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Underwater image clarifying based on human visual colour constancy using double-opponency

CAAI Transactions on Intelligence technology 2024年第3期9卷 632-648页

作者： Bin Kong Jing Qian Pinhao Song Jing Yang Amir Hussain Institute of Intelligent Machines Chinese Academy of SciencesHefeiChina Peng Cheng Laboratory ShenzhenChina Anhui Key Laboratory of Biomimetic Sensing and Advanced Robot Technology HefeiChina University of Science and Technology of China HefeiChina Peking University Shenzhen Graduate School ShenzhenChina Edinburgh Napier University EdinburghScotland

Underwater images are often with biased colours and reduced contrast because of the absorption and scattering effects when light propagates in *** images with degradation cannot meet the needs of underwater *** main problem in classic underwater image restoration or enhancement methods is that they consume long calcu-lation time,and often,the colour or contrast of the result images is still *** of using the complicated physical model of underwater imaging degradation,we propose a new method to deal with underwater images by imitating the colour constancy mechanism of human vision using ***,the original image is converted to the LMS *** the signals are linearly combined,and Gaussian convolutions are per-formed to imitate the function of receptive fields(RFs).Next,two RFs with different sizes work together to constitute the double-opponency ***,the underwater light is estimated to correct the colours in the *** contrast stretching on the luminance is *** show that the proposed method can obtain clarified underwater images with higher quality than before,and it spends significantly less time cost compared to other previously published typical methods.

关键词： computers computer vision image processing image reconstruction

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A magnetically enabled simulation of microgravity represses the auxin response during early seed germination on a microfluidic platform

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Microsystems & Nanoengineering 2022年第1期8卷 97-109页

作者： Jing Du Lin Zeng Zitong Yu Sihui Chen Xi Chen Yi Zhang Hui Yang Laboratory of Biomedical Microsystems and Nano Devices Center for Bionic Sensing and IntelligenceInstitute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Center for Medical AI Institute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

For plants on Earth,the phytohormone auxin is essential for gravitropism-regulated seedling establishment and plant ***,little is known about auxin responses under microgravity conditions due to the lack of a tool that can provide an alteration of *** this paper,a microfluidic negative magnetophoretic platform is developed to levitate Arabidopsis seeds in an equilibrium plane where the applied magnetic force compensates for gravitational *** the benefit of the microfluidic platform to simulate a microgravity environment on-chip,it is found that the auxin response is significantly repressed in levitated *** microgravity statistically interrupts auxin responses in embryos,even after chemical-mediated auxin alterations,illustrating that auxin is a critical factor that mediates the plant response to gravity ***,pretreatment with an auxin transportation inhibitor(N-1-naphthylphthalamic acid)enables a decrease in the auxin response,which is no longer affected by simulated microgravity,demonstrating that polar auxin transportation plays a vital role in gravity-regulated auxin *** presented microfluidic platform provides simulated microgravity conditions in an easy-to-implement manner,helping to study and elucidate how plants correspond to diverse gravity conditions;in the future,this may be developed into a versatile tool for biological study on a variety of samples.

关键词： magnetic auxin microgravity

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Distance Transform Guided Medical Image Segmentation With Channel Information Exchange 23

Distance Transform Guided Medical Image Segmentation With Ch...

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Proceedings of the 2023 6th International Conference on Algorithms, Computing and Artificial Intelligence

作者： Han Yang Minxia Xu Bin Cai Pengpeng Liang Zhiyong Sun Bo Song Erkang Cheng Laboratory of Bionic Sensing and Advanced Robot Technology Institute of Intelligent Machines Hefei Institutes of Physical Science Chinese Academy of Sciences China and University of Science and Technology of China China Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences China School of Computer and Artificial Intelligence Zhengzhou University China Laboratory of Bionic Sensing and Advanced Robot Technology Institute of Intelligent Machines Hefei Institutes of Physical Science Chinese Academy of Sciences China

ISBN: (纸本)9798400709203

Medical image segmentation plays an important role in the computer-aided screening of many diseases. Different from popular deep learning-based segmentation methods that mainly focus on the whole target, recent studies pay more attention to target contour by making use of the distance transform of the object boundary. In this paper, to learn both the object content and the boundary information, we incorporate a regression task that estimates a distance map of target contour into a CNN-based segmentation network. The segmentation task and the regression task share most parts of the backbone network. Moreover, we introduce a channel information exchange module that dynamically exchanges feature maps between the segmentation and the regression tasks. The proposed information exchange module is parameter-free and controlled by the batch normalization scaling factor. In addition, the output feature maps of the two tasks are further integrated to provide fused segmentation *** evaluate our method on three popular datasets, including the 2D ultrasound thyroid nodule segmentation dataset, the 3D MRI left atrial segmentation dataset and 2017 MM-WHS whole heart segmentation Challenge datasets. Experimental results show that our method achieves promising performance compared to the state-of-the-art approaches.

关键词： channel information exchange distance transform regression medical image segmentation

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Distance Transform Guided Medical Image Segmentation With Channel Information Exchange 6

Distance Transform Guided Medical Image Segmentation With Ch...

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6th International Conference on Algorithms, Computing and Artificial Intelligence, ACAI 2023

作者： Yang, Han Xu, Minxia Cai, Bin Liang, Pengpeng Sun, Zhiyong Song, Bo Cheng, Erkang Laboratory of Bionic Sensing and Advanced Robot Technology Institute of Intelligent Machines Hefei Institutes of Physical Science Chinese Academy of Sciences Anhui Hefei China University of Science and Technology of China Anhui Hefei China Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Zhejiang Hangzhou China School of Computer and Artificial Intelligence Zhengzhou University Henan Zhengzhou China

ISBN: (纸本)9798400709203

关键词： Deep learning

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Encapsulation of Micrornas in Exosomes for Efficient Intracellular Delivery by a Nanofluidic Platform 22

Encapsulation of Micrornas in Exosomes for Efficient Intrace...

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22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023

作者： Yu, Zitong Hao, Rui Chen, Sihui Zhang, Huitao Hu, Shi Ren, Jingyi Hong, Yanhang Liu, Bingrun Zuo, Qisang Yang, Hui Chinese Academy Of Sciences Laboratory Of Biomedical Microsystems And Nano Devices Center For Bionic Sensing And Intelligence Institute Of Biomedical And Health Engineering Shenzhen Institute Of Advanced Technology China SomesTech Co. Ltd. Shenzhen China

ISBN: (纸本)9784886864352

Here we report and validate a new strategy to package RNAs into exosomes using micro- and nanofluidic technology. We propose a nanofluidic constriction-based platform for miRNAs encapsulation into exosomes, referred to as the exosome nanoengineering platform (ExoNP). The device enables over 10 times microRNA-494 (miR494) enrichment in exosomes. When delivered intracellularly via these processed exosomes, the miR494 are biologically active in recipient cells to regulate downstream gene LRG1, further causing the repression of the proteins. Our results provide a proof-of-principle demonstration that the ExoNP can provide a straightforward and robust exogenous loading technique for packaging and intracellular delivery of therapeutic RNA molecules. © 2023 IEEJ.

关键词： Exosome nanoengineering platform Exosomes Intracellular delivery miRNAs encapsulation

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Detection of Molecules Based on Enhanced Backscattering Effect in Microsphere Lens 17

Detection of Molecules Based on Enhanced Backscattering Effe...

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17th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2022

作者： Zhang, Pengcheng Gu, Guoqiang Yu, Zitong Chen, Xi Huo, Xiaoqin Zeng, Lin Wang, Yuye Zhang, Yi Yang, Hui Chinese Academy of Science Laboratory of Biomedical Microsystems and Nano Devices Bionic Sensing and Intelligence Center Institute of Biomedical and Health Engineering Shenzhen Institutes of Advanced Technology Shenzhen China

ISBN: (纸本)9781665483018

Owning to the enhanced backscattering effect in the photonic nanojet, detection approach based on measuring the backscattering signal allows for the detection of micro- and nanoscale objects with single-object resolution. However, this approach fails in the detection of molecules, since the weak light-matter interaction between photonic nanojet and molecules is always insufficient to excite detectable backscattering signal. To address this issue, we employ signal amplification via ternary assembly of lens-aptamer-nanoparticle complex to enhance the backscattering signal triggered by molecules. We show that this approach reveals pronounced enhancement on backscattering signals and therefore allows successive detection of molecules in the solution. This approach provides a step forward in facilitating photonic nanojet towards practical application in the field of highly sensitive detection of bio/chemical molecules. © 2022 IEEE.

关键词： Molecules

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Lipid metabolism analysis in esophageal cancer and associated drug discovery

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Journal of Pharmaceutical Analysis 2024年第1期14卷 1-15页

作者： Ruidi Jiao Wei Jiang Kunpeng Xu Qian Luo Luhua Wang Chao Zhao Bionic Sensing and Intelligence Center Institute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong518000China Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhenGuangdong518116China School of Medicine Southern University of Science and TechnologyShenzhenGuangdong518000China University of Chinese Academy of Sciences Beijing100049China Shenzhen Key Laboratory of Precision Diagnosis and Treatment of Depression Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong518000China

Esophageal cancer is an upper gastrointestinal malignancy with a bleak *** is still being explored in depth due to its complex molecular mechanisms of occurrence and *** play a crucial role in cells by participating in energy supply,biofilm formation,and signal transduction processes,and lipid metabolic reprogramming also constitutes a significant characteristic of malignant *** and more studies have found esophageal cancer has obvious lipid metabolism abnormalities throughout its beginning,progress,and treatment *** inhibition of tumor growth and the enhancement of antitumor therapy efficacy can be achieved through the regulation of lipid ***,we reviewed and analyzed the research results and latest findings for lipid metabolism and associated analysis techniques in esophageal cancer,and comprehensively proved the value of lipid metabolic reprogramming in the evolution and treatment resistance of esophageal cancer,as well as its significance in exploring potential therapeutic targets and biomarkers.

关键词： Lipid metabolism Esophageal cancer Progression Treatment resistance New therapeutic targets

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On-Chip Magnetothermal System for Single Micro-Particle Heating 22

On-Chip Magnetothermal System for Single Micro-Particle Heat...

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22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023

作者： Zeng, Lin Wang, Shengyu Guan, Hongwei Zuo, Qisang Zhang, Yi Yang, Hui Chinese Academy Of Sciences Laboratory Of Biomedical Microsystems And Nano Devices Bionic Sensing And Intelligence Center Institute Of Biomedical And Health Engineering Shenzhen Institute Of Advanced Technology China Chinese Academy Of Sciences Center For Medical Ai Institute Of Biomedical And Health Engineering Shenzhen Institute Of Advanced Technology Shenzhen518055 China Dalian Maritime University Marine Engineering College Dalian116026 China

ISBN: (纸本)9784886864352

A high-efficiency on-chip magnetothermal system is presented in this paper, the system realizes concentration and amplification of magnetic field inside the microfluidic device by means of double magnetic core coils. Compared with existing magnetic hyperthermia or induction heating equipments, this system can generate a significantly stronger magnetic field within the microfluidic device, enabling heating of a single magnetic or metallic particle as small as 100 μm through magnetothermal effect. Thus a temperature gradient field is generated in a local area of the device, which can be utilized in various biological and chemical reactions, as well as sample manipulation. © 2023 IEEJ.

关键词： Core Coil Magnetothermal Microfluidic Device Single Particle

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A MICROFLUIDC SYSTEM FOR LABEL-FREE AND BIO-COMPATIBLE MAGNETIC SEPARATION OF SMALL EXTRACELLULAR VESICLES 26

A MICROFLUIDC SYSTEM FOR LABEL-FREE AND BIO-COMPATIBLE MAGNE...

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26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022

作者： Zeng, Lin Hu, Shi Chen, Xi Zhang, Pengcheng Gu, Guoqiang Wang, Yuye Zhang, Hongpeng Yang, Hui Laboratory of Biomedical Microsystems and Nano Devices Bionic Sensing and Intelligence Center Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced Technology Chinese Academy of Sciences China Marine Engineering College Dalian Maritime University China

ISBN: (纸本)9781733419048

A microfluidic system for label-free and biocompatible magnetic separation of small extracellular vesicles is reported. By using the on-chip magnetic pole arrays, the magnetic field gradient in the microchannel is drastically increased. Therefore, the on-chip negative magnetophoretic separation with nanoscale resolution is realized using the ferrofluid of extremely low concentration. In the experiments, the sEVs are successfully separated from cell culture supernatant, the recovery rate and purity of sEVs are 85.80% and 80.45%, superiorly exceeding the performance that ultracentrifugation method can provide. © 2022 MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.

关键词： Magnetic separation

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Droplet Laplace valve-enabled glaucoma implant for intraocular pressure management

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Droplet 2024年第2期3卷 125-137页

作者： Yuyang Wang Zecong Fang Sen Li Kexin Lin Zhifeng Zhang Junyi Chen Tingrui Pan Center for Intelligent Medical Equipment and Devices(iMED) Institute for Innovative Medical DevicesUniversity of Science and Technology of ChinaHefeiChina Suzhou Institute for Advanced Research University of Science and Technology of ChinaSuzhouChina Department of Precision Machinery and Precision Instrumentation University of Science and Technology of ChinaHefeiChina Bionic Sensing and Intelligence Center(BSIC) Institute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenChina School of Engineering Hangzhou Normal UniversityHangzhouChina School of Biomedical Engineering Division of Life Science and MedicineUniversity of Science and Technology of ChinaHefeiChina Engineering Science and Mechanics Department Penn State UniversityUniversity ParkPennsylvaniaUSA Department of Ophthalmology and Visual Science Eye and ENT HospitalShanghai Medical CollegeFudan UniversityShanghaiChina NHC Key Laboratory of Myopia Chinese Academy of Medical Sciences and Shanghai Key Laboratory of Visual Impairment and Restoration(Fudan University)ShanghaiChina

Glaucoma,the leading cause of irreversible blindness worldwide,is closely linked to aqueous overaccumulation and elevated intraocular pressure(IOP).For refractory glaucoma,aqueous shunts with valves are commonly implanted for effective aqueous drainage control and IOP ***,existing valved glaucoma implants have the disadvantages of inconsistent valve opening/closing pressures,poor long-term repeatability due to their reliance on moving parts,and complex architectures and fabrication ***,we propose a novel valving concept,the droplet Laplace valve(DLV),a three-dimensional printable moving-parts-free microvalve with customizable and consistent threshold valving *** DLV uses a flow discretization unit governed by capillarity,comprising a droplet-forming nozzle,and a separated reservoir to digitize continuous flow into quantifiable *** the classic one-time-use Laplace valves,the DLV's unique design allows for its *** opening pressure is adjustable by varying the nozzle size,like the classic Laplace valves(following the Young–Laplace equation),while the closing pressure can be modified by tuning the separation distance and the reservoir *** DLVs with customizable opening pressures from 5 to 11 mmHg have been demonstrated,with opening/closing pressure differences suppressed down to<0.5 mmHg(<0.15 mmHg under the best conditions).Thanks to its moving-parts-free nature and digitized flow properties,the DLV shows a highly repeatable valving performance(<1.7%,1000 cycles)and a predictable linear flow rate–pressure correlation(R^(2)>0.99).Preliminary ex vivo validation in an enucleated porcine eye confirms the DLV's efficiency in aqueous shunting and prompt IOP *** DLV technology holds great promise in glaucoma implants for IOP management and various microsystems for flow control.

关键词： holds irreversible inconsistent

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