions. To address this issue, a novel mechanism based on correntropy is introduced. The proposed mechanism not only can measure the relative importance of human-human interactions but also can build personal space for each pedestrian. An interaction module including this data-driven mechanism is further proposed. In the proposed module, the data-driven mechanism can effectively extract the feature representations of dynamic human-human interactions in the scene and calculate the corresponding weights to represent the importance of different interactions. To share such social messages among pedestrians, an interaction-aware architecture based on long short-term memory network for trajectory prediction is designed. Experiments are conducted on two public datasets. Experimental results demonstrate that our model can achieve better performance than several latest methods with good performance. © 2023, CC BY-NC-ND.

关键词： Long short-term memory

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Deep Learning Enables Large Depth-of-Field Images for Sub-Diffraction-Limit Scanning Superlens Microscopy

arXiv

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arXiv 2023年

作者： Sun, Hui Luo, Hao Wang, Feifei Chen, Qingjiu Chen, Meng Wang, Xiaoduo Yu, Haibo Zhang, Guanglie Liu, Lianqing Wang, Jianping Wu, Dapeng Li, Wen Jung Department of Mechanical Engineering City University of Hong Kong Hong Kong State Key Laboratory of Robotics Shenyang Institute of Automation Chinese Academy of Sciences Shenyang110016 China Institutes for Robotics and Intelligent Manufacturing Chinese Academy of Sciences Shenyang110169 China Department of Electrical and Electronics Engineering The University of Hong Kong Hong Kong Shenzhen518000 China Department of Computer Science City University of Hong Kong Hong Kong

Scanning electron microscopy (SEM) is indispensable in diverse applications ranging from microelectronics to food processing because it provides large depth-of-field images with a resolution beyond the optical diffraction limit. However, the technology requires coating conductive films on insulator samples and a vacuum environment. We use deep learning to obtain the mapping relationship between optical super-resolution (OSR) images and SEM domain images, which enables the transformation of OSR images into SEM-like large depth-of-field images. Our custom-built scanning superlens microscopy (SSUM) system, which requires neither coating samples by conductive films nor a vacuum environment, is used to acquire the OSR images with features down to ~80 nm. The peak signal-to-noise ratio (PSNR) and structural similarity index measure values indicate that the deep learning method performs excellently in image-to-image translation, with a PSNR improvement of about 0.74 dB over the optical super-resolution images. The proposed method provides a high level of detail in the reconstructed results, indicating that it has broad applicability to chip-level defect detection, biological sample analysis, forensics, and various other fields. Copyright © 2023, The Authors. All rights reserved.

关键词： Scanning electron microscopy

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Automated Leukemia Screening and Sub-types Classification Using Deep Learning

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computer Systems Science & engineering 2023年第9期46卷 3541-3558页

作者： Chaudhary Hassan Abbas Gondal Muhammad Irfan Sarmad Shafique Muhammad Salman Bashir Mansoor Ahmed Osama M.Alshehri Hassan H.Almasoudi Samar M.Alqhtani Mohammed M.Jalal Malik A.Altayar Khalaf F.Alsharif Department of Computer Science COMSATS University Islamabad44000Pakistan Electrical Engineering Department College of EngineeringNajran UniversityNajran61441Saudi Arabia Control Automotive and Robotics LabNational Center of Robotics and Automation(NCRA HEC)MirpurPakistan Mirpur University of Science and Technology(MUST)MirpurPakistan Department of Computer Science Virtual University of PakistanLahore54000Pakistan Department of Clinical Laboratory Sciences College of Applied Medical SciencesNajran UniversityNajran61441Saudi Arabia Department of Information Systems College of Computer Science and Information SystemsNajran UniversityNajran61441Saudi Arabia Department of Medical Laboratory Technology Faculty of Applied Medical SciencesUniversity of TabukTabukSaudi Arabia Department of Clinical Laboratory Sciences College of Applied Medical SciencesTaif UniversityP.O.Box 11099Taif21944Saudi Arabia

Leukemia is a kind of blood cancer that damages the cells in the blood and bone marrow of the human *** produces cancerous blood cells that disturb the human’s immune system and significantly affect bone marrow’s production ability to effectively create different types of blood cells like red blood cells(RBCs)and white blood cells(WBC),and *** can be diagnosed manually by taking a complete blood count test of the patient’s blood,from which medical professionals can investigate the signs of leukemia ***,two other methods,microscopic inspection of blood smears and bone marrow aspiration,are also utilized while examining the patient for ***,all these methods are labor-intensive,slow,inaccurate,and require a lot of human experience and *** authors have proposed automated detection systems for leukemia diagnosis to overcome these *** have deployed digital image processing and machine learning algorithms to classify the cells into normal and blast ***,these systems are more efficient,reliable,and fast than previous manual diagnosing ***,more work is required to classify leukemia-affected cells due to the complex characteristics of blood images and leukemia cells having much intra-class variability and inter-class *** this paper,we have proposed a robust automated system to diagnose leukemia and its *** have classified ALL into its sub-types based on FAB classification,i.e.,L1,L2,and L3 types with better *** have achieved 96.06%accuracy for subtypes classification,which is better when compared with the state-of-the-art methodologies.

关键词： Healthcare cancer detection deep learning convolutional neural network

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Energy Efficiency Optimization for Full-Duplex D2D Communications Underlaying Distributed Antenna Systems

IEEE Transactions on Green Communications and Networking

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IEEE Transactions on Green Communications and Networking 2024年

作者： Liu, Zhan Liao, Zhiyuan Li, Chunquan Zhang, Zhijun Yu, Junzhi Liu, P.X. Hunan University of Humanities Science and Technology School of Information Loudi417000 China Nanchang University School of Information Engineering Nanchang330031 China Jiangxi Provincial Key Laboratory of Intelligent Systems and Human-Machine Interaction Nanchang330031 China South China University of Technology School of Automation Science and Engineering Guangzhou510640 China Peking University State Key Laboratory for Turbulence and Complex Systems Department of Advanced Manufacturing and Robotics College of Engineering Beijing100871 China Carleton University Department of Systems and Computer Engineering OttawaONK1S 5B6 Canada

In this paper, we investigate the total system energy efficiency (EE) of full-duplex (FD) device-to-device (D2D) communications underlaying distributed antenna systems (DAS), where remote access units (RAUs), D2D users (DUs), and cellular users (CUs) are all capable of FD operation. Specifically, we jointly optimize subcarrier assignment and power allocation under the quality of service (QoS) requirements of CUs and DUs and the maximum power constraints of RAUs, CUs, and DUs. In addition, we propose a novel spectrum sharing strategy that allows each subcarrier to be assigned to multiple CUs and/or multiple D2D pairs (DPs) for flexibility. To solve the formulated non-convex optimization problem, we first employ fractional programming to transform the objective function in the optimization problem from the fractional form into the equivalent subtractive form. Then, an efficient iterative resource allocation algorithm is proposed, which needs to solve an inner problem in each iteration. After relaxing the variables and introducing penalty factors, the non-convex inner problem is transformed into a convex problem through the successive convex approximation (SCA) method and solved by iterative algorithm. Simulation results demonstrate that the proposed algorithm can considerably improve the system EE compared to other benchmark schemes. Furthermore, the proposed spectrum sharing strategy is superior to the existing sharing strategies. © 2017 IEEE.

关键词： Convex optimization

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MG-SLAM: Structure Gaussian Splatting SLAM with Manhattan World Hypothesis

arXiv

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arXiv 2024年

作者： Liu, Shuhong Deng, Tianchen Zhou, Heng Li, Liuzhuozheng Wang, Hongyu Wang, Danwei Li, Mingrui Department of Information Science and Technology Department of Complexity Science and Engineering The University of Tokyo Tokyo113-8654 Japan Institute of Medical Robotics Department of Automation Shanghai Jiao Tong University Key Laboratory of System Control and Information Processing Ministry of Education Shanghai200240 China Department of Mechanical Engineering Columbia University New York10027 United States School of Electrical and Electronic Engineering Nanyang Technological University Singapore Department of Computer Science Dalian University of Technology Dalian116024 China

Gaussian Splatting SLAMs have made significant advancements in improving the efficiency and fidelity of real-time reconstructions. However, these systems often encounter incomplete reconstructions in complex indoor environments, characterized by substantial holes due to unobserved geometry caused by obstacles or limited view angles. To address this challenge, we present Manhattan Gaussian SLAM, an RGB-D system that leverages the Manhattan World hypothesis to enhance geometric accuracy and completeness. By seamlessly integrating fused line segments derived from structured scenes, our method ensures robust tracking in textureless indoor areas. Moreover, The extracted lines and planar surface assumption allow strategic interpolation of new Gaussians in regions of missing geometry, enabling efficient scene completion. Extensive experiments conducted on both synthetic and real-world scenes demonstrate that these advancements enable our method to achieve state-of-the-art performance, marking a substantial improvement in the capabilities of Gaussian SLAM systems. © 2024, CC BY.

关键词： Gaussian distribution

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A Shared-Control Dexterous Robotic System for Assisting Transoral Mandibular Fracture Reduction: Development and Cadaver Study

A Shared-Control Dexterous Robotic System for Assisting Tran...

引用

IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS)

作者： Yan Wang Hao Zheng Yu-Chung Lee Catherine P. L. Chan Jason Ying-Kuen Chan Russell H. Taylor Kwok Wai Samuel Au Department of Mechanical and Automation Engineering The Chinese University of Hong Kong Hong Kong SAR China Department of Mechanical Engineering The Hong Kong Polytechnic University Hong Kong SAR China Multiscale Medical Robotics Center Hong Kong SAR China Department of Otorhinolaryngology Head and Neck Surgery The Chinese University of Hong Kong Hong Kong SAR China Director of the Laboratory for Computational Sensing and Robotics and a Professor of Computer Science Johns Hopkins University Baltimore MD USA

The rigid and straight nature of conventional surgical drills and screwdrivers makes it difficult to access the posterior mandible for fracture reduction without the creation of facial incisions. To assist transoral mandibular fracture reduction in hard-to-reach areas, we propose a shared-control dexterous robotic system. The end effector of this system is an articulated drilling/screwing tool to provide distal dexterity. This system uses an admittance-control-based approach to provide precision and stability during shared-control hole-drilling processes. A cadaver study showed the efficacy of the proposed system to assist plate fixation in the reduction of mandibular fractures. The proposed articulated surgical tool was capable of drilling holes in and driving screws into the mandible of a cadaver head. In addition, the shared-control robotic system ensured that the drill moved along its axial direction, leading to stable and precise hole drilling.

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No One Left Behind: Real-World Federated Class-Incremental Learning

arXiv

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arXiv 2023年

作者： Dong, Jiahua Li, Hongliu Cong, Yang Sun, Gan Zhang, Yulun Van Gool, Luc The State Key Laboratory of Robotics Shenyang Institute of Automation Chinese Academy of Sciences Shenyang110016 China The Institutes for Robotics and Intelligent Manufacturing Chinese Academy of Sciences Shenyang110169 China The University of Chinese Academy of Sciences Beijing100049 China The Department of Civil and Environmental Engineering Hong Kong Polytechnic University Hong Kong The College of Automation Science and Engineering South China University of Technology Guangzhou510640 China The Computer Vision Lab ETH Zürich Zürich8092 Switzerland

Federated learning (FL) is a hot collaborative training framework via aggregating model parameters of decentralized local clients. However, most FL methods unreasonably assume data categories of FL framework are known and fixed in advance. Moreover, some new local clients that collect novel categories unseen by other clients may be introduced to FL training irregularly. These issues render global model to undergo catastrophic forgetting on old categories, when local clients receive new categories consecutively under limited memory of storing old categories. To tackle the above issues, we propose a novel Local-Global Anti-forgetting (LGA) model. It ensures no local clients are left behind as they learn new classes continually, by addressing local and global catastrophic forgetting. Specifically, considering tackling class imbalance of local client to surmount local forgetting, we develop a category-balanced gradient-adaptive compensation loss and a category gradient-induced semantic distillation loss. They can balance heterogeneous forgetting speeds of hard-to-forget and easy-to-forget old categories, while ensure consistent class-relations within different tasks. Moreover, a proxy server is designed to tackle global forgetting caused by Non-IID class imbalance between different clients. It augments perturbed prototype images of new categories collected from local clients via self-supervised prototype augmentation, thus improving robustness to choose the best old global model for local-side semantic distillation loss. Experiments on representative datasets verify superior performance of our model against comparison methods. The code is available at https://***/JiahuaDong/LGA. Copyright © 2023, The Authors. All rights reserved.

关键词： Distillation

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Bioinspired Musculoskeletal Model-based Soft Wrist Exoskeleton for Stroke Rehabilitation

引用

Journal of Bionic engineering 2020年第6期17卷 1163-1174页

作者： Ning Li Tie Yang Yang Yang Peng Yu Xiujuan Xue Xingang Zhao Guoli Song Imad HElhajj Wenxue Wang Ning Xi Lianqing Liu State Key Laboratory of Robotics Shenyang Institute of AutomationChinese Academy of SciencesShenyang 110016China Institutes for Robotics and Itelligent Manufacturing Chinese Academy of SciencesShenyang 110169China University of Chinese Academy of Sciences Bejing 100049China Rehabilitation Center for the Disabled Shenyang 110015China Vision and Robotics Lab Department of Electrical and Computer EngineeringAmerican University of BeirutBeirut 11072020Lebanon Emerging Technologies Instinute Department of Industrial&Manufacturing Systems EngineeringUniversity of Hong KongPokfulamHong Kong 999077China

Exoskeleton robots have demonstrated the potential to rehabilitate stroke ***,poor human-machine physiological coupling causes unexpected damage to human of muscles and ***,inferior humanoid kinematics control would restrict human natural *** to deal with these problems results in bottlenecks and hinders its *** this paper,the simplified muscle model and muscle-liked kinematics model were proposed,based on which a soft wrist exoskeleton was established to realize natural human ***,we simplified the redundant muscular system related to the wrist joint from ten muscles to four,so as to realize the human-robot physiological ***,according to the above human-like musculoskeletal model,the humanoid distributed kinematics control was established to achieve the two DOFs coupling kinematics of the *** results show that the wearer of an exoskeleton could reduce muscle activation and joint force by 43.3%and 35.6%,***,the humanoid motion trajectories similarity of the robot reached 91.5%.Stroke patients could recover 90.3%of natural motion ability to satisfy for most daily *** work provides a fundamental understanding on human-machine physiological coupling and humanoid kinematics control of the exoskeleton robots for reducing the post-stroke complications.

关键词： stroke rehabilitation simplified muscle model soft wrist exoskeleton robot bionic kinematics model

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