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检索条件"机构=Laboratory of Function-Structure and Protein Engineering"
17 条 记 录,以下是1-10 订阅
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Efficient degradation of azo dyes by an engineered myoglobin with a modified heme active site showing high peroxidase activity
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Process Biochemistry 2025年 156卷 153-163页
作者: Jing-Jing Liu Bin-Bin Jiang Ya-Han Zhu Shu-Qin Gao Ying-Wu Lin School of Chemistry and Chemical Engineering University of South China Hengyang 421001 China Laboratory of Protein Structure and Function University of South China Hengyang 421001 China
Azo dyes, widely used in global textiles, persist in wastewater causing significant ecological and health risks, necessitating efficient degradation to protect ecosystems and public health. The development of artifici...
来源: 评论
Oncoprotein LAMTOR5-mediated CHOP silence via DNA hypermethylation and miR-182/miR-769 in promotion of liver cancer growth
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中国药理学报(英文版) 2024年 第12期45卷 2625-2645页
作者: Xue Wang Qian-qian Li Yan-xin Tang Ye Li Lu Zhang Fei-fei Xu Xue-li Fu Kai Ye Jia-qi Ma Shi-man Guo Fang-yuan Ma Zhi-yu Liu Xu-he Shi Xian-meng Li Hui-min Sun Yue Wu Wei-ying Zhang Li-hong Ye State Key Laboratory of Medicinal Chemical Biology Tianjin Key Laboratory of Protein SciencesDepartment of Biochemistry and Molecular BiologyCollege of Life SciencesNankai UniversityTianjin 300071China State Key Laboratory of Medicinal Chemical Biology Tianjin Key Laboratory of Protein SciencesDepartment of Biochemistry and Molecular BiologyCollege of Life SciencesNankai UniversityTianjin 300071China Chinese Academy of Medical Sciences & Peking Union Medical College Institute of Biomedical Engineering Tianjin 300192China State Key Laboratory of Medicinal Chemical Biology Tianjin Key Laboratory of Protein SciencesDepartment of Biochemistry and Molecular BiologyCollege of Life SciencesNankai UniversityTianjin 300071China Institute of Radiation Medicine Peking Union Medical College & Chinese Academy of Medical SciencesTianjin 300192China State Key Laboratory of Medicinal Chemical Biology Tianjin Key Laboratory of Protein SciencesDepartment of Biochemistry and Molecular BiologyCollege of Life SciencesNankai UniversityTianjin 300071China Center for Cell Structure and Function Shandong Provincial Key Laboratory of Animal Resistance BiologyCollaborative Innovation Center of Cell Biology in Universities of ShandongCollege of Life SciencesShandong Normal UniversityJinan 250014China
C/EBP homologous protein(CHOP)triggers the death of multiple cancers via endoplasmic reticulum(ER)***,the function and regulatory mechanism of CHOP in liver cancer remain *** have reported that late endosomal/lysosoma... 详细信息
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Rational Design of an Artificial Hydrolytic Nuclease by Introduction of A Sodium Copper Chlorophyllin in L29e Myoglobin
SSRN
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SSRN 2022年
作者: Dong, Yao Chen, Yu-Mei Kong, Xiang-Jun Gao, Shu-Qin Lang, Jia-Jia Lin, Ying-Wu Du, Ke-Jie School of Chemistry and Chemical Engineering Laboratory of Protein Structure and Function Hunan Key Laboratory for the Design and Application of Actinide Complexes University of South China Hengyang421001 China
Heme proteins have recently emerged as promising artificial metalloenzymes for catalyzing diverse reactions. In this report, L29E Mb, a single mutant of myoglobin, was reconstituted with a sodium copper cholorophyllin... 详细信息
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Novel Copper Complexes with Tridentate Ligand: Synthesis, Crystal structure, DNA Binding and Anticancer Studies
SSRN
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SSRN 2023年
作者: Chen, Yu-Mei Liu, Yu-Can Wang, Jin-Quan Ou, Guang-Chuan Wang, Xiao-Feng Gao, Shu-Qin Lin, Ying-Wu Du, Ke-Jie School of Chemistry and Chemical Engineering Laboratory of Protein Structure and Function Hunan Key Laboratory for the Design and Application of Actinide Complexes University of South China Hengyang421001 China School of Biosciences & Biopharmaceutics Guangdong Pharmaceutical University Guangzhou510000 China Department of Biology and Chemistry Hunan University of Science and Engineering Yongzhou425199 China
Metal complexes, particularly copper (II) complexes, are often used as anticancer drugs due to their ability to generate reactive oxygen species (ROS) in cells. Four copper (II) complexes were designed based on ligand... 详细信息
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Effects of Naturally Occurring S47f/A Mutations on the structure and function of Human Cytochrome C
SSRN
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SSRN 2023年
作者: Long, Shuang-Shuang Li, Yan-Yan Yu, Lu Liu, Ao-Kun Gao, Shu-Qin Tan, Xiangshi Lin, Ying-Wu School of Chemistry and Chemical Engineering University of South China Hengyang421001 China High Magnetic Field Laboratory Chinese Academy of Sciences Anhui Hefei230031 China Key Lab of Protein Structure and Function of Universities in Hunan Province University of South China Hengyang421001 China Department of Chemistry Institute of Biomedical Science Fudan University Shanghai200433 China
The sequence and structure of human cytochrome c (hCyt c) exhibit evolutionary conservations, with only a limited number of naturally occurring mutations in humans. Herein, we investigated the effects of naturally occ... 详细信息
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Crystal enigma: Understanding diverse protein conformational dynamics, ligand selectivity and interaction in multi-space group crystals using computational modelling
Results in Chemistry
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Results in Chemistry 2025年 16卷
作者: Mfeka, Mbalenhle Onisuru, Olalekan Pandian, Ramesh Sayed, Yasien Khoza, Thandeka Achilonu, Ikechukwu Department of Biochemistry School of Life Sciences College of Agriculture Engineering & Science University of KwaZulu-Natal Pietermaritzburg 3209 South Africa Protein Structure-Function and Research Laboratory School of Molecular and Cell Biology Faculty of Science University of the Witwatersrand Braamfontein Johannesburg 2000 South Africa
Empirical structural methods have been instrumental in drug design, but they often fall short of capturing protein dynamics. To address this limitation, computer-aided drug design (CADD) is essential. Given that Schis... 详细信息
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Rational design of functional metalloenzymes in myoglobin for green biocatalysis
Rational design of functional metalloenzymes in myoglobin fo...
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作者: Ying-Wu Lin School of Chemistry and Chemical Engineering University of South China Laboratory of Protein Structure and Function University of South China
Design of functional metalloenzymes have addressed much attention in the last decade. Myoglobin(Mb) is an ideal model protein for heme protein design, and we have rationally designed some functional enzymes in Mb by u... 详细信息
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Rational design of functional metalloenzymes in myoglobin for green biocatalysis
Rational design of functional metalloenzymes in myoglobin fo...
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中国化学会第六届全国生物物理化学会议(NCBPC-6)
作者: 林英武 School of Chemistry and Chemical Engineering University of South China Laboratory of Protein Structure and Function University of South China
Design of functional metalloenzymes have addressed much attention in the last decade. Myoglobin(Mb) is an ideal model protein for heme protein design, and we have rationally designed some functional enzymes in Mb by... 详细信息
来源: 评论
Interfacial engineering-tailored Mn-clay-based Nanozyme for Glyphosate Laccase-amplified Sensing and Inhibitor Screening
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Biosensors and Bioelectronics 2025年
作者: Sheng-Tao Wu Pei-Qiong Zhou Hui-Min Chen Zhou Zhan Ke Zeng Zhi-Yu Qiu Yi-Jia Zheng Zhan-Bing Wei Xiang-Heng Niu Zhen Fang Ying-Wu Lin School of Chemistry and Chemical Engineering University of South China Hengyang 421001 China Hunan Key Laboratory of Typical Environmental Pollution and Health Hazards School of Public Health Hengyang Medical School University of South China Hengyang 421001 China College of Chemistry and Materials Science Anhui Normal University Wuhu 241000 China Lab of Protein Structure and Function University of South China Medical School Hengyang 421001 China
Monitoring pesticide residues and lanthanide metals in water system is crucial for safeguarding human health and environmental integrity. Herein, we precisely designed a type of Mn-clay-based composite nanozyme via in...
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Steric Effect Modulating the structures of Trinuclear Zinc Carboxylate Frameworks
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Chinese Journal of Structural Chemistry 2016年 第9期35卷 1413-1419页
作者: 孙允凯 谢睿 王小峰 文格波 林英武 School of Chemistry and Chemical Engineering University of South China Laboratory of Protein Structure and Function University of South China
By the reaction of different aromatic dicarboxylic acid with zinc nitrate, three metal-carboxylate frameworks, [Zn3(BDC)3(EtOH)2](1), [Zn3(BDC)3(py)2]·2DMF(2), and [Zn3(NH2-BDC)3(H2O)2]·5DMF... 详细信息
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