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检索条件"机构=Laboratory of Functional Genomics and Bioinformatics"
106 条 记 录,以下是1-10 订阅
排序:
Developing a pipeline for identification,characterization and molecular editing of cis-regulatory elements:a case study in potato
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aBIOTECH 2025年 第1期6卷 91-96页
作者: Min Wan Handan Xie Hongwei Guo Shenglin Jing Deying Zeng Bing Li Bo Zhu Zixian Zeng Department of Biological Science College of Life SciencesSichuan Normal UniversityChengdu 610101China Plant Functional Genomics and Bioinformatics Research Center Sichuan Normal UniversityChengdu 610101China Crop Research Institute Environment-Friendly Crop Germplasm Innovation and Genetic Improvement Key Laboratory of Sichuan ProvinceSichuan Academy of Agricultural SciencesChengdu 610066China
Crop breeding requires a balance of tradeoffs among key agronomic traits caused by gene *** molecular manipulation of genes can effectively improve target traits,but this may not reduce gene pleiotropy,potentially lea... 详细信息
来源: 评论
ConsensuSV-ONT – A modern method for accurate structural variant calling
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Scientific Reports 2025年 第1期15卷 1-9页
作者: Pietryga, Antoni Chiliński, Mateusz Gadakh, Sachin Plewczynski, Dariusz Laboratory of Bioinformatics and Computational Genomics Faculty of Mathematics and Information Science Warsaw University of Technology Warsaw Poland Faculty of Electrical Engineering Warsaw University of Technology Warsaw Poland Laboratory of Functional and Structural Genomics Centre of New Technologies University of Warsaw Warsaw Poland Section for Computational and RNA Biology Department of Biology University of Copenhagen Copenhagen Denmark
Improvements in sequencing technology make the development of new tools for detection of structural variance more and more common. However, since the tools available for the long-read Oxford Nanopore sequencing are li...
来源: 评论
Characterizing somatic mutations in ovarian cancer germline risk regions
Communications Biology
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Communications Biology 2025年 第1期8卷 1-9页
作者: Lai, Ping-Hung Tyrer, Jonathan P. Pharoah, Paul Gayther, Simon A. Jones, Michelle R. Peng, Pei-Chen Department of Computational Biomedicine Cedars-Sinai Medical Center West Hollywood CA United States CR-UK Department of Oncology University of Cambridge Strangeways Research Laboratory Cambridge United Kingdom Center for Inherited Oncogenesis Department of Medicine UT Health San Antonio San Antonio TX United States Center for Bioinformatics and Functional Genomics Department of Biomedical Sciences Cedars-Sinai Medical Center Los Angeles CA United States
Epithelial ovarian cancer (EOC) genetics research has been focused on germline or somatic mutations independently. Emerging evidence suggests that the somatic mutational landscape can be shaped by the germline genetic...
来源: 评论
Non-coding Transcripts from Enhancers:New Insights into Enhancer Activity and Gene Expression Regulation
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genomics, Proteomics & bioinformatics 2017年 第3期15卷 201-207页
作者: Hongjun Chen Guangshi Du Xu Song Ling Li Center for Functional Genomics and Bioinformatics Key Laboratory of Bio-Resources and Eco-Environment of Ministry of EducationCollege of Life ScienceSichuan University State Key Laboratory of Biotherapy West China HospitalSichuan University
Long non-coding RNAs (lncRNAs) have gained widespread interest in the past decade owing to their enormous amount and surprising functions implicated in a variety of biological pro- cesses. Some lncRNAs exert functio... 详细信息
来源: 评论
Long non-coding RNA-guided regulation in organisms
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Science China(Life Sciences) 2013年 第10期56卷 891-896页
作者: QI WenChuan SONG Xu LI Ling Center for Functional Genomics and Bioinformatics Key Laboratory of Bio-Resources and Eco-Environment of Ministry of EducationCollege of Life ScienceSichuan University State Key Laboratory of Biotherapy West China HospitalSichuan University
It is clear that RNA is more than just a messenger between gene and *** mammalian genome is pervasively transcribed,giving rise to tens of thousands of non-coding *** all of these transcripts are functional remains to... 详细信息
来源: 评论
Dormancy heterogeneity among Arabidopsis thaliana seeds is linked to individual seed size
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Plant Communications 2024年 第2期5卷 215-227页
作者: Michal Krzyszton Sebastian P.Sacharowski Veena Halale Manjunath Katarzyna Muter Grzegorz Bokota Ce Wang Dariusz Plewczynski Tereza Dobisova Szymon Swiezewski Laboratory of Seeds Molecular Biology Institute of Biochemistry and BiophysicsPAS02-106 WarsawPoland Laboratory of Functional and Structural Genomics Centre of New TechnologiesUniversity of WarsawWarsawPoland Laboratory of Bioinformatics and Computational Genomics Faculty of Mathematics and Information ScienceWarsaw University of TechnologyWarsawPoland Labdeers Ltd. 680-01 BoskoviceCzech Republic
Production of morphologically and physiologically variable seeds is an important strategy that helps plants to survive in unpredictable natural ***,the model plant Arabidopsis thaliana and most agronomically essential... 详细信息
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The Non-Coding RNA Llme23 Drives the Malignant Property of Human Melanoma Cells
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Journal of Genetics and genomics 2013年 第4期40卷 179-188页
作者: Chuan-Fang Wu Guang-Hong Tan Cheng-Chuan Ma Ling Li Center for Functional Genomics and Bioinformatics Ministry of EducationKey Laboratory for Bio-Resource and Eco-EnvironmentCollege of Life ScienceSichuan University Hainan Provincial Key Laboratory of Tropical Medicine Hainan Medical College Center for Functional Genomics and Bioinformatics Ministry of EducationKey Laboratory for Bio-Resource and Eco-EnvironmemCollege of Life ScienceSichuan University
Several lines of evidence support the notion that increased RNA-binding ability of polypyrimidine tract-binding(PTB) proteinassociated splicing factor(PSF) and aberrant expression of long non-coding RNAs(IncRNAs... 详细信息
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Design and in vitro evaluation of novel tetrazole derivatives of dianisidine as anticancer agents targeting Bcl-2 apoptosis regulator
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Scientific Reports 2025年 第1期15卷 1-16页
作者: Wioletta Olejarz Karol Sadowski Piotr Roszkowski Anna Bielenica Marta Struga Daniel Szulczyk Maciej Wiśniewski Department of Biochemistry and Pharmacogenomics Faculty of Pharmacy Medical University of Warsaw 02-097 Warsaw Poland Centre for Preclinical Research Medical University of Warsaw 02-097 Warsaw Poland Faculty of Chemistry University of Warsaw Pasteura 1 02-093 Warszawa Poland Department of Biochemistry Medical University of Warsaw 02-097 Warsaw Poland Laboratory of Bioinformatics and Computational Genomics Faculty of Mathematics and Information Science Warsaw University of Technology Warsaw Poland Laboratory of Functional and Structural Genomics Centre of New Technologies University of Warsaw Warsaw Poland
This study examines the synthesis and biological evaluation of novel tetrazole derivatives of 3,3′-dimethoxybenzidine as potential anticancer agents, focusing on their cytotoxic, apoptotic, and anti-inflammatory prop... 详细信息
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Coagulation factors Ⅶ, Ⅸ and Ⅹ are effective antibacterial proteins against drug-resistant Gram-negative bacteria
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细胞研究(英文版) 2019年 第9期29卷 711-724页
作者: Jinwu Chen Xiaojie Li Ling Li Ting Zhang Qing Zhang Fangming Wu Diyue Wang Hongze Hu Changlin Tian Dongsheng Liao Liang Zhao Danxia Song Yongyun Zhao Chuanfang Wu Xu Song Center for Functional Genomics and Bioinformatics Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education College of Life Sciences Sichuan University Chengdu 610064 Sichuan China Center for Functional Genomics and Bioinformatics Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education College of Life Sciences Sichuan University Chengdu 610064 Sichuan China State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu 610041 Sichuan China High Magnetic Field Laboratory Chinese Academy of Sciences Hefei 230031 Anhui China CAS key Laboratory of Soft Matter Chemistry Department of Chemistry University of Science and Technology of China Hefei 230026 Anhui China High Magnetic Field Laboratory Chinese Academy of Sciences Hefei 230031 Anhui China Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences University of Science and Technology of China Hefei 230026 Anhui China
Infections caused by drug-resistant "superbugs" pose an urgent public health threat due to the lack of effective drugs;however,certain mammalian proteins with intrinsic antibacterial activity might be ***,we... 详细信息
来源: 评论
Aptamer blocking S-TLR4 interaction selectively inhibits SARS-CoV-2 induced inflammation
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Signal Transduction and Targeted Therapy 2022年 第5期7卷 1383-1385页
作者: Gang Yang Shengnan Zhang Yuchun Wang Ling Li Yu Li Deyu Yuan Fatao Luo Jincun Zhao Xu Song Yongyun Zhao Center for Functional Genomics and Bioinformatics College of Life ScienceSichuan UniversityChengduSichuan 610064P.R.China State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory DiseaseThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510182China
Excessive inflammatory responses lead to increased mortality from the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Nearly all deceased patients infected with SARS-CoV-2 are found to have cytokine storm ... 详细信息
来源: 评论