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3rd International Conference on computational Electronics for Wireless Communications, ICCWC 2023

作者： Chauhan, Ritu Kaur, Harleen Choudhary, Tisya Alankar, Bhavya Artificial Intelligence and IoT Lab Center for Computational Biology and Bioinformatics Amity University Uttar Pradesh Noida India Department of Computer Science and Engineering School of Engineering Sciences and Technology Jamia Hamdard New Delhi India Amity Institute of Biotechnology Amity University Uttar Pradesh Noida India

ISBN: (纸本)9789819719426

Artificial intelligence techniques are utilized in cancer research and oncology which involves medical data in the detection of cancer, subtype classification, and optimization of cancer treatment. This paper discusses artificial intelligence techniques, such as K-means cluster analysis and its data interpretation based on breast cancer diagnostic dataset. This study focuses on the database of digital images of fine needle aspirate (FNA) of breast mass which shows abnormal lump, and a clustering technique was applied on this dataset. This study represents various descriptive statistics techniques of the breast cancer diagnostic dataset. Furthermore, we have also tried to show a variety of techniques of descriptive statistics like KMO and Bartlett’s test, total variance representing initial eigenvalues and extraction sum of squared loadings, scree plots, and clustering techniques like ANOVA table, initial and final cluster centers, and the distance between initial and final cluster centers of K-means cluster analysis. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2025.

关键词： Lung cancer

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A Role of Wearable Health Technology in Smart Cities 3rd

A Role of Wearable Health Technology in Smart Cities

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3rd International Conference on computational Electronics for Wireless Communications, ICCWC 2023

作者： Chauhan, Ritu Kaur, Harleen Mehta, Khushi Alankar, Bhavya Artificial Intelligence and IoT Lab Center for Computational Biology and Bioinformatics Amity University Uttar Pradesh Noida India Department of Computer Science and Engineering School of Engineering Sciences and Technology Jamia Hamdard New Delhi India Amity Institute of Biotechnology Amity University Uttar Pradesh Noida India

ISBN: (纸本)9789819719426

In this rapidly changing era of the world, healthcare devices are revolutionizing, which enables the continuous measurement of crucial biological markers for diagnostic purposes, physiological health monitoring, and evaluation. Hence, wearable devices have transformed into accessories, embedded clothing, body adaptors, and body implants. Additionally, the emergence of wearable healthcare devices that facilitates the diagnosis and prognosis by using tiny sensing devices and biomedical devices has greatly enhanced the efficiency as well as the quality of medical care facilities results in the tremendous advancements in semiconductor technology, biomedical technologies, and nano-sized materials over the past few decades. Meanwhile, the devices could provide real-time feedback, allowing users to analyze their health and monitor in a specific period that has been assigned to the smart wearable devices, even though the industries and manufacturers are intensely interested in interpreting the factors that influence the adoption of new smart technologies, which helps to improve the performance and viability of wearable devices to fascinate consumers. Hence, the advancements in technology are regarded as trustworthy equipment for everlasting monitoring of health that are frequently used to monitor and control a diverse of health tracking predictors in the surroundings, including monitoring health and wellness of the body. In recent years, it has been focused on the study of a wide range of parameters closer to advancements in smart technology. As a result, these smart devices are now utilized in a variety of healthcare monitoring applications, one of the most crucial aspects of data collection is the various factors based on bodily activities. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2025.

关键词： Electronic health record

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Single-cell technologies: current and near future

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science China(Life sciences) 2025年第1期68卷 1-4页

作者： Chenfei Wang Qi Liu Xiaohui Fan Tieliu Shi KeyLaboratory of Spine and Spinal CordInjury Repairand Regeneration Ministry of EducationOrthopedics DepartmentTongji HospitalBioinformatics DepartmentSchoolofLifeSciencesandTechnologyTongji UniversityShanghai 200082China Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji UniversityShanghai 200092China Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji UniversityShanghai 200082China Research Institute of Intelligent Computing Zhejiang LabHangzhou 311121China Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314103China Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai 200241China Key Laboratory of Advanced Theory and Application in Statistics and Data Science(MOE) School of StatisticsEast China Normal UniversityShanghai 200062China

Single-cell technologies enable the indepth exploration of multiple biological hierarchies at the scale of individual cells,which have deepened our knowledge of cellular diversity,tissue organization,and overall organism function(Sun et al.,2024).In 2009,single-cell RNA sequencing(scRNA-seq)was first developed as a powerful tool to dissect gene expression and uncover transcriptional *** the rapid advancement of technology,single-cell approaches have expanded to encompass other omics,such as genomics,epigenomics,proteomics,and ***,multimodal technologies including spatially resolved transcriptomics and clustered regularly interspaced short palindromic repeats(CRISPR)screening at the single-cell level further advanced our ability to comprehensively understand cellular ***-cell methods provide deeper insights into disease mechanisms across various conditions,including cancer,developmental disorders,and aging-associated *** this issue,we focus on topics related to single-cell methods,covering the following four aspects:(i)single-cell multi-omic sequencing technology;(ii)single-cell spatial technology;(iii)singlecell CRISPR screening technology;(iv)applications of single-cell technology.

关键词： expanded enable insight

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A Machine Learning Approaches in Sustainable Healthcare for Predicting Lumpy Skin Disease 2nd

A Machine Learning Approaches in Sustainable Healthcare for ...

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2nd International Conference on Sustainable Development Using Machine Learning, Artificial Intelligence, and IoT, ICSD 2024

作者： Alankar, Bhavya Chauhan, Ritu Mishra, Aarushi Jena, Mehak Kaur, Harleen Center for Computational Biology and Bioinformatics Amity University UP Noida India Department of Computer Science and Engineering School of Engineering Sciences and Technology Jamia Hamdard New Delhi India

ISBN: (纸本)9783031717284

The integration of machine learning in healthcare has transformed disease prognosis and diagnosis. Healthy livestock contributes to a better environment, sustainable resource use, and the prosperity and expansion of rural communities. Various machine-learning techniques have been used in tasks such as disease prediction, medical image analysis, and drug discovery. These techniques have the potential to improve diagnostics, treatment strategies, and patient outcomes. Machine learning algorithms, using diverse data sources, enable early detection and tailored interventions. Ongoing research aims to use machine learning algorithms in healthcare databases to identify effective patterns for future predictive modeling. This study investigates machine learning algorithms and descriptive analysis methodologies to determine an individual's diabetic status. Four machine learning classifiers, including K Nearest Neighbour, Support Vector Machine, Decision Tree, and Random Forest, are examined, and compared. These classifiers show potential in enhancing diabetes prediction and improving sustainable healthcare decision-making with respective accuracies of 81.16%, 84.84%, 77.16%, and 89.83%. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.

关键词： Adversarial machine learning

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Machine Learning in Fraud Detection for Financial Sustainability in Credit Card 2nd

Machine Learning in Fraud Detection for Financial Sustainabi...

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2nd International Conference on Sustainable Development Using Machine Learning, Artificial Intelligence, and IoT, ICSD 2024

作者： Kaur, Harleen Chauhan, Ritu Shamsi, Yezdanul Haque Alankar, Bhavya Artificial Intelligence and IoT Lab Center for Computational Biology and Bioinformatics Amity University Noida India Department of Computer Science and Engineering School of Engineering Sciences and Technology Jamia Hamdard New Delhi India

ISBN: (纸本)9783031717284

In today’s financial world, various technologies have been emerged and with the evolution in the technologies it has led to the increase in the fraud cases. The sustainable growth of businesses and the financial markets are severely harmed by financial statement fraud. Consequently, it is crucial and vital to build an efficient methodology to identify financial statement fraud in businesses. Usage of credit card are very frequent these days and due to loopholes in the system fraud cases in credit card is rising which causes huge financial losses. In this paper the focus is on credit card fraud detection in real world with the help of machine learning. In this case Logistic Regression, Decision tree method and SVM (support vector machine) are applied on credit card fraud detection for knowledge discovery among the data. The applied methods can detect the fraudulent transactions with highest accuracy. However, the results are predicted using evaluation metrics such as accuracy, error rate, specificity, sensitivity, and ROC curves are calculated to assess each model's performance. Hence, the predicted results suggested that logistic regression is the most accurate model for prediction of fraud datasets in financial sustainability. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.

关键词： Decentralized finance

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Molecular architecture of mammalian pyruvate dehydrogenase complex

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Protein & Cell 2025年第1期16卷 72-78页

作者： Maofei Chen Yutong Song Sensen Zhang Yitang Zhang Xudong Chen Minghui Zhang Meng Han Xin Gao Sai Li Maojun Yang Tsinghua-Peking Center for Life Sciences Beijing Frontier Research Center for Biological StructureSchool of Life SciencesTsinghua UniversityBeijing 100084China Ministry of Education Key Laboratory of Protein Science Tsinghua UniversityBeijing 100084China State Key Laboratory of Membrane Biology Tsinghua UniversityBeijing 100084China Department of Biochemistry and Molecular Biology School of Basic Medical SciencesShenzhen University Health Science CenterShenzhen 518060China Protein Research Technology Center Protein Chemistry and Omics PlatformSchool of Life SciencesTsinghua UniversityBeijing 100084China Computer Science Program ComputerElectrical and Mathematical Sciences and Engineering DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Kingdom of Saudi Arabia Computational Bioscience Research Center King Abdullah University of Science and TechnologyThuwal 23955-6900Kingdom of Saudi Arabia Cryo-EM Facility Center Southern University of Science and TechnologyShenzhen 518055China Beijing Life Science Academy Beijing 102209China

Dear Editor,Pyruvate dehydrogenase complex(PDHc) is a large multienzyme assembly(Mr = 4–10 million Daltons) consisting of three essential components: pyruvate dehydrogenase(E1p), dihydrolipoyl transacetylase(E2p), and dihydrolipoyl dehydrogenase(E3). These three enzymes perform distinct functions sequentially to catalyze the oxidative decarboxylation of pyruvate with formation of nicotinamide adenine dinucleotide(NADH) and acetyl-coenzyme A(Patel and Roche, 1990).

关键词： sequentially oxidative Dalton

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Single-cell omics: experimental workflow, data analyses and applications

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science China(Life sciences) 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University(The Second People’s Hospital of Wuhu City)Wuhu 241000China Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration(Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji UniversityShanghai 200082China Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji UniversityShanghai 200092China Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji UniversityShanghai 200082China Research Institute of Intelligent Computing Zhejiang LabHangzhou 311121China Shanghai Research Institute for Intelligent Autonomous Systems Shanghai 201210China Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of MedicineShanghai 200025China National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314103China Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai 200241China Beijing Institutes of Life Science Chinese Academy of SciencesBeijing 100101China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology(CQB)Peking UniversityBeijing 100871China Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women’s HospitalZhejiang University School of MedicineHangzhou 310006China Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal U

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular *** exploration of how the genomes orchestrate the formation and maintenance of each cell,and control the cellular phenotypes of various organismsis,is both captivating and *** the inception of the first single-cell RNA technology,technologies related to single-cell sequencing have experienced rapid advancements in recent *** technologies have expanded horizontally to include single-cell genome,epigenome,proteome,and metabolome,while vertically,they have progressed to integrate multiple omics data and incorporate additional information such as spatial scRNA-seq and CRISPR ***-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases,including ***,we comprehensively summarize recent advances in single-cell omics technologies,with a specific focus on the methodology *** overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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Old Dog, New Tricks: Exact Seeding Strategy Improves RNA Design Performances

Old Dog, New Tricks: Exact Seeding Strategy Improves RNA Des...

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29th International Conference on Research in computational Molecular biology, RECOMB 2025

作者： Boury, Théo Sidl, Leonhard Hofacker, Ivo L. Ponty, Yann Yao, Hua-Ting Institut Polytechnique de Paris Palaiseau France Department of Theoretical Chemistry University of Vienna Vienna1090 Austria Faculty of Computer Science Research Group Bioinformatics and Computational Biology University of Vienna Vienna1090 Austria

ISBN: (纸本)9783031902512

The Inverse Folding problem involves identifying RNA sequences that adopt a target structure with respect to free-energy minimization, i.e., preferential to all alternative structures. The problem has historically been regarded as challenging, largely due to its proven NP-completeness of an extended version where the base pair maximization energy model is used. In contrast, it has recently been shown that a large subset called m-separable structures, notably including those comprising helices of length 3+, can be solved in linear time within the same energy model. This permits not only the identification of a single solution but also the characterization of a language of solutions. In this work, we seek to describe the "hardness" of Inverse Folding, bridging (at least heuristically) the gap between a simplified energy model and a more realistic Turner energy model. We used LinearBPDesign to generate seed sequences for RNAinverse, thereby improving the design process in a Turner energy model. To this end, we extended LinearBPDesign to accommodate biseparability and to handle non- or high modulo separable structures by minimalist addition of base pairs. Our study suggests that seeds generated by LinearBPDesign capture long-range interactions, thereby improving the performance of RNAinverse compared to seed focusing on refining the energy model itself. Most surprisingly, a significant number of LinearBPDesign seeds uniquely fold into the target structure in the Turner model, especially when helices are at least of length 2. This observation suggests that the "hardness" of design may arise from the intrinsic properties of the structures themselves. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.

关键词： Inverse problems

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Protein codes promote selective subcellular compartmentalization

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science (New York, N.Y.) 2025年第6738期387卷 1095-1101页

作者： Kilgore, Henry R. Chinn, Itamar Mikhael, Peter G. Mitnikov, Ilan Van Dongen, Catherine Zylberberg, Guy Afeyan, Lena Banani, Salman F. Wilson-Hawken, Susana Lee, Tong Ihn Barzilay, Regina Young, Richard A. Whitehead Institute for Biomedical Research Cambridge MA United States Computer Science and Artificial Intelligence Laboratory Massachusetts Institute of Technology (MIT) Cambridge MA United States Abdul Latif Jameel Clinic for Machine Learning in Health MIT Cambridge MA United States Department of Biology MIT Cambridge MA United States Department of Pathology Brigham and Women's Hospital Harvard Medical School Boston MA United States Computational and Systems Biology Program MIT Cambridge MA United States

Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. In this study, we demonstrate that proteins with shared functions share amino acid sequence codes that guide them to compartment destinations. We developed a protein language model, ProtGPS, that predicts with high performance the compartment localization of human proteins excluded from the training set. ProtGPS successfully guided generation of novel protein sequences that selectively assemble in the nucleolus. ProtGPS identified pathological mutations that change this code and lead to altered subcellular localization of proteins. Our results indicate that protein sequences contain not only a folding code but also a previously unrecognized code governing their distribution to diverse subcellular compartments.

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Enhancing Herbal Medicine-Drug Interaction Prediction Using Large Language Models

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IEEE Journal of Biomedical and Health Informatics 2025年

作者： Yuan, Sisi Zhou, Zhecheng Jin, Xinyuan Zhuo, Linlin Li, Keqin Shenzhen University College of Computer Science and Software Engineering China University of North Carolina Department of Bioinformatics and Computational Biology Charlotte United States Wenzhou University of Technology School of Data Science and Artificial Intelligence Wenzhou325027 China State University of New York Department of Computer Science New York United States

Investigating potential interactions between drugs and herbal medicines helps optimize combined treatment strategies and supports personalized and precision medicine. Deep learning-based methods have been successful in predicting drug-related interactions. However, these methods face challenges such as low data quality and uneven distribution. Large language models (LLMs) effectively address these challenges through their extensive knowledge bases. Motivated by this, we integrate LLMs, one-hot encoding, and variational graph autoencoders (VGAEs) to propose a herbal medicine-drug interaction (HDI) prediction model. First, LLMs are employed to extract features from drug SMILES, generating high-quality molecular representations. Second, one-hot encoding is applied to herbal medicines with multiple natural products to construct feature vectors and improve model interpretability. Finally, VGAEs are utilized to reconstruct herbal medicine-drug graphs and predict unknown HDIs. Additionally, we differentiate between herbal medicine-drug similarity and the degree of individual drug or herbal medicine nodes to mitigate the dominance of high-degree nodes in VGAE message flow. Multiple experiments were conducted to validate the significance of the proposed model and its key components. This method shows great potential for applications in traditional Chinese medicine formulation optimization, new drug development, and precision medicine. Our code and data are accessible at: https://***/sisyyuan/HDI. © 2013 IEEE.

关键词： Prediction models

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